Published in Nature on March 20, 2003
Genetic analysis of genome-wide variation in human gene expression. Nature (2004) 27.28
Population genomics of human gene expression. Nat Genet (2007) 24.49
Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science (2007) 23.38
Genome-wide associations of gene expression variation in humans. PLoS Genet (2005) 17.27
Capturing heterogeneity in gene expression studies by surrogate variable analysis. PLoS Genet (2007) 12.08
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
High-resolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet (2008) 9.68
The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci U S A (2005) 9.66
Common genetic variants account for differences in gene expression among ethnic groups. Nat Genet (2007) 9.04
Genetic inheritance of gene expression in human cell lines. Am J Hum Genet (2004) 8.97
Mapping complex disease traits with global gene expression. Nat Rev Genet (2009) 7.44
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. Nat Genet (2008) 6.69
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
Genetic interactions between polymorphisms that affect gene expression in yeast. Nature (2005) 6.42
Molecular networks as sensors and drivers of common human diseases. Nature (2009) 6.14
Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes. Am J Hum Genet (2006) 6.10
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol (2005) 5.61
Systems genetics of complex traits in Drosophila melanogaster. Nat Genet (2009) 5.41
Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature (2011) 5.01
The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics (2012) 4.48
Gene-environment interaction in yeast gene expression. PLoS Biol (2008) 4.48
Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). Proc Natl Acad Sci U S A (2006) 4.16
Genetics of human gene expression: mapping DNA variants that influence gene expression. Nat Rev Genet (2009) 4.05
Evaluation of genetic variation contributing to differences in gene expression between populations. Am J Hum Genet (2008) 4.01
A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Principles for the post-GWAS functional characterization of cancer risk loci. Nat Genet (2011) 3.73
Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification. Proc Natl Acad Sci U S A (2006) 3.68
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Rapid evolution of male-biased gene expression in Drosophila. Proc Natl Acad Sci U S A (2003) 3.45
Mapping determinants of gene expression plasticity by genetical genomics in C. elegans. PLoS Genet (2006) 3.39
Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations. PLoS Comput Biol (2007) 3.37
Learning a prior on regulatory potential from eQTL data. PLoS Genet (2009) 3.31
Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res (2011) 3.25
Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet (2011) 3.23
Local regulatory variation in Saccharomyces cerevisiae. PLoS Genet (2005) 3.23
Regulatory polymorphisms underlying complex disease traits. J Mol Med (Berl) (2004) 3.22
Extensive sex-specific nonadditivity of gene expression in Drosophila melanogaster. Genetics (2004) 3.12
Global eQTL mapping reveals the complex genetic architecture of transcript-level variation in Arabidopsis. Genetics (2006) 3.10
Correction for hidden confounders in the genetic analysis of gene expression. Proc Natl Acad Sci U S A (2010) 3.08
Analysis of allelic differential expression in human white blood cells. Genome Res (2006) 3.07
Dosage compensation is less effective in birds than in mammals. J Biol (2007) 3.04
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait loci. Proc Natl Acad Sci U S A (2007) 2.94
What has natural variation taught us about plant development, physiology, and adaptation? Plant Cell (2009) 2.94
Regulation of gene expression in the mammalian eye and its relevance to eye disease. Proc Natl Acad Sci U S A (2006) 2.91
A network view of disease and compound screening. Nat Rev Drug Discov (2009) 2.90
What would you do if you could sequence everything? Nat Biotechnol (2008) 2.89
Heritability and tissue specificity of expression quantitative trait loci. PLoS Genet (2006) 2.80
A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells. PLoS Genet (2009) 2.78
Integrating physical and genetic maps: from genomes to interaction networks. Nat Rev Genet (2007) 2.77
Regulatory divergence in Drosophila revealed by mRNA-seq. Genome Res (2010) 2.69
Genetic analysis of variation in transcription factor binding in yeast. Nature (2010) 2.69
Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. PLoS Genet (2011) 2.68
Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Res (2005) 2.66
Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (2014) 2.63
Genetical genomics: spotlight on QTL hotspots. PLoS Genet (2008) 2.63
Integrative eQTL-based analyses reveal the biology of breast cancer risk loci. Cell (2013) 2.56
Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals. PLoS Genet (2011) 2.53
Dissecting the regulatory architecture of gene expression QTLs. Genome Biol (2012) 2.51
Bayesian method to predict individual SNP genotypes from gene expression data. Nat Genet (2012) 2.50
Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet (2008) 2.49
The many faces of pleiotropy. Trends Genet (2012) 2.48
Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. PLoS Genet (2010) 2.39
Moving toward a system genetics view of disease. Mamm Genome (2007) 2.38
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. PLoS Genet (2008) 2.32
Genetic analysis of radiation-induced changes in human gene expression. Nature (2009) 2.30
High-density haplotyping with microarray-based expression and single feature polymorphism markers in Arabidopsis. Genome Res (2006) 2.30
Cis-transcriptional variation in maize inbred lines B73 and Mo17 leads to additive expression patterns in the F1 hybrid. Genetics (2006) 2.29
Inferring causal phenotype networks from segregating populations. Genetics (2008) 2.23
Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet (2012) 2.23
A comprehensive transcript index of the human genome generated using microarrays and computational approaches. Genome Biol (2004) 2.21
Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines. Proc Natl Acad Sci U S A (2012) 2.20
Single-feature polymorphism discovery in the barley transcriptome. Genome Biol (2005) 2.15
Linking metabolic QTLs with network and cis-eQTLs controlling biosynthetic pathways. PLoS Genet (2007) 2.15
Systems biology in immunology: a computational modeling perspective. Annu Rev Immunol (2011) 2.15
A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activity. Cell Cycle (2011) 2.13
Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A (2007) 2.13
The genetics of regulatory variation in the human genome. Hum Genomics (2005) 2.05
Frequent gain and loss of functional transcription factor binding sites. PLoS Comput Biol (2007) 2.04
Genomewide association analysis in diverse inbred mice: power and population structure. Genetics (2007) 2.01
Causal inference of regulator-target pairs by gene mapping of expression phenotypes. BMC Genomics (2006) 1.97
The new mutation theory of phenotypic evolution. Proc Natl Acad Sci U S A (2007) 1.97
Population genetic variation in gene expression is associated with phenotypic variation in Saccharomyces cerevisiae. Genome Biol (2004) 1.96
Detection and replication of epistasis influencing transcription in humans. Nature (2014) 1.95
Harnessing naturally randomized transcription to infer regulatory relationships among genes. Genome Biol (2007) 1.94
Combined expression trait correlations and expression quantitative trait locus mapping. PLoS Genet (2006) 1.93
Expression quantitative trait loci are highly sensitive to cellular differentiation state. PLoS Genet (2009) 1.92
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. Hum Mol Genet (2010) 1.89
The impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells. Nat Genet (2009) 1.89
A systems biology approach identifies a R2R3 MYB gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolates. PLoS One (2007) 1.89
Genetic variation in human gene expression. Mamm Genome (2006) 1.88
DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biol (2007) 1.84
Biochemical networks and epistasis shape the Arabidopsis thaliana metabolome. Plant Cell (2008) 1.84
Gene expression profiling predicts clinical outcome of breast cancer. Nature (2002) 71.36
A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med (2002) 58.15
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol (2003) 16.63
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet (2005) 11.40
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA (2006) 7.06
Cis-acting expression quantitative trait loci in mice. Genome Res (2005) 6.66
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol (2005) 6.18
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet (2006) 5.82
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat Genet (2011) 5.68
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol (2008) 5.21
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 5.16
Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients. Clin Cancer Res (2005) 4.94
Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell (2004) 4.91
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin Cancer Res (2009) 4.81
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol (2008) 4.76
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA (2006) 4.72
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov (2010) 4.25
Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A (2002) 4.23
Integrated genomic and proteomic analyses of gene expression in Mammalian cells. Mol Cell Proteomics (2004) 4.09
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet (2012) 4.07
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med (2004) 4.06
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant (2005) 4.05
Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol (2011) 4.02
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med (2007) 3.99
Effects of atmospheric ozone on microarray data quality. Anal Chem (2003) 3.93
A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res (2010) 3.81
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med (2011) 3.78
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet (2005) 3.74
Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci U S A (2006) 3.70
Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol (2004) 3.67
Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA (2008) 3.64
Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome (2007) 3.59
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology (2008) 3.38
Microarray standard data set and figures of merit for comparing data processing methods and experiment designs. Bioinformatics (2003) 3.33
Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification. Hepatology (2014) 3.31
Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res (2008) 3.26
Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet (2011) 3.23
Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet (2006) 3.23
Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science (2002) 3.13
MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT. Cell Cycle (2009) 3.07
Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes (2008) 3.05
Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A (2006) 3.03
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab (2013) 3.01
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis. Nat Methods (2004) 3.01
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet (2009) 2.97
A network view of disease and compound screening. Nat Rev Drug Discov (2009) 2.90
The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol (2006) 2.90
Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215. Cancer Res (2008) 2.86
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet (2004) 2.86
Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies. Nat Methods (2007) 2.83
The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J Lipid Res (2004) 2.72
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res (2002) 2.69
A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients. Cancer Res (2005) 2.65
MicroRNAs and cell cycle regulation. Cell Cycle (2007) 2.62
Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels. Genomics (2005) 2.61
Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A (2002) 2.56
Using genetic markers to orient the edges in quantitative trait networks: the NEO software. BMC Syst Biol (2008) 2.51
High-resolution genomic and expression analyses of copy number alterations in breast tumors. Genes Chromosomes Cancer (2008) 2.46
Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology (2002) 2.45
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
Noise amidst the silence: off-target effects of siRNAs? Trends Genet (2004) 2.38
Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J Clin Invest (2011) 2.37
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer. Sci Transl Med (2013) 2.34
Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci U S A (2002) 2.32