Published in Int J Biochem Cell Biol on January 13, 2010
Targeting interleukin-1 in heart disease. Circulation (2013) 2.52
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol (2014) 1.89
IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol (2010) 1.77
Deregulated inflammasome signaling in disease. Immunol Rev (2011) 1.39
The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol (2011) 1.22
Induction and function of virus-specific CD4+ T cell responses. Virology (2011) 1.18
Inflammasome activation in obesity-related inflammatory diseases and autoimmunity. Discov Med (2011) 1.08
Role of the nlrp3 inflammasome in microbial infection. Front Microbiol (2011) 1.01
Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus. Psychoneuroendocrinology (2013) 0.99
Mutations of the Listeria monocytogenes peptidoglycan N-deacetylase and O-acetylase result in enhanced lysozyme sensitivity, bacteriolysis, and hyperinduction of innate immune pathways. Infect Immun (2011) 0.98
NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model. PLoS One (2014) 0.97
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection. PLoS Pathog (2014) 0.95
Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes. J Immunol (2010) 0.94
Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status. Free Radic Biol Med (2013) 0.92
Inflammasomes: caspase-1-activating platforms with critical roles in host defense. Front Microbiol (2011) 0.88
Regulation of immune pathways by the NOD-like receptor NLRC5. Immunobiology (2011) 0.87
Transcriptomic and proteomic analyses reveal key innate immune signatures in the host response to the gastrointestinal pathogen Campylobacter concisus. Infect Immun (2014) 0.87
The role of inflammasome modulation in virulence. Virulence (2012) 0.87
Self-oligomerization is essential for enhanced immunological activities of soluble recombinant calreticulin. PLoS One (2013) 0.86
Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation. J Immunol (2015) 0.86
NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation. Int J Neuropsychopharmacol (2015) 0.85
Cytokine-Induced Modulation of Colorectal Cancer. Front Oncol (2016) 0.84
The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome. Brain Behav Immun (2015) 0.84
Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome. PLoS One (2013) 0.83
Pyrin- and CARD-only Proteins as Regulators of NLR Functions. Front Immunol (2013) 0.83
High fat diet-induced obesity leads to proinflammatory response associated with higher expression of NOD2 protein. Nutr Res Pract (2011) 0.82
FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes. J Leukoc Biol (2016) 0.78
Distinct role of IL-1β in instigating disease in Sharpin(cpdm) mice. Sci Rep (2016) 0.75
Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome. Oncotarget (2017) 0.75
Cryopyrin activates the inflammasome in response to toxins and ATP. Nature (2006) 18.74
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature (2004) 14.80
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity (2004) 13.55
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet (2001) 9.34
TLR signaling. Cell Death Differ (2006) 9.24
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature (2008) 9.01
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity (2007) 6.75
Intracellular NOD-like receptors in host defense and disease. Immunity (2007) 6.48
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity (2009) 6.37
Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem (2006) 5.92
Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med (2009) 5.77
Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med (2009) 5.19
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature (2009) 5.00
Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol (2004) 4.89
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet (2002) 4.84
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity (2009) 4.51
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet (2004) 4.23
Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N Engl J Med (2003) 3.86
Inflammasomes: guardians of cytosolic sanctity. Immunol Rev (2009) 3.58
An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe (2009) 3.52
Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum (2008) 3.36
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem (2006) 3.20
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity (2009) 2.93
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet (2008) 2.67
Pathogen recognition in the innate immune response. Biochem J (2009) 2.64
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity (2009) 2.59
The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol (2007) 2.57
Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem (2004) 2.26
Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J Immunol (2009) 2.18
IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. J Immunol (2005) 1.38
Fungal zymosan and mannan activate the cryopyrin inflammasome. J Biol Chem (2009) 1.32
Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death. J Bone Miner Res (2008) 0.95
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol (2006) 10.55
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity (2010) 5.12
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem (2006) 5.11
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity (2009) 4.51
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol (2008) 4.31
Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J Biol Chem (2007) 4.27
Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur J Immunol (2007) 4.19
RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol (2007) 3.43
Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci U S A (2011) 2.92
Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol (2010) 2.88
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics (2008) 2.64
Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes. J Immunol (2006) 2.21
The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell (2011) 2.18
The malarial host-targeting signal is conserved in the Irish potato famine pathogen. PLoS Pathog (2006) 2.10
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog (2009) 1.99
RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3. Nature (2013) 1.98
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol (2014) 1.89
The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation. J Immunol (2007) 1.89
Caspase-1 inflammasomes in infection and inflammation. J Leukoc Biol (2007) 1.87
Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity. Immunity (2011) 1.78
IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol (2010) 1.77
Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense. J Immunol (2006) 1.73
Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. Immunity (2011) 1.65
Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. J Immunol (2010) 1.64
NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature (2012) 1.63
Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J Immunol (2007) 1.60
The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat Immunol (2011) 1.58
MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS One (2009) 1.55
Inflammasomes and autoimmunity. Trends Mol Med (2010) 1.53
Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum (2010) 1.52
Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis. J Biol Chem (2010) 1.51
The inflammasome puts obesity in the danger zone. Cell Metab (2012) 1.49
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol (2013) 1.47
Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3. Arthritis Res Ther (2012) 1.46
Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59. Proc Natl Acad Sci U S A (2011) 1.43
Deregulated inflammasome signaling in disease. Immunol Rev (2011) 1.39
Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans. J Infect Dis (2009) 1.37
Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis. Nat Immunol (2013) 1.36
Fungal zymosan and mannan activate the cryopyrin inflammasome. J Biol Chem (2009) 1.32
Caspase-7: a protease involved in apoptosis and inflammation. Int J Biochem Cell Biol (2009) 1.30
Regulation of inflammasome activation. Immunol Rev (2015) 1.28
Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation. Nat Immunol (2012) 1.28
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood (2009) 1.24
The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol (2011) 1.22
The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis. Eur J Immunol (2011) 1.22
Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury. Toxicol Appl Pharmacol (2011) 1.21
TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J Biol Chem (2011) 1.21
Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection. Proc Natl Acad Sci U S A (2013) 1.16
Role of inflammasomes in host defense against Citrobacter rodentium infection. J Biol Chem (2012) 1.15
The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence. Cell Rep (2012) 1.14
Inflammasome activation in obesity-related inflammatory diseases and autoimmunity. Discov Med (2011) 1.08
IL-1 family cytokines trigger sterile inflammatory disease. Front Immunol (2012) 1.07
Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages. Front Microbiol (2011) 1.06
Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction. J Infect Dis (2010) 1.04
Role of the nlrp3 inflammasome in microbial infection. Front Microbiol (2011) 1.01
Computational and comparative analyses of 150 full-length cDNA sequences from the oomycete plant pathogen Phytophthora infestans. Fungal Genet Biol (2005) 1.01
An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis. J Clin Invest (2015) 1.01
Critical role for inflammasome-independent IL-1β production in osteomyelitis. Proc Natl Acad Sci U S A (2014) 1.00
Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells. J Immunol (2012) 0.99
Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism. Eur J Immunol (2010) 0.99
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. J Clin Invest (2015) 0.97
Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection. Front Cell Infect Microbiol (2013) 0.96
The expanding role of NLRs in antiviral immunity. Immunol Rev (2013) 0.96
MiR-155 induction by microbes/microbial ligands requires NF-κB-dependent de novo protein synthesis. Front Cell Infect Microbiol (2012) 0.96
Reciprocal regulation of activating and inhibitory Fc{gamma} receptors by TLR7/8 activation: implications for tumor immunotherapy. Clin Cancer Res (2010) 0.96
Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes. J Immunol (2010) 0.94
Unsolved Mysteries in NLR Biology. Front Immunol (2013) 0.92
NOD-like receptor (NLR) signaling beyond the inflammasome. Eur J Immunol (2010) 0.92
Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines. Nat Immunol (2012) 0.91
Fat chance: not much against NKT cells. Immunity (2012) 0.89
Regulation of immune pathways by the NOD-like receptor NLRC5. Immunobiology (2011) 0.87
The role of inflammasome modulation in virulence. Virulence (2012) 0.87
Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β). J Biol Chem (2013) 0.85
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. J Clin Invest (2015) 0.84
Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease. Semin Immunopathol (2014) 0.81
SHP-1 and IL-1α conspire to provoke neutrophilic dermatoses. Rare Dis (2014) 0.80
NLRP6 in infection and inflammation. Microbes Infect (2013) 0.80
Targeting NLRP6 to enhance immunity against bacterial infections. Future Microbiol (2012) 0.78
The inflammasome: a remote control for metabolic syndrome. Cell Res (2012) 0.78
IL-33 regulates the IgA-microbiota axis to restrain IL-1α-dependent colitis and tumorigenesis. J Clin Invest (2016) 0.77
Inflammasomes and Intestinal Tumorigenesis. Drug Discov Today Dis Mech (2011) 0.76
Innate immune pathways in host defense. Mediators Inflamm (2012) 0.75