Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs.

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Published in Bioorg Med Chem Lett on November 20, 2009

Authors

Savvas Kleanthous1, Alan D Borthwick, David Brown, Cynthia L Burns-Kurtis, Matthew Campbell, Laiq Chaudry, Chuen Chan, Marie-Olive Clarte, Máire A Convery, John D Harling, Eric Hortense, Wendy R Irving, Stephanie Irvine, Anthony J Pateman, Angela N Patikis, Ivan L Pinto, Derek R Pollard, Theresa J Roethka, Stefan Senger, Gita P Shah, Gary J Stelman, John R Toomey, Nigel S Watson, Robert I West, Caroline Whittaker, Ping Zhou, Robert J Young

Author Affiliations

1: GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.

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