Published in Proc Natl Acad Sci U S A on December 22, 2009
Metabolic and hedonic drives in the neural control of appetite: who is the boss? Curr Opin Neurobiol (2011) 1.60
Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proc Natl Acad Sci U S A (2011) 1.46
Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds. Diabetes (2015) 1.45
Endocannabinoid signal in the gut controls dietary fat intake. Proc Natl Acad Sci U S A (2011) 1.29
Sour taste responses in mice lacking PKD channels. PLoS One (2011) 1.29
Coding in the mammalian gustatory system. Trends Neurosci (2010) 1.14
The thrifty lipids: endocannabinoids and the neural control of energy conservation. Trends Neurosci (2012) 1.08
Glucagon signaling modulates sweet taste responsiveness. FASEB J (2010) 1.08
New insights on the role of the endocannabinoid system in the regulation of energy balance. Int J Obes (Lond) (2015) 1.00
An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity. Nutrients (2016) 1.00
A thermal window for yawning in humans: yawning as a brain cooling mechanism. Physiol Behav (2014) 0.99
Genetic analysis of chemosensory traits in human twins. Chem Senses (2012) 0.91
Responses to apical and basolateral application of glutamate in mouse fungiform taste cells with action potentials. Cell Mol Neurobiol (2011) 0.89
Endocannabinoids: an appetite for fat. Proc Natl Acad Sci U S A (2011) 0.88
Current and future drug targets in weight management. Pharm Res (2010) 0.88
Endocannabinoids measurement in human saliva as potential biomarker of obesity. PLoS One (2012) 0.86
Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. FASEB J (2013) 0.85
Greasing the wheels of managing overweight and obesity with omega-3 fatty acids. Med Hypotheses (2011) 0.85
Individual differences in response to positive and negative stimuli: endocannabinoid-based insight on approach and avoidance behaviors. Front Syst Neurosci (2014) 0.85
Diet-induced obesity reduces the responsiveness of the peripheral taste receptor cells. PLoS One (2013) 0.83
Taste perception, associated hormonal modulation, and nutrient intake. Nutr Rev (2015) 0.81
The endocrinology of taste receptors. Nat Rev Endocrinol (2015) 0.80
Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice. J Physiol (2015) 0.80
Glucagon-like peptide-1 is specifically involved in sweet taste transmission. FASEB J (2015) 0.80
Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds. J Neurosci (2014) 0.79
Dietary sugars: their detection by the gut-brain axis and their peripheral and central effects in health and diseases. Eur J Nutr (2014) 0.79
Ingestion of bacterial lipopolysaccharide inhibits peripheral taste responses to sucrose in mice. Neuroscience (2013) 0.79
Expression of adenosine A2b receptor in rat type II and III taste cells. Histochem Cell Biol (2013) 0.78
Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission. PLoS One (2012) 0.78
The endocannabinoid system: role in energy regulation. Pediatr Blood Cancer (2012) 0.77
A quick look at obesity; the enemy within. Gastroenterol Hepatol Bed Bench (2011) 0.75
A preference test for sweet taste that uses edible strips. Appetite (2013) 0.75
Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells. Neurosci Lett (2014) 0.75
New horizons on the role of cannabinoid CB1 receptors in palatable food intake, obesity and related dysmetabolism. Int J Obes Suppl (2014) 0.75
Sugars, Sweet Taste Receptors, and Brain Responses. Nutrients (2017) 0.75
Bortezomib alters sour taste sensitivity in mice. Toxicol Rep (2017) 0.75
Mammalian sweet taste receptors. Cell (2001) 8.04
An amino-acid taste receptor. Nature (2002) 6.71
Detection of sweet and umami taste in the absence of taste receptor T1r3. Science (2003) 4.54
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science (1999) 4.31
Endocannabinoid signaling in the brain. Science (2002) 4.28
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet (2001) 3.65
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest (2003) 3.62
Modern science versus the stigma of obesity. Nat Med (2004) 3.24
Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature (1992) 3.07
A candidate taste receptor gene near a sweet taste locus. Nat Neurosci (2001) 3.03
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol (2002) 2.54
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52
Separate populations of receptor cells and presynaptic cells in mouse taste buds. J Neurosci (2006) 2.46
Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem Biophys Res Commun (2001) 2.31
Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors. Psychopharmacology (Berl) (1997) 2.31
Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. Psychopharmacology (Berl) (1999) 2.17
Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. Neuropsychopharmacology (2007) 2.09
Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. Br J Pharmacol (2001) 2.07
Modulation of taste sensitivity by GLP-1 signaling. J Neurochem (2008) 1.89
Presynaptic (Type III) cells in mouse taste buds sense sour (acid) taste. J Physiol (2008) 1.86
Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci U S A (2000) 1.79
SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. Behav Pharmacol (1998) 1.65
Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology (2003) 1.54
Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins Leukot Essent Fatty Acids (2002) 1.48
The new biology of gastrointestinal hormones. Physiol Rev (1998) 1.47
Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats. J Neurosci (2008) 1.37
Expression, physiological action, and coexpression patterns of neuropeptide Y in rat taste-bud cells. Proc Natl Acad Sci U S A (2005) 1.35
Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. Neuropsychopharmacology (2005) 1.33
Discrimination of taste qualities among mouse fungiform taste bud cells. J Physiol (2009) 1.30
Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels. Diabetes (2008) 1.25
Expression and physiological actions of cholecystokinin in rat taste receptor cells. J Neurosci (2002) 1.25
Taste responsiveness of fungiform taste cells with action potentials. J Neurophysiol (2006) 1.22
Co-expression patterns of the neuropeptides vasoactive intestinal peptide and cholecystokinin with the transduction molecules alpha-gustducin and T1R2 in rat taste receptor cells. Neuroscience (2005) 1.20
Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist. Br J Pharmacol (2004) 1.16
Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. Psychopharmacology (Berl) (2002) 1.15
Effect of Delta9-tetrahydrocannabinol on sucrose palatability as measured by the taste reactivity test. Physiol Behav (2005) 1.07
Effects of the cannabinoid receptor antagonist SR 141716, alone and in combination with dexfenfluramine or naloxone, on food intake in rats. Psychopharmacology (Berl) (2001) 1.04
Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice. BMC Neurosci (2008) 1.00
A comparison of the effects of the CB(1) receptor antagonist SR141716A, pre-feeding and changed palatability on the microstructure of ingestive behaviour. Psychopharmacology (Berl) (2007) 0.88
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A (2007) 4.62
T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U S A (2007) 4.60
Detection of sweet and umami taste in the absence of taste receptor T1r3. Science (2003) 4.54
A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci (2002) 3.35
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52
Afferent neurotransmission mediated by hemichannels in mammalian taste cells. EMBO J (2007) 2.51
Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25. BMC Biol (2006) 2.41
Trpm5 null mice respond to bitter, sweet, and umami compounds. Chem Senses (2006) 2.25
The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J Biol Chem (2004) 2.11
Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci (2010) 2.03
TRPM5-expressing solitary chemosensory cells respond to odorous irritants. J Neurophysiol (2007) 2.01
Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J Biol Chem (2005) 1.99
Major taste loss in carnivorous mammals. Proc Natl Acad Sci U S A (2012) 1.81
Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Biol Chem (2005) 1.74
Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One (2009) 1.71
G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells. J Comp Neurol (2003) 1.59
T1R3 taste receptor is critical for sucrose but not Polycose taste. Am J Physiol Regul Integr Comp Physiol (2008) 1.57
Suppression of methamphetamine-seeking behavior by nicotinic agonists. Proc Natl Acad Sci U S A (2006) 1.56
Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors. Endocr J (2010) 1.56
Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology (2003) 1.54
Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A (2007) 1.50
The heterodimeric sweet taste receptor has multiple potential ligand binding sites. Curr Pharm Des (2006) 1.49
Electrophysiological characterization of voltage-gated currents in defined taste cell types of mice. J Neurosci (2003) 1.47
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A (2010) 1.46
Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proc Natl Acad Sci U S A (2011) 1.46
Multiple receptor systems for glutamate detection in the taste organ. Biol Pharm Bull (2008) 1.42
Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest (2014) 1.42
Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice. Am J Physiol Regul Integr Comp Physiol (2010) 1.41
Regional expression patterns of taste receptors and gustducin in the mouse tongue. Biochem Biophys Res Commun (2003) 1.41
Umami taste responses are mediated by alpha-transducin and alpha-gustducin. J Neurosci (2004) 1.36
Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor. J Biol Chem (2007) 1.34
Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. Am J Clin Nutr (2009) 1.34
Umami responses in mouse taste cells indicate more than one receptor. J Neurosci (2006) 1.33
Discrimination of taste qualities among mouse fungiform taste bud cells. J Physiol (2009) 1.30
Sour taste responses in mice lacking PKD channels. PLoS One (2011) 1.29
Contribution of alpha-gustducin to taste-guided licking responses of mice. Chem Senses (2005) 1.26
Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels. Diabetes (2008) 1.25
Taste responsiveness of fungiform taste cells with action potentials. J Neurophysiol (2006) 1.22
Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins. Am J Physiol Regul Integr Comp Physiol (2007) 1.20
A juvenile mouse pheromone inhibits sexual behaviour through the vomeronasal system. Nature (2013) 1.19
T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1. Ann N Y Acad Sci (2009) 1.18
Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli. J Neurosci (2003) 1.17
Taste receptor cell responses to the bitter stimulus denatonium involve Ca2+ influx via store-operated channels. J Neurophysiol (2002) 1.16
Taste responses in mice lacking taste receptor subunit T1R1. J Physiol (2013) 1.15
Endocannabinoid system modulates relapse to methamphetamine seeking: possible mediation by the arachidonic acid cascade. Neuropsychopharmacology (2004) 1.13
Action potential-enhanced ATP release from taste cells through hemichannels. J Neurophysiol (2010) 1.13
Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5. Gastroenterology (2009) 1.12
Taste cells of the gut and gastrointestinal chemosensation. Mol Interv (2008) 1.11
Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity. Am J Physiol Regul Integr Comp Physiol (2009) 1.10
Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue. Stem Cells (2013) 1.09
Involvement of T1R3 in calcium-magnesium taste. Physiol Genomics (2008) 1.09
Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. EMBO J (2002) 1.08
Umami taste in mice uses multiple receptors and transduction pathways. J Physiol (2011) 1.06
Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Hum Mol Genet (2008) 1.05
Making sense with TRP channels: store-operated calcium entry and the ion channel Trpm5 in taste receptor cells. Cell Calcium (2003) 1.05
The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions. FASEB J (2007) 1.04
Multiple receptors underlie glutamate taste responses in mice. Am J Clin Nutr (2009) 1.03
Naltrexone attenuates cue- but not drug-induced methamphetamine seeking: a possible mechanism for the dissociation of primary and secondary reward. Brain Res (2004) 1.01
Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences. J Comp Neurol (2009) 1.01