Published in Mol Biol Cell on December 16, 2009
ARF family G proteins and their regulators: roles in membrane transport, development and disease. Nat Rev Mol Cell Biol (2011) 3.38
Kinetic studies of the Arf activator Arno on model membranes in the presence of Arf effectors suggest control by a positive feedback loop. J Biol Chem (2010) 1.28
WAVE regulatory complex activation by cooperating GTPases Arf and Rac1. Proc Natl Acad Sci U S A (2011) 1.20
Whole-genome methylation analysis of benign and malignant colorectal tumours. J Pathol (2013) 1.20
I'm coming to GEF you: Regulation of RhoGEFs during cell migration. Cell Adh Migr (2014) 1.02
Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS. J Neurosci (2015) 0.94
Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells. Prostate (2011) 0.89
Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination. Mol Biol Cell (2014) 0.88
The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family. J Biol Chem (2011) 0.88
The cytohesin coiled-coil domain interacts with threonine 276 to control membrane association. PLoS One (2013) 0.83
Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells. Chem Res Toxicol (2015) 0.81
Epigenetic Modulation of Gene Expression during Keratinocyte Differentiation. Ann Dermatol (2012) 0.80
Frequent loss of heterozygosity on chromosome 12q in non-small-cell lung carcinomas. Virchows Arch (2011) 0.80
Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas. BMC Med Genomics (2015) 0.79
The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration. Biochem Biophys Res Commun (2014) 0.79
The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration. BMC Cell Biol (2013) 0.79
The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility. Cell Commun Signal (2013) 0.79
The cytohesin guanosine exchange factors (GEFs) are required to promote HGF-mediated renal recovery after acute kidney injury (AKI) in mice. Physiol Rep (2015) 0.78
Arf proteins in cancer cell migration. Small GTPases (2016) 0.75
ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment. Mol Biol Cell (2015) 0.75
Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function. Mol Biol Cell (2017) 0.75
Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol (2005) 7.07
Construction of adenovirus vectors through Cre-lox recombination. J Virol (1997) 6.72
Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol (2003) 5.38
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell (1999) 4.98
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol (2002) 4.29
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science (1997) 3.91
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell (2001) 3.67
A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains. Nature (1996) 3.54
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D. J Cell Biol (2001) 3.49
ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J Cell Sci (1999) 3.14
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature (1998) 3.02
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol (2000) 2.58
An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration. EMBO J (2001) 2.50
Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Traffic (2007) 2.47
Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J Cell Biol (1996) 2.47
DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol Cell Biol (1996) 2.44
A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis. PLoS Biol (2006) 2.37
Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization. J Cell Biol (1997) 2.36
Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading. J Cell Sci (1998) 2.26
Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts. Nat Cell Biol (2007) 2.23
Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic. Mol Biol Cell (2005) 2.21
ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6. J Biol Chem (1998) 2.17
Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains. Mol Biol Cell (2007) 2.15
Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase. Curr Biol (1998) 2.08
Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J Biol Chem (2003) 2.04
Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. Genes Dev (1998) 1.97
ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA. Mol Cell Biol (2000) 1.91
Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 1.83
The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. Curr Biol (2005) 1.82
A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages. J Biol Chem (1998) 1.82
Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell (2007) 1.76
ARF6 is required for growth factor- and rac-mediated membrane ruffling in macrophages at a stage distal to rac membrane targeting. Mol Cell Biol (1999) 1.73
The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature (2006) 1.71
Scaffold proteins in MAP kinase signaling: more than simple passive activating platforms. Bioessays (2006) 1.68
Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective. Cell Signal (2007) 1.65
Localization and function of Arf family GTPases. Biochem Soc Trans (2005) 1.58
Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes. Development (2007) 1.57
Remodeling of the actin cytoskeleton is coordinately regulated by protein kinase C and the ADP-ribosylation factor nucleotide exchange factor ARNO. Mol Biol Cell (1998) 1.56
Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. J Neurosci (2002) 1.52
Modulation of Rac1 and ARF6 activation during epithelial cell scattering. J Biol Chem (2003) 1.44
Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. J Biol Chem (2000) 1.40
New developments in phospholipase D. J Biol Chem (1997) 1.39
A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. J Cell Biol (2006) 1.24
Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation. BMC Cell Biol (2007) 1.19
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol (2006) 1.12
The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP. J Biol Chem (2002) 1.11
Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity. J Biol Chem (2003) 1.10
Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration. EMBO J (2003) 1.04
Characterization of a fast cycling ADP-ribosylation factor 6 mutant. J Biol Chem (2002) 1.03
Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. Proc Natl Acad Sci U S A (2002) 1.02
Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association. J Biol Chem (2003) 1.01
ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells. J Biol Chem (2006) 0.96
A fluorescence resonance energy transfer activation sensor for Arf6. Anal Biochem (2007) 0.93
Cybr, CYTIP or CASP: an attempt to pinpoint a molecule's functions and names. Immunobiology (2008) 0.77
The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. Mol Cell Biol (2004) 1.22
Differential effects of cytohesins 2 and 3 on beta1 integrin recycling. J Biol Chem (2010) 0.99
ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells. J Biol Chem (2006) 0.96
The guanine nucleotide exchange factor ARNO mediates the activation of ARF and phospholipase D by insulin. BMC Cell Biol (2003) 0.93
ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway. Biochem Biophys Res Commun (2006) 0.89
CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration. Exp Cell Res (2011) 0.86
The cytohesin coiled-coil domain interacts with threonine 276 to control membrane association. PLoS One (2013) 0.83
Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling. J Cell Sci (2012) 0.80
The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration. BMC Cell Biol (2013) 0.79