Published in BMC Med Genet on January 15, 2010
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med (2014) 2.28
Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study. Respir Res (2011) 1.15
Updates on the COPD gene list. Int J Chron Obstruct Pulmon Dis (2012) 1.08
Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease. J Hum Genet (2010) 0.96
The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study. BMC Med Genet (2011) 0.93
Fibrotic response of tissue remodeling in COPD. Lung (2011) 0.92
Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii. Food Chem (2012) 0.85
Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes. BMC Pulm Med (2013) 0.84
Interleukin-13 -1112 C/T promoter polymorphism confers risk for COPD: a meta-analysis. PLoS One (2013) 0.83
Gene polymorphisms and chronic obstructive pulmonary disease. J Cell Mol Med (2013) 0.81
Genetic polymorphism of matrix metalloproteinase family and chronic obstructive pulmonary disease susceptibility: a meta-analysis. Sci Rep (2013) 0.81
Matrix metalloproteinase-9 -1562C/T promoter polymorphism confers risk for COPD: a meta-analysis. PLoS One (2013) 0.80
Genetic determinants of chronic obstructive pulmonary disease in South Indian male smokers. PLoS One (2014) 0.78
Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax (2016) 0.78
Implantation of fibrin gel on mouse lung to study lung-specific angiogenesis. J Vis Exp (2014) 0.76
Phenolic-rich extract from the Costa Rican guava (Psidium friedrichsthalianum) pulp with antioxidant and anti-inflammatory activity. Potential for COPD therapy. Food Chem (2013) 0.75
Targeted high-throughput sequencing of candidate genes for chronic obstructive pulmonary disease. BMC Pulm Med (2016) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
[''R"--project for statistical computing]. Ugeskr Laeger (2008) 41.69
Global burden of COPD: risk factors, prevalence, and future trends. Lancet (2007) 9.50
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science (1997) 8.19
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res (2006) 5.60
Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest (2000) 2.92
Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell (1992) 2.75
Posterior error probabilities and false discovery rates: two sides of the same coin. J Proteome Res (2007) 2.61
Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD. Chest (2004) 2.08
A powerful strategy to account for multiple testing in the context of haplotype analysis. Am J Hum Genet (2004) 2.07
The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum Mol Genet (2002) 1.99
Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.98
Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema. Am J Respir Crit Care Med (2001) 1.96
Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax (2005) 1.76
COPD: the dangerous underestimate of 15%. Lancet (2006) 1.60
Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD. Eur Respir J (2008) 1.59
Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. Hum Mutat (2006) 1.53
Matrix metalloproteinase-9 promoter polymorphism associated with upper lung dominant emphysema. Am J Respir Crit Care Med (2005) 1.52
Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease. Inflamm Res (2005) 1.50
Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD. Eur Respir J (2007) 1.45
ABC of chronic obstructive pulmonary disease. Definition, epidemiology, and risk factors. BMJ (2006) 1.37
Genetic association analysis with FAMHAP: a major program update. Bioinformatics (2008) 1.26
Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD. Respir Res (2007) 1.16
Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema. Biochem Biophys Res Commun (2001) 1.08
The SERPINE2 gene and chronic obstructive pulmonary disease. Am J Hum Genet (2006) 0.99
The genetics of chronic obstructive pulmonary disease. Respir Res (2006) 0.95
Genotypes in matrix metalloproteinase 9 are a risk factor for COPD. Int J Chron Obstruct Pulmon Dis (2006) 0.91
Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China. Chin Med J (Engl) (2004) 0.91
Matrix metalloproteinase gene polymorphisms: lack of association with chronic obstructive pulmonary disease in a Brazilian population. Genet Mol Res (2009) 0.86
[Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China]. Zhonghua Liu Xing Bing Xue Za Zhi (2005) 0.85
Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency. Ther Adv Respir Dis (2009) 0.78
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
TREM2 variants in Alzheimer's disease. N Engl J Med (2012) 11.35
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med (2005) 7.20
Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69
Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17
Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation (2005) 4.71
Living and dying with severe chronic obstructive pulmonary disease: multi-perspective longitudinal qualitative study. BMJ (2011) 3.61
Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44
Detailed identification of plasma proteins adsorbed on copolymer nanoparticles. Angew Chem Int Ed Engl (2007) 3.41
Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center AeSOP study. Arch Gen Psychiatry (2006) 3.35
An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest (2003) 3.19
Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Part Fibre Toxicol (2005) 3.12
Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes. Thorax (2010) 3.06
Adverse cardiovascular effects of air pollution. Nat Clin Pract Cardiovasc Med (2008) 3.00
Usefulness of ultrasound lung comets as a nonradiologic sign of extravascular lung water. Am J Cardiol (2004) 2.94
Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC AESOP Study. Psychol Med (2006) 2.79
In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. J Immunol (2002) 2.76
A 2-year randomised placebo-controlled trial of doxycycline for lymphangioleiomyomatosis. Eur Respir J (2013) 2.72
Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis. N Engl J Med (2008) 2.70
Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Am J Respir Crit Care Med (2009) 2.70
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One (2010) 2.57
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52
4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2002) 2.38
Expression of adhesion molecules during apoptosis of circulating neutrophils in COPD. Chest (2004) 2.33
The COPD control panel: towards personalised medicine in COPD. Thorax (2012) 2.32
The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area. Occup Environ Med (2007) 2.29
Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radic Biol Med (2003) 2.28
Population-based study of ABCD2 score, carotid stenosis, and atrial fibrillation for early stroke prediction after transient ischemic attack: the North Dublin TIA study. Stroke (2010) 2.27
Gonadotropin-releasing hormone receptors. Endocr Rev (2004) 2.22
The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. J Immunol (2003) 2.15
Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction. Circulation (2007) 2.14
Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2004) 2.10
A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD (2012) 2.07
Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci (2009) 2.07
Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial. Clin Cancer Res (2011) 2.06
The pulmonary toxicology of ultrafine particles. J Aerosol Med (2002) 2.02
Replication of CLU, CR1, and PICALM associations with alzheimer disease. Arch Neurol (2010) 2.02
Effect of 6 months of erythromycin treatment on inflammatory cells in induced sputum and exacerbations in chronic obstructive pulmonary disease. Respiration (2010) 2.00
The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.99
Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.99
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
What sleep characteristics predict cognitive decline in the elderly? Sleep Med (2012) 1.96
Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophr Bull (2009) 1.94
Piloting tele-monitoring in COPD: a mixed methods exploration of issues in design and implementation. Prim Care Respir J (2012) 1.92
Telemedicine experience for chronic care in COPD. IEEE Trans Inf Technol Biomed (2006) 1.89
Insomnia and health-related quality of life. Sleep Med Rev (2009) 1.79
Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.79
High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis. J Invest Dermatol (2005) 1.78
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. Mol Cell Biochem (2002) 1.77
Validity of six activity monitors in chronic obstructive pulmonary disease: a comparison with indirect calorimetry. PLoS One (2012) 1.77
Macrophage migration inhibitory factor: a probable link between inflammation and cancer. Immunity (2007) 1.73
Association between acute statin therapy, survival, and improved functional outcome after ischemic stroke: the North Dublin Population Stroke Study. Stroke (2011) 1.73
A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med (2013) 1.73
An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.73
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.72
Identification of five chronic obstructive pulmonary disease subgroups with different prognoses in the ECLIPSE cohort using cluster analysis. Ann Am Thorac Soc (2015) 1.72
Self-harm in first-episode psychosis. Br J Psychiatry (2008) 1.72
Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells. Am J Respir Cell Mol Biol (2004) 1.71
Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD. Eur Respir J (2012) 1.71
Validity of activity monitors in health and chronic disease: a systematic review. Int J Behav Nutr Phys Act (2012) 1.70
Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med (2009) 1.70
Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. Eur Heart J (2013) 1.69
Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 1.68
Prevalence of diarrhoea in the community in Australia, Canada, Ireland, and the United States. Int J Epidemiol (2005) 1.67
Effects of nebulized N(G)-nitro-L-arginine methyl ester in patients with hepatopulmonary syndrome. Hepatology (2006) 1.66
Parental separation, loss and psychosis in different ethnic groups: a case-control study. Psychol Med (2007) 1.64
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD. Thorax (2007) 1.62
A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency. Hepatology (2010) 1.62
Matrix metalloproteinase-2 protein in lung periphery is related to COPD progression. Chest (2007) 1.62
Socioeconomic deprivation increases the effect of winter on admissions to hospital with COPD: retrospective analysis of 10 years of national hospitalisation data. Prim Care Respir J (2013) 1.60
Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing. Environ Health Perspect (2010) 1.57
Sildenafil to improve respiratory rehabilitation outcomes in COPD: a controlled trial. Eur Respir J (2013) 1.57
Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure? Am J Respir Crit Care Med (2003) 1.56
Cystic fibrosis-associated liver disease: a population-based study. J Pediatr (2004) 1.55
Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Arthritis Rheum (2011) 1.54
Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. Hum Mutat (2006) 1.53
Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study. Br J Psychiatry (2006) 1.53
Role of activin-A in cigarette smoke-induced inflammation and COPD. Eur Respir J (2013) 1.52
[Daily living activity in chronic obstructive pulmonary disease: validation of the Spanish version and comparative analysis of 2 questionnaires]. Med Clin (Barc) (2007) 1.48
Soluble transition metals cause the pro-inflammatory effects of welding fumes in vitro. Toxicol Appl Pharmacol (2004) 1.47
Training depletes muscle glutathione in patients with chronic obstructive pulmonary disease and low body mass index. Respiration (2006) 1.47
Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1. Biochem Biophys Res Commun (2006) 1.47