Published in Obes Facts on August 14, 2008
Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol (2011) 4.72
Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes (2010) 2.35
Adipocytes as a Link Between Gut Microbiota-Derived Flagellin and Hepatocyte Fat Accumulation. PLoS One (2016) 1.40
Natural killer T cells in adipose tissue prevent insulin resistance. J Clin Invest (2012) 1.34
A modified protocol to maximize differentiation of human preadipocytes and improve metabolic phenotypes. Obesity (Silver Spring) (2012) 1.15
Identification of hypoxia-induced genes in human SGBS adipocytes by microarray analysis. PLoS One (2011) 0.98
Neprilysin, obesity and the metabolic syndrome. Int J Obes (Lond) (2010) 0.96
Time-resolved expression profiling of the nuclear receptor superfamily in human adipogenesis. PLoS One (2010) 0.91
Reorganization of the nuclear lamina and cytoskeleton in adipogenesis. Histochem Cell Biol (2011) 0.89
TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma. Cell Death Dis (2013) 0.88
Resveratrol suppresses PAI-1 gene expression in a human in vitro model of inflamed adipose tissue. Oxid Med Cell Longev (2013) 0.84
Cell Models and Their Application for Studying Adipogenic Differentiation in Relation to Obesity: A Review. Int J Mol Sci (2016) 0.83
Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor. J Clin Immunol (2012) 0.82
Prolonged efficiency of siRNA-mediated gene silencing in primary cultures of human preadipocytes and adipocytes. Obesity (Silver Spring) (2013) 0.80
THP-1 Macrophages and SGBS Adipocytes - A New Human in vitro Model System of Inflamed Adipose Tissue. Front Endocrinol (Lausanne) (2011) 0.80
Adipose and muscle tissue profile of CD36 transcripts in obese subjects highlights the role of CD36 in fatty acid homeostasis and insulin resistance. Diabetes Care (2014) 0.79
Obesity and inflammation: reduced cytokine expression due to resveratrol in a human in vitro model of inflamed adipose tissue. Front Pharmacol (2015) 0.79
Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells. Methods Enzymol (2014) 0.79
TNF-related apoptosis-inducing ligand promotes human preadipocyte proliferation via ERK1/2 activation. FASEB J (2015) 0.78
OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype. PLoS One (2012) 0.78
Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARγ pathways. Sci Rep (2016) 0.78
BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity. Exp Mol Med (2015) 0.77
Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules. Sci Rep (2016) 0.77
The obesity-induced transcriptional regulator TRIP-Br2 mediates visceral fat endoplasmic reticulum stress-induced inflammation. Nat Commun (2016) 0.77
Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin. Sci Rep (2015) 0.77
Quercetin Impacts Expression of Metabolism- and Obesity-Associated Genes in SGBS Adipocytes. Nutrients (2016) 0.77
Fructose Alters Intermediary Metabolism of Glucose in Human Adipocytes and Diverts Glucose to Serine Oxidation in the One-Carbon Cycle Energy Producing Pathway. Metabolites (2015) 0.76
SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation. Mol Cell Biol (2016) 0.76
AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype. PLoS One (2016) 0.76
Interaction of differentiated human adipocytes with macrophages leads to trogocytosis and selective IL-6 secretion. Cell Death Dis (2015) 0.76
LipiD-QuanT: a novel method to quantify lipid accumulation in live cells. J Lipid Res (2015) 0.76
Removing the bottlenecks of cell culture metabolomics: fast normalization procedure, correlation of metabolites to cell number, and impact of the cell harvesting method. Metabolomics (2016) 0.76
Establishment of lipofection for studying miRNA function in human adipocytes. PLoS One (2014) 0.75
miR-146a-mediated suppression of the inflammatory response in human adipocytes. Sci Rep (2016) 0.75
A cellular model for the investigation of depot specific human adipocyte biology. Adipocyte (2017) 0.75
Expression analyses of the genes harbored by the type 2 diabetes and pediatric BMI associated locus on 10q23. BMC Med Genet (2012) 0.75
METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humans. Int J Obes (Lond) (2016) 0.75
HO-1 inhibits preadipocyte proliferation and differentiation at the onset of obesity via ROS dependent activation of Akt2. Sci Rep (2017) 0.75
Investigation on tissue specific effects of pro-apoptotic micro RNAs revealed miR-147b as a potential biomarker in ovarian cancer prognosis. Oncotarget (2016) 0.75
Angiotensin II signaling in human preadipose cells: participation of ERK1,2-dependent modulation of Akt. PLoS One (2013) 0.75
TRAIL (TNF-related apoptosis-inducing ligand) inhibits human adipocyte differentiation via caspase-mediated downregulation of adipogenic transcription factors. Cell Death Dis (2016) 0.75
Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes. Diabetologia (2016) 0.75
Lutein Leads to a Decrease of Factor D Secretion by Cultured Mature Human Adipocytes. J Ophthalmol (2015) 0.75
Clozapine modifies the differentiation program of human adipocytes inducing browning. Transl Psychiatry (2016) 0.75
Influence of Tyrphostin AG490 on the expression of diabetes-associated markers in human adipocytes. Immunogenetics (2012) 0.75
SFRP2 Is Associated with Increased Adiposity and VEGF Expression. PLoS One (2016) 0.75
Functional Characteristics of Multipotent Mesenchymal Stromal Cells from Pituitary Adenomas. Stem Cells Int (2016) 0.75
Cell source, differentiation, functional stimulation, and potential application of human thermogenic adipocytes in vitro. J Physiol Biochem (2017) 0.75
Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation. Nat Commun (2017) 0.75
AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome. J Clin Endocrinol Metab (2017) 0.75
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol (2008) 5.44
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab (2010) 3.11
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J (2007) 3.11
Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes (2010) 2.35
Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter. J Biol Chem (2002) 1.63
Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity. Pediatr Diabetes (2005) 1.56
Environmental factors and puberty timing: expert panel research needs. Pediatrics (2008) 1.54
The prevention and treatment of obesity. Dtsch Arztebl Int (2014) 1.44
Changes of cardiovascular risk factors in obese children effects of inpatient and outpatient interventions. J Pediatr Gastroenterol Nutr (2006) 1.41
RBP4: a controversial adipokine. Eur J Endocrinol (2011) 1.38
Protocol for effective differentiation of 3T3-L1 cells to adipocytes. Anal Biochem (2012) 1.37
Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr (2010) 1.34
Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Pediatr Allergy Immunol (2008) 1.25
Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes. FEBS Lett (2005) 1.24
Variation in the adiponutrin gene influences its expression and associates with obesity. Diabetes (2006) 1.22
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. J Clin Endocrinol Metab (2010) 1.19
Pioglitazone induces apoptosis of macrophages in human adipose tissue. J Lipid Res (2006) 1.19
Activating mutations in the calcium-sensing receptor: genetic and clinical spectrum in 25 patients with autosomal dominant hypocalcaemia - a German survey. Clin Endocrinol (Oxf) (2011) 1.18
Declining prevalence rates for overweight and obesity in German children starting school. Eur J Pediatr (2011) 1.17
Determinants of obesity in the Ulm Research on Metabolism, Exercise and Lifestyle in Children (URMEL-ICE). Eur J Pediatr (2009) 1.16
Weight loss in children and adolescents. Dtsch Arztebl Int (2014) 1.14
Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2. J Biol Chem (2005) 1.13
Sleep duration and obesity in children: is the association dependent on age and choice of the outcome parameter? Sleep (2009) 1.13
Cardiovascular risk in 26,008 European overweight children as established by a multicenter database. Obesity (Silver Spring) (2008) 1.13
Two-year follow-up in 21,784 overweight children and adolescents with lifestyle intervention. Obesity (Silver Spring) (2009) 1.13
Identification of novel human adipocyte secreted proteins by using SGBS cells. J Proteome Res (2010) 1.08
Prevalence of gallbladder stone disease in obese children and adolescents: influence of the degree of obesity, sex, and pubertal development. J Pediatr Gastroenterol Nutr (2006) 1.07
Gender-specific prevalences of fatty liver in obese children and adolescents: roles of body fat distribution, sex steroids, and insulin resistance. J Clin Endocrinol Metab (2009) 1.07
Adiponectin expression in humans is dependent on differentiation of adipocytes and down-regulated by humoral serum components of high molecular weight. Biochem Biophys Res Commun (2005) 1.06
Cardiovascular risk factors in overweight German children and adolescents: relation to gender, age and degree of overweight. Nutr Metab Cardiovasc Dis (2005) 1.05
HIV protease inhibitor-specific alterations in human adipocyte differentiation and metabolism. Obesity (Silver Spring) (2006) 1.05
Prevalence and cluster of cardiometabolic biomarkers in overweight and obese schoolchildren: results from a large survey in southwest Germany. Clin Chem (2007) 1.05
Economic evaluation of URMEL-ICE, a school-based overweight prevention programme comprising metabolism, exercise and lifestyle intervention in children. Eur J Health Econ (2011) 1.05
Identification of hypoxia-induced genes in human SGBS adipocytes by microarray analysis. PLoS One (2011) 0.98
The outcome of childhood obesity management depends highly upon patient compliance. Eur J Pediatr (2003) 0.97
Parental diabetes, pubertal stage, and extreme obesity are the main risk factors for prediabetes in children and adolescents: a simple risk score to identify children at risk for prediabetes. Pediatr Diabetes (2008) 0.96
Leptin therapy in a congenital leptin-deficient patient leads to acute and long-term changes in homeostatic, reward, and food-related brain areas. J Clin Endocrinol Metab (2011) 0.96
Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. FASEB J (2010) 0.95
Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions. FASEB J (2013) 0.94
Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like growth factor I (IGF-I)/IGF-I receptor autocrine circuit. Endocrinology (2003) 0.94
Overweight prevention implemented by primary school teachers: a randomised controlled trial. Obes Facts (2012) 0.94
Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors. Diabetes (2012) 0.94
Gestational weight gain and body mass index in children: results from three german cohort studies. PLoS One (2012) 0.93
An inflammatory micro-environment promotes human adipocyte apoptosis. Mol Cell Endocrinol (2011) 0.93
Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81). J Biol Chem (2009) 0.92
Serum uric acid levels in obese children and adolescents: linkage to testosterone levels and pre-metabolic syndrome. J Pediatr Endocrinol Metab (2003) 0.92
Time-resolved expression profiling of the nuclear receptor superfamily in human adipogenesis. PLoS One (2010) 0.91
YKL-40 secreted from adipose tissue inhibits degradation of type I collagen. Biochem Biophys Res Commun (2009) 0.90
Reorganization of the nuclear lamina and cytoskeleton in adipogenesis. Histochem Cell Biol (2011) 0.89
A putative role for endogenous FGF-2 in FGF-1 mediated differentiation of human preadipocytes. Mol Cell Endocrinol (2011) 0.89
Differential function of Akt1 and Akt2 in human adipocytes. Mol Cell Endocrinol (2012) 0.89
Allele-specific, age-dependent and BMI-associated DNA methylation of human MCHR1. PLoS One (2011) 0.89
Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes. Biochimie (2007) 0.88
Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants. BMC Med Genomics (2012) 0.87
Infant atopic eczema and subsequent attention-deficit/hyperactivity disorder--a prospective birth cohort study. Pediatr Allergy Immunol (2013) 0.87
De novo synthesis of steroids and oxysterols in adipocytes. J Biol Chem (2013) 0.87
Interleukin-1β downregulates RBP4 secretion in human adipocytes. PLoS One (2013) 0.87
TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes. Biochim Biophys Acta (2012) 0.87
HIV protease inhibitors disrupt lipid metabolism by activating endoplasmic reticulum stress and inhibiting autophagy activity in adipocytes. PLoS One (2013) 0.86
Impaired HDL function in obese adolescents: impact of lifestyle intervention and bariatric surgery. Obesity (Silver Spring) (2013) 0.86
Effects of TWEAK (TNF superfamily member 12) on differentiation, metabolism, and secretory function of human primary preadipocytes and adipocytes. Endocrinology (2009) 0.86
Medical care of obese children and adolescents. APV: a standardised multicentre documentation derived to study initial presentation and cardiovascular risk factors in patients transferred to specialised treatment institutions. Eur J Pediatr (2004) 0.85
Trans-10, cis-12 conjugated linoleic acid decreases de novo lipid synthesis in human adipocytes. J Nutr Biochem (2011) 0.85
Induction of adipocyte differentiation by a thiazolidinedione in cultured, subepidermal, fibroblast-like cells of an infant with congenital generalized lipodystrophy. J Clin Endocrinol Metab (2002) 0.85
Pioglitazone reduces inflammatory responses of human adipocytes to factors secreted by monocytes/macrophages. Am J Physiol Endocrinol Metab (2009) 0.84
Resveratrol suppresses PAI-1 gene expression in a human in vitro model of inflamed adipose tissue. Oxid Med Cell Longev (2013) 0.84
Peroxisome proliferator-activated receptors-α and -γ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue. Endocrinology (2012) 0.84
Genomic basis of aromatase excess syndrome: recombination- and replication-mediated rearrangements leading to CYP19A1 overexpression. J Clin Endocrinol Metab (2013) 0.83
Mutation analysis of the MCHR1 gene in human obesity. Eur J Endocrinol (2005) 0.83
Organized sports, overweight, and physical fitness in primary school children in Germany. J Obes (2013) 0.83
Toll-like receptor 5 in obesity: the role of gut microbiota and adipose tissue inflammation. Obesity (Silver Spring) (2015) 0.83
Childhood obesity. Curr Opin Lipidol (2011) 0.82
Relationships of IGF-I and andrrogens to skeletal maturation in obese children and adolescents. J Pediatr Endocrinol Metab (2006) 0.81
Downregulation of FLIP by cycloheximide sensitizes human fat cells to CD95-induced apoptosis. Exp Cell Res (2011) 0.81
Insulin resistance (HOMA) in relation to plasma cortisol, IGF-I and IGFBP-3. A study in normal short-statured and GH-deficient children. Horm Res (2002) 0.81
High content analysis of differentiation and cell death in human adipocytes. Cytometry A (2013) 0.81
Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. BMC Genet (2007) 0.81
THP-1 Macrophages and SGBS Adipocytes - A New Human in vitro Model System of Inflamed Adipose Tissue. Front Endocrinol (Lausanne) (2011) 0.80
The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice. PLoS One (2012) 0.80
HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes. Antivir Ther (2011) 0.79
Role of CD95-mediated adipocyte loss in autoimmune lipodystrophy. J Clin Endocrinol Metab (2005) 0.79
Levothyroxine Treatment of Euthyroid Children with Autoimmune Hashimoto Thyroiditis: Results of a Multicenter, Randomized, Controlled Trial. Horm Res Paediatr (2015) 0.78
Long-term stabilization effects of leptin on brain functions in a leptin-deficient patient. PLoS One (2013) 0.78
OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype. PLoS One (2012) 0.78
The German Working Group of Obesity in Childhood and Adolescence (AGA): improving the quality of care for overweight and obese children in Germany. Obes Facts (2008) 0.77
Methylseleninic acid is a novel suppressor of aromatase expression. J Endocrinol (2011) 0.77
Injection of acidic or neutral insulin and pain: a single-center, prospective, controlled, noninterventional study in pediatric patients with type 1 diabetes mellitus. Clin Ther (2006) 0.77
Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity. Biochem Biophys Res Commun (2009) 0.77
Plasma insulin levels in childhood are related to maternal factors--results of the Ulm Birth Cohort Study. Pediatr Diabetes (2014) 0.77
Sonographically Assessed Intra-Abdominal Fat And Cardiometabolic Risk Factors in Adolescents with Extreme Obesity. Obes Facts (2016) 0.76
Transcriptional regulation of the human growth hormone receptor (hGHR) gene V2 promoter by transcriptional activators and repressor. Mol Endocrinol (2008) 0.76
Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes. Am J Physiol Endocrinol Metab (2010) 0.76
Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact? Horm Res Paediatr (2016) 0.75
In reply. Dtsch Arztebl Int (2015) 0.75
Biologically inactive leptin and early-onset extreme obesity. N Engl J Med (2015) 0.75
Correction: Adipocytes as a Link Between Gut Microbiota-Derived Flagellin and Hepatocyte Fat Accumulation. PLoS One (2016) 0.75
A case of phace syndrome and acquired hypopituitarism? Int J Pediatr Endocrinol (2012) 0.75