Published in Nature on February 28, 1991
A temporal signal, independent of agr, is required for hla but not spa transcription in Staphylococcus aureus. J Bacteriol (1991) 4.23
Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. EMBO J (2000) 3.35
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1996) 3.09
Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA. Mol Cell Biol (1997) 2.83
Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol Cell Biol (1996) 2.41
Immediate early transcription activation by salicylic acid via the cauliflower mosaic virus as-1 element. Plant Cell (1994) 2.06
Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. Mol Cell Biol (1994) 1.99
Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1. Mol Cell Biol (1995) 1.91
Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors. EMBO J (1992) 1.91
A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.72
Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNAs in intestinal epithelial cells, resulting in increased chemokine expression. Infect Immun (2001) 1.69
Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction. Proc Natl Acad Sci U S A (1994) 1.63
A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation. Proc Natl Acad Sci U S A (1992) 1.58
Regulatory pathways governing modulation of fungal gene expression by a virulence-attenuating mycovirus. EMBO J (1992) 1.52
A labile transcriptional repressor modulates endotoxin tolerance. J Exp Med (1994) 1.47
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction. Mol Cell Biol (1998) 1.45
The role of protein synthesis during the labile phases of memory: revisiting the skepticism. Neurobiol Learn Mem (2007) 1.32
The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells. Biochem J (1995) 1.29
Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. Apoptosis (2008) 1.21
Activation of p38 mitogen-activated protein kinase attenuates Leishmania donovani infection in macrophages. Infect Immun (2002) 1.10
Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38(MAP kinase) activation and protein synthesis inhibition in mammalian cells. J Physiol (1997) 1.05
Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes. Nucleic Acids Res (2010) 1.04
A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors. J Biol Chem (2010) 1.02
Acid activation of immediate early genes in renal epithelial cells. J Clin Invest (1994) 0.99
Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction. Mol Cell Biol (1994) 0.96
A mitogen- and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and on isolated mononucleosomes. EMBO J (1994) 0.94
Protein synthesis inhibitors, gene superinduction and memory: too little or too much protein? Neurobiol Learn Mem (2007) 0.93
Differential dependence of herpes simplex virus immediate-early gene expression on de novo-infected cell protein synthesis. J Virol (1991) 0.92
Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate. Mol Cell Biol (1999) 0.86
Accelerated poly(A) loss and mRNA stabilization are independent effects of protein synthesis inhibition on alpha-tubulin mRNA in Chlamydomonas. Nucleic Acids Res (1993) 0.84
Cycloheximide treatment of cotton ovules alters the abundance of specific classes of mRNAs and generates novel ESTs for microarray expression profiling. Mol Genet Genomics (2005) 0.83
Differential regulation of nitric oxide synthase mRNA expression by lipopolysaccharide and pro-inflammatory cytokines in fetal hepatocytes treated with cycloheximide. Biochem J (1997) 0.80
A kinase associated with chromatin that can be activated by ligand-p185c-Neu or epidermal growth factor-receptor interactions. Proc Natl Acad Sci U S A (1995) 0.75
Consolidation of altered associability information by amygdala central nucleus. Neurobiol Learn Mem (2016) 0.75
Effects of deoxynivalenol (DON) and its microbial biotransformation product deepoxy-deoxynivalenol (DOM-1) on a trout, pig, mouse, and human cell line. Mycotoxin Res (2017) 0.75
Parallel signal processing among mammalian MAPKs. Trends Biochem Sci (1995) 4.46
Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci (2001) 3.71
The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J (1999) 3.58
Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. EMBO J (2000) 3.35
MicroRNAs and the hallmarks of cancer. Oncogene (2006) 2.55
Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. J Cell Biol (1988) 2.37
Matrix metalloproteinases and diseases of the CNS. Trends Neurosci (1998) 2.24
Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. Mol Cell Biol (1994) 1.99
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J Biol Chem (1994) 1.99
Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors. EMBO J (1992) 1.91
Placebo-controlled trial of lithium augmentation of fluoxetine and lofepramine. Br J Psychiatry (1995) 1.81
Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes. J Neurosci (1999) 1.81
Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction. Mol Cell (2001) 1.78
Transcriptional regulation of two serum-induced RNAs in mouse fibroblasts: equivalence of one species to B2 repetitive elements. Mol Cell Biol (1985) 1.73
Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas. Br J Cancer (1999) 1.71
Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction. Proc Natl Acad Sci U S A (1994) 1.63
Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts. J Biol Chem (2000) 1.60
p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient. Curr Biol (1996) 1.55
MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction. Semin Cell Dev Biol (1999) 1.54
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction. Arthritis Rheum (2002) 1.52
Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia. Neurosci Lett (1997) 1.49
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction. Mol Cell Biol (1998) 1.45
Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues. Br J Cancer (2005) 1.45
Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis. Am J Pathol (1998) 1.38
Gene expression during the mammalian cell cycle. Biochim Biophys Acta (1986) 1.37
Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues. FEBS Lett (1997) 1.36
Cancer. Proteases--invasion and more. Nature (1998) 1.34
Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations. Genes Dev (1990) 1.32
Characterization of the mouse met proto-oncogene. Oncogene (1988) 1.31
Tissue inhibitor of metalloproteinases (TIMP, aka EPA): structure, control of expression and biological functions. Pharmacol Ther (1993) 1.29
Acetyllysine-binding and function of bromodomain-containing proteins in chromatin. Front Biosci (2001) 1.28
A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: evidence for inducible and constitutive transcripts. Nucleic Acids Res (1986) 1.25
Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction. J Cell Sci (1995) 1.25
Growth factors and cytokines upregulate gelatinase expression in bone marrow CD34(+) cells and their transmigration through reconstituted basement membrane. Blood (1999) 1.23
Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma. Br J Cancer (2006) 1.19
Identification of anisomycin-activated kinases p45 and p55 in murine cells as MAPKAP kinase-2. Oncogene (1996) 1.19
Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues. Mol Pathol (2001) 1.19
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation period. Dev Genet (1997) 1.18
TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol (2001) 1.16
Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas. Br J Cancer (1992) 1.15
Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli. Oncogene (1997) 1.13
ERK5 signalling in prostate cancer promotes an invasive phenotype. Br J Cancer (2011) 1.10
Tissue inhibitor of metalloproteinases-1 (TIMP-1) RNA is expressed at elevated levels in malignant non-Hodgkin's lymphomas. Blood (1991) 1.08
Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species. Biochem J (2001) 1.08
Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor. Development (1995) 1.08
Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases. Br J Cancer (2000) 1.06
Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA. Development (1989) 1.04
Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas. Br J Cancer (2001) 1.03
Differential regulation of TIMP-1 and TIMP-2 mRNA expression in normal and Ha-ras-transformed murine fibroblasts. Gene (1992) 1.03
Lymph node metastases from glioblastoma multiforme. AJNR Am J Neuroradiol (1997) 1.03
Spontaneous immortalization of mouse embryo cells: strain differences and changes in gene expression with particular reference to retroviral gag-pol genes. Exp Cell Res (1991) 1.03
Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins. Cancer Res (1986) 1.01
A study of mitochondrial and nuclear transcription with cloned cDNA probes. Changes in the relative abundance of mitochondrial transcripts after stimulation of quiescent mouse fibroblasts. Exp Cell Res (1985) 1.00
Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans. Br J Cancer (1996) 1.00
Expression of matrix metalloproteinases (MMP-2 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in acute myelogenous leukaemia blasts: comparison with normal bone marrow cells. Br J Haematol (1999) 0.99
Banking of fresh-frozen prostate tissue: methods, validation and use. BJU Int (2003) 0.98
Improved design of riboprobes from pBluescript and related vectors for in situ hybridization. Biotechniques (1993) 0.97
Expression pattern of metalloproteinases and their inhibitors changes with the progression of human sporadic colorectal neoplasia. Diagn Mol Pathol (1993) 0.97
Reprogramming of TIMP-1 and TIMP-3 expression profiles in brain microvascular endothelial cells and astrocytes in response to proinflammatory cytokines. FEBS Lett (1999) 0.97
Characterization of a cDNA clone encoding murine mitogen-regulated protein: regulation of mRNA levels in mortal and immortal cell lines. Mol Cell Biol (1985) 0.97
Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction. Mol Cell Biol (1994) 0.96
Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 are key regulators of extracellular matrix degradation by mouse embryos. Biol Reprod (2001) 0.96
Localization of gelatinase-A and gelatinase-B mRNA and protein in human gliomas. Neuro Oncol (2000) 0.96
Extracellular matrix and matrix metalloproteinases in sciatic nerve. J Neurosci Res (2003) 0.95
Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1. Biochem J (1997) 0.95
A mitogen- and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and on isolated mononucleosomes. EMBO J (1994) 0.94
Oncostatin M stimulates c-Fos to bind a transcriptionally responsive AP-1 element within the tissue inhibitor of metalloproteinase-1 promoter. J Biol Chem (1998) 0.93
Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse. Biol Reprod (1996) 0.93
Embryonal carcinoma-derived growth factor activates protein kinase C in vivo and in vitro. EMBO J (1987) 0.92
Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity. Eur J Cancer (2007) 0.92
Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures. Hepatology (1993) 0.92
Comparison of platelet storage in PL146 and PL732 plastic packs: preliminary in vitro studies. J Clin Pathol (1982) 0.92
Hormonal regulation of matrix metalloproteinase inhibitors in rat granulosa cells and ovaries. Endocrinology (1991) 0.91
Expression and modulation of matrix metalloproteinase-2 and tissue inhibitors of metalloproteinases in human embryonic CNS stem cells. Neuroreport (1999) 0.90
Abelson-transformed fibroblasts contain nuclear phosphotyrosyl-proteins which preferentially bind to murine DNA. Nature (1987) 0.89
Long-term effects of poultry litter, alum-treated litter, and ammonium nitrate on phosphorus availability in soils. J Environ Qual (2007) 0.89
Evaluation of chemical amendments to reduce ammonia volatilization from poultry litter. Poult Sci (1996) 0.89
Proteolytic activity of human non-Hodgkin's lymphomas. Am J Pathol (1998) 0.88
The polyadenylated RNA directing the synthesis of the rat myelin basic proteins is present in both free and membrane-bound forebrain polyribosomes. Biochem J (1982) 0.88
Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells. Cell Growth Differ (1990) 0.87
Long-term effects of poultry litter, alum-treated litter, and ammonium nitrate on aluminum availability in soils. J Environ Qual (2005) 0.87
Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines. Br J Cancer (2008) 0.87
Reducing phosphorus runoff and improving poultry production with alum. Poult Sci (1999) 0.87
Telomere-dependent senescence. Nat Biotechnol (1999) 0.86
High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma. J Neurooncol (1998) 0.86
Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activity. Biochem Biophys Res Commun (2001) 0.86
Roles of growth factors during peri-implantation development. Hum Reprod (1995) 0.86
Tissue inhibitor of metalloproteinases-2 (TIMP-2) in rat liver cells is increased by lipopolysaccharide and prostaglandin E2. FEBS Lett (1995) 0.85
Differential mRNA expression of renal cortical tissue inhibitor of metalloproteinase-1, -2, and -3 in experimental hydronephrosis. J Am Soc Nephrol (1995) 0.85
Effects of alum and aluminum chloride on phosphorus runoff from swine manure. J Environ Qual (2001) 0.85
Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse. Dev Genet (1997) 0.84
The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1. J Biol Chem (2000) 0.83
mRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma. Br J Cancer (2012) 0.83
The brain isoform of a key ATP-regulating enzyme, creatine kinase, is a phosphoprotein. Biochem J (1984) 0.83
Patterns of expression of metalloproteinases and their inhibitors in human malignant lymphomas. Oncol Res (1993) 0.83
Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus. Mol Reprod Dev (1996) 0.83
An automated electronic method for quantifying spinning (circling) in children with autistic disorder. J Neuropsychiatry Clin Neurosci (1995) 0.82
Expression and activity of ovarian tissue inhibitors of metalloproteinases during pseudopregnancy in the rat. Biol Reprod (1995) 0.81