Cholesterol modulates ion channels via down-regulation of phosphatidylinositol 4,5-bisphosphate.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 2891522)

Published in J Neurochem on December 14, 2009

Authors

Yoon Sun Chun1, Sora Shin, Yonjung Kim, Hana Cho, Myoung Kyu Park, Tae-Wan Kim, Sergey V Voronov, Gilbert Di Paolo, Byung-Chang Suh, Sungkwon Chung

Author Affiliations

1: Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, South Korea.

Articles citing this

Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes. Hum Mol Genet (2012) 0.99

Cholesterol-induced activation of TRPM7 regulates cell proliferation, migration, and viability of human prostate cells. Biochim Biophys Acta (2014) 0.97

Preferential invasion of mitotic cells by Salmonella reveals that cell surface cholesterol is maximal during metaphase. J Cell Sci (2013) 0.84

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes. Mol Neurodegener (2014) 0.83

The KCNH2 genetic polymorphism (1956, C>T) is a novel biomarker that is associated with CCB and α,β-ADR blocker response in EH patients in China. PLoS One (2013) 0.77

Increasing Membrane Cholesterol Level Increases the Amyloidogenic Peptide by Enhancing the Expression of Phospholipase C. J Neurodegener Dis (2013) 0.77

Modulation of transient receptor potential melastatin related 7 channel by presenilins. Dev Neurobiol (2012) 0.76

Cholesterol down-regulates BK channels stably expressed in HEK 293 cells. PLoS One (2013) 0.76

Cholesterol regulates HERG K+ channel activation by increasing phospholipase C β1 expression. Channels (Austin) (2013) 0.76

Cholesterol Enrichment Impairs Capacitative Calcium Entry, eNOS Phosphorylation & Shear Stress-Induced NO Production. Cell Mol Bioeng (2016) 0.75

bSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesicles. J Gen Physiol (2016) 0.75

Cholesterol regulation of PIP(2): why cell type is so important. Front Physiol (2013) 0.75

Articles cited by this

Phosphoinositides in cell regulation and membrane dynamics. Nature (2006) 14.00

LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature (2001) 5.52

Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science (2006) 5.10

A key role for TRPM7 channels in anoxic neuronal death. Cell (2003) 4.46

Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell (2003) 4.15

Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr Opin Neurobiol (2005) 3.94

The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol (2002) 3.63

Alzheimer's disease: the cholesterol connection. Nat Neurosci (2003) 2.99

Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current. J Gen Physiol (2005) 2.98

TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions. J Gen Physiol (2003) 2.86

Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature (2004) 2.81

Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J Biol Chem (1998) 2.46

Regulation of ion transport proteins by membrane phosphoinositides. Nat Rev Neurosci (2007) 2.21

Dissociation of the store-operated calcium current I(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM. J Physiol (2002) 2.16

Correlation between acetylcholine receptor function and structural properties of membranes. Biochemistry (1986) 1.94

Cytoskeletal regulation: rich in lipids. Nat Rev Mol Cell Biol (2004) 1.94

Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol (2003) 1.67

Membrane cholesterol content modulates activation of volume-regulated anion current in bovine endothelial cells. J Gen Physiol (2000) 1.59

PIP2 signaling in lipid domains: a critical re-evaluation. EMBO J (2005) 1.59

Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys J (2004) 1.56

Attenuation of channel kinetics and conductance by cholesterol: an interpretation using structural stress as a unifying concept. J Membr Biol (1995) 1.52

Cholesterol homeostasis and function in neurons of the central nervous system. Cell Mol Life Sci (2003) 1.51

Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism. Proc Natl Acad Sci U S A (2006) 1.48

Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism. Nat Neurosci (2008) 1.46

HERG K(+) channel activity is regulated by changes in phosphatidyl inositol 4,5-bisphosphate. Circ Res (2001) 1.40

Molecular analysis of PIP2 regulation of HERG and IKr. Am J Physiol Heart Circ Physiol (2004) 1.24

Membrane cholesterol modulates Kv1.5 potassium channel distribution and function in rat cardiomyocytes. J Physiol (2007) 1.22

Cholesterol homeostasis failure as a unifying cause of synaptic degeneration. J Neurol Sci (2004) 1.17

Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomains. J Biol Chem (2003) 1.11

Cholesterol modifies the gating of Kv1.3 in human T lymphocytes. Pflugers Arch (2003) 1.09

Membrane cholesterol content modulates activation of BK channels in colonic epithelia. Biochim Biophys Acta (2004) 1.02

Cholesterol depletion modulates basal L-type Ca2+ current and abolishes its -adrenergic enhancement in ventricular myocytes. Am J Physiol Heart Circ Physiol (2007) 0.99

The mechanism of phospholipase C-gamma1 regulation. Exp Mol Med (2000) 0.89

Cellular cholesterol controls TRPC3 function: evidence from a novel dominant-negative knockdown strategy. Biochem J (2006) 0.87

Coordinated intracellular translocation of phosphoinositide-specific phospholipase C-delta with the cell cycle. Biochim Biophys Acta (2006) 0.82

Regulation of magnesium-inhibited cation current by actin cytoskeleton rearrangement. Biochem Biophys Res Commun (2005) 0.82

Localization of phospholipase C beta 1 on the detergent-resistant membrane microdomain prepared from the synaptic plasma membrane fraction of rat brain. J Neurosci Res (2007) 0.81

Cholesterol-induced growth stimulation, macromolecule synthesis, and increased phosphoinositide metabolism of ascites tumour cells in culture. Cell Signal (1999) 0.78

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

A MicroRNA feedback circuit in midbrain dopamine neurons. Science (2007) 8.33

Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science (2011) 6.93

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron (2013) 4.67

Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann Neurol (2005) 3.01

Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current. J Gen Physiol (2005) 2.98

Linking lipids to Alzheimer's disease: cholesterol and beyond. Nat Rev Neurosci (2011) 2.60

The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals. Neuron (2007) 2.36

Inhibitory effect of dietary lipids on chaperone-mediated autophagy. Proc Natl Acad Sci U S A (2012) 1.97

The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes. Mol Cell (2010) 1.97

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J Biol Chem (2001) 1.87

Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal (2012) 1.86

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons. J Biol Chem (2012) 1.79

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J Biol Chem (2003) 1.77

Phosphoinositides: lipid regulators of membrane proteins. J Physiol (2010) 1.72

The stimulatory action of amphiphysin on dynamin function is dependent on lipid bilayer curvature. EMBO J (2004) 1.72

Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry. Nat Biotechnol (2003) 1.64

Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos. Nat Neurosci (2004) 1.61

The role of lipids in the control of autophagy. Curr Biol (2013) 1.59

The phospholipase D1 pathway modulates macroautophagy. Nat Commun (2010) 1.56

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A (2008) 1.54

Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. J Biol Chem (2011) 1.51

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J Cell Biol (2011) 1.50

Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci (2010) 1.49

Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism. Proc Natl Acad Sci U S A (2006) 1.48

Adsorption and structural properties of ordered mesoporous carbons synthesized by using various carbon precursors and ordered siliceous P6mm and Ia3d mesostructures as templates. J Phys Chem B (2005) 1.47

Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases. J Cell Biol (2005) 1.47

Competition for talin results in trans-dominant inhibition of integrin activation. J Biol Chem (2004) 1.46

Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism. Nat Neurosci (2008) 1.46

Synaptojanin 1-mediated PI(4,5)P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission. Dev Cell (2011) 1.44

Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice. Proc Natl Acad Sci U S A (2002) 1.42

Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. J Biol Chem (2003) 1.41

Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain. J Biol Chem (2003) 1.37

ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. FASEB J (2007) 1.37

Epidemiologic and clinical features of anaphylaxis in Korea. Ann Allergy Asthma Immunol (2008) 1.35

Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion. Proc Natl Acad Sci U S A (2005) 1.32

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J Biol Chem (2003) 1.32

SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2. J Cell Sci (2008) 1.31

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function. J Biol Chem (2004) 1.31

Lipids and lipid modifications in the regulation of membrane traffic. Curr Opin Cell Biol (2007) 1.30

Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. PLoS One (2013) 1.28

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. Nat Commun (2013) 1.27

Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. J Biol Chem (2003) 1.27

A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. Genes Dev (2009) 1.25

Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis. World J Gastroenterol (2003) 1.24

Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis. J Cell Biol (2009) 1.23

Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast. Mol Pharmacol (2004) 1.20

The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures. Hum Mutat (2013) 1.17

MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. Nat Commun (2013) 1.16

The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport. Neurobiol Dis (2012) 1.14

Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling. Cytokine Growth Factor Rev (2004) 1.11

Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway. Proc Natl Acad Sci U S A (2005) 1.08

Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins. Nat Commun (2012) 1.08

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J (2010) 1.06

Phospholipase D in brain function and Alzheimer's disease. Biochim Biophys Acta (2010) 1.06

A role for talin in presynaptic function. J Cell Biol (2004) 1.05

Regional interaction of endoplasmic reticulum Ca2+ signals between soma and dendrites through rapid luminal Ca2+ diffusion. J Neurosci (2006) 1.02

Structural basis of the PNRC2-mediated link between mrna surveillance and decapping. Structure (2012) 1.02

L-type Ca(2+) channel facilitation mediated by H(2)O(2)-induced activation of CaMKII in rat ventricular myocytes. J Mol Cell Cardiol (2009) 1.02

Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo. Mol Brain (2013) 1.01

microRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay. EMBO Rep (2010) 1.00

Receptor-specific inhibition of GABAB-activated K+ currents by muscarinic and metabotropic glutamate receptors in immature rat hippocampus. J Physiol (2007) 0.99

Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes. Hum Mol Genet (2012) 0.99

Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation. BMB Rep (2013) 0.98

Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. PLoS Biol (2005) 0.98

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin. J Biol Chem (2011) 0.98

Cell-surface receptor for complement component C1q (gC1qR) is a key regulator for lamellipodia formation and cancer metastasis. J Biol Chem (2011) 0.97

Percutaneous short-segment pedicle screw placement without fusion in the treatment of thoracolumbar burst fractures: is it effective?: comparative study with open short-segment pedicle screw fixation with posterolateral fusion. Acta Neurochir (Wien) (2013) 0.97

Antiplatelet activities of newly synthesized derivatives of piperlongumine. Phytother Res (2008) 0.96

Inhibition of TNF-α-induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF-κB signaling pathways. Vascul Pharmacol (2010) 0.96

Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's disease. J Neurosci (2012) 0.96

Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells. J Biol Chem (2004) 0.95

The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease. J Ethnopharmacol (2010) 0.94

Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea. Food Addit Contam Part B Surveill (2015) 0.94

Pioneer round of translation occurs during serum starvation. Biochem Biophys Res Commun (2007) 0.94

Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves. J Cell Biol (2002) 0.93

Binding characteristics of a bacterial expansin (BsEXLX1) for various types of pretreated lignocellulose. Appl Microbiol Biotechnol (2012) 0.93

Regulation of transferrin recycling kinetics by PtdIns[4,5]P2 availability. FASEB J (2006) 0.93

Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation. Biochem Biophys Res Commun (2008) 0.93

Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment. PLoS One (2013) 0.92

Ago2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2. FEBS Lett (2011) 0.91

New insight into the assessment of asthma using xenon ventilation computed tomography. Ann Allergy Asthma Immunol (2013) 0.91

P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Neurobiol Dis (2005) 0.91

Radical scavenging and anti-inflammatory activity of extracts from Opuntia humifusa Raf. J Pharm Pharmacol (2006) 0.91

Activation of cyclin-dependent kinase 5 is involved in axonal regeneration. Mol Cell Neurosci (2004) 0.91

Voltage-operated Ca2+ channels regulate dopamine release from somata of dopamine neurons in the substantia nigra pars compacta. Biochem Biophys Res Commun (2008) 0.91

Role of mucosal mast cells in visceral hypersensitivity in a rat model of irritable bowel syndrome. J Vet Sci (2004) 0.91

Biochemical analysis of six genetic variants of error-prone human DNA polymerase ι involved in translesion DNA synthesis. Chem Res Toxicol (2014) 0.90

In vivo evaluation of porous hydroxyapatite/chitosan-alginate composite scaffolds for bone tissue engineering. Int J Biol Macromol (2012) 0.90

Nonselective cation channels are essential for maintaining intracellular Ca2+ levels and spontaneous firing activity in the midbrain dopamine neurons. Pflugers Arch (2007) 0.90