Published in Mol Cancer on December 14, 2009
MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor. Proc Natl Acad Sci U S A (2012) 1.20
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med (2015) 1.17
The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer. Front Oncol (2014) 0.96
The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones. Front Pharmacol (2012) 0.90
Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation. J Steroid Biochem Mol Biol (2011) 0.86
In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). Invest New Drugs (2014) 0.86
Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons. Chem Res Toxicol (2014) 0.86
Tissue distribution, ontogeny, and chemical induction of aldo-keto reductases in mice. Drug Metab Dispos (2013) 0.84
Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate. Br J Cancer (2014) 0.81
Role of aldo-keto reductase enzymes in mediating the timing of parturition. Front Pharmacol (2012) 0.80
Combination effects of dietary soy and methylselenocysteine in a mouse model of prostate cancer. Prostate (2013) 0.76
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Toxicol Appl Pharmacol (2015) 0.76
A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of c-MYC G-quadruplex and Down-regulates c-MYC Transcription in Human Cancer Cells. Sci Rep (2015) 0.75
Clustal W and Clustal X version 2.0. Bioinformatics (2007) 126.47
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res (2006) 9.87
The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis (2009) 5.01
15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci U S A (2000) 3.89
Comparative anatomy of the aldo-keto reductase superfamily. Biochem J (1997) 3.39
Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev (2001) 2.09
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. J Biol Chem (2003) 1.90
The aldo-keto reductase superfamily homepage. Chem Biol Interact (2003) 1.75
Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms. Arch Biochem Biophys (2007) 1.75
The aldo-keto reductase (AKR) superfamily: an update. Chem Biol Interact (2001) 1.52
Steroid hormone transforming aldo-keto reductases and cancer. Ann N Y Acad Sci (2009) 1.41
Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Res (2004) 1.40
Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. Arch Biochem Biophys (1988) 1.39
Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors. Mol Cell Endocrinol (2006) 1.38
Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. Endocrinology (2003) 1.35
Expression of the LIM-homeobox gene LH2 generates immortalized steel factor-dependent multipotent hematopoietic precursors. EMBO J (1998) 1.35
Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer. Endocrinology (2006) 1.27
AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer. Mol Cell Endocrinol (2005) 1.23
Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. Mol Endocrinol (2004) 1.16
cDNA cloning, expression and characterization of human prostaglandin F synthase. FEBS Lett (1999) 1.15
A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res (2002) 1.08
AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Cancer Res (2009) 1.04
The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis. Mutat Res (2008) 1.04
Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha. BMC Cancer (2009) 1.01
Prostaglandin F synthase. Prostaglandins Other Lipid Mediat (2002) 1.01
Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. Genes Cells (2000) 1.01
Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact (2008) 0.94
Multipotent hematopoietic progenitor cells immortalized by Lhx2 self-renew by a cell nonautonomous mechanism. Exp Hematol (2001) 0.93
Molecular cloning of cDNA for rat ovarian 20 alpha-hydroxysteroid dehydrogenase (HSD1). Biochem J (1994) 0.93
Potentiation of myeloid differentiation by anti-inflammatory agents, by steroids and by retinoic acid involves a single intracellular target, probably an enzyme of the aldoketoreductase family. Biochim Biophys Acta (1996) 0.90
Molecular characterization of two monkey dihydrodiol dehydrogenases. Drug Metab Pharmacokinet (2002) 0.84
Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity. Eur J Biochem (1995) 0.84
Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men. J Endocrinol (2006) 0.81
Identification of a retinoic acid responsive aldoketoreductase expressed in HL60 leukaemic cells. FEBS Lett (1998) 0.81
Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. J Mol Biol (2007) 0.81
Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach. FEBS Lett (1999) 0.79
Characterization of prostaglandin F2 alpha production in pregnant and cycling mice. Biol Reprod (1996) 0.78
Conditional inactivation of Sox9: a mouse model for campomelic dysplasia. Genesis (2002) 1.78
Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure. Proc Natl Acad Sci U S A (2002) 1.65
Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development (2010) 1.52
Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia. Mech Dev (2002) 1.44
Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3. Invest Ophthalmol Vis Sci (2008) 1.15
The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis. Mutat Res (2008) 1.04
AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Cancer Res (2009) 1.04
Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. PLoS One (2009) 1.03
A mouse model for Sorsby fundus dystrophy. Invest Ophthalmol Vis Sci (2002) 0.96
11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function. J Biol Chem (2007) 0.94
PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils. J Cell Sci (2011) 0.93
Treatment of chronic lymphocytic leukemia requires targeting of the protective lymph node environment with novel therapeutic approaches. Leuk Lymphoma (2011) 0.91
Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies. J Biol Chem (2012) 0.91
A quick, simple and unbiased method to quantify C2C12 myogenic differentiation. Muscle Nerve (2011) 0.90
Cortisone-reductase deficiency associated with heterozygous mutations in 11beta-hydroxysteroid dehydrogenase type 1. Proc Natl Acad Sci U S A (2011) 0.89
Carcinoembryonic antigen-related cell adhesion molecule 10 expressed specifically early in pregnancy in the decidua is dispensable for normal murine development. Mol Cell Biol (2003) 0.89
Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J Neurosci (2013) 0.87
New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. J Bone Miner Res (2012) 0.86
Sorsby fundus dystrophy mutation Timp3(S156C) affects the morphological and biochemical phenotype but not metalloproteinase homeostasis. J Cell Physiol (2003) 0.84
Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrate- and medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance. Haematologica (2010) 0.83
Elevated FOSB-expression; a potential marker of valproate sensitivity in AML. Br J Haematol (2008) 0.83
Prostaglandin D2 inhibits C2C12 myogenesis. Mol Cell Endocrinol (2010) 0.83
Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML). Br J Haematol (2010) 0.82
Supramolecular iron cylinder with unprecedented DNA binding is a potent cytostatic and apoptotic agent without exhibiting genotoxicity. Chem Biol (2008) 0.82
Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system. Protein Sci (2009) 0.79
Prostaglandins in muscle regeneration. J Muscle Res Cell Motil (2008) 0.79
Interpreting 4C-Seq data: how far can we go? Epigenomics (2014) 0.79
Expression of vasorin (Vasn) during embryonic development of the mouse. Gene Expr Patterns (2012) 0.79
MfERG waveform characteristics in the RS1h mouse model featuring a 'negative' ERG. Doc Ophthalmol (2003) 0.78
Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis. Birth Defects Res A Clin Mol Teratol (2010) 0.77
Response to Casellas et al. Mol Cell (2013) 0.76