Published in Biochem Biophys Res Commun on November 26, 2009
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. J Alzheimers Dis (2010) 1.19
Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability. Proc Natl Acad Sci U S A (2012) 1.16
Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins. J Biol Chem (2013) 1.10
CALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons. J Cell Sci (2013) 0.90
CALHM1 P86L polymorphism modulates CSF Aβ levels in cognitively healthy individuals at risk for Alzheimer's disease. Mol Med (2011) 0.90
Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis. PLoS One (2013) 0.87
Stabilizers of neuronal and mitochondrial calcium cycling as a strategy for developing a medicine for Alzheimer's disease. ACS Chem Neurosci (2012) 0.82
Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels. PLoS One (2014) 0.80
Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition. Biochim Biophys Acta (2015) 0.77
Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry. ACS Chem Neurosci (2012) 0.76
CALHM1 and its polymorphism P86L differentially control Ca(2+) homeostasis, mitogen-activated protein kinase signaling, and cell vulnerability upon exposure to amyloid β. Aging Cell (2015) 0.76
CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice. Sci Rep (2016) 0.75
Neuroimaging Feature Terminology: A Controlled Terminology for the Annotation of Brain Imaging Features. J Alzheimers Dis (2017) 0.75
Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum. J Neurochem (2015) 1.43
Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death. Eur J Med Chem (2007) 1.20
Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice. Prog Neuropsychopharmacol Biol Psychiatry (2008) 1.08
Redistribution of Ca2+ among cytosol and organella during stimulation of bovine chromaffin cells. FASEB J (2002) 1.02
Immunomodulatory and anti-inflammatory effects of chondroitin sulphate. J Cell Mol Med (2009) 1.02
Synthesis and pharmacology of galantamine. Chem Rev (2006) 0.99
Improving treatment adherence in your patients with schizophrenia: the STAY initiative. Clin Drug Investig (2013) 0.99
Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca(2+) signalling in hippocampal neurons. Eur J Neurosci (2007) 0.93
Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals. Eur J Med Chem (2006) 0.93
Modulatory mechanism of the endogenous peptide catestatin on neuronal nicotinic acetylcholine receptors and exocytosis. J Neurosci (2002) 0.92
Chondroitin sulfate protects SH-SY5Y cells from oxidative stress by inducing heme oxygenase-1 via phosphatidylinositol 3-kinase/Akt. J Pharmacol Exp Ther (2007) 0.92
ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? FASEB J (2002) 0.92
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties. J Med Chem (2010) 0.91
SNX482 selectively blocks P/Q Ca2+ channels and delays the inactivation of Na+ channels of chromaffin cells. Eur J Pharmacol (2003) 0.91
The neuroprotection exerted by memantine, minocycline and lithium, against neurotoxicity of CSF from patients with amyotrophic lateral sclerosis, is antagonized by riluzole. Neurodegener Dis (2013) 0.90
Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors. Neuropharmacology (2004) 0.88
Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors. J Pharmacol Exp Ther (2005) 0.87
Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties. ChemMedChem (2009) 0.86
Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells. J Pineal Res (2010) 0.85
Role of the endoplasmic reticulum and mitochondria on quantal catecholamine release from chromaffin cells of control and hypertensive rats. J Pharmacol Exp Ther (2009) 0.85
Mitochondria and chromaffin cell function. Pflugers Arch (2012) 0.85
Neuroprotective effect of the new thiadiazolidinone NP00111 against oxygen-glucose deprivation in rat hippocampal slices: implication of ERK1/2 and PPARgamma receptors. Exp Neurol (2008) 0.85
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. Eur J Med Chem (2011) 0.85
An update on the pharmacology of galantamine. Expert Opin Investig Drugs (2007) 0.84
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives. J Med Chem (2010) 0.83
CSF from amyotrophic lateral sclerosis patients produces glutamate independent death of rat motor brain cortical neurons: protection by resveratrol but not riluzole. Brain Res (2011) 0.83
Galantamine postischemia provides neuroprotection and memory recovery against transient global cerebral ischemia in gerbils. J Pharmacol Exp Ther (2007) 0.83
Chondroitin sulfate reduces cell death of rat hippocampal slices subjected to oxygen and glucose deprivation by inhibiting p38, NFκB and iNOS. Neurochem Int (2011) 0.82
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. Eur J Med Chem (2010) 0.82
Bcl2 mitigates Ca2+ entry and mitochondrial Ca2+ overload through downregulation of L-type Ca2+ channels in PC12 cells. Cell Calcium (2008) 0.82
Stabilizers of neuronal and mitochondrial calcium cycling as a strategy for developing a medicine for Alzheimer's disease. ACS Chem Neurosci (2012) 0.82
Neuroprotection by nicotine in hippocampal slices subjected to oxygen-glucose deprivation: involvement of the alpha7 nAChR subtype. J Mol Neurosci (2006) 0.82
Smaller quantal size and faster kinetics of single exocytotic events in chromaffin cells from the APP/PS1 mouse model of Alzheimer's disease. Biochem Biophys Res Commun (2012) 0.82
Increase of angiotensin-converting enzyme activity and peripheral sympathetic dysfunction could contribute to hypertension development in streptozotocin-induced diabetic rats. Diab Vasc Dis Res (2013) 0.82
Nanomolar ouabain elicits apoptosis through a direct action on HeLa cell mitochondria. Steroids (2013) 0.81
Tight coupling of the t-SNARE and calcium channel microdomains in adrenomedullary slices and not in cultured chromaffin cells. Cell Calcium (2006) 0.81
Albumin prevents mitochondrial depolarization and apoptosis elicited by endoplasmic reticulum calcium depletion of neuroblastoma cells. Eur J Pharmacol (2005) 0.81
Effects of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils. Brain Res (2008) 0.81
Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway. Free Radic Biol Med (2010) 0.80
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties. Bioorg Med Chem (2008) 0.80
Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia. Neuropharmacology (2012) 0.80
Single-vesicle catecholamine release has greater quantal content and faster kinetics in chromaffin cells from hypertensive, as compared with normotensive, rats. J Pharmacol Exp Ther (2007) 0.80
Plasmalemmal sodium-calcium exchanger shapes the calcium and exocytotic signals of chromaffin cells at physiological temperature. Am J Physiol Cell Physiol (2013) 0.79
Greater cytosolic and mitochondrial calcium transients in adrenal medullary slices of hypertensive, compared with normotensive rats. Eur J Pharmacol (2010) 0.79
New multipotent tetracyclic tacrines with neuroprotective activity. Bioorg Med Chem (2006) 0.79
Cell-permeable gomesin peptide promotes cell death by intracellular Ca(2+) overload. Mol Pharm (2012) 0.79
Distinct protein kinases regulate SNAP-25 expression in chromaffin cells. J Neurosci Res (2003) 0.79
Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress. J Neurochem (2007) 0.79
A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells. BMC Neurosci (2013) 0.79
Acetylcholine and potassium elicit different patterns of exocytosis in chromaffin cells when the intracellular calcium handling is disturbed. Pflugers Arch (2002) 0.79
DREAM controls the on/off switch of specific activity-dependent transcription pathways. Mol Cell Biol (2013) 0.79
Inhibition of N and PQ calcium channels by calcium entry through L channels in chromaffin cells. Pflugers Arch (2009) 0.79
Mitochondrial Na+/Ca2+-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine. J Pharmacol Exp Ther (2009) 0.79
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. J Med Chem (2009) 0.78
Regulation by L-type calcium channels of endocytosis: an overview. J Mol Neurosci (2012) 0.78
Activation and blockade by choline of bovine alpha7 and alpha3beta4 nicotinic receptors expressed in oocytes. Eur J Pharmacol (2006) 0.78
Galantamine and memantine produce different degrees of neuroprotection in rat hippocampal slices subjected to oxygen-glucose deprivation. Neurosci Lett (2004) 0.78
A two-step model for acetylcholine control of exocytosis via nicotinic receptors. Biochem Biophys Res Commun (2007) 0.78
Blockade of Ca2+ -activated K+ channels by galantamine can also contribute to the potentiation of catecholamine secretion from chromaffin cells. Eur J Pharmacol (2006) 0.78
On the antiatherogenity of calcium channel blockers: studies in proliferating vascular smooth muscle cells on age sensitivity, dose dependent inhibitory effect, and time of action. Arch Gerontol Geriatr (2004) 0.78
L-type calcium channels are preferentially coupled to endocytosis in bovine chromaffin cells. Biochem Biophys Res Commun (2007) 0.78
Mitochondrial Na+/Ca2+ exchanger, a new target for neuroprotection in rat hippocampal slices. Biochem Biophys Res Commun (2010) 0.78
Depolarization preconditioning produces cytoprotection against veratridine-induced chromaffin cell death. Eur J Pharmacol (2006) 0.78
A low nicotine concentration augments vesicle motion and exocytosis triggered by K(+) depolarisation of chromaffin cells. Eur J Pharmacol (2008) 0.78
Calcium entry through slow-inactivating L-type calcium channels preferentially triggers endocytosis rather than exocytosis in bovine chromaffin cells. Am J Physiol Cell Physiol (2011) 0.78
Resveratrol augments nitric oxide generation and causes store calcium release in chromaffin cells. Eur J Pharmacol (2012) 0.78
A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice. J Neurochem (2002) 0.77
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. J Med Chem (2009) 0.77
Amperometric study of the kinetics of exocytosis in mouse adrenal slice chromaffin cells: physiological and methodological insights. J Neurophysiol (2006) 0.77
Novel tacrine derivatives that block neuronal calcium channels. Bioorg Med Chem (2002) 0.77
Differences in the quantal release of catecholamines in chromaffin cells of rat embryos and their mothers. Am J Physiol Cell Physiol (2009) 0.77
Desensitized nicotinic receptors that, however, afford cytoprotection in bovine chromaffin cells. J Mol Neurosci (2006) 0.77
Ouabain enhances exocytosis through the regulation of calcium handling by the endoplasmic reticulum of chromaffin cells. Cell Calcium (2011) 0.77
Effect of ibuprofen on cyclooxygenase and nitric oxide synthase of gastric mucosa: correlation with endoscopic lesions and adverse reactions. Dig Dis Sci (2004) 0.76
Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors. Bioorg Med Chem (2004) 0.76
Calcium Channel Subtypes and Exocytosis in Chromaffin Cells at Early Life. Curr Mol Pharmacol (2015) 0.76
Dynamic association of the Ca2+ channel alpha1A subunit and SNAP-25 in round or neurite-emitting chromaffin cells. Eur J Neurosci (2005) 0.76
Multi-target novel neuroprotective compound ITH33/IQM9.21 inhibits calcium entry, calcium signals and exocytosis. Cell Calcium (2011) 0.76
A choline-evoked [Ca2+]c signal causes catecholamine release and hyperpolarization of chromaffin cells. FASEB J (2004) 0.76
Preconditioning stimuli that augment chromaffin cell secretion. Am J Physiol Cell Physiol (2009) 0.76
Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells. Pflugers Arch (2010) 0.76
Murine muscle engineered from dermal precursors: an in vitro model for skeletal muscle generation, degeneration, and fatty infiltration. Tissue Eng Part C Methods (2013) 0.76
Imatinib assay by high-performance liquid chromatography in tandem mass spectrometry with solid-phase extraction in human plasma. Biomed Chromatogr (2012) 0.76
Preclinical profile of PF9404C, a nitric oxide donor with beta receptor blocking properties. Cardiovasc Drug Rev (2005) 0.76
Lower density of L-type and higher density of P/Q-type of calcium channels in chromaffin cells of hypertensive, compared with normotensive rats. Eur J Pharmacol (2013) 0.76
Can cholinesterase inhibitors provide additional effects to cholinergic neurotransmission enhancement? J Mol Neurosci (2006) 0.76
Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action. Br J Pharmacol (2015) 0.76
Blockade of nicotinic receptors of bovine adrenal chromaffin cells by nanomolar concentrations of atropine. Eur J Pharmacol (2006) 0.76
Paradoxical facilitation of exocytosis by inhibition of L-type calcium channels of bovine chromaffin cells. Biochem Biophys Res Commun (2011) 0.76
Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry. ACS Chem Neurosci (2012) 0.76
Assessment of sex differences in pharmacokinetics and pharmacodynamics of amlodipine in a bioequivalence study. Pharmacol Res (2005) 0.76