The homeobox gene Hex regulates hepatocyte differentiation from embryonic stem cell-derived endoderm.

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells. Development (2011) 1.50

Stem cells in liver diseases and cancer: recent advances on the path to new therapies. Hepatology (2012) 1.21

Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Mol Ther (2010) 1.13

Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells. Diabetologia (2012) 1.04

Differentiation of human embryonic stem cells along a hepatic lineage. Chem Biol Interact (2011) 0.86

Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population. PLoS One (2011) 0.85

Generation of functional hepatic cells from pluripotent stem cells. J Stem Cell Res Ther (2012) 0.82

HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin. PLoS One (2014) 0.78

Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix-A Comparative Analysis of Bioartificial Liver Microenvironments. Stem Cells Transl Med (2016) 0.77

A time frame permissive for Protein Kinase D2 activity to direct angiogenesis in mouse embryonic stem cells. Sci Rep (2015) 0.76

Hhex Is Necessary for the Hepatic Differentiation of Mouse ES Cells and Acts via Vegf Signaling. PLoS One (2016) 0.75

Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell (2008) 10.34

Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell (2011) 6.71

Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial. JAMA (2008) 6.15

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest (2007) 4.80

Development of definitive endoderm from embryonic stem cells in culture. Development (2004) 4.61

Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature (2004) 4.20

Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood (2007) 3.71

Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell (2012) 3.66

Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation. Development (2003) 3.60

BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nat Biotechnol (2006) 3.02

Reprogramming of T cells from human peripheral blood. Cell Stem Cell (2010) 2.93

SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. Nat Biotechnol (2011) 2.84

Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82

A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell (2012) 2.81

Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol (2005) 2.80

Identification and targeting of the ROSA26 locus in human embryonic stem cells. Nat Biotechnol (2007) 2.75

Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN. Kidney Int (2005) 2.58

Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials. Lancet (2007) 2.48

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature (2011) 2.47

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol (2011) 2.22

OCT compared with IVUS in a coronary lesion assessment: the OPUS-CLASS study. JACC Cardiovasc Imaging (2013) 2.22

Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun (2010) 2.20

Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nat Methods (2013) 2.14

Human ES- and iPS-derived myogenic progenitors restore DYSTROPHIN and improve contractility upon transplantation in dystrophic mice. Cell Stem Cell (2012) 2.06

Prognostic value of B-type natriuretic peptide and its amino-terminal proBNP fragment for cardiovascular events with stratification by renal function. J Cardiol (2013) 2.02

T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.99

NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. EMBO J (2003) 1.87

Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation. Proc Natl Acad Sci U S A (2005) 1.85

Thin-cap fibroatheroma and microchannel findings in optical coherence tomography correlate with subsequent progression of coronary atheromatous plaques. Eur Heart J (2011) 1.77

Reconstruction of functional tissues with cell sheet engineering. Biomaterials (2007) 1.75

Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells. Stem Cells (2010) 1.75

Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro. Blood (2002) 1.72

Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia. Am Heart J (2008) 1.70

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nat Cell Biol (2011) 1.70

Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on temozolomide-resistant glioma cells. J Neurosurg (2007) 1.63

In vivo gene delivery by embryonic-stem-cell-derived astrocytes for malignant gliomas. Neuro Oncol (2008) 1.62

[Subarachnoid hemorrhage complicated with different manifestations of transient abnormal left ventricular wall motion: two case reports]. J Cardiol (2006) 1.55

Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol (2008) 1.54

Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice. Hypertension (2005) 1.53

Clinical significance of papillary muscle late enhancement detected via cardiac magnetic resonance imaging in patients with single old myocardial infarction. Int J Cardiol (2010) 1.53

Prediction of bone mineral density from vitamin D receptor polymorphisms is uncertain in representative samples of Japanese Women. The Japanese Population-based Osteoporosis (JPOS) Study. Int J Epidemiol (2004) 1.52

Determinants of hepatitis C translational initiation in vitro, in cultured cells and mice. Mol Ther (2002) 1.51

Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy. Am J Kidney Dis (2009) 1.51

Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo. J Am Soc Nephrol (2007) 1.50

Reduction of circulating soluble fms-like tyrosine kinase-1 plays a significant role in renal dysfunction-associated aggravation of atherosclerosis. Circulation (2009) 1.49

Successful in vivo propagation of factor IX-producing hepatocytes in mice: potential for cell-based therapy in haemophilia B. Thromb Haemost (2008) 1.49

Hypoxia-inducible factor signaling in the development of tissue fibrosis. Cell Cycle (2008) 1.49

Intensive lipid-lowering therapy with rosuvastatin stabilizes lipid-rich coronary plaques. -Evaluation using dual-source computed tomography.-. Circ J (2011) 1.48

Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells. Cardiovasc Res (2012) 1.47

Long-term follow-up of neointimal coverage of sirolimus-eluting stents--evaluation with optical coherence tomography. Circ J (2009) 1.47

Plasma renin activity is a strong and independent prognostic indicator in patients with acute decompensated heart failure treated with renin-angiotensin system inhibitors. Circ J (2015) 1.46

Left Ventricular Ejection Fraction (EF) of 55% as Cutoff for Late Transition From Heart Failure (HF) With Preserved EF to HF With Mildly Reduced EF. Circ J (2015) 1.46

Engineering bioartificial tracheal tissue using hybrid fibroblast-mesenchymal stem cell cultures in collagen hydrogels. Interact Cardiovasc Thorac Surg (2010) 1.46

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. J Gen Physiol (2013) 1.44

A case of autoimmune hepatitis exacerbated by the administration of etanercept in the patient with rheumatoid arthritis. Clin Rheumatol (2008) 1.43

A new drug delivery system for intravenous coronary thrombolysis with thrombus targeting and stealth activity recoverable by ultrasound. J Am Coll Cardiol (2012) 1.43

Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice. Proc Natl Acad Sci U S A (2002) 1.41

Hypoxia affects mesoderm and enhances hemangioblast specification during early development. Development (2004) 1.41

Heart Rate Control With If Inhibitor, Ivabradine, in Japanese Patients With Chronic Heart Failure　- A Randomized, Double-Blind, Placebo-Controlled Phase II Study. Circ J (2016) 1.40

Aspirin reduces cerebrovascular events in type 2 diabetic patients with poorly controlled blood pressure. Subanalysis from the JPAD trial. Circ J (2012) 1.40

Rationale and Design of the Double-Blind, Randomized, Placebo-Controlled Multicenter Trial on Efficacy of Early Initiation of Eplerenone Treatment in Patients with Acute Heart Failure (EARLIER). Cardiovasc Drugs Ther (2015) 1.39

Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Blood (2005) 1.39

Major non-cardiac surgery is a risk factor for rapid hemodynamic progression of non-rheumatic aortic stenosis. Circ J (2015) 1.39

Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes. Circ Arrhythm Electrophysiol (2013) 1.38

SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development. Blood (2005) 1.37

Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell (2009) 1.36

Directed differentiation of mouse embryonic stem cells into thyroid follicular cells. Endocrinology (2006) 1.35

Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PLoS One (2011) 1.34

Elevated levels of fractalkine expression and accumulation of CD16+ monocytes in glomeruli of active lupus nephritis. Am J Kidney Dis (2007) 1.34

In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. J Clin Invest (2003) 1.33

Cell sheet transplantation of cultured mesenchymal stem cells enhances bone formation in a rat nonunion model. Bone (2009) 1.32

Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant (2012) 1.31

The expression of Sox17 identifies and regulates haemogenic endothelium. Nat Cell Biol (2013) 1.28

A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis. EMBO Mol Med (2011) 1.28

Periadventitial adipose tissue plays a critical role in vascular remodeling. Circ Res (2009) 1.26

A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells. Mol Cell Neurosci (2013) 1.25

Retinoic acid signaling is essential for embryonic hematopoietic stem cell development. Cell (2013) 1.25

Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes. Circ Res (2005) 1.24

Committing embryonic stem cells to early endocrine pancreas in vitro. Stem Cells (2004) 1.23

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes. Development (2013) 1.23

The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation. Blood (2005) 1.21

Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes. Clin Exp Nephrol (2013) 1.20

Reference gene selection for real-time RT-PCR in regenerating mouse livers. Biochem Biophys Res Commun (2008) 1.20

Notch signaling respecifies the hemangioblast to a cardiac fate. Nat Biotechnol (2008) 1.19

Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion. Kidney Int (2012) 1.19

Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue. Arterioscler Thromb Vasc Biol (2010) 1.18

Osteocalcin secretion as an early marker of in vitro osteogenic differentiation of rat mesenchymal stem cells. Tissue Eng Part C Methods (2009) 1.17

Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers. J Am Coll Cardiol (2008) 1.16

Serial in vivo positive contrast MRI of iron oxide-labeled embryonic stem cell-derived cardiac precursor cells in a mouse model of myocardial infarction. Magn Reson Med (2008) 1.14

A prenylation inhibitor prevents production of infectious hepatitis delta virus particles. J Virol (2002) 1.13

Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart. Circulation (2002) 1.12

Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus. Biomaterials (2009) 1.12

Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and cardiac matrix metalloproteinase-9 expression after acute myocardial infarction. Circulation (2004) 1.12