Published in Cell Death Differ on May 01, 2006
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell (2010) 8.69
Antimicrobial activity of mucosal-associated invariant T cells. Nat Immunol (2010) 4.25
Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses. J Exp Med (2008) 4.21
A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol (2009) 4.19
MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci U S A (2009) 3.97
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol (2007) 3.72
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol (2008) 3.61
Targeting Toll-like receptors: emerging therapeutics? Nat Rev Drug Discov (2010) 3.35
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J (2006) 3.13
Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. J Immunol (2008) 2.87
Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen. PLoS Pathog (2008) 2.86
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood (2007) 2.72
Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation. Proc Natl Acad Sci U S A (2011) 2.67
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. J Biol Chem (2008) 2.63
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med (2012) 2.60
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest (2010) 2.48
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat Immunol (2009) 2.48
Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus. Cell Host Microbe (2008) 2.40
Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant. Cell Mol Life Sci (2008) 2.39
Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. PLoS One (2011) 2.29
MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases. Transl Res (2011) 2.15
TLR-based immune adjuvants. Vaccine (2010) 2.10
ATF3 transcription factor and its emerging roles in immunity and cancer. J Mol Med (Berl) (2009) 2.08
Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. J Histochem Cytochem (2007) 2.06
NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila. J Exp Med (2006) 2.06
Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. Nat Immunol (2009) 2.00
GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity. Int Immunol (2009) 1.96
Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol (2008) 1.95
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation. Proc Natl Acad Sci U S A (2007) 1.92
B cell intrinsic TLR signals amplify but are not required for humoral immunity. J Exp Med (2007) 1.89
Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr Opin Lipidol (2009) 1.87
Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma. Nature (2013) 1.86
Retracted Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation. Circ Res (2008) 1.85
Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator. J Virol (2007) 1.84
Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal (2011) 1.82
The type III secretion effector NleE inhibits NF-kappaB activation. PLoS Pathog (2010) 1.79
Toll-like receptor signaling in cell proliferation and survival. Cytokine (2009) 1.79
Functional consequences of toll-like receptor 4 polymorphisms. Mol Med (2008) 1.76
Bone marrow MyD88 signaling modulates neutrophil function and ischemic myocardial injury. Am J Physiol Cell Physiol (2010) 1.69
Newly described pattern recognition receptors team up against intracellular pathogens. Nat Rev Immunol (2013) 1.69
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control. PLoS Pathog (2011) 1.67
Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques. J Infect Dis (2013) 1.57
The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver. Blood (2011) 1.56
Metalloprotease type III effectors that specifically cleave JNK and NF-κB. EMBO J (2010) 1.55
Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs. Semin Immunopathol (2007) 1.54
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci U S A (2007) 1.54
Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis. BMC Cancer (2010) 1.53
Global functional analyses of cellular responses to pore-forming toxins. PLoS Pathog (2011) 1.52
Basolateral LPS inhibits NHE3 and HCOFormula absorption through TLR4/MyD88-dependent ERK activation in medullary thick ascending limb. Am J Physiol Cell Physiol (2011) 1.50
Study of the expression of toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer. J Clin Immunol (2012) 1.50
RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages. PLoS Pathog (2008) 1.49
The inflammasomes. PLoS Pathog (2009) 1.48
Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota. PLoS One (2009) 1.47
Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta. PLoS Pathog (2009) 1.47
The story of CD4+ CD28- T cells revisited: solved or still ongoing? J Immunol Res (2015) 1.47
Virus recognition by Toll-7 activates antiviral autophagy in Drosophila. Immunity (2012) 1.47
TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host Microbe (2007) 1.47
Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3. Arthritis Res Ther (2012) 1.46
No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med (2008) 1.46
CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. Blood (2016) 1.45
Heat shock proteins: linking danger and pathogen recognition. Med Microbiol Immunol (2007) 1.45
The role of Toll-like receptors in renal diseases. Nat Rev Nephrol (2010) 1.42
Feeding our immune system: impact on metabolism. Clin Dev Immunol (2008) 1.42
Toll-like receptors: lessons to learn from normal and malignant human B cells. Blood (2008) 1.42
A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. PLoS Pathog (2007) 1.41
The impact of obesity on the immune response to infection. Proc Nutr Soc (2012) 1.41
Retracted The absence of MyD88 has no effect on the induction of alternatively activated macrophage during Fasciola hepatica infection. BMC Immunol (2011) 1.40
Deregulated inflammasome signaling in disease. Immunol Rev (2011) 1.39
Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta. Proc Natl Acad Sci U S A (2011) 1.36
Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice. Am J Physiol Heart Circ Physiol (2008) 1.35
Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol (2010) 1.34
Classical swine fever virus Npro interacts with interferon regulatory factor 3 and induces its proteasomal degradation. J Virol (2007) 1.34
Murine cytomegalovirus m142 and m143 are both required to block protein kinase R-mediated shutdown of protein synthesis. J Virol (2006) 1.33
MAIT cells detect and efficiently lyse bacterially-infected epithelial cells. PLoS Pathog (2013) 1.32
Exposure-dependent effects of ethanol on the innate immune system. Alcohol (2008) 1.32
Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages. J Immunol (2010) 1.31
LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages. J Exp Med (2007) 1.30
Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity. Clin Exp Immunol (2007) 1.30
Identification of potential pathway mediation targets in Toll-like receptor signaling. PLoS Comput Biol (2009) 1.30
Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway. Am J Respir Cell Mol Biol (2008) 1.29
Activation of TLR3 in the trophoblast is associated with preterm delivery. Am J Reprod Immunol (2009) 1.29
Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells. J Virol (2008) 1.28
Preferential activation of Toll-like receptor nine by CD46-utilizing adenoviruses. J Virol (2006) 1.27
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem (2011) 1.27
Evolution of inflammatory diseases. Curr Biol (2012) 1.27
Nlrp3: an immune sensor of cellular stress and infection. Int J Biochem Cell Biol (2010) 1.24
Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population. Aging Dis (2011) 1.23
Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats. Clin Sci (Lond) (2012) 1.23
IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells. J Immunol (2008) 1.22
TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PLoS One (2011) 1.21
Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence. PLoS Pathog (2010) 1.21
Positional differences in the wound transcriptome of skin and oral mucosa. BMC Genomics (2010) 1.20
Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response. J Virol (2007) 1.20
Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages. Infect Immun (2006) 1.19
TLR9 is actively recruited to Aspergillus fumigatus phagosomes and requires the N-terminal proteolytic cleavage domain for proper intracellular trafficking. J Immunol (2010) 1.18
Phenytoin-induced gingival overgrowth: a review of the molecular, immune, and inflammatory features. ISRN Dent (2011) 1.17
Analysis of the in vitro transcriptional response of human pharyngeal epithelial cells to adherent Streptococcus pneumoniae: evidence for a distinct response to encapsulated strains. Infect Immun (2007) 1.17
A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 14.24
Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity (1999) 7.90
Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A (1997) 7.08
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol (2000) 6.61
Essential role of Stat6 in IL-4 signalling. Nature (1996) 6.56
Structure and function of a new STAT-induced STAT inhibitor. Nature (1997) 6.02
Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol (2001) 5.27
Biological and clinical aspects of interleukin 6. Immunol Today (1990) 5.17
Cytokine signal transduction. Cell (1994) 5.14
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A (2001) 5.02
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol (1998) 4.74
Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity (1998) 4.70
Interleukin-6 family of cytokines and gp130. Blood (1995) 4.52
Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J (1997) 4.51
Induction of direct antimicrobial activity through mammalian toll-like receptors. Science (2001) 4.46
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell (1995) 4.34
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A (1993) 4.23
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol (2000) 4.10
IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc Natl Acad Sci U S A (1989) 4.03
Limb and skin abnormalities in mice lacking IKKalpha. Science (1999) 3.85
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci U S A (1993) 3.59
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol (1998) 3.56
Interleukin-6 and its receptor: a paradigm for cytokines. Science (1992) 3.51
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A (2001) 3.49
Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol (2001) 3.26
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J (1999) 3.19
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev (1999) 2.91
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol (1999) 2.84
Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity (2000) 2.81
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A (1996) 2.64
Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood (1992) 2.62
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J Immunol (2001) 2.60
TLR6: A novel member of an expanding toll-like receptor family. Gene (1999) 2.55
A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci U S A (1992) 2.55
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett (1996) 2.53
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol (2000) 2.41
Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene. Mol Cell Biol (1990) 2.41
Toll-like receptors; their physiological role and signal transduction system. Int Immunopharmacol (2001) 2.36
TLR engagement prevents transplantation tolerance. Am J Transplant (2006) 2.36
IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci U S A (1999) 2.35
The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med (1999) 2.32
Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice. Trends Immunol (2001) 2.29
Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J Exp Med (2000) 2.16
NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A. J Virol (1992) 2.10
Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors. Infect Immun (2000) 2.10
Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells (2000) 2.05
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol (2000) 2.05
STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev (2000) 2.02
A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction. Mol Cell Biol (1993) 2.00
CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J Immunol (2001) 1.95
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol (1998) 1.88
Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J Exp Med (1998) 1.88
A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. J Immunol (1999) 1.86
Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human. J Immunol (1988) 1.86
Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice. Infect Immun (1999) 1.85
Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol (2001) 1.82
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr Biol (2000) 1.81
Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. J Biol Chem (1999) 1.77
IkappaB kinase alpha is essential for mature B cell development and function. J Exp Med (2001) 1.76
The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol. Eur J Immunol (2001) 1.71
Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture. Infect Immun (2001) 1.71
MyD88 as a bottle neck in Toll/IL-1 signaling. Curr Top Microbiol Immunol (2002) 1.71
Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression. New Biol (1991) 1.70
Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol (1999) 1.69
Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice. Immunity (1999) 1.67
DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem (1998) 1.65
STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells. Clin Exp Allergy (1999) 1.64
Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection. J Immunol (2000) 1.63
Critical roles of Toll-like receptors in host defense. Crit Rev Immunol (2000) 1.63
Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta. J Immunol (2001) 1.62
Expression of toll-like receptor 2 on gamma delta T cells bearing invariant V gamma 6/V delta 1 induced by Escherichia coli infection in mice. J Immunol (2000) 1.59
Roles of Toll-like receptors in innate immune responses. Genes Cells (2001) 1.56
Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol (1996) 1.56
Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J Immunol (2000) 1.52
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells (1998) 1.50
IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor. J Immunol (1999) 1.48
The role of NF-kappa B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6. J Biol Chem (1993) 1.46
Novel engagement of CD14 and multiple toll-like receptors by group B streptococci. J Immunol (2001) 1.46
Age-associated increase in interleukin 6 in MRL/lpr mice. Int Immunol (1991) 1.45
Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model. Br J Pharmacol (2009) 1.43
Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia. Neuroscience (2010) 1.43
A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences. Cell (1987) 1.42
Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice. Scand J Gastroenterol (2003) 1.41
Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol Cell Biol (2001) 1.39
Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells (1999) 1.35
Introduction of human gamma 1 immunoglobulin genes into fertilized mouse eggs. J Biochem (1984) 1.35
The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Adv Exp Med Biol (2000) 1.34
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology (2001) 1.33
Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes. Int Immunol (1998) 1.32