Published in Bioorg Med Chem on January 04, 2010
D-chiro-inositol glycans in insulin signaling and insulin resistance. Mol Med (2010) 0.99
The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast. J Biol Chem (2013) 0.87
D-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells. Mol Cell Endocrinol (2014) 0.76
Inositol, glycogen, insulin, and six nobelists. J Biol Chem (2013) 0.76
Synthesis of the C-glycoside of α-(D)-mannose-(1 → 6)-(D)-myo-inositol. Org Biomol Chem (2013) 0.75
Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation. Proc Natl Acad Sci U S A (1969) 8.09
A fast flexible docking method using an incremental construction algorithm. J Mol Biol (1996) 7.33
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. EMBO J (1996) 3.51
Thermodynamic studies of lectin-carbohydrate interactions by isothermal titration calorimetry. Chem Rev (2002) 1.55
Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation. Science (1979) 1.48
The C-glycoside analogue of the immunostimulant alpha-galactosylceramide (KRN7000): synthesis and striking enhancement of activity. Angew Chem Int Ed Engl (2004) 1.31
Insulin-mediated effect on the activity of UDPG-glycogen transglucosylase of muscle. Biochim Biophys Acta (1960) 1.08
Recent advances in the synthesis of C-oligosaccharides. Curr Top Med Chem (2005) 1.00
Crystal structure of pyruvate dehydrogenase phosphatase 1 and its functional implications. J Mol Biol (2007) 0.97
Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action. Biochemistry (2005) 0.97
Purification and characterization of Mg2+-dependent glycogen synthase phosphatase (phosphoprotein phosphatase IA) from rat liver. Eur J Biochem (1981) 0.96
The conformation of C-glycosyl compounds. Adv Carbohydr Chem Biochem (2000) 0.89
Isolation, structure, synthesis, and bioactivity of a novel putative insulin mediator. A galactosamine chiro-inositol pseudo-disaccharide Mn2+ chelate with insulin-like activity. J Med Chem (2003) 0.89
G(q/11) is involved in insulin-stimulated inositol phosphoglycan putative mediator generation in rat liver membranes: co-localization of G(q/11) with the insulin receptor in membrane vesicles. Biochem Biophys Res Commun (2002) 0.88
Conformation of glycomimetics in the free and protein-bound state: structural and binding features of the C-glycosyl analogue of the core trisaccharide alpha-D-Man-(1 --> 3)-[alpha-D-Man-(1 --> 6)]-D-Man. J Am Chem Soc (2002) 0.88
The how and why of protein-carbohydrate interaction: a primer to the theoretical concept and a guide to application in drug design. Pharm Res (1998) 0.84
Conformational selection of glycomimetics at enzyme catalytic sites: experimental demonstration of the binding of distinct high-energy distorted conformations of C-, S-, and O-glycosides by E. Coli beta-galactosidases. J Am Chem Soc (2002) 0.81
RCM-based synthesis of a variety of beta-C-glycosides and their in vitro anti-solid tumor activity. J Org Chem (2005) 0.81
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature (2008) 3.77
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med (2009) 2.17
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases. J Biol Chem (2002) 1.70
Expression of ral GTPases, their effectors, and activators in human bladder cancer. Clin Cancer Res (2007) 1.58
High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. PLoS One (2010) 1.54
Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. Endocr J (2013) 1.52
Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Proc Natl Acad Sci U S A (2004) 1.51
VMY-1-103, a dansylated analog of purvalanol B, induces caspase-3-dependent apoptosis in LNCaP prostate cancer cells. Cancer Biol Ther (2010) 1.49
AMP-activated protein kinase promotes human prostate cancer cell growth and survival. Mol Cancer Ther (2009) 1.48
Therapeutic approaches targeting prostate cancer progression using novel voltage-gated ion channel blockers. Clin Prostate Cancer (2003) 1.44
Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chem Biol (2007) 1.44
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. J Biol Chem (2006) 1.43
Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. Biochemistry (2008) 1.42
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. J Biol Chem (2006) 1.37
Voltage-sensitive ion channels and cancer. Cancer Metastasis Rev (2006) 1.34
Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits. Proc Natl Acad Sci U S A (2004) 1.30
Predicting new indications for approved drugs using a proteochemometric method. J Med Chem (2012) 1.29
Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. Biochem J (2002) 1.29
Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. Mol Cell Biol (2002) 1.29
Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells. Cell Cycle (2007) 1.27
Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA. J Biol Chem (2012) 1.25
Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats. J Pharmacol Exp Ther (2009) 1.24
A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. J Biol Chem (2002) 1.24
Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6. PLoS One (2009) 1.23
Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin. J Transl Med (2005) 1.22
Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats. Psychopharmacology (Berl) (2010) 1.20
The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A. J Biol Chem (2006) 1.20
STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain. Proc Natl Acad Sci U S A (2013) 1.20
Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. J Biol Chem (2002) 1.19
Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2. Cancer Res (2008) 1.16
Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor. Neuron (2002) 1.15
Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. J Biol Chem (2002) 1.14
TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB. J Biol Chem (2008) 1.13
Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor. Mol Cell Biol (2005) 1.13
Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants. Bioorg Med Chem (2004) 1.13
Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African-American men. Int J Oncol (2009) 1.13
Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits. J Biol Chem (2004) 1.08
Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylation. J Biol Chem (2002) 1.07
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4. Chem Biol (2005) 1.07
YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion. PLoS One (2011) 1.07
Voltage-gated sodium channel blockers as cytostatic inhibitors of the androgen-independent prostate cancer cell line PC-3. Mol Cancer Ther (2003) 1.06
Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer Res (2010) 1.05
Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls. Biochem Biophys Res Commun (2002) 1.05
Protein phosphatase-1alpha regulates centrosome splitting through Nek2. Cancer Res (2007) 1.05
Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. Oncotarget (2012) 1.04
Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole. Mol Pharmacol (2007) 1.04
Assembly of MYPT1 with protein phosphatase-1 in fibroblasts redirects localization and reorganizes the actin cytoskeleton. Cell Motil Cytoskeleton (2005) 1.04
Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R. Melanoma Res (2011) 1.03
Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. J Biol Chem (2009) 1.02
Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats. Psychopharmacology (Berl) (2011) 1.02
Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity. J Med Chem (2008) 1.02
Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Cote d'Ivoire. J Nutr (2006) 1.02
Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor. Structure (2007) 1.02
Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. Mol Biol Cell (2008) 1.02
Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK. Mol Cell Proteomics (2010) 1.02
Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: a phase II trial (CTEP 7190/Mel47). Clin Cancer Res (2013) 1.00
Systems analyses characterize integrated functions of biochemical networks. Trends Biochem Sci (2006) 1.00
Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats. Psychopharmacology (Berl) (2012) 1.00
ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation. J Biol Chem (2001) 1.00
The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation. Biochemistry (2007) 0.99
D-chiro-inositol glycans in insulin signaling and insulin resistance. Mol Med (2010) 0.99
PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53. Mol Cancer Ther (2009) 0.98
Phosphorylation and functions of inhibitor-2 family of proteins. Biochemistry (2007) 0.98
Synthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockers. Bioorg Med Chem (2011) 0.97
Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. J Biol Chem (2003) 0.97
Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A. J Biol Chem (2010) 0.97
Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. Mol Cell Biol (2007) 0.97
Tumor-targeting nanodelivery enhances the anticancer activity of a novel quinazolinone analogue. Mol Cancer Ther (2008) 0.96
DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. Proc Natl Acad Sci U S A (2013) 0.96
Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions. J Biol Chem (2007) 0.95
Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase. Bioorg Med Chem (2007) 0.95
Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions. Mol Cell Biol (2007) 0.95
Phosphorylation of the Pro-X-Thr-Pro site in phosphatase inhibitor-2 by cyclin-dependent protein kinase during M-phase of the cell cycle. Cell Signal (2005) 0.94
Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget (2013) 0.94
Small molecule inducers of angiogenesis for tissue engineering. Tissue Eng (2006) 0.92
Aurora-A kinase and inhibitor-2 regulate the cyclin threshold for mitotic entry in Xenopus early embryonic cell cycles. Cell Cycle (2006) 0.92
A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile. Neuropharmacology (2006) 0.92
Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae. PLoS One (2009) 0.92
Proper chromatin condensation and maintenance of histone H3 phosphorylation during mouse oocyte meiosis requires protein phosphatase activity. Biol Reprod (2006) 0.91
PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase. J Biol Chem (2012) 0.91
Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase. Mol Cell Proteomics (2006) 0.91
Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity. J Biol Chem (2001) 0.91
Cellular chromium enhances activation of insulin receptor kinase. Biochemistry (2005) 0.91
Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts. Am J Physiol Gastrointest Liver Physiol (2008) 0.90
Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells. Biochem Pharmacol (2013) 0.90
Synthesis of the AB subunit of angelmicin B through a tandem alkoxy radical fragmentation-etherification sequence. Org Lett (2008) 0.90
Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells. Bioorg Med Chem (2011) 0.90
Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun (2003) 0.90
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell (2009) 0.90
Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore. Bioorg Med Chem (2008) 0.89
Binding of phosphatase inhibitor-2 to prolyl isomerase Pin1 modifies specificity for mitotic phosphoproteins. Biochemistry (2007) 0.89
Isolation, structure, synthesis, and bioactivity of a novel putative insulin mediator. A galactosamine chiro-inositol pseudo-disaccharide Mn2+ chelate with insulin-like activity. J Med Chem (2003) 0.89
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. J Med Chem (2013) 0.88
Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. Biochem J (2011) 0.88
Fluorescent epigenetic small molecule induces expression of the tumor suppressor ras-association domain family 1A and inhibits human prostate xenograft. J Med Chem (2010) 0.87