Published in J Struct Biol on November 15, 2009
Human K(ATP) channelopathies: diseases of metabolic homeostasis. Pflugers Arch (2009) 1.16
ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene. Int J Cardiol (2014) 1.04
K(ATP) channels process nucleotide signals in muscle thermogenic response. Crit Rev Biochem Mol Biol (2010) 0.87
K(ATP) channel-dependent metaboproteome decoded: systems approaches to heart failure prediction, diagnosis, and therapy. Cardiovasc Res (2011) 0.86
Advances in cardiac ATP-sensitive K+ channelopathies from molecules to populations. Circ Arrhythm Electrophysiol (2011) 0.83
ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target. Ageing Res Rev (2015) 0.81
Domain organization of the ATP-sensitive potassium channel complex examined by fluorescence resonance energy transfer. J Biol Chem (2012) 0.80
Spot14/Mig12 heterocomplex sequesters polymerization and restrains catalytic function of human acetyl-CoA carboxylase 2. J Mol Recognit (2013) 0.77
Human acetyl-CoA carboxylase 2 expressed in silkworm Bombyx mori exhibits posttranslational biotinylation and phosphorylation. Appl Microbiol Biotechnol (2014) 0.75
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J (1982) 38.14
Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. Biophys J (1999) 13.18
Determination of domain structure of proteins from X-ray solution scattering. Biophys J (2001) 10.39
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science (1995) 9.16
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution. Q Rev Biophys (2007) 9.07
Global rigid body modeling of macromolecular complexes against small-angle scattering data. Biophys J (2005) 7.10
Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS). Nat Methods (2009) 6.77
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. Neuron (1996) 6.02
KATP channels as molecular sensors of cellular metabolism. Nature (2006) 5.34
ABC transporters: the power to change. Nat Rev Mol Cell Biol (2009) 4.48
Association and stoichiometry of K(ATP) channel subunits. Neuron (1997) 4.21
Structure and mechanism of ABC transporter proteins. Curr Opin Struct Biol (2007) 3.79
The ATP switch model for ABC transporters. Nat Struct Mol Biol (2004) 3.58
ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest (2005) 3.56
Octameric stoichiometry of the KATP channel complex. J Gen Physiol (1997) 3.48
ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet (2004) 2.85
ATP-Binding cassette cholesterol transporters and cardiovascular disease. Circ Res (2006) 2.64
Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering. Structure (2005) 2.53
Analysis of X-ray and neutron scattering from biomacromolecular solutions. Curr Opin Struct Biol (2007) 2.50
Subunit stoichiometry of the pancreatic beta-cell ATP-sensitive K+ channel. FEBS Lett (1997) 2.41
From molecule to malady. Nature (2006) 2.13
Cardiac KATP channels in health and disease. J Mol Cell Cardiol (2005) 2.04
Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1. Circ Res (2008) 1.98
Signaling in channel/enzyme multimers: ATPase transitions in SUR module gate ATP-sensitive K+ conductance. Neuron (2001) 1.92
ABC transporter architecture and regulatory roles of accessory domains. FEBS Lett (2005) 1.77
Structure and mechanism of the RuvB Holliday junction branch migration motor. J Mol Biol (2001) 1.74
Coupling of cell energetics with membrane metabolic sensing. Integrative signaling through creatine kinase phosphotransfer disrupted by M-CK gene knock-out. J Biol Chem (2002) 1.72
N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. EMBO J (2003) 1.68
3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1. EMBO J (2005) 1.66
Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels. Diabetes (1996) 1.65
Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. Nat Struct Mol Biol (2006) 1.64
Coupling ion channels to receptors for biomolecule sensing. Nat Nanotechnol (2008) 1.63
ATPase activity of the sulfonylurea receptor: a catalytic function for the KATP channel complex. FASEB J (2000) 1.62
KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation. Nat Clin Pract Cardiovasc Med (2007) 1.56
Structure and function of ABC transporters: the ATP switch provides flexible control. Pflugers Arch (2006) 1.54
The genetics of ATP-binding cassette transporters. Methods Enzymol (2005) 1.53
Structure and function of ABC transporters. Physiology (Bethesda) (2007) 1.52
Molecular basis of electrocardiographic ST-segment elevation. Circ Res (2000) 1.51
Advances in structure analysis using small-angle scattering in solution. Curr Opin Struct Biol (2002) 1.51
ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch (2006) 1.47
Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator. Philos Trans R Soc Lond B Biol Sci (2009) 1.47
ATP-sensitive potassium channels: metabolic sensing and cardioprotection. J Appl Physiol (1985) (2007) 1.43
The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter. FASEB J (2009) 1.43
Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance. EMBO J (2003) 1.40
ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart. J Mol Cell Cardiol (2005) 1.38
Function and distribution of the SUR isoforms and splice variants. J Mol Cell Cardiol (2005) 1.35
Overexpression of SUR2A generates a cardiac phenotype resistant to ischemia. FASEB J (2006) 1.32
Physical association between recombinant cardiac ATP-sensitive K+ channel subunits Kir6.2 and SUR2A. J Mol Cell Cardiol (1999) 1.30
The use of sarkosyl in generating soluble protein after bacterial expression. Proc Natl Acad Sci U S A (1991) 1.30
Tandem function of nucleotide binding domains confers competence to sulfonylurea receptor in gating ATP-sensitive K+ channels. J Biol Chem (2002) 1.29
Studies of the ATPase activity of the ABC protein SUR1. FEBS J (2007) 1.28
The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channel. Circ Res (2008) 1.23
SOMCD: method for evaluating protein secondary structure from UV circular dichroism spectra. Proteins (2001) 1.16
Potassium channel regulation. EMBO Rep (2003) 1.07
Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor. J Biol Chem (2008) 1.03
ATP-binding cassette transporters in Escherichia coli. Biochim Biophys Acta (2008) 1.02
Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels. Mol Pharmacol (2008) 0.99
K(ATP) channel pharmacogenomics: from bench to bedside. Clin Pharmacol Ther (2007) 0.97
Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Biochem J (2004) 0.93
Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the K(ATP) channel subunits SUR2A and Kir6.2. J Physiol (2008) 0.93
KATP channel Kir6.2 E23K variant overrepresented in human heart failure is associated with impaired exercise stress response. Hum Genet (2009) 0.92
ATP-sensitive K+ channel knockout induces cardiac proteome remodeling predictive of heart disease susceptibility. J Proteome Res (2009) 0.91
Proteomic profiling of KATP channel-deficient hypertensive heart maps risk for maladaptive cardiomyopathic outcome. Proteomics (2009) 0.91
A novel Val734Ile variant in the ABCC9 gene associated with myocardial infarction. Clin Chim Acta (2006) 0.90
Interaction of asymmetric ABCC9-encoded nucleotide binding domains determines KATP channel SUR2A catalytic activity. J Proteome Res (2008) 0.89
ATP-binding cassette transporters in the heart. Trends Cardiovasc Med (2006) 0.88
Role for SUR2A ED domain in allosteric coupling within the K(ATP) channel complex. J Gen Physiol (2008) 0.87
A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K(+) channels. J Mol Cell Cardiol (2005) 0.87
Structure-function relationships in the beta-cell K(ATP) channel. Biochem Soc Trans (2002) 0.76
Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics. J Am Coll Cardiol (2013) 5.11
Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab (2011) 4.15
Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum Mol Genet (2006) 3.15
Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation (2009) 2.93
ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet (2004) 2.85
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol (2008) 2.81
Phosphotransfer networks and cellular energetics. J Exp Biol (2003) 2.79
Kir6.2 is required for adaptation to stress. Proc Natl Acad Sci U S A (2002) 2.60
Stem cell differentiation requires a paracrine pathway in the heart. FASEB J (2002) 2.55
Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase. Arterioscler Thromb Vasc Biol (2004) 2.39
Metabolic plasticity in stem cell homeostasis and differentiation. Cell Stem Cell (2012) 2.36
Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol (2006) 2.24
Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells. Nat Clin Pract Cardiovasc Med (2007) 2.21
Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. J Physiol (2006) 2.06
Cardiac KATP channels in health and disease. J Mol Cell Cardiol (2005) 2.04
Cardiopoietic programming of embryonic stem cells for tumor-free heart repair. J Exp Med (2007) 1.97
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol (2012) 1.94
Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction. J Am Coll Cardiol (2010) 1.82
iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. Circ Res (2009) 1.77
Recommendations for successful training on methods of delivery of biologics for cardiac regeneration: a report of the International Society for Cardiovascular Translational Research. JACC Cardiovasc Interv (2010) 1.74
KATP channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart. Am J Physiol Heart Circ Physiol (2006) 1.74
Stable benefit of embryonic stem cell therapy in myocardial infarction. Am J Physiol Heart Circ Physiol (2004) 1.73
Coupling of cell energetics with membrane metabolic sensing. Integrative signaling through creatine kinase phosphotransfer disrupted by M-CK gene knock-out. J Biol Chem (2002) 1.72
Induced pluripotent stem cells: developmental biology to regenerative medicine. Nat Rev Cardiol (2010) 1.71
Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant. J Physiol (2006) 1.70
Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci (2009) 1.67
CXCR4+/FLK-1+ biomarkers select a cardiopoietic lineage from embryonic stem cells. Stem Cells (2008) 1.63
Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc (2009) 1.62
KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation. Nat Clin Pract Cardiovasc Med (2007) 1.56
Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. Am J Physiol Heart Circ Physiol (2003) 1.56
Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action. Circulation (2012) 1.56
KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension. Hum Mol Genet (2006) 1.53
ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits. Diabetes (2004) 1.53
Mitochondrial tolerance to stress impaired in failing heart. J Mol Cell Cardiol (2003) 1.45
Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance. EMBO J (2003) 1.40
Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer. Proc Natl Acad Sci U S A (2002) 1.40
Embryonic stem cell therapy of heart failure in genetic cardiomyopathy. Stem Cells (2008) 1.39
ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart. J Mol Cell Cardiol (2005) 1.38
Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation. J Mol Cell Cardiol (2010) 1.37
Platelet lysate consisting of a natural repair proteome supports human mesenchymal stem cell proliferation and chromosomal stability. Cell Transplant (2010) 1.34
Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation. Am J Physiol Heart Circ Physiol (2002) 1.32
Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight. Cell Metab (2010) 1.31
Clinical and translational science: from bench-bedside to global village. Clin Transl Sci (2010) 1.30
Tandem function of nucleotide binding domains confers competence to sulfonylurea receptor in gating ATP-sensitive K+ channels. J Biol Chem (2002) 1.29
Gene knockout of the KCNJ8-encoded Kir6.1 K(ATP) channel imparts fatal susceptibility to endotoxemia. FASEB J (2006) 1.28
K(ATP) channel therapeutics at the bedside. J Mol Cell Cardiol (2005) 1.27
Nucleotide-gated KATP channels integrated with creatine and adenylate kinases: amplification, tuning and sensing of energetic signals in the compartmentalized cellular environment. Mol Cell Biochem (2004) 1.26
Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes to catecholamine-induced ventricular dysrhythmia. Diabetes (2004) 1.23
Disease-causing mitochondrial heteroplasmy segregated within induced pluripotent stem cell clones derived from a patient with MELAS. Stem Cells (2013) 1.22
Stem cells transform into a cardiac phenotype with remodeling of the nuclear transport machinery. Nat Clin Pract Cardiovasc Med (2007) 1.21
Translating MicroRNA discovery into clinical biomarkers in cancer. JAMA (2007) 1.20
Induced pluripotent reprogramming from promiscuous human stemness related factors. Clin Transl Sci (2009) 1.20
Aging and cardioprotection. J Appl Physiol (1985) (2007) 1.20
Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther (2012) 1.19
Potassium channel openers are uncoupling protonophores: implication in cardioprotection. FEBS Lett (2004) 1.18
Human K(ATP) channelopathies: diseases of metabolic homeostasis. Pflugers Arch (2009) 1.16
Cardioinductive network guiding stem cell differentiation revealed by proteomic cartography of tumor necrosis factor alpha-primed endodermal secretome. Stem Cells (2007) 1.16
Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection. Am J Physiol Heart Circ Physiol (2003) 1.16
MicroRNA signatures as diagnostic and therapeutic targets. Clin Chem (2008) 1.15
Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myopathy and hypotension traits of myotonic dystrophy. Hum Mol Genet (2004) 1.14
Induced pluripotent stem cells: reprogrammed without a trace. Regen Med (2009) 1.14
Genomic chart guiding embryonic stem cell cardiopoiesis. Genome Biol (2008) 1.13
Structural adaptation of the nuclear pore complex in stem cell-derived cardiomyocytes. Circ Res (2003) 1.11
Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease. Proc Natl Acad Sci U S A (2003) 1.11
c-MYC independent nuclear reprogramming favors cardiogenic potential of induced pluripotent stem cells. J Cardiovasc Transl Res (2010) 1.08
Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction. J Physiol (2013) 1.08
Cells as biologics for cardiac repair in ischaemic heart failure. Heart (2010) 1.06
Impaired intracellular energetic communication in muscles from creatine kinase and adenylate kinase (M-CK/AK1) double knock-out mice. J Biol Chem (2003) 1.05
Adenylate kinase AK1 knockout heart: energetics and functional performance under ischemia-reperfusion. Am J Physiol Heart Circ Physiol (2002) 1.05
Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation. PLoS One (2011) 1.03
Phosphotransfer dynamics in skeletal muscle from creatine kinase gene-deleted mice. Mol Cell Biochem (2004) 1.03
Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart. Mech Ageing Dev (2008) 1.02
Energy metabolism plasticity enables stemness programs. Ann N Y Acad Sci (2012) 1.02
Progenitor cell therapy in a porcine acute myocardial infarction model induces cardiac hypertrophy, mediated by paracrine secretion of cardiotrophic factors including TGFbeta1. Stem Cells Dev (2008) 1.01
Stem cell transplant into preimplantation embryo yields myocardial infarction-resistant adult phenotype. Stem Cells (2009) 1.01
Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association. Circulation (2013) 1.01
Stem cell platforms for regenerative medicine. Clin Transl Sci (2009) 1.01
Guided stem cell cardiopoiesis: discovery and translation. J Mol Cell Cardiol (2008) 1.00
Developmental restructuring of the creatine kinase system integrates mitochondrial energetics with stem cell cardiogenesis. Ann N Y Acad Sci (2008) 1.00
KCNJ11 knockout morula re-engineered by stem cell diploid aggregation. Philos Trans R Soc Lond B Biol Sci (2009) 0.99
Lineage specification of Flk-1+ progenitors is associated with divergent Sox7 expression in cardiopoiesis. Differentiation (2008) 0.99
Endovascular cooling with heat exchange catheters: a new method to induce and maintain hypothermia. Intensive Care Med (2003) 0.98
Mapping hypoxia-induced bioenergetic rearrangements and metabolic signaling by 18O-assisted 31P NMR and 1H NMR spectroscopy. Mol Cell Biochem (2004) 0.98
Energy metabolism in nuclear reprogramming. Biomark Med (2011) 0.97
Strategies for therapeutic repair: The "R(3)" regenerative medicine paradigm. Clin Transl Sci (2008) 0.97
Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency. Aging (Albany NY) (2012) 0.96
Administration of allogenic stem cells dosed to secure cardiogenesis and sustained infarct repair. Ann N Y Acad Sci (2005) 0.96
Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circulation (2015) 0.96
Stable transfection of UCP1 confers resistance to hypoxia/reoxygenation in a heart-derived cell line. J Mol Cell Cardiol (2003) 0.95
Transcriptional fingerprint of human whole blood at the site of coronary occlusion in acute myocardial infarction. EuroIntervention (2011) 0.94
Deletion of mtDNA disrupts mitochondrial function and structure, but not biogenesis. Mitochondrion (2003) 0.94
Failing atrial myocardium: energetic deficits accompany structural remodeling and electrical instability. Am J Physiol Heart Circ Physiol (2003) 0.94
Lipid metabolism greases the stem cell engine. Cell Metab (2013) 0.94
Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted ³¹P NMR and mass spectrometry. Physiol Genomics (2012) 0.94
Nuclear reprogramming with c-Myc potentiates glycolytic capacity of derived induced pluripotent stem cells. J Cardiovasc Transl Res (2012) 0.93
ATP-sensitive K(+) channel-deficient dilated cardiomyopathy proteome remodeled by embryonic stem cell therapy. Stem Cells (2010) 0.93
Compartmentation of membrane processes and nucleotide dynamics in diffusion-restricted cardiac cell microenvironment. J Mol Cell Cardiol (2011) 0.93
Derivation of a cardiopoietic population from human mesenchymal stem cells yields cardiac progeny. Nat Clin Pract Cardiovasc Med (2006) 0.93
KATP channel Kir6.2 E23K variant overrepresented in human heart failure is associated with impaired exercise stress response. Hum Genet (2009) 0.92
K(ATP) channel polymorphism is associated with left ventricular size in hypertensive individuals: a large-scale community-based study. Hum Genet (2008) 0.91