Published in Immunity on August 01, 2004
How regulatory T cells work. Nat Rev Immunol (2008) 11.66
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol (2010) 9.72
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol (2005) 7.44
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol (2008) 6.56
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med (2008) 6.07
The PD-1 pathway in tolerance and autoimmunity. Immunol Rev (2010) 5.99
A role for Dicer in immune regulation. J Exp Med (2006) 5.81
Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 5.80
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med (2007) 5.52
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A (2006) 5.50
Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol (2009) 4.90
Stability of the regulatory T cell lineage in vivo. Science (2010) 4.89
The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity (2008) 4.68
Control of regulatory T cell lineage commitment and maintenance. Immunity (2009) 4.63
A two-step process for thymic regulatory T cell development. Immunity (2008) 4.29
Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe (2008) 4.14
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 4.07
Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity (2007) 3.98
A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity (2011) 3.76
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity (2008) 3.56
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med (2008) 3.45
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med (2012) 3.40
Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat Immunol (2009) 3.38
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J Exp Med (2006) 3.22
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med (2007) 3.17
Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity (2008) 2.97
Plasticity of CD4(+) FoxP3(+) T cells. Curr Opin Immunol (2009) 2.93
CD4+ Tregs and immune control. J Clin Invest (2004) 2.85
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature (2013) 2.75
Antigen-specific peripheral shaping of the natural regulatory T cell population. J Exp Med (2008) 2.68
Selection of regulatory T cells in the thymus. Nat Rev Immunol (2012) 2.51
Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis. J Exp Med (2010) 2.35
Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity (2014) 2.33
High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood (2006) 2.21
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J Exp Med (2010) 2.20
TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes. J Exp Med (2009) 2.18
TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J Exp Med (2007) 2.15
Continuous requirement for the TCR in regulatory T cell function. Nat Immunol (2014) 2.11
A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self. Immunity (2012) 2.10
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol (2009) 2.07
How do regulatory T cells work? Scand J Immunol (2009) 2.02
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2009) 2.02
A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol (2009) 2.01
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells. Immunol Rev (2009) 2.00
Selection of self-reactive T cells in the thymus. Annu Rev Immunol (2011) 1.98
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity (2013) 1.96
Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci U S A (2005) 1.90
Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. J Immunol (2010) 1.88
The initial phase of an immune response functions to activate regulatory T cells. J Immunol (2009) 1.88
Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node. J Exp Med (2005) 1.88
Identification of errors introduced during high throughput sequencing of the T cell receptor repertoire. BMC Genomics (2011) 1.87
CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J Exp Med (2013) 1.83
Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition. J Exp Med (2006) 1.80
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. J Exp Med (2005) 1.79
CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2. J Immunother (2005) 1.78
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms. Nat Immunol (2009) 1.70
A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. J Exp Med (2013) 1.69
The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66
LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med (2005) 1.65
IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood (2006) 1.64
Natural regulatory T cells and persistent viral infection. J Virol (2007) 1.62
A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. Nature (2015) 1.62
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity (2012) 1.61
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target. Immunology (2008) 1.59
Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells. Proc Natl Acad Sci U S A (2011) 1.54
Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection. PLoS Pathog (2010) 1.53
T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol (2008) 1.52
Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proc Natl Acad Sci U S A (2006) 1.47
Role of Foxp3-positive regulatory T cells during infection. Eur J Immunol (2008) 1.46
NF-κB: roles and regulation in different CD4(+) T-cell subsets. Immunol Rev (2013) 1.45
Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice. PLoS One (2009) 1.44
Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood. J Exp Med (2009) 1.41
Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation. Immunol Rev (2014) 1.38
Control of central and peripheral tolerance by Aire. Immunol Rev (2011) 1.37
In vivo sites and cellular mechanisms of T reg cell-mediated suppression. J Exp Med (2006) 1.37
CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg. Eur J Immunol (2009) 1.36
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol (2009) 1.35
Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity. J Exp Med (2006) 1.34
TSLP in epithelial cell and dendritic cell cross talk. Adv Immunol (2009) 1.33
Differential requirement for CARMA1 in agonist-selected T-cell development. Eur J Immunol (2009) 1.29
CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity. Proc Natl Acad Sci U S A (2005) 1.27
Once a Treg, always a Treg? Immunol Rev (2014) 1.27
Regulatory T cells: stability revisited. Trends Immunol (2011) 1.27
Regulatory T cells as therapeutic targets in rheumatoid arthritis. Nat Rev Rheumatol (2009) 1.26
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB. J Exp Med (2013) 1.26
Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity (2013) 1.24
MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity. Front Immunol (2013) 1.22
The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis. Front Immunol (2013) 1.22
Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Res (2010) 1.21
Autoimmunity: increasing suspects in the CD4+ T cell lineup. Nat Immunol (2009) 1.21
Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers. Immunology (2012) 1.20
Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. Immunity (2008) 1.20
Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol (2006) 1.19
MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism. Immunity (2015) 1.17
Trauma equals danger--damage control by the immune system. J Leukoc Biol (2012) 1.15
A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms. J Immunol (2007) 1.15
Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling. J Immunol (2011) 1.14
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. J Clin Invest (2014) 1.13
Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection. J Immunol (2007) 1.13
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57
Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity (2005) 23.00
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol (2006) 14.33
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26
A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol (2005) 11.48
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82
Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol (2012) 9.75
Foxp3-dependent programme of regulatory T-cell differentiation. Nature (2007) 9.48
HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet (2008) 8.37
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature (2007) 7.04
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature (2010) 6.87
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med (2005) 6.87
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol (2007) 6.80
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol (2005) 6.77
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature (2009) 6.65
In vivo analysis of dendritic cell development and homeostasis. Science (2009) 6.42
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol (2006) 6.16
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (2009) 6.14
Foxp3 in control of the regulatory T cell lineage. Nat Immunol (2007) 5.94
Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature (2006) 5.90
Th17 and regulatory T cells in mediating and restraining inflammation. Cell (2010) 5.89
Randomized trial of breast self-examination in Shanghai: final results. J Natl Cancer Inst (2002) 5.57
Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity (2003) 5.52
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A (2006) 5.50
Coordination of early protective immunity to viral infection by regulatory T cells. Science (2008) 5.33
Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial. J Infect Dis (2005) 5.14
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol (2007) 5.14
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity (2009) 5.10
Stability of the regulatory T cell lineage in vivo. Science (2010) 4.89
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell (2010) 4.57
Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature (2012) 4.33
Developmental regulation of Foxp3 expression during ontogeny. J Exp Med (2005) 4.32
Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat Med (2008) 4.24
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity (2006) 4.06
A framework for assessing immunological correlates of protection in vaccine trials. J Infect Dis (2007) 3.95
Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med (2008) 3.70
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med (2008) 3.45
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity (2011) 3.40
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity (2011) 3.38
Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat Immunol (2009) 3.38
Neonatal innate TLR-mediated responses are distinct from those of adults. J Immunol (2009) 3.29
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell (2012) 3.24
Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis. J Exp Med (2007) 3.21
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med (2007) 3.17
Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa. PLoS One (2008) 3.05
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med (2004) 3.03
TGFbeta signalling in control of T-cell-mediated self-reactivity. Nat Rev Immunol (2007) 3.02
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells. Nat Immunol (2004) 2.96
Peptide selection for human immunodeficiency virus type 1 CTL-based vaccine evaluation. Vaccine (2006) 2.89
Cellular and humoral immunity against vaccinia virus infection of mice. J Immunol (2004) 2.84
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell (2012) 2.79
Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature (2012) 2.77
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A (2011) 2.64
NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly. J Virol (2008) 2.62
Denoising array-based comparative genomic hybridization data using wavelets. Biostatistics (2005) 2.56
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. J Exp Med (2010) 2.54
Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Mol Cell (2012) 2.54
Evaluating a surrogate endpoint at three levels, with application to vaccine development. Stat Med (2008) 2.50
IPS-1 is essential for the control of West Nile virus infection and immunity. PLoS Pathog (2010) 2.39
Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor. Proc Natl Acad Sci U S A (2007) 2.38
Lysosomal cysteine proteases regulate antigen presentation. Nat Rev Immunol (2003) 2.25
Differentiation of regulatory Foxp3+ T cells in the thymic cortex. Proc Natl Acad Sci U S A (2008) 2.24
Tregs control the development of symptomatic West Nile virus infection in humans and mice. J Clin Invest (2009) 2.18
The plasticity and stability of regulatory T cells. Nat Rev Immunol (2013) 2.15
Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol (2012) 2.10
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2009) 2.02
Estimation of the initial viral growth rate and basic reproductive number during acute HIV-1 infection. J Virol (2010) 2.02
Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med (2007) 1.96
WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity. J Exp Med (2011) 1.91
On the analysis of viral load endpoints in HIV vaccine trials. Stat Med (2003) 1.89
Thymic development and peripheral homeostasis of regulatory T cells. Curr Opin Immunol (2007) 1.88
Toll-like receptor 3 mediates establishment of an antiviral state against hepatitis C virus in hepatoma cells. J Virol (2009) 1.85
Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer. Clin Cancer Res (2007) 1.84
The lysosomal cysteine proteases in MHC class II antigen presentation. Immunol Rev (2005) 1.78
Statistical positivity criteria for the analysis of ELISpot assay data in HIV-1 vaccine trials. J Immunol Methods (2006) 1.76
Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity (2011) 1.72
IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J Exp Med (2013) 1.68
Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells. PLoS One (2010) 1.66
Power to detect the effects of HIV vaccination in repeated low-dose challenge experiments. J Infect Dis (2009) 1.58
Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation. Blood (2003) 1.57
Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. J Immunol (2009) 1.55
Development of an automated analysis system for data from flow cytometric intracellular cytokine staining assays from clinical vaccine trials. Cytometry A (2008) 1.54
IL-2-dependent adaptive control of NK cell homeostasis. J Exp Med (2013) 1.50
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity (2012) 1.50
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. J Exp Med (2013) 1.47
Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. J Immunol (2007) 1.47
Control of inflammation by integration of environmental cues by regulatory T cells. J Clin Invest (2013) 1.43
What constitutes efficacy for a human immunodeficiency virus vaccine that ameliorates viremia: issues involving surrogate end points in phase 3 trials. J Infect Dis (2003) 1.38
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells. Nat Immunol (2013) 1.38
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest (2013) 1.37
Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner. Cell Rep (2013) 1.37
Statistical considerations for the design and analysis of the ELISpot assay in HIV-1 vaccine trials. J Immunol Methods (2004) 1.37