Published in Mol Cell Biol on November 01, 2004
ARF family G proteins and their regulators: roles in membrane transport, development and disease. Nat Rev Mol Cell Biol (2011) 3.38
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell (2012) 2.22
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling. Cell Signal (2008) 1.88
Illuminating the functional and structural repertoire of human TBC/RABGAPs. Nat Rev Mol Cell Biol (2012) 1.51
TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy. Am J Hum Genet (2010) 1.44
EPI64 regulates microvillar subdomains and structure. J Cell Biol (2006) 1.30
Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Mol Biol Cell (2005) 1.30
The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway. Mol Biol Cell (2008) 1.23
Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation. BMC Cell Biol (2007) 1.19
Deubiquitylating enzymes and disease. BMC Biochem (2008) 1.17
Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. Mol Biol Cell (2012) 1.06
TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. Oncogene (2010) 1.06
The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking. J Biol Chem (2008) 1.05
TRE17/ubiquitin-specific protease 6 (USP6) oncogene translocated in aneurysmal bone cyst blocks osteoblastic maturation via an autocrine mechanism involving bone morphogenetic protein dysregulation. J Biol Chem (2010) 0.97
Deubiquitinase activities required for hepatocyte growth factor-induced scattering of epithelial cells. Curr Biol (2009) 0.95
A fluorescence resonance energy transfer activation sensor for Arf6. Anal Biochem (2007) 0.93
A-RAF kinase functions in ARF6 regulated endocytic membrane traffic. PLoS One (2009) 0.91
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. Proc Natl Acad Sci U S A (2016) 0.85
Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis. Oncogene (2011) 0.84
TRE17/USP6 regulates ubiquitylation and trafficking of cargo proteins that enter cells by clathrin-independent endocytosis. J Cell Sci (2014) 0.79
Jak1-STAT3 Signals Are Essential Effectors of the USP6/TRE17 Oncogene in Tumorigenesis. Cancer Res (2016) 0.75
TLDc proteins: new players in the oxidative stress response and neurological disease. Mamm Genome (2017) 0.75
The diversity of Rab proteins in vesicle transport. Curr Opin Cell Biol (1997) 5.15
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell (1999) 4.98
ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway. J Cell Biol (1997) 4.76
A regulatory role for ARF6 in receptor-mediated endocytosis. Science (1995) 3.82
Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments. J Cell Biol (1995) 3.82
Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. J Cell Biol (2001) 3.70
A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains. Nature (1996) 3.54
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D. J Cell Biol (2001) 3.49
The role of ARF and Rab GTPases in membrane transport. Curr Opin Cell Biol (1999) 3.42
A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane. EMBO J (2002) 3.35
The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature (1993) 3.33
GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. J Cell Biol (2000) 3.15
ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J Cell Sci (1999) 3.14
Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors. Trends Cell Biol (2000) 3.12
Regulators and effectors of the ARF GTPases. Curr Opin Cell Biol (2000) 2.99
Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11. Traffic (2004) 2.91
Convergence of non-clathrin- and clathrin-derived endosomes involves Arf6 inactivation and changes in phosphoinositides. Mol Biol Cell (2003) 2.79
GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim Biophys Acta (2003) 2.71
ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly. Nat Cell Biol (2002) 2.63
EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization. EMBO J (1999) 2.63
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature (2000) 2.58
An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration. EMBO J (2001) 2.50
ARF6 targets recycling vesicles to the plasma membrane: insights from an ultrastructural investigation. J Cell Biol (1998) 2.49
Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J Cell Biol (1996) 2.47
A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J (1997) 2.39
Requirement for Arf6 in breast cancer invasive activities. Proc Natl Acad Sci U S A (2004) 2.37
Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading. J Cell Sci (1998) 2.26
ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6. J Biol Chem (1998) 2.17
Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase. Curr Biol (1998) 2.08
Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane. J Biol Chem (1996) 2.01
Arf and its many interactors. Curr Opin Cell Biol (2003) 1.94
ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA. Mol Cell Biol (2000) 1.91
A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages. J Biol Chem (1998) 1.82
Identification of the catalytic domains and their functionally critical arginine residues of two yeast GTPase-activating proteins specific for Ypt/Rab transport GTPases. EMBO J (1999) 1.75
ARF6 is required for growth factor- and rac-mediated membrane ruffling in macrophages at a stage distal to rac membrane targeting. Mol Cell Biol (1999) 1.73
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway. Proc Natl Acad Sci U S A (2004) 1.71
A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family. Nature (1993) 1.71
Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast. Mol Biol Cell (2000) 1.64
Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. EMBO J (1999) 1.64
USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. Cancer Res (2004) 1.64
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem (2001) 1.63
The Tre2 (USP6) oncogene is a hominoid-specific gene. Proc Natl Acad Sci U S A (2003) 1.62
The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion. J Cell Biol (2002) 1.59
ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1. J Biol Chem (1999) 1.53
ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages. J Cell Biol (2003) 1.51
Modulation of Rac1 and ARF6 activation during epithelial cell scattering. J Biol Chem (2003) 1.44
A shared domain between a spindle assembly checkpoint protein and Ypt/Rab-specific GTPase-activators. Trends Biochem Sci (1997) 1.38
Molecular aspects of the cellular activities of ADP-ribosylation factors. Sci STKE (2000) 1.35
Two new members of a family of Ypt/Rab GTPase activating proteins. Promiscuity of substrate recognition. J Biol Chem (1999) 1.31
GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. Biochem J (2002) 1.27
The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. J Cell Biol (2003) 1.25
The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function. Mol Biol Cell (1998) 1.20
PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. Cancer Res (2002) 1.20
Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins. EMBO J (2000) 1.19
A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells. Oncogene (1992) 1.17
Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16. Oncogene (1995) 1.14
Pollux, a novel Drosophila adhesion molecule, belongs to a family of proteins expressed in plants, yeast, nematodes, and man. Genes Dev (1996) 1.10
Msb4p, a protein involved in Cdc42p-dependent organization of the actin cytoskeleton, is a Ypt/Rab-specific GAP. Biol Chem (2000) 1.10
Myristoylation is required for the intracellular localization and endocytic function of ARF6. Exp Cell Res (1995) 1.04
Characterization of a fast cycling ADP-ribosylation factor 6 mutant. J Biol Chem (2002) 1.03
The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. Mol Cell Biol (2003) 1.00
Alterations in the Arf6-regulated plasma membrane endosomal recycling pathway in cells overexpressing the tetraspan protein Gas3/PMP22. J Cell Sci (2003) 0.98
RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain. Oncogene (1996) 0.91
Rab and ARF GTPase regulation of exocytosis. Mol Membr Biol (2003) 0.87
High expression cloning, purification, and assay of Ypt-GTPase-activating proteins. Methods Enzymol (1995) 0.87
Preparation of myristoylated Arf1 and Arf6 proteins. Methods Mol Biol (2002) 0.86
Identification and partial purification of GTPase-activating proteins from yeast and mammalian cells that preferentially act on Ypt1/Rab1 proteins. FEBS Lett (1991) 0.85
Expression and properties of ADP-ribosylation factor (ARF6) in endocytic pathways. Methods Enzymol (2001) 0.83
Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene. Biochem Biophys Res Commun (2003) 0.82
ARFs. Curr Biol (2003) 0.76
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem (2002) 4.19
Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts. Nat Cell Biol (2007) 2.23
A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Mol Cell (2009) 1.94
The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. Curr Biol (2005) 1.82
Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expression. Infect Immun (2003) 1.69
Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex. Curr Biol (2010) 1.68
The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. Curr Biol (2006) 1.59
Regulation of actin cytoskeleton dynamics by Arf-family GTPases. Trends Cell Biol (2008) 1.58
A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium. J Cell Biol (2007) 1.52
Nerve growth factor-mediated neurite outgrowth via regulation of Rab5. Mol Biol Cell (2007) 1.51
Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A (2011) 1.47
Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Mol Biol Cell (2005) 1.30
ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha. Mol Biol Cell (2003) 1.29
Mechanisms of Salmonella entry into host cells. Cell Microbiol (2007) 1.29
Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell (2005) 1.26
Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Lab Invest (2011) 1.26
Regulation of dendritic development by the ARF exchange factor ARNO. Nat Neurosci (2002) 1.22
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. J Cell Sci (2006) 1.21
USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis. Hum Pathol (2013) 1.16
Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway. J Cell Sci (2004) 1.15
WAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium. J Biol Chem (2005) 1.09
Rab14 regulates apical targeting in polarized epithelial cells. Traffic (2008) 1.06
GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180. Mol Biol Cell (2009) 1.05
Aneurysmal bone cyst: a neoplasm driven by upregulation of the USP6 oncogene. J Clin Oncol (2006) 1.05
Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. J Biol Chem (2003) 1.05
FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. PLoS One (2011) 1.04
Coordinate regulation of Salmonella enterica serovar Typhimurium invasion of epithelial cells by the Arp2/3 complex and Rho GTPases. Infect Immun (2003) 1.03
Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. J Biol Chem (2005) 1.03
Interaction of the Salmonella-containing vacuole with the endocytic recycling system. J Biol Chem (2005) 1.02
The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway. J Cell Sci (2008) 1.01
The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. Mol Cell Biol (2003) 1.00
Differential effects of cytohesins 2 and 3 on beta1 integrin recycling. J Biol Chem (2010) 0.99
Aneurysmal bone cysts of soft tissue represent true neoplasms: a report of two cases. J Bone Joint Surg Am (2011) 0.99
Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replication. J Virol (2010) 0.97
TRE17/ubiquitin-specific protease 6 (USP6) oncogene translocated in aneurysmal bone cyst blocks osteoblastic maturation via an autocrine mechanism involving bone morphogenetic protein dysregulation. J Biol Chem (2010) 0.97
Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre. J Biol Chem (2002) 0.97
ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells. J Biol Chem (2006) 0.96
Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas. Mol Biol Cell (2006) 0.95
BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5). J Biol Chem (2012) 0.95
ARF6: a newly appreciated player in G protein-coupled receptor desensitization. FEBS Lett (2002) 0.95
A novel role for MAPKAPK2 in morphogenesis during zebrafish development. PLoS Genet (2009) 0.95
A fluorescence resonance energy transfer activation sensor for Arf6. Anal Biochem (2007) 0.93
Abelson tyrosine kinase facilitates Salmonella enterica serovar Typhimurium entry into epithelial cells. Infect Immun (2008) 0.93
The guanine nucleotide exchange factor ARNO mediates the activation of ARF and phospholipase D by insulin. BMC Cell Biol (2003) 0.93
Substrate specificities and activities of AZAP family Arf GAPs in vivo. Am J Physiol Cell Physiol (2007) 0.90
Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP. Curr Biol (2007) 0.89
Cdc42 promotes G1 progression through p70 S6 kinase-mediated induction of cyclin E expression. J Biol Chem (2003) 0.89
ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway. Biochem Biophys Res Commun (2006) 0.89
Arf6-GEF BRAG1 regulates JNK-mediated synaptic removal of GluA1-containing AMPA receptors: a new mechanism for nonsyndromic X-linked mental disorder. J Neurosci (2012) 0.88
CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration. Exp Cell Res (2011) 0.86
Frequency of USP6 rearrangements in myositis ossificans, brown tumor, and cherubism: molecular cytogenetic evidence that a subset of "myositis ossificans-like lesions" are the early phases in the formation of soft-tissue aneurysmal bone cyst. Skeletal Radiol (2008) 0.84
Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2. Traffic (2007) 0.84
GTPase signaling: bridging the GAP between ARF and Rho. Curr Biol (2002) 0.83
The cytohesin coiled-coil domain interacts with threonine 276 to control membrane association. PLoS One (2013) 0.83
The TRE17/USP6 oncogene: a riddle wrapped in a mystery inside an enigma. Front Biosci (Schol Ed) (2012) 0.81
Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling. J Cell Sci (2012) 0.80
The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration. BMC Cell Biol (2013) 0.79
Extraosseous aneurysmal bone cyst of cerebello-pontine angle with USP6 rearrangement. Acta Neuropathol (2009) 0.76
There goes the neighborhood. Focus on "localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion". Am J Physiol Cell Physiol (2006) 0.75