Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease.

PubWeight™: 1.12‹?› | Rank: Top 10%

🔗 View Article (PMID 19925417)

Published in Curr Pharm Des on January 01, 2009

Authors

A Fernández-Gamba1, M C Leal, L Morelli, E M Castaño

Author Affiliations

1: Fundación Instituto Leloir and Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina.

Articles citing this

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment? Br J Clin Pharmacol (2011) 1.22

Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease. Microbiol Mol Biol Rev (2012) 1.13

Analysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins. Mol Biosyst (2010) 1.05

Hepatic insulin clearance is the primary determinant of insulin sensitivity in the normal dog. Obesity (Silver Spring) (2013) 1.02

Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease. Front Aging Neurosci (2014) 0.94

Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme. J Biol Chem (2011) 0.90

The immunoglobulin super family protein RIG-3 prevents synaptic potentiation and regulates Wnt signaling. Neuron (2011) 0.90

Insulin-degrading enzyme (IDE): a novel heat shock-like protein. J Biol Chem (2012) 0.90

Peroxisomes in brain development and function. Biochim Biophys Acta (2015) 0.88

Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic aβ peptide aggregates. PLoS One (2013) 0.87

Ginsenoside Rg1 decreases Aβ(1-42) level by upregulating PPARγ and IDE expression in the hippocampus of a rat model of Alzheimer's disease. PLoS One (2013) 0.86

Consequences of Aberrant Insulin Regulation in the Brain: Can Treating Diabetes be Effective for Alzheimer's Disease. Curr Neuropharmacol (2011) 0.85

Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice. Acta Pharmacol Sin (2015) 0.84

The association of diabetes and dementia and possible implications for nondiabetic populations. Expert Rev Neurother (2011) 0.82

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis. Eur J Med Chem (2014) 0.82

Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease. Biochem Res Int (2010) 0.81

Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality. J Biol Chem (2013) 0.80

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun (2015) 0.80

Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Eur J Med Chem (2014) 0.78

Endurance training inhibits insulin clearance and IDE expression in Swiss mice. PLoS One (2015) 0.78

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota. Sci Rep (2017) 0.76

Metal-dependent amyloid β-degrading catalytic antibody construct. J Biotechnol (2014) 0.76

Novel Platinum(II) compounds modulate insulin-degrading enzyme activity and induce cell death in neuroblastoma cells. J Biol Inorg Chem (2014) 0.76

Acute Exercise Improves Insulin Clearance and Increases the Expression of Insulin-Degrading Enzyme in the Liver and Skeletal Muscle of Swiss Mice. PLoS One (2016) 0.76

Proteasome Activity Is Affected by Fluctuations in Insulin-Degrading Enzyme Distribution. PLoS One (2015) 0.76

No major role for insulin-degrading enzyme in antigen presentation by MHC molecules. PLoS One (2014) 0.75

Alteration in amyloid β42, phosphorylated tau protein, interleukin 6, and acetylcholine during diabetes-accelerated memory dysfunction in diabetic rats: correlation of amyloid β42 with changes in glucose metabolism. Behav Brain Funct (2015) 0.75

Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes. Proc Natl Acad Sci U S A (2017) 0.75

Articles by these authors

Classification of European mtDNAs from an analysis of three European populations. Genetics (1996) 6.28

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat Med (1998) 4.17

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J Exp Med (1993) 3.59

Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J Exp Med (1998) 3.09

Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J Exp Med (1999) 3.08

Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. J Exp Med (1995) 2.75

p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J Exp Med (1997) 2.70

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. Am J Pathol (1994) 2.66

bcl-2 expression in pleural and extrapleural solitary fibrous tumours. J Pathol (1997) 2.66

In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein. Biochem Biophys Res Commun (1986) 2.16

Demonstration of safety of probiotics -- a review. Int J Food Microbiol (1998) 2.02

Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles. J Exp Med (1994) 1.98

Thrombosis in the portal venous system after elective laparoscopic splenectomy. Surg Endosc (2004) 1.92

Development and application of an in vitro methodology to determine the transit tolerance of potentially probiotic Lactobacillus and Bifidobacterium species in the upper human gastrointestinal tract. J Appl Microbiol (1998) 1.90

Drug resistance plasmids in Lactobacillus acidophilus and Lactobacillus reuteri. Appl Environ Microbiol (1982) 1.83

Conjugal Transfer of Broad-Host-Range Plasmid pAMbeta1 into Enteric Species of Lactic Acid Bacteria. Appl Environ Microbiol (1983) 1.68

Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis. J Infect Dis (1999) 1.58

Proliferative activity in human breast cancer: Ki-67 automated evaluation and the influence of different Ki-67 equivalent antibodies. Diagn Pathol (2011) 1.57

Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease. Proc Natl Acad Sci U S A (1987) 1.56

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochem Res (2000) 1.46

The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations. Tissue Antigens (2000) 1.44

Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. Eur J Immunol (1999) 1.42

Safety of recreational scuba diving in type 1 diabetic patients: the Deep Monitoring programme. Diabetes Metab (2009) 1.42

Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer. Clin Cancer Res (1995) 1.39

Functions of S-layers. FEMS Microbiol Rev (1997) 1.38

Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein. Am J Pathol (1987) 1.36

Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells. Eur J Immunol (1994) 1.32

Peopling of three Mediterranean islands (Corsica, Sardinia, and Sicily) inferred by Y-chromosome biallelic variability. Am J Phys Anthropol (2003) 1.30

A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation. Eur J Immunol (1996) 1.29

Archival, demographic and genetic studies define a Sardinian sub-isolate as a suitable model for mapping complex traits. Hum Genet (2001) 1.28

Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia. Genes Immun (2008) 1.27

The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation. J Biol Chem (1995) 1.27

Antibiotic susceptibility of potentially probiotic Lactobacillus species. J Food Prot (1998) 1.23

Local anticandidal immune responses in a rat model of vaginal infection by and protection against Candida albicans. Infect Immun (2000) 1.20

The human natural killer cell receptor for major histocompatibility complex class I molecules. Surface modulation of p58 molecules and their linkage to CD3 zeta chain, Fc epsilon RI gamma chain and the p56lck kinase. Eur J Immunol (1994) 1.18

Russell body gastritis associated with Helicobacter pylori infection in an HIV-positive patient: case report and review of the literature. Z Gastroenterol (2009) 1.15

The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases. Hum Mol Genet (2000) 1.15

Bcl-2 and p53 expression in node-negative breast carcinoma: a study with long-term follow-up. Hum Pathol (1996) 1.15

In vitro proliferation and cloning of CD3- CD16+ cells from human thymocyte precursors. J Exp Med (1991) 1.15

Prognostic value of p21(WAF1) and p53 expression in breast carcinoma: an immunohistochemical study in 261 patients with long-term follow-up. Clin Cancer Res (1996) 1.14

On the fate of ingested Bacillus spores. Res Microbiol (2000) 1.11

Selective detection, enumeration and identification of potentially probiotic Lactobacillus and Bifidobacterium species in mixed bacterial populations. Int J Food Microbiol (1997) 1.10

The conformation of Alzheimer's beta peptide determines the rate of amyloid formation and its resistance to proteolysis. Biochem J (1996) 1.10

CD45-mediated regulation of LFA1 function in human natural killer cells. Anti-CD45 monoclonal antibodies inhibit the calcium mobilization induced via LFA1 molecules. Eur J Immunol (1993) 1.06

Iron requirement of Lactobacillus spp. in completely chemically defined growth media. J Appl Microbiol (2000) 1.06

p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival. Br J Cancer (1996) 1.04

A 70-kilodalton recombinant heat shock protein of Candida albicans is highly immunogenic and enhances systemic murine candidiasis. Infect Immun (1998) 1.04

The S-layer gene of Lactobacillus helveticus CNRZ 892: cloning, sequence and heterologous expression. Microbiology (1998) 1.01

Defective ubiquitination of cerebral proteins in Alzheimer's disease. J Neurosci Res (2000) 1.01

S-layer gene as a molecular marker for identification of Lactobacillus helveticus. FEMS Microbiol Lett (2000) 1.01

Rapid amplified ribosomal DNA restriction analysis (ARDRA) identification of Lactobacillus spp. isolated from fecal and vaginal samples. Syst Appl Microbiol (2000) 1.00

Gradient diffusion antibiotic susceptibility testing of potentially probiotic lactobacilli. J Food Prot (2001) 1.00

Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure. Neurosci Lett (1995) 1.00

Lactobacillus crispatus and its nonaggregating mutant in human colonization trials. J Dairy Sci (2001) 0.98

Experimental pathogenicity and acid proteinase secretion of vaginal isolates of Candida parapsilosis. J Med Vet Mycol (1990) 0.97

Detection of bovine mitochondrial DNA in ruminant feeds: a molecular approach to test for the presence of bovine-derived materials. J Food Prot (1998) 0.95

Lactobacillus protoplast transformation. Plasmid (1987) 0.94

Different processing of Alzheimer's beta-protein precursor in the vessel wall of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. Biochem Biophys Res Commun (1988) 0.93

Antibiotic susceptibility of potentially probiotic Bifidobacterium isolates from the human gastrointestinal tract. Lett Appl Microbiol (1998) 0.93

Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity. Eur J Immunol (1996) 0.92

Epidemiological survey of the enteropathogenic Escherichia coli isolated from children with diarrhoea. J Trop Pediatr (1990) 0.92

Novel surface molecules involved in human NK cell activation and triggering of the lytic machinery. Int J Cancer Suppl (1992) 0.91

Post mortem investigations on cetaceans found stranded on the coasts of Italy between 1990 and 1993. Vet Rec (1995) 0.91

Erythromycin- and tetracycline-resistant lactobacilli in Italian fermented dry sausages. J Appl Microbiol (2009) 0.90

Probiotics: from research to consumer. Dig Liver Dis (2006) 0.90

Cimetidine (Tagamet) is a reproductive toxicant in male rats affecting peritubular cells. Biol Reprod (2000) 0.90

Animal transmissible spongiform encephalopathies and genetics. Vet Res Commun (2003) 0.90

PrP genotype in Sarda breed sheep and its relevance to scrapie. Brief report. Arch Virol (2001) 0.90

Human brucellosis: immunoblotting analysis of three Brucella abortus antigenic fractions allows the detection of components of diagnostic importance. Medicina (B Aires) (1991) 0.89

Single-stranded DNA plasmid, vector construction and cloning of Bacillus stearothermophilus alpha-amylase in Lactobacillus. Res Microbiol (1992) 0.88

Beta-protein deposition: a pathogenetic link between Alzheimer's disease and cerebral amyloid angiopathies. Brain Res (1988) 0.88

The aggregation-promoting factor of Lactobacillus crispatus M247 and its genetic locus. J Appl Microbiol (2004) 0.87

The Veneto Region's Barrett's Oesophagus Registry: aims, methods, preliminary results. Dig Liver Dis (2006) 0.87

p40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humans. Eur J Immunol (1995) 0.87

Identification of murine natural killer cell subsets with monoclonal antibodies derived from 129 anti-C57BL/6 immune spleen cells. Cell Immunol (1991) 0.86

Strain typing among enterococci isolated from home-made Pecorino Sardo cheese. FEMS Microbiol Lett (1999) 0.86

Instability of the amyloidogenic cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. J Biol Chem (1998) 0.86

Potentiometric determination of carbonic anhydrase activity in rabbit carotid bodies: comparison among normoxic, hyperoxic and hypoxic animals. Neurosci Lett (1994) 0.86

Specific detection of a probiotic Lactobacillus strain in faecal samples by using multiplex PCR. FEMS Microbiol Lett (1998) 0.86

Novel methods for the determination of the angiogenic activity of human tumors. Breast Cancer Res Treat (1995) 0.86

MELAS: clinical phenotype and morphological brain abnormalities. Acta Neuropathol (2003) 0.85

Regional procurement team for abdominal organs. Transplant Proc (2004) 0.84

Changes of gut microbiota and immune markers during the complementary feeding period in healthy breast-fed infants. J Pediatr Gastroenterol Nutr (2006) 0.84

Effect of conjugated bile salts on antibiotic susceptibility of bile salt-tolerant Lactobacillus and Bifidobacterium isolates. J Food Prot (2000) 0.84

Alzheimer's beta-amyloid peptide is conformationally modified by apolipoprotein E in vitro. Neuroreport (1996) 0.83

Primer extension assay for prion protein genotype determination in sheep. Mol Cell Probes (2004) 0.83

Experimental rat vaginal infection with Candida parapsilosis. FEMS Microbiol Lett (1989) 0.83

[Hemoglobin "S" positive newborn detected by cord blood and its characteristics] J Pediatr (Rio J) (2003) 0.83

Isolation and amino terminal sequence of beta-trace, a novel protein from human cerebrospinal fluid. Brain Res (1991) 0.83

Transient global brain hypoxia-ischemia in adult rats: neuronal damage, glial proliferation, and alterations in inositol phospholipid hydrolysis. Neurochem Int (1997) 0.83

[Crepitant abdominal cellulitis: a rare clinical presentation of sigmoid tumor]. Arq Gastroenterol (1991) 0.82

Aetiology of acute diarrhoea in hospitalized children in Rio de Janeiro City, Brazil. J Trop Pediatr (1993) 0.82

Apolipoprotein E increases the fibrillogenic potential of synthetic peptides derived from Alzheimer's, gelsolin and AA amyloids. FEBS Lett (1995) 0.82

Spontaneous canine mammary tumors. A model for monoclonal antibody diagnosis and treatment of human breast cancer. Lab Invest (1994) 0.82

Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. J Neurochem (2001) 0.82

Presenilin 1 Met146Leu variant due to an A --> T transversion in an early-onset familial Alzheimer's disease pedigree from Argentina. Clin Genet (1998) 0.82

Fast and slow milk-coagulating variants of Lactobacillus helveticus HLM 1. Can J Microbiol (1986) 0.81