Published in Hum Mutat on March 01, 2010
Diverse somatic mutation patterns and pathway alterations in human cancers. Nature (2010) 10.83
Recurrent R-spondin fusions in colon cancer. Nature (2012) 5.10
Assessment of computational methods for predicting the effects of missense mutations in human cancers. BMC Genomics (2013) 1.64
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. Genome Res (2012) 1.47
Scan-statistic approach identifies clusters of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders, in three datasets. Am J Hum Genet (2012) 1.23
Domain landscapes of somatic mutations in cancer. BMC Genomics (2012) 1.14
Germline fitness-based scoring of cancer mutations. Genetics (2011) 1.02
Structural and functional impact of cancer-related missense somatic mutations. J Mol Biol (2011) 0.89
Pan-Cancer Analysis of Mutation Hotspots in Protein Domains. Cell Syst (2015) 0.89
The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors. Mol Cancer (2011) 0.87
A protein domain-centric approach for the comparative analysis of human and yeast phenotypically relevant mutations. BMC Genomics (2013) 0.85
Incorporating molecular and functional context into the analysis and prioritization of human variants associated with cancer. J Am Med Inform Assoc (2012) 0.84
PI3Kγ deletion reduces variability in the in vivo osteolytic response induced by orthopaedic wear particles. J Orthop Res (2011) 0.79
Feature-based classification of amino acid substitutions outside conserved functional protein domains. ScientificWorldJournal (2013) 0.77
MutationAligner: a resource of recurrent mutation hotspots in protein domains in cancer. Nucleic Acids Res (2015) 0.77
Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung Cancer. Sci Rep (2015) 0.76
Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples. PLoS Comput Biol (2017) 0.75
HUMAN KINASES DISPLAY MUTATIONAL HOTSPOTS AT COGNATE POSITIONS WITHIN CANCER. Pac Symp Biocomput (2016) 0.75
Identification and analysis of mutational hotspots in oncogenes and tumour suppressors. Oncotarget (2017) 0.75
Empirical Bayes scan statistics for detecting clusters of disease risk variants in genetic studies. Biometrics (2015) 0.75
An improved understanding of cancer genomics through massively parallel sequencing. Transl Cancer Res (2014) 0.75
Cancerouspdomains: comprehensive analysis of cancer type-specific recurrent somatic mutations in proteins and domains. BMC Bioinformatics (2017) 0.75
The genomic landscapes of human breast and colorectal cancers. Science (2007) 38.12
Genetics of gene expression surveyed in maize, mouse and man. Nature (2003) 22.17
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell (2006) 21.66
Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol (2003) 16.63
Diverse somatic mutation patterns and pathway alterations in human cancers. Nature (2010) 10.83
The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature (2010) 10.04
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. Genome Biol (2002) 8.59
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
Recurrent R-spondin fusions in colon cancer. Nature (2012) 5.10
Heterochromatic sequences in a Drosophila whole-genome shotgun assembly. Genome Biol (2002) 5.09
Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients. Clin Cancer Res (2005) 4.94
Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell (2004) 4.91
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin Cancer Res (2009) 4.81
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet (2012) 4.70
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med (2007) 3.99
DUBA: a deubiquitinase that regulates type I interferon production. Science (2007) 3.88
A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell (2010) 3.34
Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics (2003) 3.33
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science (2004) 3.28
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol (2011) 3.23
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models. Nat Biotechnol (2010) 3.15
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis. Nat Methods (2004) 3.01
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res (2003) 2.91
CanPredict: a computational tool for predicting cancer-associated missense mutations. Nucleic Acids Res (2007) 2.86
Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A (2010) 2.77
Distinguishing cancer-associated missense mutations from common polymorphisms. Cancer Res (2007) 2.57
High-resolution genomic and expression analyses of copy number alterations in breast tumors. Genes Chromosomes Cancer (2008) 2.46
MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res (2008) 2.33
Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci U S A (2002) 2.32
A comprehensive transcript index of the human genome generated using microarrays and computational approaches. Genome Biol (2004) 2.21
The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients. Genome Res (2012) 2.19
Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer. Mol Cancer Ther (2009) 2.16
Genetic alterations and oncogenic pathways associated with breast cancer subtypes. Mol Cancer Res (2009) 2.05
Identification and functional analysis of endothelial tip cell-enriched genes. Blood (2010) 2.02
Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas. Clin Cancer Res (2012) 1.76
Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers. Cancer Res (2005) 1.69
Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching. Blood (2010) 1.68
Assessment of computational methods for predicting the effects of missense mutations in human cancers. BMC Genomics (2013) 1.64
ERK inhibition overcomes acquired resistance to MEK inhibitors. Mol Cancer Ther (2012) 1.55
Development of a DNA microarray for toxicology based on hepatotoxin-regulated sequences. EHP Toxicogenomics (2003) 1.54
Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proc Natl Acad Sci U S A (2007) 1.54
Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity. Arthritis Care Res (Hoboken) (2012) 1.53
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proc Natl Acad Sci U S A (2013) 1.53
The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression. Genome Biol (2007) 1.53
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. Genome Res (2012) 1.47
Serum pyridinoline levels and prediction of severity of joint destruction in rheumatoid arthritis. J Rheumatol (2013) 1.45
Quantitation of the distribution and flux of myosin-II during cytokinesis. BMC Cell Biol (2002) 1.44
Analytical methods for inferring functional effects of single base pair substitutions in human cancers. Hum Genet (2009) 1.39
Comment on "The consensus coding sequences of human breast and colorectal cancers". Science (2007) 1.35
High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors. BMC Med Genomics (2009) 1.33
Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis. Differentiation (2006) 1.29
Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study. Ann Rheum Dis (2012) 1.28
Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer. Cancer Res (2008) 1.26
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. J Biol Chem (2013) 1.26
In situ validation of an intestinal stem cell signature in colorectal cancer. Gut (2012) 1.26
Development of a multi-biomarker disease activity test for rheumatoid arthritis. PLoS One (2013) 1.24
Genome-wide identification of chromosomal regions of increased tumor expression by transcriptome analysis. Cancer Res (2003) 1.21
Oncogenic activating mutations are associated with local copy gain. Mol Cancer Res (2009) 1.21
Bi-directional SIFT predicts a subset of activating mutations. PLoS One (2009) 1.19
Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis. Ann Rheum Dis (2012) 1.17
Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models. J Pathol (2012) 1.15
Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice. Curr Biol (2002) 1.14
A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life. Cancer Res (2010) 1.10
Death receptors DR6 and TROY regulate brain vascular development. Dev Cell (2012) 1.10
Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice. Proc Natl Acad Sci U S A (2007) 1.10
Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspective. Genome Biol (2008) 1.08
Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach. J Biol Chem (2003) 1.08
Spatially coordinated kinase signaling regulates local axon degeneration. J Neurosci (2012) 1.07
Characterization of a multiplex, 12-biomarker test for rheumatoid arthritis. J Pharm Biomed Anal (2012) 1.03
Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies. Clin Cancer Res (2013) 1.02
A microarray platform comparison for neuroscience applications. J Neurosci Methods (2004) 1.01
GeneHub-GEPIS: digital expression profiling for normal and cancer tissues based on an integrated gene database. Nucleic Acids Res (2007) 1.00
Diverse modes of genomic alteration in hepatocellular carcinoma. Genome Biol (2014) 0.99
An evaluation of molecular and clinical remission in rheumatoid arthritis by assessing radiographic progression. Rheumatology (Oxford) (2013) 0.99
Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling. Proc Natl Acad Sci U S A (2013) 0.99
Blocking vascular endothelial growth factor-A inhibits the growth of pituitary adenomas and lowers serum prolactin level in a mouse model of multiple endocrine neoplasia type 1. Clin Cancer Res (2008) 0.97
GEPIS--quantitative gene expression profiling in normal and cancer tissues. Bioinformatics (2004) 0.96
A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress. Cancer Res (2010) 0.95
Genomic landscape of liver cancer. Nat Genet (2012) 0.93
MBASED: allele-specific expression detection in cancer tissues and cell lines. Genome Biol (2014) 0.93
A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study. Rheumatology (Oxford) (2013) 0.93
Complementary proteomic tools for the dissection of apoptotic proteolysis events. J Proteome Res (2012) 0.91
Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis. Endocrinology (2003) 0.90
Unconditional and conditional QTL mapping for the developmental behavior of tiller number in rice (Oryza sativa L.). Genetica (2010) 0.90
Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus. Proc Natl Acad Sci U S A (2003) 0.90
Detection of QTLs with additive effects and additive-by-environment interaction effects on panicle number in rice (Oryza sativa L.) with single-segment substitution lines. Theor Appl Genet (2008) 0.90
A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels. Mol Cell Neurosci (2006) 0.88
Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer. BMC Genomics (2015) 0.88
Large-scale integrative network-based analysis identifies common pathways disrupted by copy number alterations across cancers. BMC Genomics (2013) 0.87
Regulation of ERK3/MAPK6 expression by BRAF. Int J Oncol (2006) 0.86
Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia. Genomics (2007) 0.85
Identification and fine mapping of S-d, a new locus conferring the partial pollen sterility of intersubspecific F1 hybrids in rice (Oryza sativa L.). Theor Appl Genet (2008) 0.84