Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors.

PubWeight™: 1.52‹?› | Rank: Top 4%

🔗 View Article (PMC 2799783)

Published in Proc Natl Acad Sci U S A on December 11, 2009

Authors

Gretchen L Hermes1, Bertha Delgado, Maria Tretiakova, Sonia A Cavigelli, Thomas Krausz, Suzanne D Conzen, Martha K McClintock

Author Affiliations

1: Departments of Comparative Human Development, Institute for Mind and Biology, The University of Chicago, Chicago, IL 60637, USA.

Articles citing this

Molecular pathways: beta-adrenergic signaling in cancer. Clin Cancer Res (2011) 1.84

Impact of stress on cancer metastasis. Future Oncol (2010) 1.52

Human social genomics. PLoS Genet (2014) 1.24

Stress and breast cancer: from epidemiology to molecular biology. Breast Cancer Res (2011) 1.16

Using community-based participatory research to ameliorate cancer disparities. Health Soc Work (2010) 1.12

Morphine suppresses tumor angiogenesis through a HIF-1alpha/p38MAPK pathway. Am J Pathol (2010) 1.11

Social relationships and physiological determinants of longevity across the human life span. Proc Natl Acad Sci U S A (2016) 0.99

The influence of glucocorticoid signaling on tumor progression. Brain Behav Immun (2012) 0.97

Toward an integrative understanding of social behavior: new models and new opportunities. Front Behav Neurosci (2010) 0.94

Interaction of glucocorticoid receptor (GR) with estrogen receptor (ER) α and activator protein 1 (AP1) in dexamethasone-mediated interference of ERα activity. J Biol Chem (2013) 0.93

Chronic social isolation is associated with metabolic gene expression changes specific to mammary adipose tissue. Cancer Prev Res (Phila) (2013) 0.92

Longitudinal change in telomere length and the chronic stress response in a randomized pilot biobehavioral clinical study: implications for cancer prevention. Cancer Prev Res (Phila) (2012) 0.91

The significance of meaning: why do over 90% of behavioral neuroscience results fail to translate to humans, and what can we do to fix it? ILAR J (2014) 0.88

Early impact of social isolation and breast tumor progression in mice. Brain Behav Immun (2012) 0.87

Social isolation reduces mammary development, tumor incidence, and expression of epigenetic regulators in wild-type and p53-heterozygotic mice. Cancer Prev Res (Phila) (2010) 0.87

Nervous system regulation of the cancer genome. Brain Behav Immun (2012) 0.86

Cardiac coherence, self-regulation, autonomic stability, and psychosocial well-being. Front Psychol (2014) 0.86

β2-AR-HIF-1α: a novel regulatory axis for stress-induced pancreatic tumor growth and angiogenesis. Curr Mol Med (2013) 0.86

Psychosocially influenced cancer: diverse early-life stress experiences and links to breast cancer. Cancer Prev Res (Phila) (2010) 0.85

Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage. Br J Cancer (2015) 0.84

High-anxious individuals show increased chronic stress burden, decreased protective immunity, and increased cancer progression in a mouse model of squamous cell carcinoma. PLoS One (2012) 0.84

Regulation of cancer progression by β-endorphin neuron. Cancer Res (2012) 0.84

Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues. Brain Res (2010) 0.84

Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model. J Exp Clin Cancer Res (2014) 0.83

Impact of marital status and race on outcomes of patients enrolled in Radiation Therapy Oncology Group prostate cancer trials. Support Care Cancer (2011) 0.83

Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment. Nat Commun (2014) 0.83

Breast cancer and social environment: getting by with a little help from our friends. Breast Cancer Res (2016) 0.82

Introducing Therioepistemology: the study of how knowledge is gained from animal research. Lab Anim (NY) (2017) 0.82

Efficacy of an Emotion Self-regulation Program for Promoting Development in Preschool Children. Glob Adv Health Med (2012) 0.80

Household income is associated with the p53 mutation frequency in human breast tumors. PLoS One (2013) 0.79

Day-to-day dynamics of associations between sleep, napping, fatigue, and the cortisol diurnal rhythm in women diagnosed as having breast cancer. Psychosom Med (2014) 0.79

Stress, rejection, and hormones: Cortisol and progesterone reactivity to laboratory speech and rejection tasks in women and men. F1000Res (2014) 0.78

A model of spontaneous mouse mammary tumor for human estrogen receptor- and progesterone receptor-negative breast cancer. Int J Oncol (2014) 0.78

Job Authority and Breast Cancer. Soc Forces (2013) 0.75

Higher-status occupations and breast cancer: a life-course stress approach. Soc Sci Med (2013) 0.75

Knowing it When You See it: The Need for Continuing Innovation in Research on Healthcare Discrimination. J Gen Intern Med (2015) 0.75

Gene expression of peripheral blood cells reveals pathways downstream of glucocorticoid receptor antagonism and nab-paclitaxel treatment. Pharmacogenet Genomics (2014) 0.75

Role of the autonomic nervous system in tumorigenesis and metastasis. Mol Cell Oncol (2015) 0.75

Impact of stress and levels of corticosterone on the development of breast cancer in rats. Psychol Res Behav Manag (2016) 0.75

Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom. Breast Cancer Res (2016) 0.75

Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid. Genes Environ (2017) 0.75

Individual differences in pre-carcinogen cytokine and corticosterone concentrations and depressive-like behavior predict tumor onset in rats exposed to a carcinogen. Psychoneuroendocrinology (2012) 0.75

Restraint and Social Isolation Stressors Differentially Regulate Adaptive Immunity and Tumor Angiogenesis in a Breast Cancer Mouse Model. Cancer Clin Oncol (2016) 0.75

Extreme population-level events: Do they have an impact on cancer? Cancer (2017) 0.75

Articles cited by this

Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med (2006) 6.18

Social regulation of gene expression in human leukocytes. Genome Biol (2007) 4.65

Stress and disorders of the stress system. Nat Rev Endocrinol (2009) 4.61

Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst (2000) 4.50

The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer (2006) 4.27

Stress, depression, the immune system, and cancer. Lancet Oncol (2004) 3.48

A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling. Biol Psychiatry (2008) 3.08

Dexamethasone decreases xenograft response to Paclitaxel through inhibition of tumor cell apoptosis. Cancer Biol Ther (2006) 1.92

Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol (2003) 1.85

Depression, social support, and beta-adrenergic transcription control in human ovarian cancer. Brain Behav Immun (2008) 1.66

Mammary cancer and social interactions: identifying multiple environments that regulate gene expression throughout the life span. J Gerontol B Psychol Sci Soc Sci (2005) 1.55

Tumor incidence in normal Sprague-Dawley female rats. Cancer Res (1956) 1.52

The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res (2000) 1.45

Atlas and histologic classification of tumors of the rat mammary gland. J Mammary Gland Biol Neoplasia (2000) 1.45

2006 Curt P. Richter award winner: Social influences on stress responses and health. Psychoneuroendocrinology (2007) 1.34

Energy restriction and the risk of spontaneous mammary tumors in mice: a meta-analysis. Int J Cancer (2003) 1.30

Social isolation and the inflammatory response: sex differences in the enduring effects of a prior stressor. Am J Physiol Regul Integr Comp Physiol (2005) 1.24

Cortisol, dehydroepiandrosterone, and estradiol measured over 24 hours in women with childhood sexual abuse-related posttraumatic stress disorder. J Nerv Ment Dis (2007) 1.24

Cellular expression of estrogen and progesterone receptors in mammary glands: regulation by hormones, development and aging. J Steroid Biochem Mol Biol (2002) 1.24

Infant temperament predicts life span in female rats that develop spontaneous tumors. Horm Behav (2006) 1.21

Reciprocal affiliation among adolescent rats during a mild group stressor predicts mammary tumors and lifespan. Psychosom Med (2008) 1.20

Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder. Am J Psychiatry (1991) 1.17

Stress-like responses to common procedures in individually and group-housed female rats. Contemp Top Lab Anim Sci (2003) 1.13

Peripheral tumors induce depressive-like behaviors and cytokine production and alter hypothalamic-pituitary-adrenal axis regulation. Proc Natl Acad Sci U S A (2009) 1.10

Hydrocortisone down-regulates the tumor suppressor gene BRCA1 in mammary cells: a possible molecular link between stress and breast cancer. Genes Chromosomes Cancer (2008) 1.02

Stress, behavioral arousal, and open field activity--a reexamination of emotionality in the rat. Neurosci Biobehav Rev (1979) 0.99

Genotoxicity of hormonal steroids. Toxicol Lett (2004) 0.91

Mechanisms of hormone carcinogenesis: evolution of views, role of mitochondria. Adv Exp Med Biol (2008) 0.89

Loneliness, emotional repression, marital quality, and major life events in women who develop breast cancer. J Community Health (1994) 0.87

Effects of social housing condition on the response of the Shionogi mouse mammary carcinoma (SC115) to chemotherapy. Cancer Res (1997) 0.84

Isolation and the timing of mammary gland development, gonadarche, and ovarian senescence: implications for mammary tumor burden. Dev Psychobiol (2008) 0.84

Effects of social housing condition and behavior on growth of the Shionogi mouse mammary carcinoma. Physiol Behav (1996) 0.83

Isolation accelerates reproductive senescence and alters its predictors in female rats. Horm Behav (1991) 0.81

Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms. Toxicol Pathol (1995) 0.81

Biliary adenocarcinoma in a stranded northern elephant seal (Mirounga angustirostris). J Wildl Dis (2003) 0.81

Determinants of social organization exemplified in a single population of domesticated rats. Trans N Y Acad Sci (1961) 0.80

Microcysts and breast cancer: a study of biological markers in archival biopsy material. Breast Cancer Res Treat (2002) 0.78

In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone. Mutat Res (1994) 0.77

Articles by these authors

The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics (2006) 12.45

Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity (2004) 4.36

Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res (2009) 3.83

Paternally inherited HLA alleles are associated with women's choice of male odor. Nat Genet (2002) 3.79

A new dynamic Bayesian network (DBN) approach for identifying gene regulatory networks from time course microarray data. Bioinformatics (2004) 3.29

Vaginal self-swab specimen collection in a home-based survey of older women: methods and applications. J Gerontol B Psychol Sci Soc Sci (2009) 3.27

In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J Pathol (2004) 3.08

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med (2005) 3.01

Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer. J Clin Oncol (2011) 2.90

The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res (2006) 2.84

Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues. FASEB J (2009) 2.82

Differential diagnosis of cardiac masses using contrast echocardiographic perfusion imaging. J Am Coll Cardiol (2004) 2.50

Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med (2012) 2.46

Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res (2004) 2.35

Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. Cancer Res (2008) 2.35

Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum. Int J Cancer (2007) 2.31

BAP1 and cancer. Nat Rev Cancer (2013) 2.23

Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am J Pathol (2010) 2.20

Concomitant radiation therapy and paclitaxel for unresectable locally advanced breast cancer: results from two consecutive phase I/II trials. Int J Radiat Oncol Biol Phys (2005) 2.11

c-Met is a potentially new therapeutic target for treatment of human melanoma. Clin Cancer Res (2007) 2.06

Expression and mutational analysis of MET in human solid cancers. Genes Chromosomes Cancer (2008) 2.06

Reprogramming of CTLs into natural killer-like cells in celiac disease. J Exp Med (2006) 2.03

Ductal carcinoma in situ: X-ray fluorescence microscopy and dynamic contrast-enhanced MR imaging reveals gadolinium uptake within neoplastic mammary ducts in a murine model. Radiology (2009) 2.02

Dexamethasone decreases xenograft response to Paclitaxel through inhibition of tumor cell apoptosis. Cancer Biol Ther (2006) 1.92

Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med (2009) 1.85

Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients. Cancer (2004) 1.85

Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science (2009) 1.83

BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. J Transl Med (2012) 1.76

Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation. Proc Natl Acad Sci U S A (2010) 1.72

BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. Cancer Res (2005) 1.71

Prostate cancer: differentiation of central gland cancer from benign prostatic hyperplasia by using diffusion-weighted and dynamic contrast-enhanced MR imaging. Radiology (2010) 1.70

Primary benign vascular tumors and tumorlike lesions of the kidney: a clinicopathologic analysis of 15 cases. Virchows Arch (2012) 1.67

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest (2008) 1.64

Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. Cancer Res (2008) 1.60

A molecular classification of papillary renal cell carcinoma. Cancer Res (2005) 1.60

Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior. Mod Pathol (2008) 1.56

Mammary cancer and social interactions: identifying multiple environments that regulate gene expression throughout the life span. J Gerontol B Psychol Sci Soc Sci (2005) 1.55

Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. J Biol Chem (2004) 1.55

High molecular weight polyethylene glycol (PEG 15-20) maintains mucosal microbial barrier function during intestinal graft preservation. J Surg Res (2013) 1.51

Protocol for the examination of specimens from patients with soft tissue tumors of intermediate malignant potential, malignant soft tissue tumors, and benign/locally aggressive and malignant bone tumors. Arch Pathol Lab Med (2006) 1.47

Diffusion-weighted and dynamic contrast-enhanced MRI of prostate cancer: correlation of quantitative MR parameters with Gleason score and tumor angiogenesis. AJR Am J Roentgenol (2011) 1.45

Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma. Genes Chromosomes Cancer (2013) 1.45

Molecular subclassification of kidney tumors and the discovery of new diagnostic markers. Oncogene (2003) 1.42

Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res (2011) 1.40

The E2F3-Oncomir-1 axis is activated in Wilms' tumor. Cancer Res (2008) 1.33

Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer. Clin Cancer Res (2013) 1.31

RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma. Cancer Biol Ther (2011) 1.26

Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1). J Biol Chem (2002) 1.24

Social isolation and the inflammatory response: sex differences in the enduring effects of a prior stressor. Am J Physiol Regul Integr Comp Physiol (2005) 1.24

Sleep duration and all-cause mortality: a critical review of measurement and associations. Ann Epidemiol (2013) 1.23

A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway. FEBS J (2006) 1.22

Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases. Hum Pathol (2005) 1.21

Infant temperament predicts life span in female rats that develop spontaneous tumors. Horm Behav (2006) 1.21

Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model. Clin Cancer Res (2008) 1.21

Reciprocal affiliation among adolescent rats during a mild group stressor predicts mammary tumors and lifespan. Psychosom Med (2008) 1.20

Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer. Horm Cancer (2014) 1.14

Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation. J Exp Med (2011) 1.14

Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15. J Exp Med (2009) 1.14

Vitamin D receptor expression in normal, premalignant, and malignant human lung tissue. Cancer Epidemiol Biomarkers Prev (2008) 1.14

Primary aortoduodenal fistula: Pitfalls and success in the endoscopic diagnosis. Eur J Intern Med (2005) 1.11

Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. Cancer Res (2006) 1.11

Peripheral tumors induce depressive-like behaviors and cytokine production and alter hypothalamic-pituitary-adrenal axis regulation. Proc Natl Acad Sci U S A (2009) 1.10

Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis. Cancer Treat Res (2009) 1.10

A validation of extraction methods for noninvasive sampling of glucocorticoids in free-living ground squirrels. Physiol Biochem Zool (2005) 1.09

Estrogen receptor-beta expression in extraabdominal fibromatoses: an analysis of 40 cases. Cancer (2006) 1.08

Pneumocytic adenomyoepithelioma: a distinctive lung tumor with epithelial, myoepithelial, and pneumocytic differentiation. Am J Surg Pathol (2007) 1.08

Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. J Clin Pathol (2010) 1.08

Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms. Am J Surg Pathol (2010) 1.07

Expression of alpha-Methylacyl-CoA racemase (P504S) in atypical adenomatous hyperplasia of the prostate. Am J Surg Pathol (2002) 1.07

Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res (2007) 1.07

Gene expression profiling of favorable histology Wilms tumors and its correlation with clinical features. Cancer Res (2002) 1.06

Administration of glucocorticoids to ovarian cancer patients is associated with expression of the anti-apoptotic genes SGK1 and MKP1/DUSP1 in ovarian tissues. Clin Cancer Res (2009) 1.06

Phase II trial of temsirolimus in patients with metastatic breast cancer. Breast Cancer Res Treat (2012) 1.05

Coordinate expression of the PI3-kinase downstream effectors serum and glucocorticoid-induced kinase (SGK-1) and Akt-1 in human breast cancer. Eur J Cancer (2005) 1.05

Women's sexual experience during the menstrual cycle: identification of the sexual phase by noninvasive measurement of luteinizing hormone. J Sex Res (2004) 1.05

Analysis of alpha-methylacyl-CoA racemase (P504S) expression in high-grade prostatic intraepithelial neoplasia. Hum Pathol (2004) 1.05

Densely granulated murine NK cells eradicate large solid tumors. Cancer Res (2012) 1.04

PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription. Lab Invest (2009) 1.04

Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein. Nutr Cancer (2008) 1.04

CREB3L2-PPARgamma fusion mutation identifies a thyroid signaling pathway regulated by intramembrane proteolysis. Cancer Res (2008) 1.04

Pneumonic plague pathogenesis and immunity in Brown Norway rats. Am J Pathol (2009) 1.04

Social isolation and adult mortality: the role of chronic inflammation and sex differences. J Health Soc Behav (2013) 1.02

Psychological effects of musky compounds: comparison of androstadienone with androstenol and muscone. Horm Behav (2002) 1.02

Prognostic significance of E-cadherin protein expression in pathological stage I-III endometrial cancer. Clin Cancer Res (2004) 1.02

Glucocorticoid receptor activation signals through forkhead transcription factor 3a in breast cancer cells. Mol Endocrinol (2006) 1.02

Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin. Cancer Epidemiol Biomarkers Prev (2002) 1.01

Protocol for the examination of specimens from patients with tumors of bone. Arch Pathol Lab Med (2010) 1.00

Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells. Exp Cell Res (2003) 1.00

Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma. Am J Surg Pathol (2004) 1.00

Tailgut cyst initially misdiagnosed as ovarian tumor. Arch Gynecol Obstet (2005) 1.00