| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.
|
Nat Rev Drug Discov
|
2009
|
3.26
|
|
2
|
S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies.
|
CNS Drug Rev
|
2002
|
1.08
|
|
3
|
Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons.
|
Neuropharmacology
|
2007
|
0.92
|
|
4
|
Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.
|
J Med Chem
|
2007
|
0.92
|
|
5
|
New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.
|
J Med Chem
|
2010
|
0.88
|
|
6
|
Development of thiophenic analogues of benzothiadiazine dioxides as new powerful potentiators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors.
|
J Med Chem
|
2013
|
0.83
|
|
7
|
In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin.
|
PLoS One
|
2012
|
0.82
|
|
8
|
Working memory deficits and related disinhibition of the cAMP/PKA/CREB are alleviated by prefrontal α4β2*-nAChRs stimulation in aged mice.
|
Neurobiol Aging
|
2013
|
0.81
|
|
9
|
The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis.
|
J Pharmacol Exp Ther
|
2004
|
0.81
|
|
10
|
DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer.
|
CNS Neurosci Ther
|
2010
|
0.80
|
|
11
|
Novel 2-alkylamino-1,4-benzoxazine derivatives as potent neuroprotective agents: structure-activity relationship studies.
|
J Med Chem
|
2005
|
0.79
|
|
12
|
Modulatory effects of S 38232, a non alpha-7 containing nicotine acetylcholine receptor agonist on network activity in the mouse hippocampus.
|
Neuropharmacology
|
2009
|
0.78
|
|
13
|
Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold.
|
J Med Chem
|
2013
|
0.78
|
|
14
|
S18986: a positive modulator of AMPA-receptors enhances (S)-AMPA-mediated BDNF mRNA and protein expression in rat primary cortical neuronal cultures.
|
Eur J Pharmacol
|
2007
|
0.78
|
|
15
|
Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides.
|
J Med Chem
|
2014
|
0.77
|
|
16
|
Thermodynamic characterization of new positive allosteric modulators binding to the glutamate receptor A2 ligand-binding domain: combining experimental and computational methods unravels differences in driving forces.
|
J Chem Inf Model
|
2014
|
0.77
|
|
17
|
[Synaptic plasticity and neuropathology: new approaches in drug discovery].
|
Med Sci (Paris)
|
2005
|
0.76
|
|
18
|
Identification of 9-fluoro substituted (-)-cytisine derivatives as ligands with high affinity for nicotinic receptors.
|
Bioorg Med Chem Lett
|
2010
|
0.75
|
|
19
|
In vivo neuroprotective effects of the novel imidazolyl nitrone free-radical scavenger (Z)-alpha-[2-thiazol-2-yl)imidazol-4-yl]-N-tert-butylnitrone (S34176).
|
Eur J Pharmacol
|
2005
|
0.75
|
|
20
|
Synthesis and pharmacological evaluation of new 1,2-dithiolane based antioxidants.
|
Eur J Med Chem
|
2003
|
0.75
|
|
21
|
Molecular characterization of the AMPA-receptor potentiator S70340 in rat primary cortical culture: whole-genome expression profiling.
|
Neurosci Res
|
2011
|
0.75
|
|
22
|
Novel quinolinone-phosphonic acid AMPA antagonists devoid of nephrotoxicity.
|
Farmaco
|
2002
|
0.75
|
|
23
|
[The concept of neuroprotective agents as a treatment modulator in the development of brain diseases].
|
Therapie
|
2008
|
0.75
|
|
24
|
Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.
|
Bioorg Med Chem
|
2008
|
0.75
|
|
25
|
Preparation and affinity profile of novel nicotinic ligands.
|
Bioorg Med Chem Lett
|
2008
|
0.75
|
|
26
|
Neuroprotection: Present and future.
|
Therapie
|
2008
|
0.75
|
|
27
|
S 18986 reverses spatial working memory impairments in aged mice: comparison with memantine.
|
Psychopharmacology (Berl)
|
2011
|
0.75
|