Published in Arthritis Rheum on October 01, 2009
The mediating effect of leptin on the relationship between body weight and knee osteoarthritis in older adults. Arthritis Rheumatol (2015) 2.06
Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol (2012) 1.75
What's new in our understanding of the role of adipokines in rheumatic diseases? Nat Rev Rheumatol (2011) 1.63
High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury. Arthritis Res Ther (2011) 1.62
Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol (2011) 1.56
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther (2010) 1.48
Obesity punches above its weight in osteoarthritis. Nat Rev Rheumatol (2010) 1.32
Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rheumatol Rep (2013) 1.31
Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. Arthritis Rheum (2012) 1.29
Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Ther Adv Musculoskelet Dis (2012) 1.23
Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol Aging Age Relat Dis (2012) 1.22
Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice. Arthritis Rheum (2012) 1.02
Tackling obesity in knee osteoarthritis. Nat Rev Rheumatol (2012) 1.02
The effects of adipokines on cartilage and meniscus catabolism. Connect Tissue Res (2011) 1.01
Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI. J Orthop Res (2010) 1.01
Histopathology of naturally occurring and surgically induced osteoarthritis in mice. Osteoarthritis Cartilage (2012) 0.98
Varus malalignment negates the structure-modifying benefits of doxycycline in obese women with knee osteoarthritis. Osteoarthritis Cartilage (2010) 0.98
Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis (2011) 0.98
Adipokines: Biomarkers for osteoarthritis? World J Orthop (2014) 0.98
Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. Ann Rheum Dis (2014) 0.96
Adipokines, metabolic syndrome and rheumatic diseases. J Immunol Res (2014) 0.95
Role of adipokines in atherosclerosis: interferences with cardiovascular complications in rheumatic diseases. Mediators Inflamm (2012) 0.95
Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis. Arthritis Res Ther (2010) 0.94
Obesity and osteoarthritis: is leptin the link? Arthritis Rheum (2009) 0.90
The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study. Arthritis Res Ther (2010) 0.90
Beyond fat mass: exploring the role of adipokines in rheumatic diseases. ScientificWorldJournal (2011) 0.87
Subchondral bone and osteoarthritis: biological and cellular aspects. Osteoporos Int (2012) 0.85
Longitudinal (4 year) change of thigh muscle and adipose tissue distribution in chronically painful vs painless knees--data from the Osteoarthritis Initiative. Osteoarthritis Cartilage (2015) 0.84
Do synovial leptin levels correlate with pain in end stage arthritis? Int Orthop (2013) 0.84
Leptin in the interplay of inflammation, metabolism and immune system disorders. Nat Rev Rheumatol (2017) 0.83
Does lipopolysaccharide-mediated inflammation have a role in OA? Nat Rev Rheumatol (2015) 0.83
Arthroplasty in veterans: analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes. J Rehabil Res Dev (2011) 0.83
Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis. Mol Cells (2015) 0.83
Obesity versus osteoarthritis: beyond the mechanical overload. Einstein (Sao Paulo) (2014) 0.82
Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic Approaches. Arthritis (2012) 0.81
Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice. Osteoarthritis Cartilage (2014) 0.81
Review: Metabolic Regulation of Inflammation in Osteoarthritis. Arthritis Rheumatol (2017) 0.78
Upregulation of Bone Morphogenetic Protein-2 Synthesis and Consequent Collagen II Expression in Leptin-stimulated Human Chondrocytes. PLoS One (2015) 0.78
Life-long caloric restriction does not alter the severity of age-related osteoarthritis. Age (Dordr) (2014) 0.78
Wolff's law in action: a mechanism for early knee osteoarthritis. Arthritis Res Ther (2015) 0.77
Adipokines as potential prognostic biomarkers in patients with acute knee injury. Biomarkers (2015) 0.77
Exploratory secondary analyses of a cognitive-behavioral intervention for knee osteoarthritis demonstrate reduction in biomarkers of adipocyte inflammation. Osteoarthritis Cartilage (2016) 0.77
Serum leptin concentration positively correlates with body weight and total fat mass in postmenopausal Japanese women with osteoarthritis of the knee. Arthritis (2011) 0.76
Catabolic and proinflammatory effects of leptin in chondrocytes are regulated by suppressor of cytokine signaling-3. Arthritis Res Ther (2016) 0.75
Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts. Arthritis Res Ther (2016) 0.75
Oral Administration of Resveratrol Alleviates Osteoarthritis Pathology in C57BL/6J Mice Model Induced by a High-Fat Diet. Mediators Inflamm (2017) 0.75
Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype. PLoS One (2017) 0.75
The current progress in understanding the molecular functions and mechanisms of visfatin in osteoarthritis. J Bone Miner Metab (2016) 0.75
Innate Immune Responses and Osteoarthritis. Curr Rheumatol Rep (2017) 0.75
Leptin and the regulation of body weight in mammals. Nature (1998) 14.84
Effects of the obese gene product on body weight regulation in ob/ob mice. Science (1995) 13.57
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell (2000) 7.87
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature (1998) 7.36
The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA (2001) 7.15
Leptin. Annu Rev Physiol (2000) 4.78
Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum (2003) 3.66
Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone (2004) 2.75
Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology (1999) 2.69
Expression and biologic characterization of the murine chemokine KC. J Immunol (1995) 2.66
Adipose tissue as an endocrine organ. Obesity (Silver Spring) (2006) 2.63
Leptin in immunology. J Immunol (2005) 2.62
The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum (2004) 2.58
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A (1997) 2.57
Adipocytokines in synovial fluid. JAMA (2003) 2.48
Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum (2005) 2.40
Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: the Framingham Study. Arthritis Rheum (2007) 2.12
Effect of menopausal status on body composition and abdominal fat distribution. Int J Obes Relat Metab Disord (2000) 2.08
Obesity is not associated with increased knee joint torque and power during level walking. J Biomech (2003) 1.99
Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol (2002) 1.95
Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol (1999) 1.90
The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol (1995) 1.86
Early onset of reproductive function in normal female mice treated with leptin. Science (1997) 1.79
Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage (2006) 1.77
Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthritis Cartilage (2007) 1.69
Functional estrogen receptors in adult articular cartilage: estrogen replacement therapy increases chondrocyte synthesis of proteoglycans and insulin-like growth factor binding protein 2. Arthritis Rheum (2000) 1.63
Contribution of a sedentary lifestyle and inactivity to the etiology of overweight and obesity: current evidence and research issues. Med Sci Sports Exerc (1999) 1.52
Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res Ther (2005) 1.47
Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment - a systematic approach. Osteoarthritis Cartilage (2008) 1.40
Understanding the relationship between body weight and osteoarthritis. Baillieres Clin Rheumatol (1997) 1.39
Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse. Arthritis Rheum (2008) 1.35
Cytokines and inflammation in cartilage degradation. Rheum Dis Clin North Am (1993) 1.33
A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis. Osteoarthritis Cartilage (2002) 1.32
Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Ann Rheum Dis (2007) 1.31
A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models. BMC Musculoskelet Disord (2008) 1.30
Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis Rheum (2003) 1.29
Subchondral bone of the human knee joint in aging and osteoarthritis. Osteoarthritis Cartilage (2002) 1.26
Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification. Bone (2005) 1.24
Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice. Am J Physiol (1998) 1.18
Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology (2008) 1.17
Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice. Arthritis Res Ther (2004) 1.12
Proinflammatory cytokines and leptin are increased in serum of prepubertal obese children. Mediators Inflamm (2005) 1.10
More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise. Osteoarthritis Cartilage (2001) 1.08
Functional and histological characteristics of skeletal muscle and the effects of leptin in the genetically obese (ob/ob) mouse. Int J Obes Relat Metab Disord (2000) 1.02
Effects of a high fat diet on the joints of aging mice. AMA Arch Pathol (1950) 1.02
Central leptin gene therapy blocks ovariectomy-induced adiposity. Obesity (Silver Spring) (2006) 0.93
Degenerative joint disease in mice fed a high-fat diet at various ages. Exp Med Surg (1952) 0.86
Obesity and joint disease. Gerontology (1976) 0.81
RNA-guided gene activation by CRISPR-Cas9-based transcription factors. Nat Methods (2013) 4.85
Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nat Methods (2013) 3.26
A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nat Mater (2007) 3.06
Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J Orthop Res (2011) 2.63
Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. Biomaterials (2004) 2.46
Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Commun (2002) 2.44
Determination of the Poisson's ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration. J Biomech (2005) 2.29
Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T. Arthritis Rheum (2005) 2.15
Multipotent stromal cells derived from the infrapatellar fat pad of the knee. Clin Orthop Relat Res (2003) 2.10
The role of mechanical loading in the onset and progression of osteoarthritis. Exerc Sport Sci Rev (2005) 2.09
Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc (2010) 2.02
Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum (2009) 2.02
Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells. Biomaterials (2009) 1.97
Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. J Biomech (2007) 1.90
The role of biomechanics and inflammation in cartilage injury and repair. Clin Orthop Relat Res (2004) 1.89
Site-specific molecular diffusion in articular cartilage measured using fluorescence recovery after photobleaching. Ann Biomed Eng (2003) 1.85
Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis. J Orthop Res (2007) 1.85
New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options. Arthritis Res Ther (2010) 1.84
Biomechanics: cell research and applications for the next decade. Ann Biomed Eng (2009) 1.81
The role of the cytoskeleton in the viscoelastic properties of human articular chondrocytes. J Orthop Res (2004) 1.77
Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. Arthritis Rheum (2010) 1.75
Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis. Am J Physiol Heart Circ Physiol (2005) 1.73
A thin-layer model for viscoelastic, stress-relaxation testing of cells using atomic force microscopy: do cell properties reflect metastatic potential? Biophys J (2006) 1.69
Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254). Arthritis Res Ther (2010) 1.61
Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. Proc Natl Acad Sci U S A (2011) 1.59
Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. Stem Cell Res Ther (2010) 1.59
The biomechanical role of the chondrocyte pericellular matrix in articular cartilage. Acta Biomater (2005) 1.57
Differentiation potential of adipose derived adult stem (ADAS) cells. Curr Top Dev Biol (2003) 1.57
Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arthritis Rheum (2006) 1.56
Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. J Biomech (2007) 1.55
Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cells. Tissue Eng (2003) 1.54
Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. J Biomech Eng (2003) 1.52
The development of posttraumatic arthritis after articular fracture. J Orthop Trauma (2006) 1.51
Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions. J Biomed Mater Res B Appl Biomater (2004) 1.51
Concise review: Adipose-derived stromal vascular fraction cells and stem cells: let's not get lost in translation. Stem Cells (2011) 1.50
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther (2010) 1.48
Tissue engineering for articular cartilage repair--the state of the art. Eur Cell Mater (2013) 1.48
Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. Biomaterials (2006) 1.48
Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration. Arthritis Res Ther (2011) 1.47
Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix. Tissue Eng Part A (2010) 1.45
Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix. Tissue Eng Part A (2009) 1.44
Extended passaging, but not aldehyde dehydrogenase activity, increases the chondrogenic potential of human adipose-derived adult stem cells. J Cell Physiol (2006) 1.42
Urea as a passive transport marker for arthritis biomarker studies. Arthritis Rheum (2002) 1.41
Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project. Arthritis Rheum (2003) 1.41
Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. J Biomech (2005) 1.41
Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling. Tissue Eng (2006) 1.41
Pain catastrophizing and pain-related fear in osteoarthritis patients: relationships to pain and disability. J Pain Symptom Manage (2008) 1.39
Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project. Arthritis Rheum (2005) 1.39
Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. Arthritis Rheum (2007) 1.38
The mechanical properties of the human hip capsule ligaments. J Arthroplasty (2002) 1.38
Influence of oxygen on the proliferation and metabolism of adipose derived adult stem cells. J Cell Physiol (2005) 1.37
Developmental and osteoarthritic changes in Col6a1-knockout mice: biomechanics of type VI collagen in the cartilage pericellular matrix. Arthritis Rheum (2009) 1.36
Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. Arthritis Rheum (2010) 1.36
Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse. Arthritis Rheum (2008) 1.35
Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. Arthritis Rheum (2009) 1.35
Mechanical signals as regulators of stem cell fate. Curr Top Dev Biol (2004) 1.35
Human adipose-derived cells: an update on the transition to clinical translation. Regen Med (2012) 1.33
TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. Proc Natl Acad Sci U S A (2014) 1.32
Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 1.31
Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy. Biophys J (2010) 1.31
A thermally responsive biopolymer for intra-articular drug delivery. J Control Release (2006) 1.30
Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. J Am Soc Nephrol (2005) 1.30
Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. Arthritis Rheum (2012) 1.29
Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice. Arthritis Rheum (2013) 1.25
Diffusional anisotropy in collagenous tissues: fluorescence imaging of continuous point photobleaching. Biophys J (2006) 1.24
The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model. J Biomech Eng (2003) 1.23
Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. Arthritis Rheum (2004) 1.22
Quantitative phase microscopy of articular chondrocyte dynamics by wide-field digital interferometry. J Biomed Opt (2010) 1.21
Enhanced integrative repair of the porcine meniscus in vitro by inhibition of interleukin-1 or tumor necrosis factor alpha. Arthritis Rheum (2007) 1.21
Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice. Dev Biol (2005) 1.20
Circadian oscillation of gene expression in murine calvarial bone. J Bone Miner Res (2007) 1.20
Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. J Appl Physiol (1985) (2003) 1.20
Compressive properties of mouse articular cartilage determined in a novel micro-indentation test method and biphasic finite element model. J Biomech Eng (2006) 1.19
Differential effects of static and dynamic compression on meniscal cell gene expression. J Orthop Res (2003) 1.19
Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng (2012) 1.19
Composite scaffolds for cartilage tissue engineering. Biorheology (2008) 1.18
Advanced material strategies for tissue engineering scaffolds. Adv Mater (2009) 1.18
Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology (2008) 1.17
Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis. Arthritis Res Ther (2012) 1.16
Differentiation of adipose stem cells. Methods Mol Biol (2008) 1.15
Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. Arthritis Rheum (2009) 1.15
Conformational mechanics, adsorption, and normal force interactions of lubricin and hyaluronic acid on model surfaces. Langmuir (2008) 1.14
Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering. Tissue Eng Part A (2010) 1.14
Monolayer cell expansion conditions affect the chondrogenic potential of adipose-derived stem cells. Biotechnol Bioeng (2008) 1.14
Pain coping skills training and lifestyle behavioral weight management in patients with knee osteoarthritis: a randomized controlled study. Pain (2012) 1.13
Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. Pain (2013) 1.12