Published in Development on December 01, 2009
Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer (2012) 6.82
Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant. PLoS Biol (2012) 2.75
Development and applications of single-cell transcriptome analysis. Nat Methods (2011) 2.62
Highly multiplexed and strand-specific single-cell RNA 5' end sequencing. Nat Protoc (2012) 2.21
Single cell genomics: advances and future perspectives. PLoS Genet (2014) 2.16
NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment. Cell Stem Cell (2012) 2.15
Deconstructing transcriptional heterogeneity in pluripotent stem cells. Nature (2014) 1.91
Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One (2011) 1.82
Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells. Mol Cell (2016) 1.61
Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. PLoS One (2014) 1.58
Human haematopoietic stem cell lineage commitment is a continuous process. Nat Cell Biol (2017) 1.52
Nonequilibrium population dynamics of phenotype conversion of cancer cells. PLoS One (2014) 1.41
OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. EMBO J (2012) 1.23
A deterministic map of Waddington's epigenetic landscape for cell fate specification. BMC Syst Biol (2011) 1.21
Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Curr Biol (2011) 1.18
Adaptability of non-genetic diversity in bacterial chemotaxis. Elife (2014) 1.07
Cell lineage determination in state space: a systems view brings flexibility to dogmatic canonical rules. PLoS Biol (2010) 1.06
Episensitization: Defying Time's Arrow. Front Oncol (2015) 1.04
Dynamical systems approach to endothelial heterogeneity. Circ Res (2012) 1.03
Hard-wired heterogeneity in blood stem cells revealed using a dynamic regulatory network model. Bioinformatics (2013) 1.02
Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal. Cancer Cell Int (2013) 1.01
Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: 'What does not kill me strengthens me'. Br J Cancer (2015) 0.99
In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay. Nat Protoc (2013) 0.99
Systems biology of stem cells: three useful perspectives to help overcome the paradigm of linear pathways. Philos Trans R Soc Lond B Biol Sci (2011) 0.99
Transcriptional profiles of bovine in vivo pre-implantation development. BMC Genomics (2014) 0.97
High throughput ratio imaging to profile caspase activity: potential application in multiparameter high content apoptosis analysis and drug screening. PLoS One (2011) 0.95
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle (2015) 0.95
Conceptualizing a tool to optimize therapy based on dynamic heterogeneity. Phys Biol (2012) 0.93
Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions. Development (2014) 0.92
Adaptive transcriptional dynamics of A2 neurons and central cardiovascular control pathways. Exp Physiol (2011) 0.90
RNA Sequencing and Analysis. Cold Spring Harb Protoc (2015) 0.90
Stochastic fluctuations and distributed control of gene expression impact cellular memory. PLoS One (2014) 0.89
Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration. Front Physiol (2012) 0.89
Whole-mount single molecule FISH method for zebrafish embryo. Sci Rep (2015) 0.88
Deconstructing stem cell population heterogeneity: single-cell analysis and modeling approaches. Biotechnol Adv (2013) 0.88
DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells. Cell Cycle (2012) 0.88
Chromatin features and the epigenetic regulation of pluripotency states in ESCs. Development (2014) 0.88
Imaging flow cytometry: coping with heterogeneity in biological systems. J Histochem Cytochem (2012) 0.88
A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity. Nat Commun (2016) 0.87
Single-cell sequencing in stem cell biology. Genome Biol (2016) 0.85
Tools for Single-Cell Kinetic Analysis of Virus-Host Interactions. PLoS One (2016) 0.85
Stochastic simulation in systems biology. Comput Struct Biotechnol J (2014) 0.85
What Population Reveals about Individual Cell Identity: Single-Cell Parameter Estimation of Models of Gene Expression in Yeast. PLoS Comput Biol (2016) 0.84
Affinity and competition for TBP are molecular determinants of gene expression noise. Nat Commun (2016) 0.84
Visualizing the appearance and disappearance of the attractor of differentiation using Raman spectral imaging. Sci Rep (2015) 0.83
Single-cell gene expression profiling and cell state dynamics: collecting data, correlating data points and connecting the dots. Curr Opin Biotechnol (2016) 0.83
Populational heterogeneity vs. temporal fluctuation in Escherichia coli flagellar motor switching. Biophys J (2013) 0.82
Single cell studies of mouse embryonic stem cell (mESC) differentiation by electrical impedance measurements in a microfluidic device. Biosens Bioelectron (2016) 0.82
Transcript profiling of individual twin blastomeres derived by splitting two-cell stage murine embryos. Biol Reprod (2010) 0.82
Multiclass classification of microarray data samples with a reduced number of genes. BMC Bioinformatics (2011) 0.82
Endogenous molecular network reveals two mechanisms of heterogeneity within gastric cancer. Oncotarget (2015) 0.82
Transcriptional mechanisms of cell fate decisions revealed by single cell expression profiling. Bioessays (2014) 0.82
Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development. PLoS Genet (2015) 0.82
Modelling emergence of oscillations in communicating bacteria: a structured approach from one to many cells. J R Soc Interface (2013) 0.82
The function of chromatin modifiers in lineage commitment and cell fate specification. FEBS J (2014) 0.81
Emerging concepts promising new horizons for marine biodiscovery and synthetic biology. Mar Drugs (2015) 0.80
Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression. Proc Natl Acad Sci U S A (2015) 0.80
Stochastic dynamics of interacting haematopoietic stem cell niche lineages. PLoS Comput Biol (2014) 0.80
Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process. PLoS Biol (2016) 0.80
Transcription factor-based biosensors in biotechnology: current state and future prospects. Appl Microbiol Biotechnol (2015) 0.79
Hes1 oscillations contribute to heterogeneous differentiation responses in embryonic stem cells. Genes (Basel) (2011) 0.79
Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock. Elife (2016) 0.79
Global genetic response in a cancer cell: self-organized coherent expression dynamics. PLoS One (2014) 0.78
Generalized principles of stochasticity can be used to control dynamic heterogeneity. Phys Biol (2012) 0.78
A microchip platform for interrogating tumor-macrophage paracrine signaling at the single-cell level. Lab Chip (2014) 0.78
A millifluidic study of cell-to-cell heterogeneity in growth-rate and cell-division capability in populations of isogenic cells of Chlamydomonas reinhardtii. PLoS One (2015) 0.78
Long-term sphere culture cannot maintain a high ratio of cancer stem cells: a mathematical model and experiment. PLoS One (2011) 0.78
Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaques. BMC Biol (2015) 0.77
Lifetime Distributions from Tracking Individual BC3H1 Cells Subjected to Yessotoxin. Front Bioeng Biotechnol (2015) 0.77
Label-free imaging to study phenotypic behavioural traits of cells in complex co-cultures. Sci Rep (2016) 0.76
Unsupervised lineage-based characterization of primate precursors reveals high proliferative and morphological diversity in the OSVZ. J Comp Neurol (2015) 0.76
Distributions of reproductive and somatic cell numbers in diverse Volvox (Chlorophyta) species. Evol Ecol Res (2012) 0.76
Challenges and Opportunities to Harnessing the (Hematopoietic) Stem Cell Niche. Curr Stem Cell Rep (2016) 0.76
On the limitations of biological knowledge. Curr Genomics (2012) 0.76
Modeling epigenetic regulation of PRC1 protein accumulation in the cell cycle. Biol Direct (2015) 0.75
A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. J Biomol Screen (2016) 0.75
Bistable Epigenetic States Explain Age-Dependent Decline in Mesenchymal Stem Cell Heterogeneity. Stem Cells (2016) 0.75
Image-predicated sorting of adherent cells using photopatterned hydrogels. Adv Healthc Mater (2012) 0.75
Droplet Microarray Based on Superhydrophobic-Superhydrophilic Patterns for Single Cell Analysis. Microarrays (Basel) (2016) 0.75
Dynamic monitoring of single cell lysis in an impedance-based microfluidic device. Biomed Microdevices (2016) 0.75
The evolution of heterogeneities altered by mutational robustness, gene expression noise and bottlenecks in gene regulatory networks. PLoS One (2014) 0.75
Differential variability and correlation of gene expression identifies key genes involved in neuronal differentiation. BMC Syst Biol (2015) 0.75
Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging. Genetics (2016) 0.75
A dynamic picture of protein behavior in cells. Nat Biotechnol (2015) 0.75
Dichotomous noise models of gene switches. J Chem Phys (2015) 0.75
A metric and workflow for quality control in the analysis of heterogeneity in phenotypic profiles and screens. Methods (2015) 0.75
Phenotypic Plasticity and Cell Fate Decisions in Cancer: Insights from Dynamical Systems Theory. Cancers (Basel) (2017) 0.75
Integrated time-lapse and single-cell transcription studies highlight the variable and dynamic nature of human hematopoietic cell fate commitment. PLoS Biol (2017) 0.75
Evolution viewed from physics, physiology and medicine. Interface Focus (2017) 0.75
Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov (2017) 0.75
Chromatin modifications and their function. Cell (2007) 55.98
Stochastic gene expression in a single cell. Science (2002) 34.54
Genetic instabilities in human cancers. Nature (1998) 22.76
The energy landscapes and motions of proteins. Science (1991) 18.93
Bacterial persistence as a phenotypic switch. Science (2004) 15.80
Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet (2005) 14.39
ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON. Proc Natl Acad Sci U S A (1957) 14.34
Metabolic stability and epigenesis in randomly constructed genetic nets. J Theor Biol (1969) 13.14
Nanog safeguards pluripotency and mediates germline development. Nature (2007) 13.01
Nature, nurture, or chance: stochastic gene expression and its consequences. Cell (2008) 12.13
Summing up the noise in gene networks. Nature (2004) 9.62
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30
Epigenetics: a landscape takes shape. Cell (2007) 8.29
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature (2008) 7.60
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature (2009) 7.24
Variability and memory of protein levels in human cells. Nature (2006) 6.15
Non-genetic individuality: chance in the single cell. Nature (1976) 5.52
Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell (2008) 5.47
Dynamic proteomics of individual cancer cells in response to a drug. Science (2008) 5.43
Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc Natl Acad Sci U S A (2006) 5.21
Capturing pluripotency. Cell (2008) 5.08
Single-cell gene expression profiling. Science (2002) 5.07
Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol (2009) 4.60
A mutator phenotype in cancer. Cancer Res (2001) 4.41
Stochasticity and cell fate. Science (2008) 4.39
A heterogeneous expression pattern for Nanog in embryonic stem cells. Stem Cells (2007) 4.04
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science (2002) 3.93
Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett (2005) 3.90
Stochastic patterning in the mouse pre-implantation embryo. Development (2007) 3.83
Bifurcation dynamics in lineage-commitment in bipotent progenitor cells. Dev Biol (2007) 3.49
Gene network shaping of inherent noise spectra. Nature (2006) 3.25
A genomewide oscillation in transcription gates DNA replication and cell cycle. Proc Natl Acad Sci U S A (2004) 3.23
On the use of the word 'epigenetic'. Curr Biol (2007) 3.21
Origins of extrinsic variability in eukaryotic gene expression. Nature (2005) 3.18
Homeostasis and differentiation in random genetic control networks. Nature (1969) 3.13
Stem cell states, fates, and the rules of attraction. Cell Stem Cell (2009) 2.96
Stochastic gene expression: from single molecules to the proteome. Curr Opin Genet Dev (2007) 2.81
Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications. Clin Immunol (2004) 2.69
Non-genetic heterogeneity--a mutation-independent driving force for the somatic evolution of tumours. Nat Rev Genet (2009) 2.69
Heterogeneity of embryonic and adult stem cells. Cell Stem Cell (2008) 2.57
Potential landscape and flux framework of nonequilibrium networks: robustness, dissipation, and coherence of biochemical oscillations. Proc Natl Acad Sci U S A (2008) 2.43
Reprogramming cell fates: reconciling rarity with robustness. Bioessays (2009) 2.38
Adaptive response of a gene network to environmental changes by fitness-induced attractor selection. PLoS One (2006) 2.30
The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev (2009) 2.19
Differentiation plasticity of hematopoietic cells. Blood (2002) 2.17
Heritable stochastic switching revealed by single-cell genealogy. PLoS Biol (2007) 2.11
Imaging stem-cell-driven regeneration in mammals. Nature (2008) 1.99
Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo. Nat Rev Genet (2009) 1.94
Hematopoiesis and stem cells: plasticity versus developmental heterogeneity. Nat Immunol (2002) 1.90
Absolute rate theories of epigenetic stability. Proc Natl Acad Sci U S A (2005) 1.89
Epigenetics as a first exit problem. Phys Rev Lett (2002) 1.89
How does intracellular Ca2+ oscillate: by chance or by the clock? Biophys J (2007) 1.60
Multistable and multistep dynamics in neutrophil differentiation. BMC Cell Biol (2006) 1.56
Potency and fate specification in CNS stem cell populations in vitro. Cell Stem Cell (2008) 1.54
Evolution of robustness to noise and mutation in gene expression dynamics. PLoS One (2007) 1.51
Conrad Hal Waddington: the last Renaissance biologist? Nat Rev Genet (2002) 1.51
How many mutations in a cancer? Am J Pathol (2002) 1.37
The changing concept of epigenetics. Ann N Y Acad Sci (2002) 1.36
Quantitative approaches in developmental biology. Nat Rev Genet (2009) 1.34
Dynamic changes in prolactin promoter activation in individual living lactotrophic cells. Endocrinology (1998) 1.34
Systems biology. Attractors and democratic dynamics. Science (2009) 1.27
The coming Kuhnian revolution in biology. Nat Biotechnol (1997) 1.20
Theory of robustness of irreversible differentiation in a stem cell system: chaos hypothesis. J Theor Biol (2001) 1.18
The origin of phenotypic heterogeneity in a clonal cell population in vitro. PLoS One (2007) 1.16
How transcription factors program chromatin--lessons from studies of the regulation of myeloid-specific genes. Semin Immunol (2008) 0.99
Using cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation. BMC Syst Biol (2009) 0.99
Inheritance systems and the evolution of new levels of individuality. J Theor Biol (1994) 0.98
Stochastic and deterministic simulations of heterogeneous cell population dynamics. J Theor Biol (2006) 0.97
Epigenesis: the missing beat in biotechnology? Biotechnology (N Y) (1994) 0.89
Stochasticity in single gene expression with both intrinsic noise and fluctuation in kinetic parameters. J Theor Biol (2008) 0.89
Plasticity revisited. Curr Opin Cell Biol (2002) 0.88
Resolving cell population heterogeneity: real-time PCR for simultaneous multiplexed gene detection in multiple single-cell samples. PLoS One (2009) 0.87
Maintenance of multiplication rate stability by cell populations in the face of heterogeneity among individual cells. J Cell Sci (1988) 0.84
Mechanisms for enduring biological change. Am J Physiol (1992) 0.81
Poincaré resonances and the limits of trajectory dynamics. Proc Natl Acad Sci U S A (1993) 0.78