Published in J R Soc Interface on December 18, 2009
Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med (2009) 42.75
Strategies for containing an emerging influenza pandemic in Southeast Asia. Nature (2005) 30.92
Pandemic potential of a strain of influenza A (H1N1): early findings. Science (2009) 26.24
Strategies for mitigating an influenza pandemic. Nature (2006) 25.20
Containing pandemic influenza at the source. Science (2005) 23.95
Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science (2001) 18.43
Mitigation strategies for pandemic influenza in the United States. Proc Natl Acad Sci U S A (2006) 17.88
Transmissibility of 1918 pandemic influenza. Nature (2004) 16.14
Containing pandemic influenza with antiviral agents. Am J Epidemiol (2004) 12.82
Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature (2009) 11.34
Global epidemiology of influenza: past and present. Annu Rev Med (2000) 7.80
Public health interventions and epidemic intensity during the 1918 influenza pandemic. Proc Natl Acad Sci U S A (2007) 5.90
Reducing the impact of the next influenza pandemic using household-based public health interventions. PLoS Med (2006) 3.86
A preliminary estimation of the reproduction ratio for new influenza A(H1N1) from the outbreak in Mexico, March-April 2009. Euro Surveill (2009) 3.38
Economic evaluation of influenza pandemic mitigation strategies in the United States using a stochastic microsimulation transmission model. Value Health (2008) 2.31
Contact tracing and epidemics control in social networks. Phys Rev E Stat Nonlin Soft Matter Phys (2002) 1.81
Transmissibility of the influenza virus in the 1918 pandemic. PLoS One (2008) 1.56
Assessing the role of basic control measures, antivirals and vaccine in curtailing pandemic influenza: scenarios for the US, UK and the Netherlands. J R Soc Interface (2007) 1.49
The continued pandemic threat posed by avian influenza viruses in Hong Kong. Trends Microbiol (2002) 1.03
Metabolic engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation. Appl Environ Microbiol (2005) 2.13
Systems biotechnology for strain improvement. Trends Biotechnol (2005) 1.98
Metabolite essentiality elucidates robustness of Escherichia coli metabolism. Proc Natl Acad Sci U S A (2007) 1.26
Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement. Microb Cell Fact (2010) 1.23
WEbcoli: an interactive and asynchronous web application for in silico design and analysis of genome-scale E.coli model. Bioinformatics (2009) 1.17
Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture. Biotechnol Bioeng (2012) 1.17
BioSilico: an integrated metabolic database system. Bioinformatics (2004) 1.12
Software applications for flux balance analysis. Brief Bioinform (2012) 1.06
Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells. PLoS One (2011) 0.99
Genome-scale modeling and in silico analysis of mouse cell metabolic network. Mol Biosyst (2009) 0.95
Genome-scale modeling and in silico analysis of ethanologenic bacteria Zymomonas mobilis. Biotechnol Bioeng (2010) 0.95
Flux-sum analysis: a metabolite-centric approach for understanding the metabolic network. BMC Syst Biol (2009) 0.94
Exploring the effects of carbon sources on the metabolic capacity for shikimic acid production in Escherichia coli using in silico metabolic predictions. J Microbiol Biotechnol (2008) 0.92
Centralized modularity of N-linked glycosylation pathways in mammalian cells. PLoS One (2009) 0.92
Elucidating rice cell metabolism under flooding and drought stresses using flux-based modeling and analysis. Plant Physiol (2013) 0.88
Identification of cellular objective for elucidating the physiological state of plasmid-bearing Escherichia coli using genome-scale in silico analysis. Biotechnol Prog (2009) 0.87
LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells. Biotechnol Bioeng (2012) 0.87
Multiobjective flux balancing using the NISE method for metabolic network analysis. Biotechnol Prog (2009) 0.86
MetaFluxNet, a program package for metabolic pathway construction and analysis, and its use in large-scale metabolic flux analysis of Escherichia coli. Genome Inform (2003) 0.86
Incorporating metabolic flux ratios into constraint-based flux analysis by using artificial metabolites and converging ratio determinants. J Biotechnol (2007) 0.85
Integrated transcriptome and binding sites analysis implicates E2F in the regulation of self-renewal in human pluripotent stem cells. PLoS One (2011) 0.85
Computational codon optimization of synthetic gene for protein expression. BMC Syst Biol (2012) 0.85
Characterizing Escherichia coli DH5alpha growth and metabolism in a complex medium using genome-scale flux analysis. Biotechnol Bioeng (2009) 0.84
Modeling and optimization of a multi-product biosynthesis factory for multiple objectives. Metab Eng (2010) 0.84
Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II. J Biotechnol (2010) 0.83
Patterns of cis-element enrichment reveal potential regulatory modules involved in the transcriptional regulation of anoxia response of japonica rice. Gene (2012) 0.82
Identifying essential genes/reactions of the rice photorespiration by in silico model-based analysis. Rice (N Y) (2013) 0.82
Elucidation of metabolism in hybridoma cells grown in fed-batch culture by genome-scale modeling. Biotechnol Bioeng (2009) 0.81
Enhanced production of neuroprogenitors, dopaminergic neurons, and identification of target genes by overexpression of sonic hedgehog in human embryonic stem cells. Stem Cells Dev (2011) 0.79
Overexpression of microRNAs enhances recombinant protein production in Chinese hamster ovary cells. Biotechnol J (2014) 0.79
MFAML: a standard data structure for representing and exchanging metabolic flux models. Bioinformatics (2005) 0.79
Combined data preprocessing and multivariate statistical analysis characterizes fed-batch culture of mouse hybridoma cells for rational medium design. J Biotechnol (2010) 0.79
An alpha-numeric code for representing N-linked glycan structures in secreted glycoproteins. Bioprocess Biosyst Eng (2008) 0.79
Enhanced expression of codon optimized interferon gamma in CHO cells. J Biotechnol (2013) 0.79
Translatome analysis of CHO cells to identify key growth genes. J Biotechnol (2013) 0.79
NADPH-dependent pgi-gene knockout Escherichia coli metabolism producing shikimate on different carbon sources. FEMS Microbiol Lett (2011) 0.78
Mathematical modeling and sensitivity analysis of the integrated TNFα-mediated apoptotic pathway for identifying key regulators. Comput Biol Med (2011) 0.78
In silico analyses for the discovery of tuberculosis drug targets. J Antimicrob Chemother (2013) 0.78
Cofactor modification analysis: a computational framework to identify cofactor specificity engineering targets for strain improvement. J Bioinform Comput Biol (2013) 0.78
Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media. J Biotechnol (2010) 0.77
Metabolic reconstruction and flux analysis of industrial Pichia yeasts. Appl Microbiol Biotechnol (2013) 0.77
Strain improvement and process development for biobutanol production. Recent Pat Biotechnol (2009) 0.76
Integrative analysis workflow for the structural and functional classification of C-type lectins. BMC Bioinformatics (2011) 0.75