Published in Cell Stem Cell on January 08, 2010
Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood (2011) 3.43
Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell (2011) 3.32
A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells. Cell Stem Cell (2010) 2.65
In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells (2011) 2.52
Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy. Proc Natl Acad Sci U S A (2011) 2.41
Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells. Cell Stem Cell (2012) 1.79
An effective approach to prevent immune rejection of human ESC-derived allografts. Cell Stem Cell (2014) 1.73
Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun (2013) 1.73
Present state and future perspectives of using pluripotent stem cells in toxicology research. Arch Toxicol (2011) 1.69
p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol (2012) 1.63
Phosphorylation stabilizes Nanog by promoting its interaction with Pin1. Proc Natl Acad Sci U S A (2010) 1.57
A cut above the rest: targeted genome editing technologies in human pluripotent stem cells. J Biol Chem (2013) 1.47
Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol (2010) 1.41
Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants. PLoS One (2010) 1.39
Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation. PLoS Pathog (2012) 1.29
Quality control: Genome maintenance in pluripotent stem cells. J Cell Biol (2014) 1.27
Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice. Cell Res (2012) 1.18
Hematopoietic stem cell engineering at a crossroads. Blood (2011) 1.10
ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells. Aging (Albany NY) (2010) 1.09
Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors. Mol Ther (2011) 1.06
Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template. Protein Cell (2014) 1.04
ZFX controls the self-renewal of human embryonic stem cells. PLoS One (2012) 1.03
Safety paradigm: genetic evaluation of therapeutic grade human embryonic stem cells. J R Soc Interface (2010) 1.02
Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells. Nucleic Acids Res (2013) 1.02
Embryonic heart progenitors and cardiogenesis. Cold Spring Harb Perspect Med (2013) 1.01
Error-prone nonhomologous end joining repair operates in human pluripotent stem cells during late G2. Aging (Albany NY) (2011) 0.98
Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9. Cell Stem Cell (2015) 0.98
A scalable approach to prevent teratoma formation of human embryonic stem cells. J Biol Chem (2012) 0.97
Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation. Stem Cells (2014) 0.97
Find and replace: editing human genome in pluripotent stem cells. Protein Cell (2011) 0.93
Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability. Sci Rep (2014) 0.93
Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype. Stem Cells Transl Med (2012) 0.92
Repair at single targeted DNA double-strand breaks in pluripotent and differentiated human cells. PLoS One (2011) 0.91
The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle (2012) 0.90
Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells. Mol Ther (2012) 0.90
Concise review: Human cell engineering: cellular reprogramming and genome editing. Stem Cells (2012) 0.90
Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair. Nucleic Acids Res (2016) 0.89
Genomic editing tools to model human diseases with isogenic pluripotent stem cells. Stem Cells Dev (2014) 0.89
Context-dependent enhancement of induced pluripotent stem cell reprogramming by silencing Puma. Stem Cells (2012) 0.89
New frontier in regenerative medicine: site-specific gene correction in patient-specific induced pluripotent stem cells. Hum Gene Ther (2013) 0.89
Embryonic stem cells shed new light on the developmental roles of p53. Cell Biosci (2013) 0.88
Targeted isolation of cloned genomic regions by recombineering for haplotype phasing and isogenic targeting. Nucleic Acids Res (2011) 0.86
p53 Induces skin aging by depleting Blimp1+ sebaceous gland cells. Cell Death Dis (2014) 0.86
Genetic approach to track neural cell fate decisions using human embryonic stem cells. Protein Cell (2014) 0.86
Challenges to the clinical application of pluripotent stem cells: towards genomic and functional stability. Genome Med (2012) 0.86
Bacterial artificial chromosome mutagenesis using recombineering. J Biomed Biotechnol (2010) 0.83
Functional Restoration of gp91phox-Oxidase Activity by BAC Transgenesis and Gene Targeting in X-linked Chronic Granulomatous Disease iPSCs. Mol Ther (2015) 0.82
Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies. Sci Rep (2014) 0.81
Analysis of SOX2-expressing cell populations derived from human pluripotent stem cells. Stem Cell Reports (2013) 0.81
Derivation of genetically modified human pluripotent stem cells with integrated transgenes at unique mapped genomic sites. Nat Protoc (2011) 0.81
Global identification of target recognition and cleavage by the Microprocessor in human ES cells. Nucleic Acids Res (2014) 0.81
The genomic stability of induced pluripotent stem cells. Protein Cell (2012) 0.80
Non-integrative lentivirus drives high-frequency cre-mediated cassette exchange in human cells. PLoS One (2011) 0.80
Global identification of transcriptional regulators of pluripotency and differentiation in embryonic stem cells. Nucleic Acids Res (2012) 0.80
Human induced pluripotent stem cells for monogenic disease modelling and therapy. World J Stem Cells (2016) 0.80
Functional analysis of the acetylation of human p53 in DNA damage responses. Protein Cell (2014) 0.79
Distinct allelic patterns of nanog expression impart embryonic stem cell population heterogeneity. PLoS Comput Biol (2013) 0.79
Targeting of the human coagulation factor IX gene at rDNA locus of human embryonic stem cells. PLoS One (2012) 0.79
Methods of cell purification: a critical juncture for laboratory research and translational science. Cells Tissues Organs (2011) 0.78
Precise BAC targeting of genetically polymorphic mouse ES cells. Nucleic Acids Res (2011) 0.78
Comparative Analysis of piggyBac, CRISPR/Cas9 and TALEN Mediated BAC Transgenesis in the Zygote for the Generation of Humanized SIRPA Rats. Sci Rep (2016) 0.77
Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells. Sci Rep (2016) 0.77
Progress and bottleneck in induced pluripotency. Cell Regen (Lond) (2012) 0.76
Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC. Exp Mol Med (2016) 0.76
May I Cut in? Gene Editing Approaches in Human Induced Pluripotent Stem Cells. Cells (2017) 0.75
Integrating Gene Correction in the Reprogramming and Transdifferentiation Processes: A One-Step Strategy to Overcome Stem Cell-Based Gene Therapy Limitations. Stem Cells Int (2016) 0.75
Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness. Int J Mol Sci (2016) 0.75
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
Immunogenicity of induced pluripotent stem cells. Nature (2011) 7.31
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol (2004) 5.82
Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol (2007) 5.28
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study. Lancet Oncol (2012) 4.21
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol (2007) 3.86
Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res (2009) 3.39
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature (2002) 2.60
Molecular symmetry in mitochondrial cardiolipins. Chem Phys Lipids (2005) 2.23
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature (2016) 2.21
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J (2006) 2.12
The Effect of Erythropoietin-Stimulating Agents on Health-Related Quality of Life in Anemia of Chronic Kidney Disease: A Systematic Review and Meta-analysis. Ann Intern Med (2016) 2.09
Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. ACS Nano (2010) 2.05
Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses. J Biol Chem (2003) 2.02
Incidence of second malignancies among patients treated with proton versus photon radiation. Int J Radiat Oncol Biol Phys (2013) 1.89
Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res (2008) 1.85
Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection. Hepatology (2013) 1.84
Proteomic fingerprints for potential application to early diagnosis of severe acute respiratory syndrome. Clin Chem (2004) 1.76
Retracted Carbon nanotubes are able to penetrate plant seed coat and dramatically affect seed germination and plant growth. ACS Nano (2009) 1.73
Coexistence of hepatitis B surface antigen (HBsAg) and heterologous subtype-specific antibodies to HBsAg among patients with chronic hepatitis B virus infection. Clin Infect Dis (2007) 1.69
Mutation of mouse p53 Ser23 and the response to DNA damage. Mol Cell Biol (2002) 1.65
A DNA nanostructure platform for directed assembly of synthetic vaccines. Nano Lett (2012) 1.64
Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J (2002) 1.64
Phosphorylation site interdependence of human p53 post-translational modifications in response to stress. J Biol Chem (2003) 1.63
Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation. Nat Immunol (2002) 1.63
Cardiolipin affects the supramolecular organization of ATP synthase in mitochondria. Biophys J (2011) 1.57
Phosphorylation stabilizes Nanog by promoting its interaction with Pin1. Proc Natl Acad Sci U S A (2010) 1.57
Pharmacokinetics of ertapenem in patients with varying degrees of renal insufficiency and in patients on hemodialysis. J Clin Pharmacol (2006) 1.56
Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma. Hepatology (2009) 1.56
Liver-intestine cadherin predicts microvascular invasion and poor prognosis of hepatitis B virus-positive hepatocellular carcinoma. Cancer (2009) 1.54
p53 and stem cells: new developments and new concerns. Trends Cell Biol (2010) 1.53
Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome. Proc Natl Acad Sci U S A (2009) 1.51
Proteomic characteristics of human sperm cryopreservation. Proteomics (2014) 1.51
Variegation mutants and mechanisms of chloroplast biogenesis. Plant Cell Environ (2007) 1.50
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol (2006) 1.45
The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein. J Immunol (2010) 1.44
Atomic structure, energetics, and dynamics of topological solitons in indium chains on Si(111) surfaces. Phys Rev Lett (2011) 1.42
Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol (2010) 1.41
A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.41
Up-regulation of Krüppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma. Gastroenterology (2010) 1.37
Anti-tumor activities of matrine and oxymatrine: literature review. Tumour Biol (2014) 1.33
CD151 modulates expression of matrix metalloproteinase 9 and promotes neoangiogenesis and progression of hepatocellular carcinoma. Hepatology (2010) 1.32
Comparison of lymphoblast mitochondria from normal subjects and patients with Barth syndrome using electron microscopic tomography. Lab Invest (2006) 1.32
Characterization of domain-peptide interaction interface: a generic structure-based model to decipher the binding specificity of SH3 domains. Mol Cell Proteomics (2008) 1.31
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol (2005) 1.31
FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma. Clin Cancer Res (2005) 1.29
Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance. J Cancer Res Clin Oncol (2011) 1.29
Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species. Biochim Biophys Acta (2009) 1.28
Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials. J Cancer Res Clin Oncol (2008) 1.28
Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangement. J Exp Med (2004) 1.27
Generation of transgenic maize with enhanced provitamin A content. J Exp Bot (2008) 1.26
Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells. Nat Immunol (2008) 1.24
Negative regulation of MAVS-mediated innate immune response by PSMA7. J Immunol (2009) 1.24
CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery. Clin Cancer Res (2009) 1.22
DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53. EMBO J (2002) 1.21
Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential. Clin Cancer Res (2005) 1.19
Comorbidity of posttraumatic stress disorder with alcohol dependence among US adults: results from National Epidemiological Survey on Alcohol and Related Conditions. Drug Alcohol Depend (2013) 1.19
p53, oxidative stress, and aging. Antioxid Redox Signal (2011) 1.18
CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro. Mol Cancer Res (2008) 1.18
Stable aqueous ZnO@polymer core-shell nanoparticles with tunable photoluminescence and their application in cell imaging. J Am Chem Soc (2008) 1.16
Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo. Cancer Res (2005) 1.16
Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas. J Hepatol (2009) 1.16
The physical state of lipid substrates provides transacylation specificity for tafazzin. Nat Chem Biol (2012) 1.15
Yes-associated protein regulates the hepatic response after bile duct ligation. Hepatology (2012) 1.15
Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence. Hepatology (2008) 1.15
Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence. Cell Cycle (2006) 1.15
The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma. J Natl Cancer Inst (2011) 1.14
Experimental demonstration of a free-space cylindrical cloak without superluminal propagation. Phys Rev Lett (2012) 1.14
Modeling, prediction, and in vitro in vivo correlation of CYP3A4 induction. Drug Metab Dispos (2008) 1.14
HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates. J Clin Invest (2012) 1.14
Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection. Clin Cancer Res (2008) 1.13
The amino Acid residues at positions 120 to 123 are crucial for the antigenicity of hepatitis B surface antigen. J Clin Microbiol (2007) 1.12
Liver transplantation outcomes in 1,078 hepatocellular carcinoma patients: a multi-center experience in Shanghai, China. J Cancer Res Clin Oncol (2009) 1.12
P48 is a predictive marker for outcome of postoperative interferon-alpha treatment in patients with hepatitis B virus infection-related hepatocellular carcinoma. Cancer (2006) 1.11
Decoding and cortical source localization for intended movement direction with MEG. J Neurophysiol (2010) 1.10
Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit. J Med Chem (2008) 1.08
Hepatitis B virus polymerase impairs interferon-α-induced STA T activation through inhibition of importin-α5 and protein kinase C-δ. Hepatology (2013) 1.08
Osteopontin combined with CD44, a novel prognostic biomarker for patients with hepatocellular carcinoma undergoing curative resection. Oncologist (2008) 1.08
Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines. Mol Cancer Ther (2011) 1.08
Radical nanomedicine. Nanomedicine (Lond) (2006) 1.06
Blockade of platelet-derived growth factor receptor-beta pathway induces apoptosis of vascular endothelial cells and disrupts glomerular capillary formation in neonatal mice. Am J Pathol (2002) 1.05
Selection of reference genes for real-time PCR in human hepatocellular carcinoma tissues. J Cancer Res Clin Oncol (2008) 1.05
R/BHC: fast Bayesian hierarchical clustering for microarray data. BMC Bioinformatics (2009) 1.04
Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template. Protein Cell (2014) 1.04
Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cells. ACS Nano (2011) 1.03
Hepatitis B virus polymerase inhibits the interferon-inducible MyD88 promoter by blocking nuclear translocation of Stat1. J Gen Virol (2007) 1.03
Gain of function of p53 cancer mutants in disrupting critical DNA damage response pathways. Cell Cycle (2007) 1.03
In vivo Raman flow cytometry for real-time detection of carbon nanotube kinetics in lymph, blood, and tissues. J Biomed Opt (2009) 1.02
Flexible surface acoustic wave resonators built on disposable plastic film for electronics and lab-on-a-chip applications. Sci Rep (2013) 1.02
Molecular epidemiological and virological study of dengue virus infections in Guangzhou, China, during 2001-2010. Virol J (2013) 1.01
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun (2013) 1.01
DNA immunization with fusion of CTLA-4 to hepatitis B virus (HBV) core protein enhanced Th2 type responses and cleared HBV with an accelerated kinetic. PLoS One (2011) 1.01
Genome integrity: linking pluripotency and tumorgenicity. Trends Genet (2009) 1.01
Effect of sanguinarine from the leaves of Macleaya cordata against Ichthyophthirius multifiliis in grass carp (Ctenopharyngodon idella). Parasitol Res (2010) 1.01
Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci. J Exp Med (2006) 1.01
Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutation. J Immunol (2006) 1.00
Coxsackievirus B3 infection induces cyr61 activation via JNK to mediate cell death. J Virol (2004) 1.00
The design and synthesis of 9-phenylcyclohepta[d]pyrimidine-2,4-dione derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase. Org Biomol Chem (2006) 1.00