PubRank

Alexander Y Rudensky

Author PubWeight™ 349.16‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003 38.57
2 Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005 23.00
3 Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2006 14.33
4 TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 2008 14.26
5 A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005 11.48
6 Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008 9.82
7 Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012 9.75
8 Foxp3-dependent programme of regulatory T-cell differentiation. Nature 2007 9.48
9 Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 2007 7.04
10 Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 2004 6.89
11 Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010 6.87
12 TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med 2005 6.87
13 Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 2007 6.80
14 A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005 6.77
15 Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 2009 6.65
16 In vivo analysis of dendritic cell development and homeostasis. Science 2009 6.42
17 An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol 2006 6.16
18 CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 2009 6.14
19 Foxp3 in control of the regulatory T cell lineage. Nat Immunol 2007 5.94
20 Th17 and regulatory T cells in mediating and restraining inflammation. Cell 2010 5.89
21 Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity 2003 5.52
22 Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A 2006 5.50
23 Coordination of early protective immunity to viral infection by regulatory T cells. Science 2008 5.33
24 Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol 2007 5.14
25 Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity 2009 5.10
26 Stability of the regulatory T cell lineage in vivo. Science 2010 4.89
27 Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 2010 4.57
28 Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature 2012 4.33
29 Developmental regulation of Foxp3 expression during ontogeny. J Exp Med 2005 4.32
30 Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 2006 4.06
31 Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med 2008 3.70
32 The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med 2008 3.45
33 Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity 2011 3.40
34 Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 2011 3.38
35 Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat Immunol 2009 3.38
36 Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell 2012 3.24
37 Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis. J Exp Med 2007 3.21
38 Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med 2007 3.17
39 TGFbeta signalling in control of T-cell-mediated self-reactivity. Nat Rev Immunol 2007 3.02
40 Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med 2012 2.97
41 Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell 2012 2.79
42 Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature 2012 2.77
43 Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. J Exp Med 2010 2.54
44 Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Mol Cell 2012 2.54
45 IPS-1 is essential for the control of West Nile virus infection and immunity. PLoS Pathog 2010 2.39
46 Lysosomal cysteine proteases regulate antigen presentation. Nat Rev Immunol 2003 2.25
47 Differentiation of regulatory Foxp3+ T cells in the thymic cortex. Proc Natl Acad Sci U S A 2008 2.24
48 Tregs control the development of symptomatic West Nile virus infection in humans and mice. J Clin Invest 2009 2.18
49 The plasticity and stability of regulatory T cells. Nat Rev Immunol 2013 2.15
50 Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol 2012 2.10
51 Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol 2009 2.02
52 Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med 2007 1.96
53 Thymic development and peripheral homeostasis of regulatory T cells. Curr Opin Immunol 2007 1.88
54 Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer. Clin Cancer Res 2007 1.84
55 The lysosomal cysteine proteases in MHC class II antigen presentation. Immunol Rev 2005 1.78
56 Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity 2011 1.72
57 IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J Exp Med 2013 1.68
58 Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation. Blood 2003 1.57
59 Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. J Immunol 2009 1.55
60 IL-2-dependent adaptive control of NK cell homeostasis. J Exp Med 2013 1.50
61 An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity 2012 1.50
62 Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. J Exp Med 2013 1.47
63 Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. J Immunol 2007 1.47
64 Control of inflammation by integration of environmental cues by regulatory T cells. J Clin Invest 2013 1.43
65 A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation. J Immunol 2002 1.35
66 Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM). Blood 2004 1.34
67 A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. J Exp Med 2010 1.32
68 Thymocyte expression of cathepsin L is essential for NKT cell development. Nat Immunol 2002 1.27
69 Lack of Foxp3 function and expression in the thymic epithelium. J Exp Med 2007 1.22
70 Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation. J Immunol 2005 1.22
71 Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo. J Immunol 2005 1.15
72 The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells. Nat Commun 2011 1.15
73 Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif. J Mol Biol 2003 1.14
74 Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proc Natl Acad Sci U S A 2013 1.12
75 The effects of commensal microbiota on immune cell subsets and inflammatory responses. Immunol Rev 2012 1.11
76 Molecular aspects of regulatory T cell development. Semin Immunol 2004 1.09
77 The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning. J Immunol 2002 1.04
78 Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse. J Autoimmun 2009 0.94
79 Treg cells in cancer: a case of multiple personality disorder. Sci Transl Med 2012 0.93
80 Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M. J Immunol 2004 0.86
81 Microbial metabolites control gut inflammatory responses. Proc Natl Acad Sci U S A 2014 0.85
82 G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Mol Cell Biol 2007 0.85
83 Antigen-specific dose-dependent system for the study of an inheritable and reversible phenotype in mouse CD4+ T cells. Immunology 2002 0.83
84 Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proc Natl Acad Sci U S A 2002 0.81
85 Dual TCR T cells: gaining entry into the periphery. Nat Immunol 2002 0.79
86 Editorial overview: lymphocyte development. Curr Opin Immunol 2009 0.78
87 Pillars Article: Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells. Nat. Immunol. 2003. 4: 330-336. J Immunol 2017 0.76
88 Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature 2017 0.75