Published in Proc Natl Acad Sci U S A on December 04, 2009
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Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation. J Gen Physiol (2012) 1.15
Potassium-selective block of barium permeation through single KcsA channels. J Gen Physiol (2011) 1.13
A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporter. J Biol Chem (2011) 1.03
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Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. Mol Pharmacol (2012) 0.96
Identification of a novel post-hydrolytic state in CFTR gating. J Gen Physiol (2012) 0.93
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Nonequilibrium gating of CFTR on an equilibrium theme. Physiology (Bethesda) (2012) 0.91
Alternating access to the transmembrane domain of the ATP-binding cassette protein cystic fibrosis transmembrane conductance regulator (ABCC7). J Biol Chem (2012) 0.89
Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating. J Gen Physiol (2011) 0.88
Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating. Proc Natl Acad Sci U S A (2014) 0.87
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Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR. J Gen Physiol (2014) 0.86
Modulation of CFTR gating by permeant ions. J Gen Physiol (2014) 0.86
CFTR: an ion channel with a transporter-type energy-coupling mechanism. J Gen Physiol (2012) 0.86
Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating. J Gen Physiol (2014) 0.85
Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. J Gen Physiol (2013) 0.84
Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability. Cold Spring Harb Perspect Med (2013) 0.83
Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels. J Gen Physiol (2015) 0.83
Cystic fibrosis transmembrane conductance regulator in the gills of the climbing perch, Anabas testudineus, is involved in both hypoosmotic regulation during seawater acclimation and active ammonia excretion during ammonia exposure. J Comp Physiol B (2012) 0.82
Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps. J Biol Chem (2014) 0.82
Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutations. J Biol Chem (2013) 0.82
The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity. Elife (2016) 0.82
Accurate encoding and decoding by single cells: amplitude versus frequency modulation. PLoS Comput Biol (2015) 0.81
Rescue of NBD2 mutants N1303K and S1235R of CFTR by small-molecule correctors and transcomplementation. PLoS One (2015) 0.81
Altering intracellular pH reveals the kinetic basis of intraburst gating in the CFTR Cl(-) channel. J Physiol (2016) 0.81
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Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR. J Gen Physiol (2017) 0.80
Structure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects. J Gen Physiol (2014) 0.80
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CFTR is a mechanosensitive anion channel: a real stretch? Cellscience (2010) 0.79
A single amino acid substitution in CFTR converts ATP to an inhibitory ligand. J Gen Physiol (2014) 0.79
Integrated analysis of residue coevolution and protein structure in ABC transporters. PLoS One (2012) 0.78
Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating. J Physiol (2015) 0.78
Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization. Elife (2016) 0.78
Cystic fibrosis lung environment and Pseudomonas aeruginosa infection. BMC Pulm Med (2016) 0.77
Saccharomyces cerivisiae as a model system for kidney disease: what can yeast tell us about renal function? Am J Physiol Renal Physiol (2011) 0.77
New structural insights into the gating movements of CFTR. J Gen Physiol (2015) 0.75
CFTR gating: Invisible transitions made visible. J Gen Physiol (2017) 0.75
The Nucleotide-Binding Sites of SUR1: A Mechanistic Model. Biophys J (2015) 0.75
Complement yourself: Transcomplementation rescues partially folded mutant proteins. Biophys Rev (2014) 0.75
Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel. Cell (2017) 0.75
A single active catalytic site is sufficient to promote transport in P-glycoprotein. Sci Rep (2016) 0.75
How Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). J Biol Chem (2016) 0.75
Know the Single-Receptor Sensing Limit? Think Again. J Stat Phys (2015) 0.75
Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions. Elife (2017) 0.75
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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell (2000) 7.63
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The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p. J Biol Chem (2003) 1.52
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Formation of the productive ATP-Mg2+-bound dimer of GlcV, an ABC-ATPase from Sulfolobus solfataricus. J Mol Biol (2003) 1.28
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Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysis. Biochemistry (2006) 0.87
The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature (2006) 3.66
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains. Nature (2005) 3.24
On the mechanism of MgATP-dependent gating of CFTR Cl- channels. J Gen Physiol (2003) 2.39
In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer. EMBO J (2006) 2.04
Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating. J Gen Physiol (2003) 2.03
Na+/K+-pump ligands modulate gating of palytoxin-induced ion channels. Proc Natl Acad Sci U S A (2002) 1.36
Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps. J Gen Physiol (2014) 1.29
Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle. J Gen Physiol (2006) 1.24
Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA. J Gen Physiol (2005) 1.22
Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands. J Gen Physiol (2004) 1.22
The ion pathway through the opened Na(+),K(+)-ATPase pump. Nature (2008) 1.20
Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain. J Gen Physiol (2004) 1.16
Ion permeation through the Na+,K+-ATPase. Nature (2006) 1.13
Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2. J Gen Physiol (2010) 1.00
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Distinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel. J Gen Physiol (2002) 0.98
Ion transport: spot the difference. Nature (2004) 0.94
Ouabain affinity determining residues lie close to the Na/K pump ion pathway. Proc Natl Acad Sci U S A (2006) 0.92
The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions. J Gen Physiol (2010) 0.89
Ion occlusion/deocclusion partial reactions in individual palytoxin-modified Na/K pumps. Ann N Y Acad Sci (2003) 0.89
Ion channel-like properties of the Na+/K+ Pump. Ann N Y Acad Sci (2002) 0.89
Increased apical Na+ permeability in cystic fibrosis is supported by a quantitative model of epithelial ion transport. J Physiol (2013) 0.88
Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating. J Gen Physiol (2011) 0.88
Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid. Proc Natl Acad Sci U S A (2011) 0.87
Single ion occupancy and steady-state gating of Na channels in squid giant axon. J Gen Physiol (2002) 0.84
Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. J Gen Physiol (2013) 0.84
Degenerate ABC composite site is stably glued together by trapped ATP. J Gen Physiol (2010) 0.82
Sodium flux ratio in Na/K pump-channels opened by palytoxin. J Gen Physiol (2007) 0.81
Visualizing the mapped ion pathway through the Na,K-ATPase pump. Channels (Austin) (2009) 0.79
Structural biology: ion pumps made crystal clear. Nature (2007) 0.77
Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation. Methods Mol Biol (2011) 0.76