Gene polymorphisms and chronic obstructive pulmonary disease.

Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in Muğla province. Kardiochir Torakochirurgia Pol (2014) 0.75

SUV39H1 Reduction Is Implicated in Abnormal Inflammation in COPD. Sci Rep (2017) 0.75

Autophagy and inflammation. Clin Transl Med (2017) 0.75

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2007) 47.86

The natural history of chronic airflow obstruction. Br Med J (1977) 13.04

International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet (2007) 10.12

Innate immunity. N Engl J Med (2000) 7.03

Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A (1997) 6.99

Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet (2004) 6.17

Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med (1996) 5.53

Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene. Thorax (2009) 4.86

Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med (1998) 3.83

Developing COPD: a 25 year follow up study of the general population. Thorax (2006) 3.72

Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema. Lancet (1997) 3.42

Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product. Hum Mol Genet (1992) 3.12

Quantitative relationships between cigarette smoking and ventilatory function. Am Rev Respir Dis (1977) 2.77

Role for interleukin-6 in COPD-related pulmonary hypertension. Chest (2009) 2.73

Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum Mol Genet (1994) 2.44

Mannose-binding lectin and its genetic variants. Genes Immun (2006) 2.35

Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy. J Clin Invest (1990) 2.35

COPD in China: the burden and importance of proper management. Chest (2011) 2.22

The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19

Clinical bioinformatics: a new emerging science. J Clin Bioinforma (2011) 2.09

Associations of IL6 polymorphisms with lung function decline and COPD. Thorax (2009) 2.00

Polymorphisms of IL4, IL13, and ADRB2 genes in COPD. Chest (2004) 1.79

Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers. Thorax (2001) 1.72

Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens (2006) 1.66

Familial prevalence of chronic obstructive pulmonary disease in a matched pair study. Am J Med (1977) 1.63

Effects of captopril administration on pulmonary haemodynamics and tissue oxygenation during exercise in ACE gene subtypes in patients with COPD: a preliminary study. Thorax (2003) 1.61

Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. COPD (2010) 1.60

Tumor necrosis factor gene complex in COPD and disseminated bronchiectasis. Chest (2000) 1.57

Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet (2009) 1.52

Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis. Thorax (2004) 1.48

Role of clinical bioinformatics in the development of network-based Biomarkers. J Clin Bioinforma (2011) 1.38

The genetics of chronic obstructive pulmonary disease. Respir Res (2001) 1.33

Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers. Respir Res (2009) 1.25

Genetic polymorphism of epoxide hydrolase and glutathione S-transferase in COPD. Eur Respir J (2004) 1.23

Clinical and translational medicine: Integrative and practical science. Clin Transl Med (2012) 1.23

Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study. Eur Respir J (2009) 1.16

A new vision of definition, commentary, and understanding in clinical and translational medicine. Clin Transl Med (2012) 1.15

Deletion polymorphisms in the angiotensin converting enzyme gene are associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2000) 1.13

Association of tumor necrosis factor-alpha gene promoter polymorphism with low attenuation areas on high-resolution CT in patients with COPD. Chest (2002) 1.11

Differential susceptibility to tobacco smoke: possible mechanisms. Pharmacogenetics (1991) 1.11

Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation. Respir Res (2010) 1.10

Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population. BMC Med Genet (2010) 1.08

Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma. Eur J Hum Genet (2002) 1.07

A decade plus of translation: what do we understand? Clin Transl Med (2012) 1.04

A polymorphism in the tumor necrosis factor-alpha gene promoter region may predispose to a poor prognosis in COPD. Chest (2000) 1.04

The protease inhibitor PI*S allele and COPD: a meta-analysis. Eur Respir J (2005) 1.04

Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections. Genes Immun (2003) 1.02

Leptin receptor polymorphisms and lung function decline in COPD. Eur Respir J (2009) 1.00

Association of the ASP299GLY TLR4 polymorphism with COPD. Respir Med (2005) 0.99

Neither IL-1beta, IL-1 receptor antagonist, nor TNF-alpha polymorphisms are associated with susceptibility to COPD. Respir Med (2000) 0.99

Decorin and TGF-beta1 polymorphisms and development of COPD in a general population. Respir Res (2006) 0.98

Association of the TNF-alpha-308 (G-->A) polymorphism with self-reported history of childhood asthma. Hum Genet (2000) 0.98

COPD is associated with a macrophage scavenger receptor-1 gene sequence variation. Chest (2010) 0.97

Association of IL-6 gene polymorphisms and COPD in a Spanish population. Respir Med (2008) 0.96

Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD. Respirology (2008) 0.95

Gene polymorphisms of endothelial nitric oxide synthase enzyme associated with pulmonary hypertension in patients with COPD. Respir Med (2003) 0.94

The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese. Intern Med (2008) 0.94

Genetic risk factors for chronic obstructive pulmonary disease. Curr Opin Pulm Med (2002) 0.94

Lack of association between glutathione S-transferase P1 polymorphism and COPD in Koreans. Lung (2002) 0.93

Beta2-adrenergic receptor polymorphisms are associated with asthma and COPD in adults. J Hum Genet (2006) 0.93

Can lung cancer stem cells be targeted for therapies? Cancer Treat Rev (2012) 0.92

Polymorphism of the beta(2)-adrenoceptor in COPD in Chinese subjects. Chest (2001) 0.91

The DD genotype of the angiotensin converting enzyme gene is negatively associated with right ventricular hypertrophy in male patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1999) 0.90

Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients. Eur Respir J (2008) 0.88

Beta2-adrenergic receptor genetic polymorphisms and short-term bronchodilator responses in patients with COPD. Chest (2007) 0.88

Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. BMC Med Genet (2009) 0.88

Bioinformatics insights into acute lung injury/acute respiratory distress syndrome. Clin Transl Med (2012) 0.87

Association between polymorphisms of microsomal epoxide hydrolase and COPD: results from meta-analyses. Respirology (2008) 0.87

Polymorphisms in the type IV collagen alpha3 gene and the risk of COPD. Eur Respir J (2008) 0.86

Mannose-binding lectin gene polymorphism contributes to recurrence of infective exacerbation in patients with COPD. Chest (2010) 0.86

A report of cytokine polymorphisms and COPD risk in Xuan Wei, China. Int J Hyg Environ Health (2007) 0.86

Association between the XRCC3 T241M polymorphism and risk of cancer: evidence from 157 case-control studies. Gene (2013) 0.84

Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD. Eur Respir J (2007) 0.84

Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Eur Respir J (2007) 0.84

Surfactant protein B polymorphisms, pulmonary function and COPD in 10,231 individuals. Eur Respir J (2010) 0.83

Significance of bioinformatics in research of chronic obstructive pulmonary disease. J Clin Bioinforma (2011) 0.82

Endothelial nitric oxide synthase gene variants contribute to oxidative stress in COPD. Biochem Biophys Res Commun (2007) 0.82

Alpha-1 antitrypsin gene polymorphism in Chronic Obstructive Pulmonary Disease (COPD). Genet Mol Biol (2010) 0.82

The CFTR M470V gene variant as a potential modifier of COPD severity: study of Serbian population. Genet Test (2008) 0.82

Metabonomics-based omics study and atherosclerosis. J Clin Bioinforma (2011) 0.82

Glutathione S-transferase M1 gene polymorphism is related to COPD in patients with non-small-cell lung cancer. Wien Klin Wochenschr (2004) 0.81

TNF-308 gene polymorphism is associated with COPD risk among Asians: meta-analysis of data for 6,118 subjects. Mol Biol Rep (2010) 0.81

Association analysis of tissue inhibitor of metalloproteinase2 gene polymorphisms with COPD in Egyptians. Respir Med (2005) 0.81

Association of Hck genetic polymorphisms with gene expression and COPD. Hum Genet (2006) 0.81

Lack of association between the TGF-β(1) gene and development of COPD in Asians: a case-control study and meta-analysis. Lung (2011) 0.79

EPHX1 polymorphisms, COPD and asthma in 47,000 individuals and in meta-analysis. Eur Respir J (2010) 0.79

Association of ADAM33 gene with susceptibility to COPD in Tibetan population of China. Mol Biol Rep (2010) 0.78

Polymorphisms of glutathione S-transferase genes and functional activity in smokers with or without COPD. Int J Tuberc Lung Dis (2007) 0.78

Association of genetic polymorphism of GSTT1, GSTM1 and GSTM3 in COPD patients in a north Indian population. COPD (2011) 0.78

Genetic polymorphism of GSTT1 and GSTM1 and susceptibility to chronic obstructive pulmonary disease (COPD). J Crit Care (2009) 0.77

A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD. Biochem Biophys Res Commun (2009) 0.77

Decline in FEV1 related to genetic polymorphisms (+138insA/delA and Lys198Asn) of the endothelin-1 gene in COPD. A pilot study. Eur Rev Med Pharmacol Sci (2010) 0.76

Polymorphism of glutathione S-transferase M1 and T1 gene loci in COPD. Int J Immunogenet (2010) 0.76

Association of ET-1 gene polymorphisms with COPD phenotypes in a Caucasian population. Monaldi Arch Chest Dis (2011) 0.75

Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial. Lancet Oncol (2013) 2.94

Deletion of peroxiredoxin 6 potentiates lipopolysaccharide-induced acute lung injury in mice. Crit Care Med (2011) 2.89

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85

System for assisted mobility using eye movements based on electrooculography. IEEE Trans Neural Syst Rehabil Eng (2002) 2.37

Lung cancer in China: challenges and interventions. Chest (2013) 2.31

Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology (2011) 1.85

Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. Am J Physiol Gastrointest Liver Physiol (2004) 1.73

Genetic comparison of mouse lung telocytes with mesenchymal stem cells and fibroblasts. J Cell Mol Med (2013) 1.61

Noninvasive bioluminescence imaging in small animals. ILAR J (2008) 1.59

Chinese water-pipe smoking and the risk of COPD. Chest (2014) 1.51

Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet (2012) 1.49

Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology (2008) 1.47

The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. Cancer Res (2012) 1.45

Selection of disease-specific biomarkers by integrating inflammatory mediators with clinical informatics in AECOPD patients: a preliminary study. J Cell Mol Med (2012) 1.42

Telocyte morphologies and potential roles in diseases. J Cell Physiol (2012) 1.41

Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates. Am J Physiol Gastrointest Liver Physiol (2006) 1.40

The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine. Expert Rev Respir Med (2010) 1.40

Early diagnosis of complex diseases by molecular biomarkers, network biomarkers, and dynamical network biomarkers. Med Res Rev (2013) 1.34

Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats. J Clin Invest (2012) 1.28

Effect of recA inactivation on mutagenesis of Escherichia coli exposed to sublethal concentrations of antimicrobials. J Antimicrob Chemother (2011) 1.27

Media guidelines for the responsible reporting of suicide: a review of effectiveness. Crisis (2012) 1.27

An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways. Sci Rep (2013) 1.26

Potential mechanism of interleukin-8 production from lung cancer cells: an involvement of EGF-EGFR-PI3K-Akt-Erk pathway. J Cell Physiol (2012) 1.25

A detailed epidemiological and clinical description of 6 human cases of avian-origin influenza A (H7N9) virus infection in Shanghai. PLoS One (2013) 1.25

Clinical and translational medicine: Integrative and practical science. Clin Transl Med (2012) 1.23

Comparative proteomic analysis of human lung telocytes with fibroblasts. J Cell Mol Med (2014) 1.22

Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome. Hepatology (2003) 1.21

A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy of paclitaxel-carboplatin alone or with endostar for advanced non-small cell lung cancer. J Thorac Oncol (2011) 1.19

Primary salivary gland-type lung cancer: clinicopathological analysis of 88 cases from China. J Thorac Oncol (2013) 1.18

Complete low-cost implementation of a teleoperated control system for a humanoid robot. Sensors (Basel) (2013) 1.16

Telocytes in the urinary system. J Transl Med (2012) 1.16

Potential significance of telocytes in the pathogenesis of lung diseases. Expert Rev Respir Med (2012) 1.16

Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury. Gastroenterology (2009) 1.16

Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology (2003) 1.16

Telocytes in human oesophagus. J Cell Mol Med (2013) 1.14

Opportunities and challenges of disease biomarkers: a new section in the Journal of Translational Medicine. J Transl Med (2012) 1.13

Primary care physician perceptions on the diagnosis and management of chronic obstructive pulmonary disease in diverse regions of the world. Int J Chron Obstruct Pulmon Dis (2012) 1.13

Overexpression of thymic stromal lymphopoietin in allergic rhinitis. Acta Otolaryngol (2009) 1.13

Gonadal agenesis 46,XX associated with the atypical form of Rokitansky syndrome. Fertil Steril (2002) 1.12

Alterations of plasma inflammatory biomarkers in the healthy and chronic obstructive pulmonary disease patients with or without acute exacerbation. J Proteomics (2012) 1.12

Telocytes in the human kidney cortex. J Cell Mol Med (2012) 1.12

Expression of aquaporin 5 increases proliferation and metastasis potential of lung cancer. J Pathol (2010) 1.11

Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol (2008) 1.11

Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes. J Cell Mol Med (2014) 1.10

Immune status and inflammatory response differ locally and systemically in severe acute pancreatitis. Scand J Gastroenterol (2006) 1.09

Cancer bioinformatics: a new approach to systems clinical medicine. BMC Bioinformatics (2012) 1.08

FoxM1 is associated with poor prognosis of non-small cell lung cancer patients through promoting tumor metastasis. PLoS One (2013) 1.06

Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity. Lipids Health Dis (2012) 1.06

Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling. Mol Endocrinol (2003) 1.05

Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide. Intensive Care Med (2003) 1.05

Family outbreak of severe pneumonia induced by H7N9 infection. Am J Respir Crit Care Med (2013) 1.04

Variations of chromosomes 2 and 3 gene expression profiles among pulmonary telocytes, pneumocytes, airway cells, mesenchymal stem cells and lymphocytes. J Cell Mol Med (2014) 1.01

Five critical elements to ensure the precision medicine. Cancer Metastasis Rev (2015) 1.00

Determinants of growth hormone receptor down-regulation. Mol Endocrinol (2007) 1.00

Proteomics-based biomarkers in chronic obstructive pulmonary disease. J Proteome Res (2010) 0.99

Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity. Am J Physiol Gastrointest Liver Physiol (2010) 0.99

Deletion of IGF-I receptor (IGF-IR) in primary osteoblasts reduces GH-induced STAT5 signaling. Mol Endocrinol (2010) 0.99

Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant. Biochem Pharmacol (2005) 0.99

Roflumilast for the treatment of COPD in an Asian population: a randomized, double-blind, parallel-group study. Chest (2014) 0.99

Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages. Atherosclerosis (2013) 0.98

Janus kinase 2 enhances the stability of the mature growth hormone receptor. Endocrinology (2005) 0.98

The role of aquaporin-1 (AQP1) expression in a murine model of lipopolysaccharide-induced acute lung injury. Respir Physiol Neurobiol (2004) 0.98

Role of the growth hormone (GH) receptor transmembrane domain in receptor predimerization and GH-induced activation. Mol Endocrinol (2007) 0.98

Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. J Hepatol (2005) 0.98

Anti-asthmatic agents alleviate pulmonary edema by upregulating AQP1 and AQP5 expression in the lungs of mice with OVA-induced asthma. Respir Physiol Neurobiol (2011) 0.97

Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury. Intensive Care Med (2003) 0.97

Important steps to improve translation from medical research to health policy. J Transl Med (2013) 0.96

Protein profiling of human lung telocytes and microvascular endothelial cells using iTRAQ quantitative proteomics. J Cell Mol Med (2014) 0.96

Effects of budesonide and N-acetylcysteine on acute lung hyperinflation, inflammation and injury in rats. Vascul Pharmacol (2005) 0.96

Role of airway epithelial cells in development of asthma and allergic rhinitis. Respir Med (2008) 0.96

Human adrenocortical cell xenotransplantation: model of cotransplantation of human adrenocortical cells and 3T3 cells in scid mice to form vascularized functional tissue and prevent adrenal insufficiency. Xenotransplantation (2002) 0.95

Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage. J Biol Chem (2005) 0.95

Pulmonary epithelial CCR3 promotes LPS-induced lung inflammation by mediating release of IL-8. J Cell Physiol (2011) 0.95

Associations of inflammatory factors with glycaemic status among middle-aged and older Chinese people. Clin Endocrinol (Oxf) (2008) 0.95

Developments in biobanking workflow standardization providing sample integrity and stability. J Proteomics (2013) 0.94

Activation of growth hormone receptors by growth hormone and growth hormone antagonist dimers: insights into receptor triggering. Mol Endocrinol (2007) 0.93

Regulatory mechanisms of interleukin-8 production induced by tumour necrosis factor-α in human hepatocellular carcinoma cells. J Cell Mol Med (2012) 0.93

Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. Am J Physiol Gastrointest Liver Physiol (2003) 0.93

Translational medicine as a permanent glue and force of clinical medicine and public health: perspectives (1) from 2012 Sino-American symposium on clinical and translational medicine. Clin Transl Med (2012) 0.92

Can lung cancer stem cells be targeted for therapies? Cancer Treat Rev (2012) 0.92

The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment. J Cell Mol Med (2013) 0.92

Janus kinase 2 influences growth hormone receptor metalloproteolysis. Endocrinology (2006) 0.91

Comparative study of cluster and conventional immunotherapy schedules with dermatophagoides pteronyssinus in the treatment of persistent allergic rhinitis. Int Arch Allergy Immunol (2008) 0.91

Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cells. Gastroenterology (2012) 0.91

Role of CCR2 and IL-8 in acute lung injury: a new mechanism and therapeutic target. Expert Rev Respir Med (2011) 0.91

[Comparison of peroral endoscopic myotomy with transverse entry incision versus longitudinal entry incision for achalasia]. Nan Fang Yi Ke Da Xue Xue Bao (2013) 0.91

Lung inflammatory responses and hyperinflation induced by an intratracheal exposure to lipopolysaccharide in rats. Lung (2004) 0.90