Published in Am J Physiol Gastrointest Liver Physiol on December 03, 2009
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther (2011) 1.24
HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2012) 0.92
Gastroesophageal reflux disease--from reflux episodes to mucosal inflammation. Nat Rev Gastroenterol Hepatol (2011) 0.91
Viewpoints on Acid-induced inflammatory mediators in esophageal mucosa. J Neurogastroenterol Motil (2010) 0.89
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes. Am J Physiol Gastrointest Liver Physiol (2010) 0.88
Human esophageal myofibroblasts secrete proinflammatory cytokines in response to acid and Toll-like receptor 4 ligands. Am J Physiol Gastrointest Liver Physiol (2015) 0.88
ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. Am J Physiol Gastrointest Liver Physiol (2011) 0.85
GPR84 and TREM-1 signaling contribute to the pathogenesis of reflux esophagitis. Mol Med (2015) 0.79
Upregulation of Vanilloid Receptor-1 in Functional Dyspepsia With or Without Helicobacter pylori Infection. Medicine (Baltimore) (2016) 0.77
Involvement of the TRPV1 channel in the modulation of spontaneous locomotor activity, physical performance and physical exercise-induced physiological responses. Braz J Med Biol Res (2016) 0.77
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20
The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59
Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev (1999) 7.20
Platelet-activating factor and related lipid mediators. Annu Rev Biochem (2000) 3.44
Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science (1999) 3.19
Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils. J Clin Invest (1986) 2.90
Ca(2+)/CaM-dependent kinases: from activation to function. Annu Rev Pharmacol Toxicol (2001) 2.60
Platelet-activating factor. J Biol Chem (1990) 2.13
Lipid mediator networks in cell signaling: update and impact of cytokines. FASEB J (1996) 2.09
Targeting of calcium/calmodulin-dependent protein kinase II. Biochem J (2004) 2.08
Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells. Cancer Res (1991) 1.88
Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid. J Biol Chem (1980) 1.73
Calcium induces increases in peroxisome proliferator-activated receptor gamma coactivator-1alpha and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activation. J Biol Chem (2007) 1.71
The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. Crit Care Med (2002) 1.66
Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1. J Biol Chem (2000) 1.59
Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. Proc Natl Acad Sci U S A (1996) 1.57
Biochemical pharmacology of the vanilloid receptor TRPV1. An update. Eur J Biochem (2004) 1.42
Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus. Eur J Gastroenterol Hepatol (2004) 1.37
Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase. J Biol Chem (1995) 1.30
Ca(2+)/calmodulin-dependent protein kinases. Cell Mol Life Sci (2008) 1.30
Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiol Dis (2002) 1.28
The biochemical basis of the regulation of smooth-muscle contraction. Trends Biochem Sci (1994) 1.22
Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor. J Immunol (1988) 1.21
Platelet-activating factor and its analogs: metabolic pathways and related intracellular processes. Biochim Biophys Acta (1995) 1.18
Capsaicin receptor (TRPV1) and non-erosive reflux disease. Eur J Gastroenterol Hepatol (2006) 1.17
CaM Kinase II-dependent pathophysiological signalling in endothelial cells. Cardiovasc Res (2007) 1.17
Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther (2002) 1.16
Vanilloid receptor 1 regulates multiple calcium compartments and contributes to Ca2+-induced Ca2+ release in sensory neurons. J Biol Chem (2004) 1.15
Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia. Pain (2005) 1.11
The Year in Basic Science: calmodulin kinase cascades. Mol Endocrinol (2008) 1.09
Cytosolic phospholipase A2: biochemical properties and physiological roles. IUBMB Life (2006) 1.06
Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells. Cancer Res (2005) 1.04
Biosynthesis of platelet-activating factor (PAF-ACETHER). II. Involvement of phospholipase A2 in the formation of PAF-ACETHER and lyso-PAF-ACETHER from rabbit platelets. Thromb Res (1982) 1.02
Acute keratinocyte damage stimulates platelet-activating factor production. Arch Dermatol Res (2000) 1.01
Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. Biochem Biophys Res Commun (2000) 0.96
CO2 chemosensing in rat oesophagus. Gut (2008) 0.95
Calmodulin and its role in intracellular calcium regulation. Prog Neurobiol (1987) 0.94
Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle. J Pharmacol Exp Ther (2006) 0.93
Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. Am J Physiol Gastrointest Liver Physiol (2005) 0.92
Preferential human eosinophil chemotactic activity of the platelet-activating factor (PAF) 1-0-hexadecyl-2-acetyl-sn-glyceryl-3-phosphocholine (AGEPC). J Clin Immunol (1987) 0.92
HCl-induced inflammatory mediators in cat esophageal mucosa and inflammatory mediators in esophageal circular muscle in an in vitro model of esophagitis. Am J Physiol Gastrointest Liver Physiol (2006) 0.92
Platelet-activating factor produced by endothelial cells. A molecule with autocrine and paracrine properties. Eur J Biochem (1995) 0.91
Differential signal transduction pathways in cat lower esophageal sphincter tone and response to ACh. Am J Physiol (1994) 0.91
The effect of platelet-activating factor on the generation of superoxide anion in human eosinophils and neutrophils. J Allergy Clin Immunol (1991) 0.90
Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis. Gastroenterology (2005) 0.90
HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. Am J Physiol Gastrointest Liver Physiol (2009) 0.90
Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. J Exp Med (2005) 0.89
Rapid induction and Ca(2+) influx-mediated suppression of vitamin D3 up-regulated protein 1 (VDUP1) mRNA in cerebellar granule neurons undergoing apoptosis. J Neurochem (2001) 0.88
Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils. J Allergy Clin Immunol (2003) 0.88
Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating factor. Int Arch Allergy Immunol (2004) 0.87
Biosynthesis of platelet-activating factor and enzyme inhibitors. Adv Exp Med Biol (1996) 0.87
Transmigration of eosinophils through basement membrane components in vitro: synergistic effects of platelet-activating factor and eosinophil-active cytokines. Am J Respir Cell Mol Biol (1997) 0.86
Regulation of VEGF-induced endothelial cell PAF synthesis: role of p42/44 MAPK, p38 MAPK and PI3K pathways. Br J Pharmacol (2001) 0.85
The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats. J Biol Chem (1987) 0.85
Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. Biochim Biophys Acta (2002) 0.83
Role of platelet-activating factor in acid-induced esophageal mucosal injury. Dig Dis Sci (2007) 0.82
Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue. Eur J Biochem (2003) 0.82
Studies of cellular mechanisms for the generation of superoxide by guinea-pig eosinophils and its dissociation from granule peroxidase release. Biochem Pharmacol (1990) 0.81
A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases? Circulation (1985) 0.79
Reactive oxygen species are messengers in maintenance of human and guinea pig gallbladder tonic contraction. Am J Physiol Gastrointest Liver Physiol (2007) 1.44
cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells. J Biol Chem (2006) 1.42
Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Gastroenterology (2006) 1.41
Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis. J Pharmacol Exp Ther (2004) 1.27
Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma. Gut (2009) 1.20
Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. Am J Physiol Gastrointest Liver Physiol (2010) 1.20
MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol (2003) 1.18
Proinflammatory cytokines alter/reduce esophageal circular muscle contraction in experimental cat esophagitis. Am J Physiol Gastrointest Liver Physiol (2004) 1.17
Signal-transduction pathways that regulate smooth muscle function I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles. Am J Physiol Gastrointest Liver Physiol (2005) 1.09
NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells. J Biol Chem (2007) 1.06
Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines. Arch Surg (2002) 1.02
Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S. Am J Physiol Gastrointest Liver Physiol (2010) 0.98
Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle. J Pharmacol Exp Ther (2006) 0.93
Abnormalities of prostaglandins and cyclooxygenase enzymes in female patients with slow-transit constipation. Gastroenterology (2007) 0.93
Role of progesterone signaling in the regulation of G-protein levels in female chronic constipation. Gastroenterology (2005) 0.93
HCl-induced inflammatory mediators in cat esophageal mucosa and inflammatory mediators in esophageal circular muscle in an in vitro model of esophagitis. Am J Physiol Gastrointest Liver Physiol (2006) 0.92
Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. Am J Physiol Gastrointest Liver Physiol (2005) 0.92
HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2012) 0.92
Retracted Role of STAT3 and vitamin D receptor in EZH2-mediated invasion of human colorectal cancer. J Pathol (2013) 0.90
Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis. Gastroenterology (2005) 0.90
HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. Am J Physiol Gastrointest Liver Physiol (2009) 0.90
Effects of bile acids on the muscle functions of guinea pig gallbladder. Am J Physiol Gastrointest Liver Physiol (2002) 0.89
In vitro model of acute esophagitis in the cat. Am J Physiol Gastrointest Liver Physiol (2005) 0.89
Viewpoints on Acid-induced inflammatory mediators in esophageal mucosa. J Neurogastroenterol Motil (2010) 0.89
Role of caveolae in the pathogenesis of cholesterol-induced gallbladder muscle hypomotility. Am J Physiol Gastrointest Liver Physiol (2007) 0.88
Hydrophilic but not hydrophobic bile acids prevent gallbladder muscle dysfunction in acute cholecystitis. Hepatology (2003) 0.88
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes. Am J Physiol Gastrointest Liver Physiol (2010) 0.88
IL-1beta signaling in cat lower esophageal sphincter circular muscle. Am J Physiol Gastrointest Liver Physiol (2006) 0.87
Calcium-dependent and calcium-independent contractions in smooth muscles. Am J Med (2003) 0.87
STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. Am J Physiol Gastrointest Liver Physiol (2007) 0.87
Role of Rac1 in regulation of NOX5-S function in Barrett's esophageal adenocarcinoma cells. Am J Physiol Cell Physiol (2011) 0.87
Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle. Am J Physiol Gastrointest Liver Physiol (2004) 0.86
Impaired cytoprotective function of muscle in human gallbladders with cholesterol stones. Am J Physiol Gastrointest Liver Physiol (2004) 0.86
Ursodeoxycholic acid improves muscle contractility and inflammation in symptomatic gallbladders with cholesterol gallstones. Gut (2006) 0.86
ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. Am J Physiol Gastrointest Liver Physiol (2011) 0.85
Reactive oxygen species (H(2)O(2)): effects on the gallbladder muscle of guinea pigs. Am J Physiol Gastrointest Liver Physiol (2002) 0.85
Esophageal disease: updated information on inflammation. Ann N Y Acad Sci (2011) 0.84
H(2)O(2): a mediator of esophagitis-induced damage to calcium-release mechanisms in cat lower esophageal sphincter. Am J Physiol Gastrointest Liver Physiol (2005) 0.84
Distinct kinases are involved in contraction of cat esophageal and lower esophageal sphincter smooth muscles. Am J Physiol Cell Physiol (2004) 0.84
Prostaglandins mediate tonic contraction of the guinea pig and human gallbladder. Am J Physiol Gastrointest Liver Physiol (2006) 0.84
PGF(2alpha)-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol (2002) 0.83
Role of PGE2 on gallbladder muscle cytoprotection of guinea pigs. Am J Physiol Gastrointest Liver Physiol (2003) 0.83