Published in Cell Mol Bioeng on September 01, 2009
Chondrocyte deformations as a function of tibiofemoral joint loading predicted by a generalized high-throughput pipeline of multi-scale simulations. PLoS One (2012) 1.09
Three-dimensional finite element modeling of pericellular matrix and cell mechanics in the nucleus pulposus of the intervertebral disk based on in situ morphology. Biomech Model Mechanobiol (2010) 0.92
The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review. J Biomech Eng (2014) 0.86
Molecular mechanisms of biological aging in intervertebral discs. J Orthop Res (2016) 0.85
Cells from degenerative intervertebral discs demonstrate unfavorable responses to mechanical and inflammatory stimuli: a pilot study. Am J Phys Med Rehabil (2012) 0.81
Commentary: Does needle injection cause disc degeneration? News in the continuing debate regarding pathophysiology associated with intradiscal injections. Spine J (2012) 0.78
Biphasic creep and stress relaxation of articular cartilage in compression? Theory and experiments. J Biomech Eng (1980) 7.76
A triphasic theory for the swelling and deformation behaviors of articular cartilage. J Biomech Eng (1991) 4.61
An analysis of the unconfined compression of articular cartilage. J Biomech Eng (1984) 2.57
The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage. J Biomech (2000) 2.32
Regional variation in tensile properties and biochemical composition of the human lumbar anulus fibrosus. Spine (Phila Pa 1976) (1994) 2.07
Mechanobiology of the intervertebral disc and relevance to disc degeneration. J Bone Joint Surg Am (2006) 1.96
The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Ann N Y Acad Sci (2006) 1.71
Degeneration affects the anisotropic and nonlinear behaviors of human anulus fibrosus in compression. J Biomech (1998) 1.69
Anisotropic and inhomogeneous tensile behavior of the human anulus fibrosus: experimental measurement and material model predictions. J Biomech Eng (2001) 1.62
Degeneration and aging affect the tensile behavior of human lumbar anulus fibrosus. Spine (Phila Pa 1976) (1995) 1.61
Regional variations in the cellular matrix of the annulus fibrosus of the intervertebral disc. J Anat (2002) 1.58
The biomechanical role of the chondrocyte pericellular matrix in articular cartilage. Acta Biomater (2005) 1.57
Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. J Biomech (2007) 1.55
The role of the physicochemical environment in determining disc cell behaviour. Biochem Soc Trans (2002) 1.53
Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. J Biomech Eng (2003) 1.52
ISSLS prize winner: Collagen fibril sliding governs cell mechanics in the anulus fibrosus: an in situ confocal microscopy study of bovine discs. Spine (Phila Pa 1976) (2004) 1.42
Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. J Biomech (2005) 1.41
1991 Volvo Award in basic sciences. Collagen types around the cells of the intervertebral disc and cartilage end plate: an immunolocalization study. Spine (Phila Pa 1976) (1991) 1.39
Characterisation of cytoplasm-filled processes in cells of the intervertebral disc. J Anat (1998) 1.38
Fluid flow and convective transport of solutes within the intervertebral disc. J Biomech (2004) 1.37
The deformation behavior and viscoelastic properties of chondrocytes in articular cartilage. Biorheology (2000) 1.35
Tensile properties of nondegenerate human lumbar anulus fibrosus. Spine (Phila Pa 1976) (1996) 1.34
The anisotropic hydraulic permeability of human lumbar anulus fibrosus. Influence of age, degeneration, direction, and water content. Spine (Phila Pa 1976) (1999) 1.31
Effects of mechanical loading on intervertebral disc metabolism in vivo. J Bone Joint Surg Am (2006) 1.30
Type VI collagen of the intervertebral disc. Biochemical and electron-microscopic characterization of the native protein. Biochem J (1987) 1.24
The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model. J Biomech Eng (2003) 1.23
Influence of fixed charge density magnitude and distribution on the intervertebral disc: applications of a poroelastic and chemical electric (PEACE) model. J Biomech Eng (2003) 1.20
Viscoelastic properties of intervertebral disc cells. Identification of two biomechanically distinct cell populations. Spine (Phila Pa 1976) (1999) 1.17
Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability. J Biomech (2004) 1.16
Cell mechanics and mechanobiology in the intervertebral disc. Spine (Phila Pa 1976) (2004) 1.15
Internal strains in healthy and degenerated lumbar intervertebral discs. Spine (Phila Pa 1976) (2005) 1.13
Three-dimensional inhomogeneous triphasic finite-element analysis of physical signals and solute transport in human intervertebral disc under axial compression. J Biomech (2006) 1.11
The dynamic mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions under cyclic compressive loading. J Biomech Eng (2008) 1.11
An integrated finite-element approach to mechanics, transport and biosynthesis in tissue engineering. J Biomech Eng (2004) 1.08
The role of F-actin in hypo-osmotically induced cell volume change and calcium signaling in anulus fibrosus cells. Ann Biomed Eng (2004) 1.07
Transfer of macroscale tissue strain to microscale cell regions in the deformed meniscus. Biophys J (2008) 1.06
Human intervertebral disc cell morphology and cytoskeletal composition: a preliminary study of regional variations in health and disease. J Anat (2003) 1.03
In situ intercellular mechanics of the bovine outer annulus fibrosus subjected to biaxial strains. J Biomech (2004) 1.03
Electrical conductivity of lumbar anulus fibrosis: effects of porosity and fixed charge density. Spine (Phila Pa 1976) (2002) 1.03
In situ cell nucleus deformation in tendons under tensile load; a morphological analysis using confocal laser microscopy. J Orthop Res (2002) 1.03
Finite element simulation of location- and time-dependent mechanical behavior of chondrocytes in unconfined compression tests. Ann Biomed Eng (2000) 1.02
Modelling of location- and time-dependent deformation of chondrocytes during cartilage loading. J Biomech (1999) 1.01
Finite element modeling predictions of region-specific cell-matrix mechanics in the meniscus. Biomech Model Mechanobiol (2006) 1.00
Regional variations in certain cellular characteristics in human lumbar intervertebral discs, including the presence of alpha-smooth muscle actin. J Orthop Res (2001) 0.99
A mechano-chemical model for the passive swelling response of an isolated chondron under osmotic loading. Biomech Model Mechanobiol (2006) 0.99
Analysis of the mechanical behavior of chondrocytes in unconfined compression tests for cyclic loading. J Biomech (2006) 0.98
A special theory of biphasic mixtures and experimental results for human annulus fibrosus tested in confined compression. J Biomech Eng (2000) 0.97
Mechanobiology of the intervertebral disc. Biochem Soc Trans (2002) 0.96
A numerical study to determine pericellular matrix modulus and evaluate its effects on the micromechanical environment of chondrocytes. J Biomech (2006) 0.96
Physical signals and solute transport in human intervertebral disc during compressive stress relaxation: 3D finite element analysis. Biorheology (2006) 0.96
Effects of degeneration on the elastic modulus distribution in the lumbar intervertebral disc. Spine (Phila Pa 1976) (1996) 0.95
Three-dimensional morphology of the pericellular matrix of intervertebral disc cells in the rat. J Anat (2007) 0.93
Application of the u-p finite element method to the study of articular cartilage. J Biomech Eng (1991) 0.92
In-situ measurements of chondrocyte deformation under transient loading. Eur Cell Mater (2007) 0.91
The micromechanical environment of intervertebral disc cells: effect of matrix anisotropy and cell geometry predicted by a linear model. J Biomech Eng (2000) 0.90
The effect of matrix tension-compression nonlinearity and fixed negative charges on chondrocyte responses in cartilage. Mol Cell Biomech (2005) 0.90
Collagen network of articular cartilage modulates fluid flow and mechanical stresses in chondrocyte. Biomech Model Mechanobiol (2006) 0.89
Effects of friction on the unconfined compressive response of articular cartilage: a finite element analysis. J Biomech Eng (1990) 0.89
Application of a Three-Dimensional Poroelastic BEM to Modeling the Biphasic Mechanics of Cell-Matrix Interactions in Articular Cartilage (REVISION). Comput Methods Appl Mech Eng (2007) 0.88
Immunolocalisation of type VI collagen in the intervertebral disc. Ann Rheum Dis (1991) 0.85
Dynamic behavior of a biphasic cartilage model under cyclic compressive loading. J Biomech (1995) 0.80
RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat Methods (2013) 4.85
Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum (2010) 3.45
Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nat Methods (2013) 3.26
A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nat Mater (2007) 3.06
Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res (2011) 2.63
Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. Biomaterials (2004) 2.46
Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Commun (2002) 2.44
Determination of the Poisson's ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration. J Biomech (2005) 2.29
Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum (2009) 2.24
Multipotent stromal cells derived from the infrapatellar fat pad of the knee. Clin Orthop Relat Res (2003) 2.10
The role of mechanical loading in the onset and progression of osteoarthritis. Exerc Sport Sci Rev (2005) 2.09
Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc (2010) 2.02
Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum (2009) 2.02
Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells. Biomaterials (2009) 1.97
Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. J Biomech (2007) 1.90
The role of biomechanics and inflammation in cartilage injury and repair. Clin Orthop Relat Res (2004) 1.89
Site-specific molecular diffusion in articular cartilage measured using fluorescence recovery after photobleaching. Ann Biomed Eng (2003) 1.85
Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis. J Orthop Res (2007) 1.85
Biomechanics: cell research and applications for the next decade. Ann Biomed Eng (2009) 1.81
The role of the cytoskeleton in the viscoelastic properties of human articular chondrocytes. J Orthop Res (2004) 1.77
Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. Arthritis Rheum (2010) 1.75
Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis. Am J Physiol Heart Circ Physiol (2005) 1.73
The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Ann N Y Acad Sci (2006) 1.71
A thin-layer model for viscoelastic, stress-relaxation testing of cells using atomic force microscopy: do cell properties reflect metastatic potential? Biophys J (2006) 1.69
Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair. Tissue Eng (2006) 1.68
Swelling and mechanical behaviors of chemically cross-linked hydrogels of elastin-like polypeptides. Biomacromolecules (2003) 1.66
Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. Stem Cell Res Ther (2010) 1.59
The biomechanical role of the chondrocyte pericellular matrix in articular cartilage. Acta Biomater (2005) 1.57
Differentiation potential of adipose derived adult stem (ADAS) cells. Curr Top Dev Biol (2003) 1.57
Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arthritis Rheum (2006) 1.56
Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. J Biomech (2007) 1.55
Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cells. Tissue Eng (2003) 1.54
Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. J Biomech Eng (2003) 1.52
The development of posttraumatic arthritis after articular fracture. J Orthop Trauma (2006) 1.51
Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions. J Biomed Mater Res B Appl Biomater (2004) 1.51
Concise review: Adipose-derived stromal vascular fraction cells and stem cells: let's not get lost in translation. Stem Cells (2011) 1.50
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther (2010) 1.48
Tissue engineering for articular cartilage repair--the state of the art. Eur Cell Mater (2013) 1.48
Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. Biomaterials (2006) 1.48
Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair. Ann Biomed Eng (2004) 1.47
Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration. Arthritis Res Ther (2011) 1.47
Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix. Tissue Eng Part A (2010) 1.45
Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix. Tissue Eng Part A (2009) 1.44
Extended passaging, but not aldehyde dehydrogenase activity, increases the chondrogenic potential of human adipose-derived adult stem cells. J Cell Physiol (2006) 1.42
Urea as a passive transport marker for arthritis biomarker studies. Arthritis Rheum (2002) 1.41
Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. J Biomech (2005) 1.41
Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling. Tissue Eng (2006) 1.41
Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair. Biomacromolecules (2002) 1.39
Discussion: "On the Thermodynamical Admissibility of the Triphasic Theory of Charged Hydrated Tissues" (Huyghe, J. M., Wilson, W., and Malakpoor, K., ASME J. Biomech. Eng., 2009, 131, p. 044504). J Biomech Eng (2009) 1.39
Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. Arthritis Rheum (2007) 1.38
The mechanical properties of the human hip capsule ligaments. J Arthroplasty (2002) 1.38
Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution. Biomacromolecules (2007) 1.37
Influence of oxygen on the proliferation and metabolism of adipose derived adult stem cells. J Cell Physiol (2005) 1.37
Molecular phenotypes of notochordal cells purified from immature nucleus pulposus. Eur Spine J (2006) 1.36
Developmental and osteoarthritic changes in Col6a1-knockout mice: biomechanics of type VI collagen in the cartilage pericellular matrix. Arthritis Rheum (2009) 1.36
Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. Arthritis Rheum (2010) 1.36
Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse. Arthritis Rheum (2008) 1.35
Mechanical signals as regulators of stem cell fate. Curr Top Dev Biol (2004) 1.35
Human adipose-derived cells: an update on the transition to clinical translation. Regen Med (2012) 1.33
TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. Proc Natl Acad Sci U S A (2014) 1.32
Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 1.31
Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy. Biophys J (2010) 1.31
In situ cross-linking of elastin-like polypeptide block copolymers for tissue repair. Biomacromolecules (2007) 1.30
Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. J Am Soc Nephrol (2005) 1.30
A thermally responsive biopolymer for intra-articular drug delivery. J Control Release (2006) 1.30
Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. Arthritis Rheum (2012) 1.29
Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice. Arthritis Rheum (2013) 1.25
Diffusional anisotropy in collagenous tissues: fluorescence imaging of continuous point photobleaching. Biophys J (2006) 1.24
The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model. J Biomech Eng (2003) 1.23
Introduction: disc degeneration: summary. Spine (Phila Pa 1976) (2004) 1.21
Quantitative phase microscopy of articular chondrocyte dynamics by wide-field digital interferometry. J Biomed Opt (2010) 1.21
Enhanced integrative repair of the porcine meniscus in vitro by inhibition of interleukin-1 or tumor necrosis factor alpha. Arthritis Rheum (2007) 1.21
Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice. Dev Biol (2005) 1.20
Circadian oscillation of gene expression in murine calvarial bone. J Bone Miner Res (2007) 1.20
Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. J Appl Physiol (1985) (2003) 1.20
Compressive properties of mouse articular cartilage determined in a novel micro-indentation test method and biphasic finite element model. J Biomech Eng (2006) 1.19
Differential effects of static and dynamic compression on meniscal cell gene expression. J Orthop Res (2003) 1.19
Zonal uniformity in mechanical properties of the chondrocyte pericellular matrix: micropipette aspiration of canine chondrons isolated by cartilage homogenization. Ann Biomed Eng (2005) 1.19
Applications of elastin-like polypeptides in tissue engineering. Adv Drug Deliv Rev (2010) 1.19
Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng (2012) 1.19
Composite scaffolds for cartilage tissue engineering. Biorheology (2008) 1.18
Advanced material strategies for tissue engineering scaffolds. Adv Mater (2009) 1.18
Matrix protein gene expression in intervertebral disc cells subjected to altered osmolarity. Biochem Biophys Res Commun (2002) 1.18
Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology (2008) 1.17
Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis. Arthritis Res Ther (2012) 1.16
Region-specific constitutive gene expression in the adult porcine meniscus. J Orthop Res (2006) 1.15
Differentiation of adipose stem cells. Methods Mol Biol (2008) 1.15
Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. Arthritis Rheum (2009) 1.15
Conformational mechanics, adsorption, and normal force interactions of lubricin and hyaluronic acid on model surfaces. Langmuir (2008) 1.14
Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering. Tissue Eng Part A (2010) 1.14
Monolayer cell expansion conditions affect the chondrogenic potential of adipose-derived stem cells. Biotechnol Bioeng (2008) 1.14
Direct measurement of the Poisson's ratio of human patella cartilage in tension. J Biomech Eng (2002) 1.14