Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis.

Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. Mar Drugs (2013) 1.21

The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. J Nat Prod (2013) 0.91

Stictamides A-C, MMP12 inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid subunits. J Org Chem (2011) 0.88

Marine cyanobacteria compounds with anticancer properties: a review on the implication of apoptosis. Mar Drugs (2012) 0.85

Stigonemapeptin, an Ahp-containing depsipeptide with elastase inhibitory activity from the bloom-forming freshwater cyanobacterium Stigonema sp. J Nat Prod (2012) 0.83

Total synthesis and antimicrobial activity of a natural cycloheptapeptide of marine origin. Mar Drugs (2010) 0.83

Sebestenoids A-D, BACE1 inhibitors from Cordia sebestena. Phytochemistry (2010) 0.80

Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties. Mar Drugs (2010) 0.80

Depsipeptides from a Guamanian Marine Cyanobacterium, Lyngbya bouillonii, with Selective Inhibition of Serine Proteases. Tetrahedron Lett (2010) 0.78

α,β-Dehydroamino acids in naturally occurring peptides. Amino Acids (2014) 0.78

Exploring marine cyanobacteria for lead compounds of pharmaceutical importance. ScientificWorldJournal (2012) 0.78

Antineoplastic agents. 590. X-ray crystal structure of dolastatin 16 and syntheses of the dolamethylleuine and dolaphenvaline units. J Nat Prod (2011) 0.75

Recent region-wide declines in Caribbean reef fish abundance. Curr Biol (2009) 2.63

Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. J Am Chem Soc (2008) 2.34

Climate change: links to global expansion of harmful cyanobacteria. Water Res (2011) 2.14

Regionally isolated populations of an imperiled Caribbean coral, Acropora palmata. Mol Ecol (2005) 1.97

Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. J Am Chem Soc (2008) 1.76

A small-molecule inducer of the antioxidant response element. Chem Biol (2010) 1.65

Marine natural products: a new wave of drugs? Future Med Chem (2011) 1.57

Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol (2010) 1.47

A genomic screen for activators of the antioxidant response element. Proc Natl Acad Sci U S A (2007) 1.44

Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp. J Nat Prod (2007) 1.42

Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides. J Nat Prod (2007) 1.32

Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation. Mol Pharmacol (2009) 1.28

Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii. J Nat Prod (2008) 1.28

Diversity and dynamics of bacterial communities in early life stages of the Caribbean coral Porites astreoides. ISME J (2011) 1.28

Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula. J Nat Prod (2010) 1.27

New apratoxins of marine cyanobacterial origin from Guam and Palau. Bioorg Med Chem (2002) 1.24

Morphological, chemical, and genetic diversity of tropical marine cyanobacteria Lyngbya spp. and Symploca spp. (Oscillatoriales). Appl Environ Microbiol (2004) 1.19

Coral-associated micro-organisms and their roles in promoting coral health and thwarting diseases. Proc Biol Sci (2013) 1.18

Biogeography of sponge chemical ecology: comparisons of tropical and temperate defenses. Oecologia (2003) 1.18

Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida. Appl Environ Microbiol (2009) 1.17

Structure and biosynthesis of the antibiotic bottromycin D. Org Lett (2012) 1.16

Carriebowmide, a new cyclodepsipeptide from the marine cyanobacterium Lyngbya polychroa. J Nat Prod (2008) 1.16

Lyngbyaloside B, a new glycoside macrolide from a Palauan marine cyanobacterium, Lyngbya sp. J Nat Prod (2002) 1.15

Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole. Chembiochem (2009) 1.14

Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. J Pharmacol Exp Ther (2010) 1.13

Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam. J Nat Prod (2010) 1.13

Macroalgal extracts induce bacterial assemblage shifts and sublethal tissue stress in Caribbean corals. PLoS One (2012) 1.10

A bacterial source for mollusk pyrone polyketides. Chem Biol (2013) 1.09

Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem (2009) 1.09

Ecological functions of tetrodotoxin in a deadly polyclad flatworm. Proc Natl Acad Sci U S A (2006) 1.07

Synthesis and activity of largazole analogues with linker and macrocycle modification. Org Lett (2008) 1.07

Total structure determination of grassypeptolide, a new marine cyanobacterial cytotoxin. Org Lett (2008) 1.06

Bacterial acquisition in juveniles of several broadcast spawning coral species. PLoS One (2010) 1.05

Largazole: from discovery to broad-spectrum therapy. Nat Prod Rep (2012) 1.03

Isolation and structure determination of lyngbyastatin 3, a lyngbyastatin 1 homologue from the marine cyanobacterium Lyngbya majuscula. Determination of the configuration of the 4-amino-2,2-dimethyl-3-oxopentanoic acid unit in majusculamide C, dolastatin 12, lyngbyastatin 1, and lyngbyastatin 3 from cyanobacteria. J Nat Prod (2003) 1.02

Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity. ACS Med Chem Lett (2011) 1.02

Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena. Mar Drugs (2009) 1.01

Evidence for multiple phototransduction pathways in a reef-building coral. PLoS One (2012) 1.00

Marine chemical ecology in benthic environments. Nat Prod Rep (2014) 0.97

Chemical deterrence of a cyanobacterial metabolite against generalized and specialized grazers. J Chem Ecol (2006) 0.97

Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa. Mol Biosyst (2011) 0.97

Inhibition of marine biofouling by bacterial quorum sensing inhibitors. Biofouling (2011) 0.95

Total synthesis and biological evaluation of grassypeptolide A. Chemistry (2013) 0.95

Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp. J Nat Prod (2008) 0.94

Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria. Appl Environ Microbiol (2013) 0.94

Palatability of macroalgae that use different types of chemical defenses. J Chem Ecol (2006) 0.94

Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452. J Nat Prod (2002) 0.94

Grassypeptolides A-C, cytotoxic bis-thiazoline containing marine cyclodepsipeptides. J Org Chem (2010) 0.93

Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides. Planta Med (2009) 0.93

The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog. Int J Cancer (2003) 0.93

Malyngolide from the cyanobacterium Lyngbya majuscula interferes with quorum sensing circuitry. Environ Microbiol Rep (2010) 0.92

Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida. J Nat Prod (2010) 0.92

Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam. J Nat Prod (2010) 0.92

The isolation and structure elucidation of Tasiamide B, a 4-amino-3-hydroxy-5-phenylpentanoic acid containing peptide from the marine Cyanobacterium Symploca sp. J Nat Prod (2003) 0.92

Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. J Med Chem (2012) 0.92

Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway. Free Radic Biol Med (2013) 0.91

Ulongamides A-F, new beta-amino acid-containing cyclodepsipeptides from Palauan collections of the marine cyanobacterium Lyngbya sp. J Nat Prod (2002) 0.91

Ulongapeptin, a cytotoxic cyclic depsipeptide from a Palauan marine cyanobacterium Lyngbya sp. J Nat Prod (2003) 0.91

Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radic Biol Med (2009) 0.90

Biological targets and mechanisms of action of natural products from marine cyanobacteria. Nat Prod Rep (2015) 0.90

Tasiamide, a cytotoxic peptide from the marine cyanobacterium Symploca sp. J Nat Prod (2002) 0.90

Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. J Med Chem (2013) 0.89

Isolation and structure determination of obyanamide, a novel cytotoxic cyclic depsipeptide from the marine cyanobacterium Lyngbya confervoides. J Nat Prod (2002) 0.88

Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa. J Nat Prod (2008) 0.88

Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides. Phytochemistry (2009) 0.88

Caldora penicillata gen. nov., comb. nov. (cyanobacteria), a pantropical marine species with biomedical relevance. J Phycol (2015) 0.88

Discovery and mechanism of natural products as modulators of histone acetylation. Curr Drug Targets (2012) 0.87

Combination therapy for renal cell cancer: what are possible options? Oncology (2011) 0.86

Chemical defenses of cryptic and aposematic Gastropterid molluscs feeding on their host sponge Dysidea granulosa. J Chem Ecol (2006) 0.85

Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam. J Nat Prod (2011) 0.85

Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam. J Nat Prod (2011) 0.85

Total synthesis of grassystatin A, a probe for cathepsin E function. Bioorg Med Chem (2012) 0.84

Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. Phytochemistry (2011) 0.84

Continuing studies on the cyanobacterium Lyngbya sp.: isolation and structure determination of 15-norlyngbyapeptin A and lyngbyabellin D. J Nat Prod (2003) 0.83

Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma? Oncol Rev (2011) 0.83