Published in J Biotechnol on December 16, 2010
CHO microRNA engineering is growing up: recent successes and future challenges. Biotechnol Adv (2013) 0.84
Modeling and Classification of Kinetic Patterns of Dynamic Metabolic Biomarkers in Physical Activity. PLoS Comput Biol (2015) 0.75
Metabolic engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation. Appl Environ Microbiol (2005) 2.13
Systems biotechnology for strain improvement. Trends Biotechnol (2005) 1.98
Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian Indians. Indian J Med Res (2005) 1.72
Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PLoS One (2008) 1.46
A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer? Biotechnol Bioeng (2009) 1.45
Mechanisms of protein stabilization and prevention of protein aggregation by glycerol. Biochemistry (2009) 1.28
Metabolite essentiality elucidates robustness of Escherichia coli metabolism. Proc Natl Acad Sci U S A (2007) 1.26
Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement. Microb Cell Fact (2010) 1.23
WEbcoli: an interactive and asynchronous web application for in silico design and analysis of genome-scale E.coli model. Bioinformatics (2009) 1.17
Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture. Biotechnol Bioeng (2012) 1.17
Silicon-based microfilters for whole blood cell separation. Biomed Microdevices (2008) 1.16
FGF-2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3-K/GSK3beta signaling. J Cell Physiol (2010) 1.14
Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. J Biol Chem (2003) 1.13
BioSilico: an integrated metabolic database system. Bioinformatics (2004) 1.12
Maximizing interferon-gamma production by Chinese hamster ovary cells through temperature shift optimization: experimental and modeling. Biotechnol Bioeng (2004) 1.09
Software applications for flux balance analysis. Brief Bioinform (2012) 1.06
Multitagging proteomic strategy to estimate protein turnover rates in dynamic systems. J Proteome Res (2010) 1.06
Reduced transcriptional activity in individuals with IL-18 gene variants detected from functional but not association study. Biochem Biophys Res Commun (2005) 1.04
Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells. PLoS One (2011) 0.99
Engineering mammalian cells in bioprocessing - current achievements and future perspectives. Biotechnol Appl Biochem (2010) 0.99
A detailed understanding of the enhanced hypothermic productivity of interferon-gamma by Chinese-hamster ovary cells. Biotechnol Appl Biochem (2005) 0.98
IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines. J Biotechnol (2011) 0.97
Genome-scale modeling and in silico analysis of mouse cell metabolic network. Mol Biosyst (2009) 0.95
Genome-scale modeling and in silico analysis of ethanologenic bacteria Zymomonas mobilis. Biotechnol Bioeng (2010) 0.95
Flux-sum analysis: a metabolite-centric approach for understanding the metabolic network. BMC Syst Biol (2009) 0.94
Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells. Biotechnol Bioeng (2008) 0.94
Exploring the effects of carbon sources on the metabolic capacity for shikimic acid production in Escherichia coli using in silico metabolic predictions. J Microbiol Biotechnol (2008) 0.92
DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines. J Biotechnol (2010) 0.92
Centralized modularity of N-linked glycosylation pathways in mammalian cells. PLoS One (2009) 0.92
Application of destabilizing sequences on selection marker for improved recombinant protein productivity in CHO-DG44. Metab Eng (2007) 0.92
High-density transient gene expression in suspension-adapted 293 EBNA1 cells. Biotechnol Bioeng (2008) 0.89
Targeting early apoptotic genes in batch and fed-batch CHO cell cultures. Biotechnol Bioeng (2006) 0.89
Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture. Rapid Commun Mass Spectrom (2009) 0.89
Zinc as an insulin replacement in hybridoma cultures. Biotechnol Bioeng (2006) 0.89
Low-glutamine fed-batch cultures of 293-HEK serum-free suspension cells for adenovirus production. Biotechnol Prog (2003) 0.88
An investigation of intracellular glycosylation activities in CHO cells: effects of nucleotide sugar precursor feeding. Biotechnol Bioeng (2010) 0.88
Elucidating rice cell metabolism under flooding and drought stresses using flux-based modeling and analysis. Plant Physiol (2013) 0.88
Evaluation of insulin-mimetic trace metals as insulin replacements in mammalian cell cultures. Cytotechnology (2004) 0.88
LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells. Biotechnol Bioeng (2012) 0.87
Identification of cellular objective for elucidating the physiological state of plasmid-bearing Escherichia coli using genome-scale in silico analysis. Biotechnol Prog (2009) 0.87
Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells. Biotechnol Prog (2010) 0.86
Meeting report: second Singapore biologics manufacturing conference. Biotechnol J (2007) 0.86
Mutated polyadenylation signals for controlling expression levels of multiple genes in mammalian cells. Biotechnol Bioeng (2009) 0.86
Overexpression of heat shock proteins (HSPs) in CHO cells for extended culture viability and improved recombinant protein production. J Biotechnol (2009) 0.86
MetaFluxNet, a program package for metabolic pathway construction and analysis, and its use in large-scale metabolic flux analysis of Escherichia coli. Genome Inform (2003) 0.86
Multiobjective flux balancing using the NISE method for metabolic network analysis. Biotechnol Prog (2009) 0.86
Incorporating metabolic flux ratios into constraint-based flux analysis by using artificial metabolites and converging ratio determinants. J Biotechnol (2007) 0.85
CD14 promoter polymorphisms have no functional significance and are not associated with atopic phenotypes. Pharmacogenet Genomics (2006) 0.85
Computational codon optimization of synthetic gene for protein expression. BMC Syst Biol (2012) 0.85
Integrated transcriptome and binding sites analysis implicates E2F in the regulation of self-renewal in human pluripotent stem cells. PLoS One (2011) 0.85
Vector fragmentation: characterizing vector integrity in transfected clones by Southern blotting. Biotechnol Prog (2010) 0.84
Characterizing Escherichia coli DH5alpha growth and metabolism in a complex medium using genome-scale flux analysis. Biotechnol Bioeng (2009) 0.84
Modeling and optimization of a multi-product biosynthesis factory for multiple objectives. Metab Eng (2010) 0.84
Active hypothermic growth: a novel means for increasing total interferon-gamma production by Chinese-hamster ovary cells. Biotechnol Appl Biochem (2005) 0.84
Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II. J Biotechnol (2010) 0.83
Overexpression of cold-inducible RNA-binding protein increases interferon-gamma production in Chinese-hamster ovary cells. Biotechnol Appl Biochem (2008) 0.83
Evaluating post-transcriptional regulatory elements for enhancing transient gene expression levels in CHO K1 and HEK293 cells. Protein Expr Purif (2010) 0.83
Global insights into the Chinese hamster and CHO cell transcriptomes. Biotechnol Bioeng (2015) 0.82
Identifying essential genes/reactions of the rice photorespiration by in silico model-based analysis. Rice (N Y) (2013) 0.82
Patterns of cis-element enrichment reveal potential regulatory modules involved in the transcriptional regulation of anoxia response of japonica rice. Gene (2012) 0.82
Elucidation of metabolism in hybridoma cells grown in fed-batch culture by genome-scale modeling. Biotechnol Bioeng (2009) 0.81
How necessary is a fast testkit for mitigation of pandemic flu? J R Soc Interface (2009) 0.80
Transcriptional profiling of apoptotic pathways in batch and fed-batch CHO cell cultures. Biotechnol Bioeng (2006) 0.80
Enhancement of transient gene expression by fed-batch culture of HEK 293 EBNA1 cells in suspension. Biotechnol Lett (2006) 0.80
Absence of the toll-like receptor 4 gene polymorphisms Asp299Gly and Thr399Ile in Singaporean Chinese. Ther Clin Risk Manag (2005) 0.79
Combined data preprocessing and multivariate statistical analysis characterizes fed-batch culture of mouse hybridoma cells for rational medium design. J Biotechnol (2010) 0.79
MFAML: a standard data structure for representing and exchanging metabolic flux models. Bioinformatics (2005) 0.79
Transcriptional profiling of batch and fed-batch protein-free 293-HEK cultures. Metab Eng (2006) 0.79
Enhanced production of neuroprogenitors, dopaminergic neurons, and identification of target genes by overexpression of sonic hedgehog in human embryonic stem cells. Stem Cells Dev (2011) 0.79
Overexpression of microRNAs enhances recombinant protein production in Chinese hamster ovary cells. Biotechnol J (2014) 0.79
Modeling amino acid metabolism in mammalian cells-toward the development of a model library. Biotechnol Prog (2007) 0.79
Enhanced expression of codon optimized interferon gamma in CHO cells. J Biotechnol (2013) 0.79
Molecular anatomy of preferential interaction coefficients by elucidating protein solvation in mixed solvents: methodology and application for lysozyme in aqueous glycerol. J Phys Chem B (2009) 0.79
Post-transcriptional regulatory elements for enhancing transient gene expression levels in mammalian cells. Methods Mol Biol (2012) 0.79
Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells. Stem Cell Res (2009) 0.79
An alpha-numeric code for representing N-linked glycan structures in secreted glycoproteins. Bioprocess Biosyst Eng (2008) 0.79
Translatome analysis of CHO cells to identify key growth genes. J Biotechnol (2013) 0.79
In silico analyses for the discovery of tuberculosis drug targets. J Antimicrob Chemother (2013) 0.78