Variable Field Proton-Electron Double-Resonance Imaging: Application to pH mapping of aqueous samples.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMC 2818733)

Published in J Magn Reson on November 26, 2009

Authors

Valery V Khramtsov1, George L Caia, Keerthi Shet, Eric Kesselring, Sergey Petryakov, Jay L Zweier, Alexandre Samouilov

Author Affiliations

1: Davis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, The Ohio State University, College of Medicine, 420 West 12th Ave., Room 611B, Columbus, OH 43210, USA.

Articles cited by this

Enzyme-independent formation of nitric oxide in biological tissues. Nat Med (1995) 4.28

pH imaging. A review of pH measurement methods and applications in cancers. IEEE Eng Med Biol Mag (2004) 2.68

EPR and DNP properties of certain novel single electron contrast agents intended for oximetric imaging. J Magn Reson (1998) 2.64

Overhauser enhanced magnetic resonance imaging for tumor oximetry: coregistration of tumor anatomy and tissue oxygen concentration. Proc Natl Acad Sci U S A (2002) 2.62

Oxymetry deep in tissues with low-frequency electron paramagnetic resonance. Proc Natl Acad Sci U S A (1994) 2.53

Magnetic resonance imaging of biological specimens by electron paramagnetic resonance of nitroxide spin labels. Science (1985) 1.85

Dynamic in vivo oxymetry using overhauser enhanced MR imaging. J Magn Reson Imaging (2000) 1.77

Trityl radicals as persistent dual function pH and oxygen probes for in vivo electron paramagnetic resonance spectroscopy and imaging: concept and experiment. J Am Chem Soc (2007) 1.53

Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes. J Am Chem Soc (2008) 1.39

Overhauser-enhanced MR imaging (OMRI). Acta Radiol (1998) 1.36

Simultaneous molecular imaging of redox reactions monitored by Overhauser-enhanced MRI with 14N- and 15N-labeled nitroxyl radicals. Proc Natl Acad Sci U S A (2006) 1.31

In vivo EPR measurement of glutathione in tumor-bearing mice using improved disulfide biradical probe. Free Radic Biol Med (2008) 1.19

Field-cycled PEDRI imaging of free radicals with detection at 450 mT. Magn Reson Imaging (2005) 1.19

Development of a hybrid EPR/NMR coimaging system. Magn Reson Med (2007) 1.17

In vivo proton electron double resonance imaging of the distribution and clearance of nitroxide radicals in mice. Magn Reson Med (2006) 1.17

EPR/NMR co-imaging for anatomic registration of free-radical images. Magn Reson Med (2002) 1.16

Biological applications of spin pH probes. Cell Mol Biol (Noisy-le-grand) (2000) 1.15

Real-time monitoring of drug-induced changes in the stomach acidity of living rats using improved pH-sensitive nitroxides and low-field EPR techniques. J Magn Reson (2006) 1.12

Cardiac applications of EPR imaging. NMR Biomed (2004) 1.12

Non-invasive in vivo characterization of release processes in biodegradable polymers by low-frequency electron paramagnetic resonance spectroscopy. Biomaterials (1996) 1.11

Trityl-based EPR probe with enhanced sensitivity to oxygen. Free Radic Biol Med (2009) 1.11

Proton electron double resonance imaging of the in vivo distribution and clearance of a triaryl methyl radical in mice. Magn Reson Med (2002) 1.11

Pulsed EPR imaging of nitroxides in mice. J Magn Reson (2008) 1.09

pH-sensitive imaging by low-frequency EPR: a model study for biological applications. Phys Med Biol (1998) 1.08

Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy. Clin Cancer Res (2006) 1.05

Modified Alderman-Grant resonator with high-power stability for proton electron double resonance imaging. Magn Reson Med (2006) 1.05

Spatially resolved biologic information from in vivo EPRI, OMRI, and MRI. Antioxid Redox Signal (2007) 1.01

In vivo EPR imaging of the distribution and metabolism of nitroxide radicals in human skin. J Magn Reson (2001) 1.00

Synthesis of the tetraethyl substituted pH-sensitive nitroxides of imidazole series with enhanced stability towards reduction. Org Biomol Chem (2004) 0.99

DANCING WITH THE ELECTRONS: TIME-DOMAIN AND CW IN VIVO EPR IMAGING. Magn Reson Insights (2008) 0.97

In vivo imaging of free radicals: applications from mouse to man. Mol Cell Biochem (2002) 0.97

In vivo detection of a pH-sensitive nitroxide in the rat stomach by low-field ESR-based techniques. Magn Reson Med (2003) 0.95

Development of functional electron paramagnetic resonance imaging. Breast Dis (1998) 0.93

Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides. Analyst (2009) 0.93

The application of PEDRI to the study of free radicals in vivo. Phys Med Biol (1998) 0.90

Use of diethyl(2-methylpyrrolidin-2-yl)phosphonate as a highly sensitive extra- and intracellular 31P NMR pH indicator in isolated organs. Direct NMR evidence of acidic compartments in the ischemic and reperfused rat liver. J Biol Chem (2000) 0.88

[Molecular imaging of in-vivo ROS generation in oxidative diseases using ESRI and OMRI]. Nihon Ronen Igakkai Zasshi (2007) 0.78

Oxygen imaging in perfused hearts by dynamic nuclear polarization. Magn Reson Imaging (1993) 0.77

Articles by these authors

MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab (2009) 3.30

A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal. Nature (2002) 2.86

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation (2003) 2.68

Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels. Cancer Res (2002) 2.56

Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition. Circulation (2008) 2.37

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature (2010) 2.35

Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol (2009) 2.29

Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells. Am J Physiol Lung Cell Mol Physiol (2002) 2.18

Novel particulate spin probe for targeted determination of oxygen in cells and tissues. Free Radic Biol Med (2003) 2.18

Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev (2009) 2.15

Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function. J Biol Chem (2006) 2.01

Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. Arterioscler Thromb Vasc Biol (2008) 1.97

Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall. Am J Physiol Heart Circ Physiol (2008) 1.88

Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase. J Biol Chem (2008) 1.82

Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4. Proc Natl Acad Sci U S A (2007) 1.78

On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies. Br J Pharmacol (2003) 1.77

In vivo atherosclerotic plaque characterization using magnetic susceptibility distinguishes symptom-producing plaques. JACC Cardiovasc Imaging (2008) 1.69

Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation. J Biol Chem (2007) 1.68

Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology. Cardiovasc Res (2011) 1.65

Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice. Circ Res (2006) 1.58

Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme. J Biol Chem (2008) 1.55

Trityl radicals as persistent dual function pH and oxygen probes for in vivo electron paramagnetic resonance spectroscopy and imaging: concept and experiment. J Am Chem Soc (2007) 1.53

Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. FEBS Lett (2005) 1.53

Endothelium-derived nitric oxide regulates postischemic myocardial oxygenation and oxygen consumption by modulation of mitochondrial electron transport. Circulation (2005) 1.51

Cardiac mitochondria and reactive oxygen species generation. Circ Res (2014) 1.51

Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging. Bioorg Med Chem Lett (2007) 1.48

Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation. J Biol Chem (2004) 1.48

Fast EPR imaging at 300 MHz using spinning magnetic field gradients. J Magn Reson (2004) 1.45

In vivo imaging of changes in tumor oxygenation during growth and after treatment. Magn Reson Med (2007) 1.42

Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues. Biochemistry (2003) 1.41

Synthesis and characterization of ester-derivatized tetrathiatriarylmethyl radicals as intracellular oxygen probes. J Org Chem (2008) 1.40

Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart. J Biol Chem (2003) 1.40

Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes. J Am Chem Soc (2008) 1.39

Methods for noninvasive imaging of tissue hypoxia. Antioxid Redox Signal (2007) 1.39

Nitric oxide uptake by erythrocytes is primarily limited by extracellular diffusion not membrane resistance. J Biol Chem (2002) 1.38

Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation. J Biol Chem (2005) 1.38

Detection of reactive oxygen and nitrogen species by EPR spin trapping. Antioxid Redox Signal (2004) 1.38

In vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors. Magn Reson Med (2011) 1.33

Esterified trityl radicals as intracellular oxygen probes. Free Radic Biol Med (2008) 1.31

Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix. Physiol Genomics (2006) 1.31

Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin. J Biol Chem (2004) 1.30

Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice. Am J Physiol Heart Circ Physiol (2010) 1.29

Application of a trityl-based radical probe for measuring superoxide. Free Radic Biol Med (2003) 1.29

Regulation of eNOS-derived superoxide by endogenous methylarginines. Biochemistry (2008) 1.27

Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol (2008) 1.25

Characterization of the mechanism and magnitude of cytoglobin-mediated nitrite reduction and nitric oxide generation under anaerobic conditions. J Biol Chem (2012) 1.23

Progressive EPR imaging with adaptive projection acquisition. J Magn Reson (2005) 1.22

Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase. Biochemistry (2009) 1.22

Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite. J Biol Chem (2009) 1.21

Pulsed ESR dipolar spectroscopy for distance measurements in immobilized spin labeled proteins in liquid solution. J Am Chem Soc (2012) 1.21

Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin. Proc Natl Acad Sci U S A (2006) 1.20

Targeting of phospholamban by peroxynitrite decreases beta-adrenergic stimulation in cardiomyocytes. Cardiovasc Res (2007) 1.19

S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling. Antioxid Redox Signal (2011) 1.19

Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues. J Biol Chem (2004) 1.19

Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase. Biochemistry (2007) 1.19

Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27. Am J Physiol Heart Circ Physiol (2006) 1.19

A naphthalocyanine-based EPR probe for localized measurements of tissue oxygenation. Free Radic Biol Med (2002) 1.18

Simultaneous acquisition of T1ρ and T2 quantification in knee cartilage: repeatability and diurnal variation. J Magn Reson Imaging (2013) 1.17

Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function. Am J Physiol Heart Circ Physiol (2007) 1.17

Mapping of the B1 field distribution of a surface coil resonator using EPR imaging. Magn Reson Med (2002) 1.17

Development of a hybrid EPR/NMR coimaging system. Magn Reson Med (2007) 1.17

In vivo proton electron double resonance imaging of the distribution and clearance of nitroxide radicals in mice. Magn Reson Med (2006) 1.17

EPR/NMR co-imaging for anatomic registration of free-radical images. Magn Reson Med (2002) 1.16

Characterization of in vivo tissue redox status, oxygenation, and formation of reactive oxygen species in postischemic myocardium. Antioxid Redox Signal (2007) 1.16

Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction. Am J Physiol Heart Circ Physiol (2007) 1.16

Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition. Biochemistry (2010) 1.16

Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase. Arch Biochem Biophys (2008) 1.16

Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults. J Clin Endocrinol Metab (2013) 1.16

Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues. Arch Biochem Biophys (2007) 1.14

Measurement of oxygen consumption in mouse aortic endothelial cells using a microparticulate oximetry probe. Arch Biochem Biophys (2003) 1.14

Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: mitochondria as the major target. Biochim Biophys Acta (2008) 1.14

Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals. J Org Chem (2006) 1.14

Fast 3D spatial EPR imaging using spiral magnetic field gradient. J Magn Reson (2007) 1.14

Reaction of superoxide with trityl radical: implications for the determination of superoxide by spectrophotometry. Arch Biochem Biophys (2004) 1.12

Cardiac applications of EPR imaging. NMR Biomed (2004) 1.12

Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium. J Biol Chem (2008) 1.12

Synthesis of 14N- and 15N-labeled trityl-nitroxide biradicals with strong spin-spin interaction and improved sensitivity to redox status and oxygen. J Org Chem (2010) 1.11

Deconvolution algorithm based on automatic cutoff frequency selection for EPR imaging. Magn Reson Med (2003) 1.11

Pulmonary surfactant protein a inhibits macrophage reactive oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity. J Immunol (2004) 1.11

Trityl-based EPR probe with enhanced sensitivity to oxygen. Free Radic Biol Med (2009) 1.11

Proton electron double resonance imaging of the in vivo distribution and clearance of a triaryl methyl radical in mice. Magn Reson Med (2002) 1.11

Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice. Am J Physiol Heart Circ Physiol (2008) 1.10

Doxorubicin-induced cardiotoxicity: direct correlation of cardiac fibroblast and H9c2 cell survival and aconitase activity with heat shock protein 27. Am J Physiol Heart Circ Physiol (2007) 1.08

Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing. Free Radic Biol Med (2007) 1.07

Reactivity of superoxide radical anion with cyclic nitrones: role of intramolecular H-bond and electrostatic effects. J Am Chem Soc (2007) 1.07

Application of magnetic field over-modulation for improved EPR linewidth measurements using probes with Lorentzian lineshape. J Magn Reson (2006) 1.07