Published in Science on September 21, 2006
Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature (2009) 6.74
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science (2006) 6.25
PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Neural KCNQ (Kv7) channels. Br J Pharmacol (2009) 3.20
Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev (2009) 2.53
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2007) 2.52
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling. Dev Cell (2015) 2.26
Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS One (2008) 2.21
The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem (2008) 2.03
H bonding at the helix-bundle crossing controls gating in Kir potassium channels. Neuron (2007) 2.02
Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A (2008) 1.96
Optogenetic control of phosphoinositide metabolism. Proc Natl Acad Sci U S A (2012) 1.92
Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells. Chem Rev (2011) 1.88
Light-based feedback for controlling intracellular signaling dynamics. Nat Methods (2011) 1.79
HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K(+) channels. Nat Neurosci (2009) 1.76
Tolerance to drought and salt stress in plants: Unraveling the signaling networks. Front Plant Sci (2014) 1.73
Phosphoinositides: lipid regulators of membrane proteins. J Physiol (2010) 1.72
Organelle-specific, rapid induction of molecular activities and membrane tethering. Nat Methods (2010) 1.69
Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol (2010) 1.59
Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications. J Physiol (2008) 1.59
Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circ Res (2010) 1.55
The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol (2009) 1.53
Optimal experimental design for parameter estimation of a cell signaling model. PLoS Comput Biol (2009) 1.47
Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem (2008) 1.47
Fluorescence changes reveal kinetic steps of muscarinic receptor-mediated modulation of phosphoinositides and Kv7.2/7.3 K+ channels. J Gen Physiol (2009) 1.45
Target-specific PIP(2) signalling: how might it work? J Physiol (2007) 1.45
Modulation of high-voltage activated Ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate. Neuron (2010) 1.44
Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling. EMBO Rep (2007) 1.43
Channelopathies linked to plasma membrane phosphoinositides. Pflugers Arch (2010) 1.42
Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling. Proc Natl Acad Sci U S A (2010) 1.42
Phospholipase C-mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane. J Cell Biol (2009) 1.41
Phosphoinositide signaling: new tools and insights. Physiology (Bethesda) (2009) 1.41
Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. Biochem J (2009) 1.38
Determinants of molecular specificity in phosphoinositide regulation. Phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is the endogenous lipid regulating TRPV1. J Biol Chem (2008) 1.37
Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. J Biol Chem (2009) 1.36
The intracellular trafficking pathway of transferrin. Biochim Biophys Acta (2011) 1.36
Signalling scaffolds and local organization of cellular behaviour. Nat Rev Mol Cell Biol (2015) 1.35
Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathway. J Gen Physiol (2008) 1.33
A carboxy-terminal inter-helix linker as the site of phosphatidylinositol 4,5-bisphosphate action on Kv7 (M-type) K+ channels. J Gen Physiol (2008) 1.33
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi. J Cell Biol (2014) 1.31
Lipids and lipid modifications in the regulation of membrane traffic. Curr Opin Cell Biol (2007) 1.30
Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium (2009) 1.29
Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. Proc Natl Acad Sci U S A (2011) 1.29
A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity. J Am Chem Soc (2010) 1.29
Role for cell density in antifungal drug resistance in Candida albicans biofilms. Antimicrob Agents Chemother (2007) 1.28
Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology. Pflugers Arch (2013) 1.27
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2007) 1.25
Regulation of M(Kv7.2/7.3) channels in neurons by PIP(2) and products of PIP(2) hydrolysis: significance for receptor-mediated inhibition. J Physiol (2007) 1.24
Cooperative activation of PI3K by Ras and Rho family small GTPases. Mol Cell (2012) 1.23
Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion. Nat Cell Biol (2012) 1.23
Electrostatic interaction of internal Mg2+ with membrane PIP2 Seen with KCNQ K+ channels. J Gen Physiol (2007) 1.22
Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol (2009) 1.22
Regulation of voltage-gated potassium channels by PI(4,5)P2. J Gen Physiol (2012) 1.22
Modulation of cyclic nucleotide-regulated HCN channels by PIP(2) and receptors coupled to phospholipase C. Pflugers Arch (2007) 1.21
Rapid and orthogonal logic gating with a gibberellin-induced dimerization system. Nat Chem Biol (2012) 1.20
Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby. J Physiol (2008) 1.19
Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity. Sci Rep (2011) 1.18
Regulation of KCNQ channels by manipulation of phosphoinositides. J Physiol (2007) 1.18
Allosteric modulation of ATP-gated P2X receptor channels. Rev Neurosci (2011) 1.16
Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflugers Arch (2007) 1.16
Regulation of Ca(V)2 calcium channels by G protein coupled receptors. Biochim Biophys Acta (2012) 1.15
Synthetic spatially graded Rac activation drives cell polarization and movement. Proc Natl Acad Sci U S A (2012) 1.14
Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains. Pflugers Arch (2007) 1.14
Dual-mode phospholipid regulation of human inward rectifying potassium channels. Biophys J (2011) 1.14
Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases. Pflugers Arch (2007) 1.14
Regulation of voltage-gated Ca2+ channels by lipids. Cell Calcium (2009) 1.12
The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J Cell Biol (2010) 1.11
Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2. J Biol Chem (2008) 1.11
Live cell imaging of phosphoinositides with expressed inositide binding protein domains. Methods (2008) 1.11
Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganization. Sci Signal (2011) 1.10
Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor. J Cell Sci (2008) 1.10
Phosphoinositides regulate ion channels. Biochim Biophys Acta (2014) 1.09
Ca2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channels. J Neurosci (2010) 1.09
Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2010) 1.09
Imaging and manipulating phosphoinositides in living cells. J Physiol (2007) 1.08
An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis. J Cell Biol (2009) 1.08
Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel. J Gen Physiol (2015) 1.08
A multi-colour/multi-affinity marker set to visualize phosphoinositide dynamics in Arabidopsis. Plant J (2013) 1.07
Quantitative properties and receptor reserve of the DAG and PKC branch of G(q)-coupled receptor signaling. J Gen Physiol (2013) 1.07
Phosphoinositide isoforms determine compartment-specific ion channel activity. Proc Natl Acad Sci U S A (2012) 1.06
Calmodulin binding to M-type K+ channels assayed by TIRF/FRET in living cells. J Physiol (2008) 1.06
Affinity for phosphatidylinositol 4,5-bisphosphate determines muscarinic agonist sensitivity of Kv7 K+ channels. J Gen Physiol (2009) 1.04
Strategies for protein synthetic biology. Nucleic Acids Res (2010) 1.04
The lipid connection-regulation of voltage-gated Ca(2+) channels by phosphoinositides. Pflugers Arch (2007) 1.03
Quantitative properties and receptor reserve of the IP(3) and calcium branch of G(q)-coupled receptor signaling. J Gen Physiol (2013) 1.03
Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. EMBO J (2012) 1.02
Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. J Biol Chem (2008) 1.01
The Ca2+ channel beta subunit determines whether stimulation of Gq-coupled receptors enhances or inhibits N current. J Gen Physiol (2009) 1.01
Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching. Mol Biol Cell (2008) 1.01
Cholesterol modulates ion channels via down-regulation of phosphatidylinositol 4,5-bisphosphate. J Neurochem (2009) 1.01
Polyphosphoinositide binding domains: Key to inositol lipid biology. Biochim Biophys Acta (2015) 1.00
PIP(2)-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP(2) depletion by Gq-coupled receptors in single living neurons. Pflugers Arch (2007) 1.00
Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems. J Cell Sci (2014) 0.99
The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem (2007) 0.99
Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proc Natl Acad Sci U S A (2013) 0.99
Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels. Annu Rev Physiol (2014) 0.99
Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. J Neurosci (2009) 0.98
Acid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation. BMB Rep (2013) 0.98
The phosphoinositide 3-kinase pathway. Science (2002) 24.72
Controlling signal transduction with synthetic ligands. Science (1993) 6.70
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell (1989) 6.26
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science (2006) 6.25
Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells. Curr Biol (1998) 5.94
Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron (2002) 4.58
Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci (2005) 4.54
The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE (2001) 4.45
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell (2000) 4.45
An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nat Methods (2005) 4.23
Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr Opin Neurobiol (2005) 3.94
Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell (1998) 3.90
Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns. Science (1999) 3.70
Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature (2002) 3.46
Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science (1995) 3.42
1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc Natl Acad Sci U S A (1994) 3.37
Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current. J Gen Physiol (2005) 2.98
Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J Biol Chem (1998) 2.42
Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. Mol Cell Biol (1998) 2.28
Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate. J Neurosci (2005) 2.28
Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides. J Biol Chem (1999) 2.08
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels. J Neurosci (2005) 2.05
Regulation of KCNQ2/KCNQ3 current by G protein cycling: the kinetics of receptor-mediated signaling by Gq. J Gen Physiol (2004) 1.82
Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. Cell (2001) 1.60
Ion channel defects in idiopathic epilepsies. Curr Pharm Des (2005) 1.17
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol (2005) 14.53
Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science (2005) 6.88
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science (2006) 6.25
Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci U S A (2007) 5.31
Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron (2002) 4.58
An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nat Methods (2005) 4.23
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell (2009) 4.17
Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr Opin Neurobiol (2005) 3.94
PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89
STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels. Cell (2007) 3.75
Feedback loops shape cellular signals in space and time. Science (2008) 3.42
Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing. Nat Biotechnol (2003) 3.17
Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proc Natl Acad Sci U S A (2008) 3.07
A local coupling model and compass parameter for eukaryotic chemotaxis. Dev Cell (2005) 3.02
Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current. J Gen Physiol (2005) 2.98
A localized Wnt signal orients asymmetric stem cell division in vitro. Science (2013) 2.82
Modular control of endothelial sheet migration. Genes Dev (2008) 2.50
Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases. Cell (2003) 2.42
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc Natl Acad Sci U S A (2008) 2.42
The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell (2013) 2.37
Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron (2003) 2.36
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A (2003) 2.34
Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS One (2008) 2.21
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Kinetics of PIP2 metabolism and KCNQ2/3 channel regulation studied with a voltage-sensitive phosphatase in living cells. J Gen Physiol (2010) 2.02
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. Mol Cell (2011) 2.02
Optogenetic control of phosphoinositide metabolism. Proc Natl Acad Sci U S A (2012) 1.92
STIM proteins and the endoplasmic reticulum-plasma membrane junctions. Annu Rev Biochem (2011) 1.91
Regulation of KCNQ2/KCNQ3 current by G protein cycling: the kinetics of receptor-mediated signaling by Gq. J Gen Physiol (2004) 1.82
Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia. Nat Methods (2013) 1.76
Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella. Nat Cell Biol (2002) 1.75
Probing the precision of the mitotic clock with a live-cell fluorescent biosensor. Nat Biotechnol (2004) 1.74
Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Mol Cell (2008) 1.73
Phosphoinositides: lipid regulators of membrane proteins. J Physiol (2010) 1.72
Organelle-specific, rapid induction of molecular activities and membrane tethering. Nat Methods (2010) 1.69
Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol (2007) 1.63
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. Proc Natl Acad Sci U S A (2005) 1.62
Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery. J Virol (2007) 1.58
An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling. Proc Natl Acad Sci U S A (2003) 1.57
A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium. J Cell Biol (2007) 1.52
Robust neuronal symmetry breaking by Ras-triggered local positive feedback. Curr Biol (2007) 1.49
Optimal experimental design for parameter estimation of a cell signaling model. PLoS Comput Biol (2009) 1.47
Fluorescence changes reveal kinetic steps of muscarinic receptor-mediated modulation of phosphoinositides and Kv7.2/7.3 K+ channels. J Gen Physiol (2009) 1.45
Modulation of high-voltage activated Ca(2+) channels by membrane phosphatidylinositol 4,5-bisphosphate. Neuron (2010) 1.44
siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake. Genome Biol (2007) 1.41
Identical phenotypes of CatSper1 and CatSper2 null sperm. J Biol Chem (2005) 1.40
Molecular mechanisms of CaMKII activation in neuronal plasticity. Curr Opin Neurobiol (2002) 1.37
Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin. J Cell Biol (2005) 1.35
Calcium clearance mechanisms of mouse sperm. J Gen Physiol (2003) 1.34
Antibodies and a cysteine-modifying reagent show correspondence of M current in neurons to KCNQ2 and KCNQ3 K+ channels. Br J Pharmacol (2002) 1.34
Dynamics of calcium clearance in mouse pancreatic beta-cells. Diabetes (2003) 1.33
Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors. Cell Cycle (2009) 1.31
A PI3-kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane. Curr Biol (2002) 1.31
Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. Mol Biol Cell (2008) 1.30
Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells. J Gen Physiol (2010) 1.29
A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity. J Am Chem Soc (2010) 1.29
Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology. Pflugers Arch (2013) 1.27
Spatial positive feedback at the onset of mitosis. Cell (2012) 1.26
Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module. Science (2002) 1.26
An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol (2007) 1.25
Cooperative activation of PI3K by Ras and Rho family small GTPases. Mol Cell (2012) 1.23
Electrostatic interaction of internal Mg2+ with membrane PIP2 Seen with KCNQ K+ channels. J Gen Physiol (2007) 1.22
Regulation of voltage-gated potassium channels by PI(4,5)P2. J Gen Physiol (2012) 1.22
Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions. Neuron (2003) 1.21
The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole. Cell Host Microbe (2010) 1.20
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase. Autophagy (2011) 1.20
Rapid and orthogonal logic gating with a gibberellin-induced dimerization system. Nat Chem Biol (2012) 1.20
Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation. Proc Natl Acad Sci U S A (2008) 1.18
Ca2+ pulses control local cycles of lamellipodia retraction and adhesion along the front of migrating cells. Curr Biol (2012) 1.18
Regulation of KCNQ channels by manipulation of phosphoinositides. J Physiol (2007) 1.18
Synthetic spatially graded Rac activation drives cell polarization and movement. Proc Natl Acad Sci U S A (2012) 1.14
A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Dev (2008) 1.14
A steering model of endothelial sheet migration recapitulates monolayer integrity and directed collective migration. Mol Cell Biol (2010) 1.13
External Ca2+ acts upstream of adenylyl cyclase SACY in the bicarbonate signaled activation of sperm motility. Dev Biol (2007) 1.12
Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems. Trends Cell Biol (2011) 1.12
Suspended-drop electroporation for high-throughput delivery of biomolecules into cells. Nat Methods (2008) 1.10
A comparative Raman and CARS imaging study of colon tissue. J Biophotonics (2009) 1.10
Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganization. Sci Signal (2011) 1.10
Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor. J Cell Sci (2008) 1.10
Contributions of intracellular compartments to calcium dynamics: implicating an acidic store. Traffic (2006) 1.09
Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signaling. J Cell Sci (2002) 1.08
An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis. J Cell Biol (2009) 1.08
Quantitative properties and receptor reserve of the DAG and PKC branch of G(q)-coupled receptor signaling. J Gen Physiol (2013) 1.07
Spines and neurite branches function as geometric attractors that enhance protein kinase C action. J Cell Biol (2005) 1.07
Membrane-localized β-subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels. Proc Natl Acad Sci U S A (2012) 1.06
A critical intramolecular interaction for protein kinase Cepsilon translocation. J Biol Chem (2004) 1.06
The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. J Cell Biol (2014) 1.06
Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA. Sci Signal (2013) 1.06
Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD. PLoS Biol (2009) 1.05
Quantitative properties and receptor reserve of the IP(3) and calcium branch of G(q)-coupled receptor signaling. J Gen Physiol (2013) 1.03