Published in Sci Rep on August 18, 2011
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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
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Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci (2014) 2.37
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Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Cell Metab (2013) 1.86
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The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Rep (2014) 1.42
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Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man. Br J Clin Pharmacol (2013) 1.24
SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. PLoS One (2012) 1.23
The sirtuin family's role in aging and age-associated pathologies. J Clin Invest (2013) 1.12
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Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. Eur Heart J (2015) 1.11
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol (2012) 1.06
Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia-reperfusion injury. Toxicol Appl Pharmacol (2013) 1.03
Mitochondrial dysfunction and insulin resistance: an update. Endocr Connect (2014) 1.02
Mitochondrial metabolic reprogramming induced by calorie restriction. Antioxid Redox Signal (2012) 0.98
Germline energetics, aging, and female infertility. Cell Metab (2013) 0.97
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell (2014) 0.94
A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers. PLoS One (2012) 0.94
Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget (2013) 0.94
Mitochondrial biogenesis through activation of nuclear signaling proteins. Cold Spring Harb Perspect Biol (2013) 0.94
The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice. Am J Physiol Heart Circ Physiol (2014) 0.91
High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab (2014) 0.90
The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol (2015) 0.89
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. Genes Cancer (2013) 0.89
Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds. Nat Rev Mol Cell Biol (2016) 0.86
Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. Am J Transl Res (2013) 0.85
NAD and the aging process: Role in life, death and everything in between. Mol Cell Endocrinol (2016) 0.85
Epigenetics and aging. Sci Adv (2016) 0.84
Effects of nutritional components on aging. Aging Cell (2014) 0.84
The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes. Aging (Albany NY) (2012) 0.83
Biochemical Genetic Pathways that Modulate Aging in Multiple Species. Cold Spring Harb Perspect Med (2015) 0.81
Potential Modulation of Sirtuins by Oxidative Stress. Oxid Med Cell Longev (2015) 0.81
Sirtuins, a promising target in slowing down the ageing process. Biogerontology (2017) 0.80
Sirtuin functions and modulation: from chemistry to the clinic. Clin Epigenetics (2016) 0.80
Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice. Eur J Med Res (2015) 0.79
NAD(+) Metabolism in Age-Related Hearing Loss. Aging Dis (2014) 0.79
The endothelium abridges insulin resistance to premature aging. J Am Heart Assoc (2013) 0.79
Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects. Br J Pharmacol (2014) 0.79
Targeting sirtuins for the treatment of diabetes. Diabetes Manag (Lond) (2013) 0.79
Screening SIRT1 Activators from Medicinal Plants as Bioactive Compounds against Oxidative Damage in Mitochondrial Function. Oxid Med Cell Longev (2016) 0.78
Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice. Aging Cell (2014) 0.78
SIRT1 activators: the evidence STACks up. Aging (Albany NY) (2013) 0.78
Biochemistry. Red wine, toast of the town (again). Science (2013) 0.78
Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α). J Biol Chem (2015) 0.78
Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction. Mech Ageing Dev (2014) 0.78
The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice. Stem Cell Res (2015) 0.77
Nicotinamide Mononucleotide, an NAD(+) Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manner. J Am Soc Nephrol (2017) 0.77
Pharmacologic Means of Extending Lifespan. J Clin Exp Pathol (2012) 0.76
Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. PLoS One (2014) 0.76
Deficiency of myeloid-related proteins 8 and 14 (Mrp8/Mrp14) does not block inflammaging but prevents steatosis. Oncotarget (2016) 0.76
Pharmacological Strategies to Retard Cardiovascular Aging. Circ Res (2016) 0.76
Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis. J Biol Chem (2016) 0.76
SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway. Clin Cancer Res (2015) 0.76
In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes. Aging Cell (2015) 0.76
Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocytes by repressing SIRT1. Oncotarget (2016) 0.75
Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis. Cancer Sci (2015) 0.75
SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction. Cell Death Dis (2017) 0.75
Do altered energy metabolism or spontaneous locomotion 'mediate' decelerated senescence? Aging Cell (2015) 0.75
Interaction of growth hormone receptor/binding protein gene disruption and caloric restriction for insulin sensitivity and attenuated aging. F1000Res (2014) 0.75
Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK. EBioMedicine (2017) 0.75
SIRT6 suppresses mitochondrial defects and cell death via the NF-κB pathway in myocardial hypoxia/reoxygenation induced injury. Am J Transl Res (2016) 0.75
Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules. F1000Res (2016) 0.75
SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease. PLoS Pathog (2016) 0.75
SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium. Am J Transl Res (2016) 0.75
'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue. J Physiol (2016) 0.75
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Determination of serum proteins by means of the biuret reaction. J Biol Chem (1949) 16.38
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44
Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem (2010) 5.43
Substrate-specific activation of sirtuins by resveratrol. J Biol Chem (2005) 5.28
Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A (2008) 5.21
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
Mechanism of human SIRT1 activation by resveratrol. J Biol Chem (2005) 4.86
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature (2008) 4.43
Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc Natl Acad Sci U S A (2006) 3.97
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One (2008) 3.25
Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des (2009) 3.20
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun (2010) 2.97
Sirtuins--novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov (2008) 2.89
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol (2008) 2.73
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev (2010) 2.55
Sarcopenic obesity and inflammation in the InCHIANTI study. J Appl Physiol (1985) (2006) 2.50
Sarcopenia, obesity, and inflammation--results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study. Am J Clin Nutr (2005) 2.44
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem Biophys Res Commun (2003) 2.27
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 2.25
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest (2010) 1.97
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol (2009) 1.94
Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest (2010) 1.90
Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response. Aging Cell (2007) 1.87
The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}. Proc Natl Acad Sci U S A (2008) 1.80
PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem (2009) 1.78
SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator. J Biol Chem (2010) 1.75
Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. Am J Physiol Endocrinol Metab (2009) 1.68
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J (2011) 1.65
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol (2008) 1.49
SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J Pharmacol Exp Ther (2010) 1.47
Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell (2009) 1.44
A high-throughput respirometric assay for mitochondrial biogenesis and toxicity. Anal Biochem (2010) 1.38
Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutr Rev (2008) 1.22
Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging. BMC Genomics (2007) 1.14
Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy. Toxicol Sci (2000) 1.06
The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption. Exp Gerontol (2004) 1.04
Mitochondrially mediated synergistic cell killing by bile acids. Biochim Biophys Acta (2003) 0.86
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36
Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
The genetic association database. Nat Genet (2004) 11.29
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature (2006) 9.36
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab (2009) 6.91
Analysis of microarray data using Z score transformation. J Mol Diagn (2003) 6.82
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science (2012) 6.69
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature (2003) 6.25
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem (2002) 6.15
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44
Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell (2007) 5.29
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci U S A (2004) 5.15
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A (2007) 4.62
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J (2004) 4.45
Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov (2008) 4.43
HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev (2009) 4.41
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab (2008) 4.36
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci U S A (2003) 4.34
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell (2002) 4.31
Mitonuclear protein imbalance as a conserved longevity mechanism. Nature (2013) 4.18
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
HST2 mediates SIR2-independent life-span extension by calorie restriction. Science (2005) 4.12
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol (2009) 4.09
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A (2003) 4.03
LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87
Systematic discovery of multicomponent therapeutics. Proc Natl Acad Sci U S A (2003) 3.86
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell (2004) 3.73
Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc Natl Acad Sci U S A (2002) 3.71
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58
Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys. Lancet (2003) 3.57
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res (2002) 3.51
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev (2006) 3.48
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab (2010) 3.46
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40