24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 2826556)

Published in Brain Res on January 04, 2010

Authors

Casandra M Cartagena1, Mark P Burns, G William Rebeck

Author Affiliations

1: Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, DC 20057, USA.

Articles cited by this

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest (2002) 21.08

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell (1997) 17.78

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev (2000) 9.09

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science (2000) 6.52

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest (1997) 6.18

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A (1999) 5.08

Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. FASEB J (2002) 4.83

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem (1997) 4.81

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest (1998) 4.78

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol (2003) 4.71

Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem (2000) 4.24

Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins. J Intern Med (2008) 3.38

Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res (2004) 3.30

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A (2001) 3.29

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. J Biol Chem (1987) 3.04

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc Natl Acad Sci U S A (2007) 3.01

Multiplicity of cerebrospinal fluid functions: New challenges in health and disease. Cerebrospinal Fluid Res (2008) 2.95

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J Biol Chem (2004) 2.82

Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2. J Biol Chem (1996) 2.67

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr Opin Lipidol (1999) 2.54

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proc Natl Acad Sci U S A (2007) 2.46

27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem (2001) 2.27

SREBPs: the crossroads of physiological and pathological lipid homeostasis. Trends Endocrinol Metab (2008) 2.21

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci U S A (1999) 2.20

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J Biol Chem (2003) 2.11

Sustained sensory/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse. J Neurotrauma (1998) 1.75

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. J Biol Chem (2005) 1.74

Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein. J Biol Chem (1998) 1.73

Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. J Intern Med (2006) 1.72

Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding. J Biol Chem (2000) 1.60

Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. Biochem J (2005) 1.55

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J Biol Chem (2002) 1.48

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain. J Comp Neurol (2008) 1.47

Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem (2004) 1.46

Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised. Prog Lipid Res (2008) 1.46

Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration. J Lipid Res (2003) 1.45

Cholesterol for synthesis of myelin is made locally, not imported into brain. J Neurochem (1995) 1.35

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats. Neuroscience (1993) 1.34

Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol Endocrinol (2002) 1.31

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. J Biol Chem (2006) 1.28

Oxysterols, cholesterol homeostasis, and Alzheimer disease. J Neurochem (2007) 1.26

Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. Mol Ther (2009) 1.23

A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. J Neurochem (2004) 1.23

24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. Biochim Biophys Acta (1993) 1.21

Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet. J Nutr Health Aging (2002) 1.17

24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. J Psychiatr Res (2001) 1.16

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. J Biol Chem (2002) 1.14

Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. J Lipid Res (2007) 1.11

Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes. J Biol Chem (2005) 1.10

The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver. J Lipid Res (2005) 1.08

Interactions of oxysterols with membranes and proteins. Mol Aspects Med (2009) 1.07

Oxysterol regulators of 3-hydroxy-3-methylglutaryl-CoA reductase in liver. Effect of dietary cholesterol. J Biol Chem (1989) 1.06

Brain does not utilize low density lipoprotein-cholesterol during fetal and neonatal development in the sheep. J Lipid Res (1996) 1.06

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. Neurosci Lett (2001) 1.05

The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. J Proteome Res (2008) 1.04

Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum. J Biol Chem (2004) 1.04

Inhibitory effects of long-chain acyl coenzyme A analogues on rat liver acetyl coenzyme A carboxylase. FEBS Lett (1979) 1.03

Sterol efflux mediated by endogenous macrophage ApoE expression is independent of ABCA1. Arterioscler Thromb Vasc Biol (2001) 1.03

Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury. Neurosci Lett (2003) 1.01

Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis. J Biol Chem (2002) 0.99

Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Exp Neurol (1998) 0.98

Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins. J Biol Chem (1998) 0.97

Preferential utilization of newly synthesized cholesterol for brain growth in neonatal lambs. Am J Physiol (1998) 0.94

Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders. Neurosci Lett (2007) 0.92

Magnetic resonance lipid signals in rat brain after experimental stroke correlate with neutral lipid accumulation. Neurosci Lett (2001) 0.90

Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. J Neuropathol Exp Neurol (2006) 0.88

24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression. J Neurochem (2006) 0.87

Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells. J Lipid Res (2007) 0.86

Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling. Neuroscience (2009) 0.84

Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. Diabetes (1997) 0.83

Regional levels of free fatty acids and Evans blue extravasation after experimental brain injury. J Neurotrauma (1994) 0.83

A closer look at the cholesterol sensor. Trends Biochem Sci (2002) 0.83

24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis. J Neurosci Res (2007) 0.81

Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain. J Neurotrauma (2008) 0.80

Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase. J Appl Physiol (1985) (2004) 0.79

Severity of experimental brain injury on lactate and free fatty acid accumulation and Evans blue extravasation in the rat cortex and hippocampus. J Neurotrauma (1999) 0.78

Temporal and spatial changes of free cholesterol and neutral lipids in rat brain after transient middle cerebral artery occlusion. Neurosci Res (2003) 0.77

Cholesterol efflux as a critical component of Alzheimer's disease pathogenesis. J Mol Neurosci (2004) 0.77

Articles by these authors

Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med (2003) 3.10

ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. J Neurosci (2009) 2.31

Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann Neurol (2004) 1.95

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med (2009) 1.95

APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis. Exp Neurol (2003) 1.73

Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci (2009) 1.68

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res (2008) 1.51

Fyn kinase regulates the association between amyloid precursor protein and Dab1 by promoting their localization to detergent-resistant membranes. J Neurochem (2011) 1.43

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiol Aging (2012) 1.41

APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. J Biol Chem (2012) 1.34

DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing. J Biol Chem (2006) 1.33

F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol Cell Biol (2005) 1.30

The effects of amyloid precursor protein on postsynaptic composition and activity. J Biol Chem (2009) 1.25

Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci (2006) 1.24

The effect of injury severity on behavior: a phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in mice. J Neurotrauma (2012) 1.20

Parkin promotes intracellular Abeta1-42 clearance. Hum Mol Genet (2009) 1.18

Multiple pathways of apolipoprotein E signaling in primary neurons. J Neurochem (2005) 1.17

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. J Biol Chem (2002) 1.14

Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons. J Biol Chem (2004) 1.14

The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. J Neurochem (2006) 1.14

Regulation of ApoE receptor proteolysis by ligand binding. Brain Res Mol Brain Res (2005) 1.13

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models. Hum Mol Genet (2011) 1.12

alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons. J Biol Chem (2002) 1.11

Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem (2005) 1.11

The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis. J Neurosci (2007) 1.09

Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn Mem (2011) 1.09

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Mol Neurodegener (2014) 1.09

FE65 interaction with the ApoE receptor ApoEr2. J Biol Chem (2006) 1.08

APOE genotype alters glial activation and loss of synaptic markers in mice. Glia (2012) 1.04

Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase. Glia (2009) 1.04

The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome. Dev Neurosci (2011) 1.04

LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes. Brain Res Mol Brain Res (2002) 1.03

Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. J Biol Chem (2007) 1.03

APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals. J Neurochem (2012) 1.01

Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. J Neuropathol Exp Neurol (2005) 0.99

Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury. J Neurotrauma (2011) 0.98

ApoE receptor 2 regulates synapse and dendritic spine formation. PLoS One (2011) 0.96

APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature. J Neuropathol Exp Neurol (2013) 0.96

Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiol Aging (2011) 0.95

Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex. Learn Mem (2013) 0.95

Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. J Neurochem (2004) 0.92

Abeta species, including IsoAsp23 Abeta, in Iowa-type familial cerebral amyloid angiopathy. Acta Neuropathol (2002) 0.92

Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation. J Neuroimmunol (2009) 0.92

Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse. J Psychopharmacol (2012) 0.91

Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice. Brain Res (2011) 0.91

Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test. Eur Neuropsychopharmacol (2004) 0.89

Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons. Mol Neurodegener (2006) 0.89

The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement. FASEB J (2009) 0.88

Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model. J Neurotrauma (2013) 0.88

β-amyloid triggers ALS-associated TDP-43 pathology in AD models. Brain Res (2011) 0.88

Regulated proteolysis of APP and ApoE receptors. Mol Neurobiol (2008) 0.87

Age-related loss of noradrenergic neurons in the brains of triple transgenic mice. Age (Dordr) (2011) 0.86

Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits. Am J Pathol (2010) 0.86

FE65 as a link between VLDLR and APP to regulate their trafficking and processing. Mol Neurodegener (2012) 0.86

Effects of apoE on neuronal signaling and APP processing in rodent brain. Brain Res (2006) 0.85

Cholesterol independent effect of LXR agonist TO-901317 on gamma-secretase. J Neurochem (2007) 0.85

Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models. Mol Cell Neurosci (2011) 0.85

Controlled cortical impact results in an extensive loss of dendritic spines that is not mediated by injury-induced amyloid-beta accumulation. J Neurotrauma (2013) 0.84

Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease. Neurosci Lett (2004) 0.84

Lack of association of two lipoprotein lipase polymorphisms with Alzheimer's disease. Neurosci Lett (2002) 0.83

Regulation of central nervous system cholesterol homeostasis by the liver X receptor agonist TO-901317. Neurosci Lett (2007) 0.83

Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease. J Neuroinflammation (2010) 0.82

Inhibition of c-Jun N-terminal kinase increases apoE expression in vitro and in vivo. Biochem Biophys Res Commun (2009) 0.82

No cross-sectional influence of APOE epsilon4 dose on clinical tests in Alzheimer's disease. Neurobiol Aging (2008) 0.82

Tarenflurbil protection from cytotoxicity is associated with an upregulation of neurotrophins. J Alzheimers Dis (2008) 0.82

Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models. Exp Neurol (2012) 0.81

Intracellular cholesterol homeostasis and amyloid precursor protein processing. Biochim Biophys Acta (2010) 0.81

Levels of soluble and insoluble tau reflect overall status of tau phosphorylation in vivo. Neurosci Lett (2008) 0.81

Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain. J Neurotrauma (2008) 0.80

Vascular changes in Iowa-type hereditary cerebral amyloid angiopathy. Ann N Y Acad Sci (2002) 0.80

Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1. J Neurochem (2002) 0.79

ApoE mimetic peptide decreases Abeta production in vitro and in vivo. Mol Neurodegener (2010) 0.78

Brain on steroids resists neurodegeneration. Nat Med (2004) 0.76

Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. Neuroreport (2017) 0.75

Challenges in neurodegeneration research. Front Psychiatry (2010) 0.75