PubRank

Yuzo Ninomiya

Author PubWeight™ 81.66‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U S A 2007 4.60
2 Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 2003 4.54
3 Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature 2005 2.52
4 Trpm5 null mice respond to bitter, sweet, and umami compounds. Chem Senses 2006 2.25
5 Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci 2010 2.03
6 Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One 2009 1.71
7 Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors. Endocr J 2010 1.56
8 Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology 2003 1.54
9 Multiple receptor systems for glutamate detection in the taste organ. Biol Pharm Bull 2008 1.42
10 Regional expression patterns of taste receptors and gustducin in the mouse tongue. Biochem Biophys Res Commun 2003 1.41
11 Umami taste responses are mediated by alpha-transducin and alpha-gustducin. J Neurosci 2004 1.36
12 Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor. J Biol Chem 2007 1.34
13 Discrimination of taste qualities among mouse fungiform taste bud cells. J Physiol 2009 1.30
14 Sour taste responses in mice lacking PKD channels. PLoS One 2011 1.29
15 Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels. Diabetes 2008 1.25
16 Endocannabinoids selectively enhance sweet taste. Proc Natl Acad Sci U S A 2009 1.24
17 Taste responsiveness of fungiform taste cells with action potentials. J Neurophysiol 2006 1.22
18 Taste responses in mice lacking taste receptor subunit T1R1. J Physiol 2013 1.15
19 Action potential-enhanced ATP release from taste cells through hemichannels. J Neurophysiol 2010 1.13
20 Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity. Am J Physiol Regul Integr Comp Physiol 2009 1.10
21 Umami taste in mice uses multiple receptors and transduction pathways. J Physiol 2011 1.06
22 The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions. FASEB J 2007 1.04
23 Multiple receptors underlie glutamate taste responses in mice. Am J Clin Nutr 2009 1.03
24 REEP2 enhances sweet receptor function by recruitment to lipid rafts. J Neurosci 2010 1.00
25 G alpha14 is a candidate mediator of sweet/umami signal transduction in the posterior region of the mouse tongue. Biochem Biophys Res Commun 2008 0.99
26 Variation in umami perception and in candidate genes for the umami receptor in mice and humans. Am J Clin Nutr 2009 0.99
27 Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha-subunit in mice. Am J Physiol Regul Integr Comp Physiol 2007 0.98
28 Expression of leptin receptor (Ob-R) isoforms and signal transducers and activators of transcription (STATs) mRNAs in the mouse taste buds. Arch Histol Cytol 2003 0.98
29 Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion. Am J Physiol Gastrointest Liver Physiol 2012 0.97
30 Genetic and molecular basis of individual differences in human umami taste perception. PLoS One 2009 0.96
31 Adiponectin inhibits induction of TNF-alpha/RANKL-stimulated NFATc1 via the AMPK signaling. FEBS Lett 2008 0.94
32 Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin. Biochem Biophys Res Commun 2008 0.94
33 Co-expression pattern of Shh with Prox1 and that of Nkx2.2 with Mash1 in mouse taste bud. Gene Expr Patterns 2003 0.94
34 Modulation of sweet responses of taste receptor cells. Semin Cell Dev Biol 2012 0.93
35 Recovery of amiloride-sensitive neural coding during regeneration of the gustatory nerve: behavioral-neural correlation of salt taste discrimination. J Neurosci 2003 0.93
36 Gustatory sensation of (L)- and (D)-amino acids in humans. Amino Acids 2012 0.92
37 Residual chemoresponsiveness to acids in the superior laryngeal nerve in "taste-blind" (P2X2/P2X3 double-KO) mice. Chem Senses 2012 0.91
38 Multimodal function of the sweet taste receptor expressed in pancreatic β-cells: generation of diverse patterns of intracellular signals by sweet agonists. Endocr J 2013 0.91
39 A strong nerve dependence of sonic hedgehog expression in basal cells in mouse taste bud and an autonomous transcriptional control of genes in differentiated taste cells. Chem Senses 2004 0.91
40 Temporal changes in NCAM immunoreactivity during taste cell differentiation and cell lineage relationships in taste buds. Chem Senses 2005 0.90
41 Behavioral responses to glutamate receptor agonists and antagonists implicate the involvement of brain-expressed mGluR4 and mGluR1 in taste transduction for umami in mice. Physiol Behav 2011 0.90
42 Responses to apical and basolateral application of glutamate in mouse fungiform taste cells with action potentials. Cell Mol Neurobiol 2011 0.89
43 New frontiers in gut nutrient sensor research: nutrient sensors in the gastrointestinal tract: modulation of sweet taste sensitivity by leptin. J Pharmacol Sci 2010 0.88
44 Recovery of two independent sweet taste systems during regeneration of the mouse chorda tympani nerve after nerve crush. Eur J Neurosci 2007 0.88
45 Coding channels for taste perception: information transmission from taste cells to gustatory nerve fibers. Arch Histol Cytol 2006 0.87
46 Angiotensin II modulates salty and sweet taste sensitivities. J Neurosci 2013 0.87
47 Amiloride inhibition on NaCl responses of the chorda tympani nerve in two 129 substrains of mice, 129P3/J and 129X1/SvJ. Chem Senses 2006 0.86
48 The discovery of umami. Chem Senses 2002 0.86
49 The neural differentiation gene Mash-1 has a distinct pattern of expression from the taste reception-related genes gustducin and T1R2 in the taste buds. Chem Senses 2002 0.86
50 Expression of amiloride-sensitive epithelial sodium channels in mouse taste cells after chorda tympani nerve crush. Chem Senses 2005 0.85
51 Gustatory signaling in the periphery: detection, transmission, and modulation of taste information. Biol Pharm Bull 2010 0.83
52 Expression of sweet receptor components in equine small intestine: relevance to intestinal glucose transport. Am J Physiol Regul Integr Comp Physiol 2012 0.83
53 New insights into the signal transmission from taste cells to gustatory nerve fibers. Int Rev Cell Mol Biol 2010 0.82
54 Regional expression patterns of T1r family in the mouse tongue. Chem Senses 2005 0.82
55 Taste receptor cells responding with action potentials to taste stimuli and their molecular expression of taste related genes. Chem Senses 2005 0.81
56 Modulation and transmission of sweet taste information for energy homeostasis. Ann N Y Acad Sci 2009 0.81
57 Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice. J Physiol 2015 0.81
58 Gurmarin suppression of licking responses to sweetener-quinine mixtures in C57BL mice. Chem Senses 2003 0.81
59 Gα-gustducin is extensively coexpressed with sweet and bitter taste receptors in both the soft palate and fungiform papillae but has a different functional significance. Chem Senses 2011 0.80
60 Multiple receptor systems for umami taste in mice. Ann N Y Acad Sci 2009 0.80
61 Mouse strain differences in Gurmarin-sensitivity of sweet taste responses are not associated with polymorphisms of the sweet receptor gene, Tas1r3. Chem Senses 2005 0.80
62 The role of the dpa locus in mice. Chem Senses 2005 0.79
63 Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states. Endocr J 2014 0.79
64 Conditioned taste aversion learning in leptin-receptor-deficient db/db mice. Neurobiol Learn Mem 2003 0.79
65 Reciprocal modulation of sweet taste by leptin and endocannabinoids. Results Probl Cell Differ 2010 0.78
66 Signal transduction of umami taste: insights from knockout mice. Chem Senses 2005 0.78
67 Induction of salivary kallikreins by the diet containing a sweet-suppressive peptide, gurmarin, in the rat. Biochem Biophys Res Commun 2006 0.78
68 Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats. Lab Invest 2012 0.78
69 cDNA microarray screening for taste-bud-specific genes. Chem Senses 2005 0.77
70 Genetically-increased taste cell population with G(alpha)-gustducin-coupled sweet receptors is associated with increase of gurmarin-sensitive taste nerve fibers in mice. BMC Neurosci 2009 0.77
71 Recovery of salt taste responses and PGP 9.5 immunoreactive taste bud cells during regeneration of the mouse chorda tympani nerve. Chem Senses 2005 0.76
72 Localization of brain activation by umami taste in humans. Brain Res 2011 0.76
73 Shh signaling and regulatory gene expression in mouse taste buds. Chem Senses 2005 0.76
74 The development of a novel automated taste stimulus delivery system for fMRI studies on the human cortical segregation of taste. J Neurosci Methods 2008 0.76
75 The temporal change in the cortical activations due to salty and sweet tastes in humans: fMRI and time-intensity sensory evaluation. Neuroreport 2012 0.76
76 Introductory remarks on umami research: candidate receptors and signal transduction mechanisms on umami. Chem Senses 2005 0.75