Published in Cell on February 23, 2007
Effect of in utero and early-life conditions on adult health and disease. N Engl J Med (2008) 14.46
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity (2009) 9.73
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90
Next-generation genomics: an integrative approach. Nat Rev Genet (2010) 5.88
Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell (2009) 5.74
Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13
The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer (2012) 4.97
Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly. Cell (2008) 3.96
Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J Neurosci (2008) 3.86
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 3.52
The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS One (2009) 3.41
Chemical probes for histone-modifying enzymes. Nat Chem Biol (2008) 3.30
Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat Rev Endocrinol (2009) 3.25
Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer (2013) 3.23
A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome. Cell (2008) 3.10
Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell (2013) 3.09
Retracted DNA demethylation in hormone-induced transcriptional derepression. Nature (2009) 2.90
HIV latency. Cold Spring Harb Perspect Med (2011) 2.90
Non-genetic heterogeneity of cells in development: more than just noise. Development (2009) 2.48
Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci (2010) 2.39
Histone methylation regulates memory formation. J Neurosci (2010) 2.30
MEDME: an experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment. Genome Res (2008) 2.28
The epigenetics of sex differences in the brain. J Neurosci (2009) 2.25
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology (2009) 2.17
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol (2008) 2.14
Genome-wide screen of promoter methylation identifies novel markers in melanoma. Genome Res (2009) 2.13
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. Genome Res (2011) 2.07
Manifestations and mechanisms of stem cell aging. J Cell Biol (2011) 1.93
Dynamics of inner kinetochore assembly and maintenance in living cells. J Cell Biol (2008) 1.84
Examining histone posttranslational modification patterns by high-resolution mass spectrometry. Methods Enzymol (2012) 1.83
Mitotic bookmarking of genes: a novel dimension to epigenetic control. Nat Rev Genet (2010) 1.76
Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer. Pancreatology (2009) 1.76
Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet (2009) 1.76
Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. Mol Cell (2010) 1.73
Tolerance and exhaustion: defining mechanisms of T cell dysfunction. Trends Immunol (2013) 1.70
Genomic approaches towards finding cis-regulatory modules in animals. Nat Rev Genet (2012) 1.65
Helper T cell diversity and plasticity. Curr Opin Immunol (2012) 1.63
Dynamics of B cells in germinal centres. Nat Rev Immunol (2015) 1.61
The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression. Dev Cell (2013) 1.60
The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis. Epigenetics Chromatin (2009) 1.59
Transgenerational epigenetic inheritance in plants. Biochim Biophys Acta (2011) 1.58
Epigenetic control of skull morphogenesis by histone deacetylase 8. Genes Dev (2009) 1.55
Environmental epigenetics of asthma: an update. J Allergy Clin Immunol (2010) 1.53
The epigenetic landscape of addiction. Ann N Y Acad Sci (2011) 1.51
A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A. Nat Cell Biol (2010) 1.49
Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol (2016) 1.49
Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease. Mol Cell Proteomics (2015) 1.49
MSRE-HTPrimer: a high-throughput and genome-wide primer design pipeline optimized for epigenetic research. Clin Epigenetics (2016) 1.48
Interventions to Slow Aging in Humans: Are We Ready? Aging Cell (2015) 1.46
Human RNA methyltransferase BCDIN3D regulates microRNA processing. Cell (2012) 1.46
Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia. Sci Transl Med (2015) 1.44
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation. Genes Dev (2012) 1.43
Small RNA-directed epigenetic natural variation in Arabidopsis thaliana. PLoS Genet (2008) 1.43
Genome-environment interactions that modulate aging: powerful targets for drug discovery. Pharmacol Rev (2011) 1.42
Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation. Respir Res (2009) 1.35
Epigenetic control of sexual differentiation of the bed nucleus of the stria terminalis. Endocrinology (2009) 1.35
Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming. Nat Cell Biol (2012) 1.35
The dynamic nature of eukaryotic genomes. Mol Biol Evol (2008) 1.32
Quantitative proteomic analysis of histone modifications. Chem Rev (2015) 1.32
Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl Psychiatry (2012) 1.31
A native chromatin purification system for epigenomic profiling in Caenorhabditis elegans. Nucleic Acids Res (2009) 1.30
Epigenetics meets endocrinology. J Mol Endocrinol (2011) 1.30
Definition, conservation and epigenetics of housekeeping and tissue-enriched genes. BMC Genomics (2009) 1.30
Genome-wide analysis reveals gene expression and metabolic network dynamics during embryo development in Arabidopsis. Plant Physiol (2011) 1.29
Dynamic changes in gene expression during human early embryo development: from fundamental aspects to clinical applications. Hum Reprod Update (2010) 1.28
Quantitative proteomic analyses of influenza virus-infected cultured human lung cells. J Virol (2010) 1.27
Chromatin-mediated epigenetic regulation in the malaria parasite Plasmodium falciparum. Eukaryot Cell (2010) 1.26
Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays. Epigenetics (2011) 1.26
Aging by epigenetics--a consequence of chromatin damage? Exp Cell Res (2008) 1.25
Programmed heterogeneity: epigenetic mechanisms in bacteria. J Biol Chem (2013) 1.25
Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes. Cell Stem Cell (2014) 1.25
Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol (2015) 1.24
Control of cell identity in pancreas development and regeneration. Gastroenterology (2013) 1.24
Aging and epigenetics: longitudinal changes in gene-specific DNA methylation. Epigenetics (2012) 1.23
Metaphors in search of a target: the curious case of epigenetics. New Genet Soc (2015) 1.23
Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol (2011) 1.22
Stochasticity and the molecular mechanisms of induced pluripotency. PLoS One (2008) 1.20
The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. Nutr Rev (2008) 1.20
Yeast CAF-1 assembles histone (H3-H4)2 tetramers prior to DNA deposition. Nucleic Acids Res (2012) 1.18
Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition. PLoS One (2011) 1.18
The future of human DNA vaccines. J Biotechnol (2012) 1.18
Immunohistochemical Analysis of Histone H3 Modifications in Germ Cells during Mouse Spermatogenesis. Acta Histochem Cytochem (2011) 1.17
Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion. Proc Natl Acad Sci U S A (2010) 1.17
Profiling RE1/REST-mediated histone modifications in the human genome. Genome Biol (2009) 1.16
Genome-wide epigenetic data facilitate understanding of disease susceptibility association studies. J Biol Chem (2012) 1.15
Bookmarking the genome: maintenance of epigenetic information. J Biol Chem (2011) 1.15
Epigenetic regulation in mammalian preimplantation embryo development. Reprod Biol Endocrinol (2009) 1.15
Functional roles of gangliosides in neurodevelopment: an overview of recent advances. Neurochem Res (2012) 1.14
Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach. Elife (2014) 1.13
Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. Age (Dordr) (2014) 1.12
HP1 promotes tumor suppressor BRCA1 functions during the DNA damage response. Nucleic Acids Res (2013) 1.11
Assisted reproduction treatment and epigenetic inheritance. Hum Reprod Update (2012) 1.11
Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos. Mol Pharmacol (2008) 1.10
Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J (2012) 1.10
Saccharomyces cerevisiae Yta7 regulates histone gene expression. Genetics (2008) 1.09
Stable-isotope-labeled histone peptide library for histone post-translational modification and variant quantification by mass spectrometry. Mol Cell Proteomics (2014) 1.08
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79
Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature (2002) 7.54
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell (2003) 6.44
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (2013) 6.29
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27
Extraction, purification and analysis of histones. Nat Protoc (2007) 6.25
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12
Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol (2006) 5.99
Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80
RNA meets chromatin. Genes Dev (2005) 5.66
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59
Human PAD4 regulates histone arginine methylation levels via demethylimination. Science (2004) 5.46
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol (2009) 5.27
Binary switches and modification cassettes in histone biology and beyond. Nature (2003) 4.75
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73
Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56
Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol (2002) 4.50
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell (2011) 4.04
Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell (2006) 3.87
Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem (2006) 3.84
Gene silencing: trans-histone regulatory pathway in chromatin. Nature (2002) 3.77
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat Genet (2001) 3.63
Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37
Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23
Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena. Cell (2002) 3.16
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature (2009) 3.13
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell (2008) 3.09
Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86
RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos. Dev Biol (2004) 2.82
Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation. Genes Dev (2007) 2.81
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell (2011) 2.68
Histone H3 variants and their potential role in indexing mammalian genomes: the "H3 barcode hypothesis". Proc Natl Acad Sci U S A (2006) 2.68
ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature (2010) 2.65
Chromatin remodeling and cancer, Part I: Covalent histone modifications. Trends Mol Med (2007) 2.60
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature (2010) 2.49
Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription. J Biol Chem (2003) 2.48
Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol Cell (2007) 2.47
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell (2010) 2.44
Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism. Curr Biol (2002) 2.44
Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc Natl Acad Sci U S A (2007) 2.43
Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol (2004) 2.43
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell (2013) 2.34
PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. Mutat Res (2008) 2.31
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat Struct Mol Biol (2006) 2.29
RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes Dev (2007) 2.26
Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol Cell (2010) 2.25
The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast. Mol Cell (2005) 2.19
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol (2011) 2.18
Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc Natl Acad Sci U S A (2003) 2.16
Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae. Cell (2005) 2.15
Histone arginine methylation and its dynamic regulation. Front Biosci (2006) 2.06
Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Mol Cell Biol (2008) 2.05
Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Genes Dev (2006) 2.05
Operating on chromatin, a colorful language where context matters. J Mol Biol (2011) 2.00
New functions for an old variant: no substitute for histone H3.3. Curr Opin Genet Dev (2010) 1.93
Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Proc Natl Acad Sci U S A (2005) 1.91
Proteome-wide prediction of acetylation substrates. Proc Natl Acad Sci U S A (2009) 1.81
Polycomb Group proteins: an evolutionary perspective. Trends Genet (2007) 1.79
Cancer. New epigenetic drivers of cancers. Science (2011) 1.73
Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells (2009) 1.72
Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10. Mol Cell (2006) 1.72
MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell Stem Cell (2012) 1.72
Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons. J Cell Sci (2003) 1.70
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proc Natl Acad Sci U S A (2010) 1.68
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature (2012) 1.65
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes. Proc Natl Acad Sci U S A (2011) 1.65
Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. Mol Cell Biol (2002) 1.63
Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling. Trends Mol Med (2007) 1.59
Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes Dev (2008) 1.51
Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. J Biol Chem (2006) 1.50
Phosphorylation of histone H2B at DNA double-strand breaks. J Exp Med (2004) 1.49
The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved. Chromosoma (2004) 1.47
Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. Proc Natl Acad Sci U S A (2002) 1.46
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol Cell (2012) 1.43
Histone variants in metazoan development. Dev Cell (2010) 1.42
Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S. cerevisiae. Curr Biol (2005) 1.41
MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Nat Commun (2013) 1.39
Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. J Biol Chem (2009) 1.38
Taking LSD 1 to a new high. Cell (2005) 1.34