Published in Structure on December 09, 2009
The collagen family. Cold Spring Harb Perspect Biol (2011) 2.10
Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev (2012) 1.96
Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling. Structure (2012) 1.68
X-linked juvenile retinoschisis: clinical diagnosis, genetic analysis, and molecular mechanisms. Prog Retin Eye Res (2012) 1.66
The evolution of extracellular matrix. Mol Biol Cell (2010) 1.40
Discoidin domain receptor functions in physiological and pathological conditions. Int Rev Cell Mol Biol (2014) 1.29
Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling. J Biol Chem (2013) 1.27
Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1. Matrix Biol (2010) 1.17
Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients. Hum Mol Genet (2010) 1.10
Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation. PLoS One (2012) 1.04
Discoidin domain receptors in disease. Matrix Biol (2013) 1.01
Implications for collagen I chain registry from the structure of the collagen von Willebrand factor A3 domain complex. Proc Natl Acad Sci U S A (2012) 1.01
Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. Cancer Res (2013) 0.96
Collagen recognition and transmembrane signalling by discoidin domain receptors. Biochim Biophys Acta (2012) 0.96
Computational design of self-assembling register-specific collagen heterotrimers. Nat Commun (2012) 0.92
Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. J Mol Biol (2014) 0.90
Discoidin domain receptor 2 is a critical regulator of epithelial-mesenchymal transition. Matrix Biol (2011) 0.90
The Function of SPARC as a Mediator of Fibrosis. Open Rheumatol J (2012) 0.89
Polyproline and triple helix motifs in host-pathogen recognition. Curr Protein Pept Sci (2012) 0.89
Molecular modeling indicates distinct classes of missense variants with mild and severe XLRS phenotypes. Hum Mol Genet (2013) 0.87
Structural basis for collagen recognition by the immune receptor OSCAR. Blood (2015) 0.83
Role of hydration in collagen recognition by bacterial adhesins. Biophys J (2011) 0.81
Concern Discoidin Domain Receptors: Potential Actors and Targets in Cancer. Front Pharmacol (2016) 0.80
Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications. J Biol Chem (2014) 0.80
An activating mutation reveals a second binding mode of the integrin α2 I domain to the GFOGER motif in collagens. PLoS One (2013) 0.79
The effect of purity upon the triple-helical stability of collagenous peptides. Biomaterials (2011) 0.79
Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor. J Biol Chem (2015) 0.78
A novel mutation in DDR2 causing spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL) results in defective intra-cellular trafficking. BMC Med Genet (2014) 0.76
Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors. Proc Natl Acad Sci U S A (2016) 0.76
Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Structure (2015) 0.76
SPARC/osteonectin in mineralized tissue. Matrix Biol (2016) 0.76
Unique charge-dependent constraint on collagen recognition by integrin α10β1. Matrix Biol (2016) 0.75
Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts. J Biol Chem (2017) 0.75
The collαgen III fibril has a "flexi-rod" structure of flexible sequences interspersed with rigid bioactive domains including two with hemostatic roles. PLoS One (2017) 0.75
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25
Likelihood-enhanced fast translation functions. Acta Crystallogr D Biol Crystallogr (2005) 29.38
Likelihood-enhanced fast rotation functions. Acta Crystallogr D Biol Crystallogr (2004) 23.86
Cell signaling by receptor tyrosine kinases. Cell (2000) 18.16
MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes. Nucleic Acids Res (2004) 9.86
Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science (1992) 7.00
Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet (2004) 5.47
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell (2003) 5.06
Structural basis of collagen recognition by integrin alpha2beta1. Cell (2000) 4.84
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell (2009) 4.78
Microfibrillar structure of type I collagen in situ. Proc Natl Acad Sci U S A (2006) 4.31
The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell (1997) 4.11
An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell (1997) 2.89
Radial packing, order, and disorder in collagen fibrils. Biophys J (1995) 2.60
The collagen-binding A-domains of integrins alpha(1)beta(1) and alpha(2)beta(1) recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens. J Biol Chem (2000) 2.56
Molecular structure of the collagen triple helix. Adv Protein Chem (2005) 2.25
Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis. Proc Natl Acad Sci U S A (2008) 2.13
Mammalian collagen receptors. Matrix Biol (2006) 2.09
Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signal (2006) 2.09
Properties of the extracellular calcium binding module of the proteoglycan testican. FEBS Lett (1997) 2.08
C-H...pi-interactions in proteins. J Mol Biol (2001) 2.06
Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. Mol Cell Biol (2001) 2.01
The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep (2001) 1.76
Sequence dependent conformational variations of collagen triple-helical structure. Nat Struct Biol (1999) 1.71
Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen. J Biol Chem (2008) 1.69
Molecular analysis of collagen binding by the human discoidin domain receptors, DDR1 and DDR2. Identification of collagen binding sites in DDR2. J Biol Chem (2003) 1.68
Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III. J Biol Chem (2005) 1.63
Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions. Biochem Soc Trans (2008) 1.56
Multiple binding sites in collagen type I for the integrins alpha1beta1 and alpha2beta1. J Biol Chem (2000) 1.54
The collagen family members as cell adhesion proteins. Bioessays (2007) 1.45
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding. EMBO J (2007) 1.43
Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. J Biol Chem (2002) 1.38
A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. J Biol Chem (2006) 1.37
Structural basis of sequence-specific collagen recognition by SPARC. Proc Natl Acad Sci U S A (2008) 1.35
The discoidin domain receptor DDR2 is a receptor for type X collagen. Matrix Biol (2006) 1.29
A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1. J Biol Chem (2006) 1.27
A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides. Blood (2006) 1.27
Structural basis of the collagen-binding mode of discoidin domain receptor 2. EMBO J (2007) 1.26
The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest (2001) 1.25
Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens. J Biol Chem (2008) 1.21
Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications. Am J Hum Genet (2008) 1.18
A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1. J Biol Chem (2005) 1.15
DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria. Kidney Int (2004) 1.15
Structural insights into the interactions between platelet receptors and fibrillar collagen. J Biol Chem (2009) 1.14
A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse. Mol Endocrinol (2008) 1.13
Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. J Biol Chem (2005) 1.09
Mapping of DDR1 distribution and oligomerization on the cell surface by FRET microscopy. J Mol Biol (2008) 1.07
Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. J Biol Chem (2005) 1.04
Exploring the collagen-binding site of the DDR1 tyrosine kinase receptor. J Biol Chem (2004) 1.01
Identification of disulfide-linked dimers of the receptor tyrosine kinase DDR1. J Biol Chem (2007) 1.00
Helical twists of collagen model peptides. Biopolymers (2006) 0.94
Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling. Structure (2012) 1.68
Collagen recognition and transmembrane signalling by discoidin domain receptors. Biochim Biophys Acta (2012) 0.96
Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42. Fibrogenesis Tissue Repair (2011) 0.89
Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4. Structure (2015) 0.76
A fluorescent approach for identifying P2X1 ligands. Neuropharmacology (2015) 0.75