Stem-like cancer cells are inducible by increasing genomic instability in cancer cells.

PubWeight™: 1.42‹?› | Rank: Top 5%

🔗 View Article (PMC 2836097)

Published in J Biol Chem on December 09, 2009

Authors

Yi Liang1, Zhendong Zhong, Yijun Huang, Wen Deng, Junxia Cao, George Tsao, Quentin Liu, Duanqing Pei, Tiebang Kang, Yi-Xin Zeng

Author Affiliations

1: State Key Laboratory of Oncology in Southern China, Guangzhou, China.

Articles citing this

Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species. J Biol Chem (2011) 1.36

Telomerase at the intersection of cancer and aging. Trends Genet (2013) 1.16

Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma. J Natl Cancer Inst (2012) 1.15

MicroRNA expression profiling identifies miR-328 regulates cancer stem cell-like SP cells in colorectal cancer. Br J Cancer (2012) 1.12

Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma. FEBS J (2013) 1.12

Epithelial mesenchymal transition and lung cancer. J Thorac Dis (2010) 1.11

CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma. J Clin Invest (2012) 1.09

Recombinant human endostatin normalizes tumor vasculature and enhances radiation response in xenografted human nasopharyngeal carcinoma models. PLoS One (2012) 1.07

Cancer cells cyclically lose and regain drug-resistant highly tumorigenic features characteristic of a cancer stem-like phenotype. Mol Cancer Ther (2011) 1.02

Cancer stem-like cells in Epstein-Barr virus-associated nasopharyngeal carcinoma. Chin J Cancer (2014) 1.02

Cancer stem cell-like side population cells in clear cell renal cell carcinoma cell line 769P. PLoS One (2013) 1.00

XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway. J Exp Clin Cancer Res (2013) 0.99

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer. Oncogenesis (2014) 0.96

Dynamic equilibrium between cancer stem cells and non-stem cancer cells in human SW620 and MCF-7 cancer cell populations. Br J Cancer (2012) 0.96

Carbon nanotubes: an emerging drug carrier for targeting cancer cells. J Drug Deliv (2014) 0.91

Metastatic cancer stem cells: from the concept to therapeutics. Am J Stem Cells (2014) 0.89

WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis. Oncotarget (2015) 0.89

CD133, Stem Cells, and Cancer Stem Cells: Myth or Reality? Curr Colorectal Cancer Rep (2011) 0.88

The implications of cancer stem cells for cancer therapy. Int J Mol Sci (2012) 0.87

Correlation of Skp2 overexpression to prognosis of patients with nasopharyngeal carcinoma from South China. Chin J Cancer (2011) 0.87

Sorafenib modulates the radio sensitivity of hepatocellular carcinoma cells in vitro in a schedule-dependent manner. BMC Cancer (2012) 0.86

Enrichment of osteosarcoma stem cells by chemotherapy. Chin J Cancer (2011) 0.84

Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma. Oncotarget (2014) 0.84

Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis. Cell Cycle (2014) 0.84

Solitary fibrous tumors: loss of chimeric protein expression and genomic instability mark dedifferentiation. Mod Pathol (2015) 0.84

Side population cells as prototype of chemoresistant, tumor-initiating cells. Biomed Res Int (2013) 0.83

Expression of betapapillomavirus oncogenes increases the number of keratinocytes with stem cell-like properties. J Virol (2013) 0.83

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila. Biol Open (2012) 0.81

Dynamics between cancer cell subpopulations reveals a model coordinating with both hierarchical and stochastic concepts. PLoS One (2014) 0.81

The propensity for tumorigenesis in human induced pluripotent stem cells is related with genomic instability. Chin J Cancer (2012) 0.81

Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers. J Gastroenterol (2012) 0.80

Monoacylglycerol lipase promotes metastases in nasopharyngeal carcinoma. Int J Clin Exp Pathol (2014) 0.80

Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer. Cell Death Discov (2017) 0.80

Stem cell expansion during carcinogenesis in stem cell-depleted conditional telomeric repeat factor 2 null mutant mice. Oncogene (2012) 0.79

Dysregulation of the PI3K/Akt signaling pathway affects cell cycle and apoptosis of side population cells in nasopharyngeal carcinoma. Oncol Lett (2015) 0.78

NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway. Oncotarget (2015) 0.77

Breast cancer stem cells, pathways and therapeutic perspectives 2011. Indian J Surg (2012) 0.77

Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions. Sci Rep (2016) 0.76

Differential effect of long-term drug selection with doxorubicin and vorinostat on neuroblastoma cells with cancer stem cell characteristics. Cell Death Dis (2013) 0.76

Cancer stem cells of differentiated B-cell malignancies: models and consequences. Cancers (Basel) (2011) 0.75

Bub1 is required for maintaining cancer stem cells in breast cancer cell lines. Sci Rep (2015) 0.75

Induced cancer stem cells generated by radiochemotherapy and their therapeutic implications. Oncotarget (2016) 0.75

Liver cancer stem cells are selectively enriched by low-dose cisplatin. Braz J Med Biol Res (2014) 0.75

Articles cited by this

The hallmarks of cancer. Cell (2000) 113.05

Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42

Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50

Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17

Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63

Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2006) 24.52

Identification and expansion of human colon-cancer-initiating cells. Nature (2006) 24.44

Cancer genes and the pathways they control. Nat Med (2004) 24.22

Identification of a cancer stem cell in human brain tumors. Cancer Res (2003) 24.02

Genetic instabilities in human cancers. Nature (1998) 22.76

Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35

Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res (2005) 13.89

Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66

Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One (2008) 8.97

A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A (2004) 6.84

Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med (1997) 6.13

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell (2006) 5.88

Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci U S A (2004) 5.32

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60

Cancer stem cells: lessons from leukemia. Trends Cell Biol (2005) 3.90

Characterization of a side population of cancer cells from human gastrointestinal system. Stem Cells (2005) 3.66

The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nat Cell Biol (2004) 3.27

Leukaemia stem cells and the evolution of cancer-stem-cell research. Nat Rev Cancer (2005) 3.01

Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Cancer Res (2007) 2.68

Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells. Cancer Res (2006) 1.94

A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell (2007) 1.51

EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A. Proc Natl Acad Sci U S A (2008) 1.28

Effects of low confluency, serum starvation and hypoxia on the side population of cancer cell lines. Cell Cycle (2007) 1.28

Cytogenetic studies on an epithelial cell line derived from poorly differentiated nasopharyngeal carcinoma. Int J Cancer (1983) 1.17

Stem cells and cancer. Semin Cancer Biol (2006) 1.10

Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer. Gene Ther (2007) 1.07

A new method for improving metaphase chromosome spreading. Cytometry A (2003) 1.03

Evolution of cancer stem cells. Semin Cancer Biol (2006) 0.97

Genomic instability en route to and from cancer stem cells. Cell Cycle (2009) 0.88

Articles by these authors

let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell (2007) 13.69

A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell (2010) 7.94

MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA (2008) 6.04

Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell (2009) 5.49

Lrp5 functions in bone to regulate bone mass. Nat Med (2011) 5.33

Genomic instability in laminopathy-based premature aging. Nat Med (2005) 4.54

Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet (2010) 4.01

Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell (2013) 3.32

Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res (2006) 3.12

Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern China. BMC Cancer (2006) 2.71

Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Cancer Res (2007) 2.68

The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell (2011) 2.65

A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet (2010) 2.62

Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology (2012) 2.57

The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52

H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet (2012) 2.47

Generation of induced pluripotent stem cells from urine. J Am Soc Nephrol (2011) 2.36

Genetic structure of the Han Chinese population revealed by genome-wide SNP variation. Am J Hum Genet (2009) 2.33

The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut (2011) 2.33

miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res (2011) 2.22

A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J (2006) 2.17

Generation of induced pluripotent stem cell lines from Tibetan miniature pig. J Biol Chem (2009) 2.17

MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem (2011) 2.08

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. Nat Genet (2011) 2.05

Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nat Genet (2002) 2.00

Stem cell pluripotency and transcription factor Oct4. Cell Res (2002) 1.99

Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition. Gut (2011) 1.95

Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. J Biol Chem (2008) 1.95

Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients. J Alzheimers Dis (2005) 1.88

EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. Gut (2011) 1.87

GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet (2012) 1.86

Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Nat Genet (2012) 1.85

Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China. Cancer (2004) 1.77

Generation of human induced pluripotent stem cells from urine samples. Nat Protoc (2012) 1.76

Single-molecule approach to bacterial genomic comparisons via optical mapping. J Bacteriol (2004) 1.76

Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning. Cell Res (2011) 1.74

Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol (2005) 1.73

A whole-genome shotgun optical map of Yersinia pestis strain KIM. Appl Environ Microbiol (2002) 1.68

Transient protein states in designing inhibitors of the MDM2-p53 interaction. Structure (2013) 1.63

Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinoma. Head Neck (2012) 1.61

Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists. PLoS One (2012) 1.60

Generation of integration-free neural progenitor cells from cells in human urine. Nat Methods (2012) 1.58

Functional variant in the 3'-untranslated region of Toll-like receptor 4 is associated with nasopharyngeal carcinoma risk. Cancer Biol Ther (2006) 1.55

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria. Blood (2014) 1.55

Telomere dysfunction, genome instability and cancer. Front Biosci (2008) 1.53

High frequency somatic mutations in RASSF1A in nasopharyngeal carcinoma. Cancer Biol Ther (2005) 1.53

Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma. Cancer Sci (2010) 1.51

BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Res (2010) 1.51

Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. Cancer Res (2011) 1.49

Concern Concomitant targeting of multiple key transcription factors effectively disrupts cancer stem cells enriched in side population of human pancreatic cancer cells. PLoS One (2013) 1.49

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. Development (2014) 1.49

The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity. J Biol Chem (2006) 1.49

Comparison of plasma Epstein-Barr virus (EBV) DNA levels and serum EBV immunoglobulin A/virus capsid antigen antibody titers in patients with nasopharyngeal carcinoma. Cancer (2004) 1.49

Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB. J Transl Med (2009) 1.48

Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol (2013) 1.47

High frequency of common deletion (4981 bp) in mitochondrial DNA in nasopharyngeal carcinoma and its correlation with patient age and clinical stages. Cancer Biol Ther (2004) 1.47

Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy (2010) 1.47

Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia. Blood (2007) 1.46

Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet (2013) 1.45

Positive lymph node ratio is an independent prognostic factor in gastric cancer after d2 resection regardless of the examined number of lymph nodes. Ann Surg Oncol (2008) 1.44

Regulation of the pluripotency marker Rex-1 by Nanog and Sox2. J Biol Chem (2006) 1.41

Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. J Biol Chem (2010) 1.41

Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog (2010) 1.40

Membrane type-matrix metalloproteinases (MT-MMP). Curr Top Dev Biol (2003) 1.39

Variable sensitivity of endothelial cells to epirubicin in xenografts of human nasopharyngeal carcinoma CNE-2 cells. Cancer Biol Ther (2002) 1.38

Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO Rep (2011) 1.38

Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma. BMC Cancer (2010) 1.37

Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Res (2007) 1.36

The clinical significance of twist expression in nasopharyngeal carcinoma. Cancer Lett (2006) 1.35

EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients. Carcinogenesis (2010) 1.34

The mitotic kinase Aurora-A induces mammary cell migration and breast cancer metastasis by activating the Cofilin-F-actin pathway. Cancer Res (2010) 1.33

The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer. J Transl Med (2010) 1.33

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network. J Biol Chem (2004) 1.33

MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. Carcinogenesis (2011) 1.32

Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells. J Biol Chem (2003) 1.31

Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells. Carcinogenesis (2008) 1.30

Genomic sequence analysis of Epstein-Barr virus strain GD1 from a nasopharyngeal carcinoma patient. J Virol (2005) 1.30

Direct sequencing and characterization of a clinical isolate of Epstein-Barr virus from nasopharyngeal carcinoma tissue by using next-generation sequencing technology. J Virol (2011) 1.30

Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase. J Biol Chem (2002) 1.30

An epidemiological and molecular study of the relationship between smoking, risk of nasopharyngeal carcinoma, and Epstein-Barr virus activation. J Natl Cancer Inst (2012) 1.29

Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53/Hdm2 antagonists. Angew Chem Int Ed Engl (2010) 1.29

High pretreatment serum lactate dehydrogenase level correlates with disease relapse and predicts an inferior outcome in locally advanced nasopharyngeal carcinoma. Eur J Cancer (2013) 1.29

Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine. Cancer Immunol Immunother (2007) 1.29

Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells. Autophagy (2012) 1.28

MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene. Cell Cycle (2012) 1.28

Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways. Mol Cancer (2010) 1.28

Traditional Cantonese diet and nasopharyngeal carcinoma risk: a large-scale case-control study in Guangdong, China. BMC Cancer (2010) 1.28

Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. Exp Cell Res (2004) 1.27

Salinomycin inhibits osteosarcoma by targeting its tumor stem cells. Cancer Lett (2011) 1.27

As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling. Carcinogenesis (2012) 1.26

High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients. Mol Med (2010) 1.26

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest (2012) 1.25

Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma. Clin Cancer Res (2009) 1.24

Eight-signature classifier for prediction of nasopharyngeal [corrected] carcinoma survival. J Clin Oncol (2011) 1.23

CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin. Nucleus (2012) 1.22