| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
|
2
|
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
|
Nat Genet
|
2010
|
6.66
|
|
3
|
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
|
Diabetes
|
2010
|
4.07
|
|
4
|
Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study.
|
Circulation
|
2003
|
3.49
|
|
5
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
|
6
|
Uric acid and the development of hypertension: the normative aging study.
|
Hypertension
|
2006
|
2.45
|
|
7
|
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.
|
Diabetes
|
2010
|
2.44
|
|
8
|
Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function.
|
Endocrinology
|
2014
|
2.17
|
|
9
|
Ala92 type 2 deiodinase allele increases risk for the development of hypertension.
|
Hypertension
|
2007
|
1.98
|
|
10
|
Exercise training versus propranolol in the treatment of the postural orthostatic tachycardia syndrome.
|
Hypertension
|
2011
|
1.85
|
|
11
|
A comparison of the aldosterone-blocking agents eplerenone and spironolactone.
|
Clin Cardiol
|
2008
|
1.85
|
|
12
|
Body mass index predicts aldosterone production in normotensive adults on a high-salt diet.
|
J Clin Endocrinol Metab
|
2007
|
1.78
|
|
13
|
Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines.
|
Circulation
|
2008
|
1.73
|
|
14
|
Inflammation and hypertension: the interplay of interleukin-6, dietary sodium, and the renin-angiotensin system in humans.
|
Am J Hypertens
|
2011
|
1.72
|
|
15
|
Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension.
|
Hypertension
|
2006
|
1.72
|
|
16
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
|
17
|
50th anniversary of aldosterone.
|
J Clin Endocrinol Metab
|
2003
|
1.70
|
|
18
|
Effect of acute aldosterone administration on gene expression profile in the heart.
|
Endocrinology
|
2006
|
1.58
|
|
19
|
A double-blind, randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism.
|
J Hypertens
|
2011
|
1.57
|
|
20
|
Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes.
|
Clin J Am Soc Nephrol
|
2006
|
1.56
|
|
21
|
Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone.
|
Hypertension
|
2013
|
1.55
|
|
22
|
Aldosterone--villain or bystander?
|
N Engl J Med
|
2004
|
1.49
|
|
23
|
Effects of estradiol and the angiotensin II receptor blocker irbesartan on vascular function in postmenopausal women.
|
Menopause
|
2008
|
1.49
|
|
24
|
Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus.
|
Endocrinology
|
2006
|
1.34
|
|
25
|
Controlled analysis of blood pressure sensitivity to sodium intake: interactions with hypertension type.
|
J Hypertens
|
2003
|
1.34
|
|
26
|
Uric acid and the state of the intrarenal renin-angiotensin system in humans.
|
Kidney Int
|
2004
|
1.24
|
|
27
|
Genetics of human hypertension.
|
Trends Endocrinol Metab
|
2005
|
1.23
|
|
28
|
Aldosterone production and insulin resistance in healthy adults.
|
J Clin Endocrinol Metab
|
2010
|
1.23
|
|
29
|
Cortisol circadian rhythm alterations in psychotic major depression.
|
Biol Psychiatry
|
2006
|
1.20
|
|
30
|
Diurnal variation of aldosterone and plasma renin activity: timing relation to melatonin and cortisol and consistency after prolonged bed rest.
|
J Appl Physiol (1985)
|
2003
|
1.14
|
|
31
|
A mechanism for salt-sensitive hypertension: abnormal dietary sodium-mediated vascular response to angiotensin-II.
|
J Hypertens
|
2010
|
1.12
|
|
32
|
Rosiglitazone improves insulin sensitivity and lowers blood pressure in hypertensive patients.
|
Diabetes Care
|
2003
|
1.11
|
|
33
|
Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice.
|
Am J Physiol Heart Circ Physiol
|
2008
|
1.11
|
|
34
|
Cardiac damage prevention by eplerenone: comparison with low sodium diet or potassium loading.
|
Hypertension
|
2002
|
1.10
|
|
35
|
Thyroid function and blood pressure homeostasis in euthyroid subjects.
|
J Clin Endocrinol Metab
|
2004
|
1.09
|
|
36
|
Insulin induces renal vasodilation, increases plasma renin activity, and sensitizes the renal vasculature to angiotensin receptor blockade in healthy subjects.
|
J Am Soc Nephrol
|
2007
|
1.07
|
|
37
|
Menstrual cycle affects renal-adrenal and hemodynamic responses during prolonged standing in the postural orthostatic tachycardia syndrome.
|
Hypertension
|
2010
|
1.06
|
|
38
|
Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus.
|
Kidney Int
|
2003
|
1.06
|
|
39
|
Low-salt diet increases insulin resistance in healthy subjects.
|
Metabolism
|
2010
|
1.06
|
|
40
|
Genetic determinants of nonmodulating hypertension.
|
Hypertension
|
2003
|
1.06
|
|
41
|
Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice.
|
Am J Physiol Heart Circ Physiol
|
2010
|
1.05
|
|
42
|
The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians.
|
Clin Endocrinol (Oxf)
|
2011
|
1.03
|
|
43
|
Renal perfusion in blacks: alterations caused by insuppressibility of intrarenal renin with salt.
|
Hypertension
|
2002
|
1.03
|
|
44
|
Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II.
|
Endocrinology
|
2010
|
1.03
|
|
45
|
Plasma aldosterone concentration in the patient with diabetes mellitus.
|
Kidney Int
|
2004
|
0.98
|
|
46
|
Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension.
|
J Clin Endocrinol Metab
|
2011
|
0.98
|
|
47
|
Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension.
|
J Clin Endocrinol Metab
|
2007
|
0.98
|
|
48
|
Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes.
|
J Hypertens
|
2010
|
0.97
|
|
49
|
The influence of body mass index and renin-angiotensin-aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men.
|
Eur J Endocrinol
|
2011
|
0.97
|
|
50
|
C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.
|
Atherosclerosis
|
2007
|
0.96
|
|
51
|
Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice.
|
J Pharmacol Exp Ther
|
2013
|
0.95
|
|
52
|
Abnormal aldosterone physiology and cardiometabolic risk factors.
|
Hypertension
|
2013
|
0.95
|
|
53
|
Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension.
|
Am J Physiol Heart Circ Physiol
|
2011
|
0.94
|
|
54
|
Low-renin hypertension, altered sodium homeostasis, and an alpha-adducin polymorphism.
|
Hypertension
|
2002
|
0.93
|
|
55
|
Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertension.
|
Circulation
|
2002
|
0.93
|
|
56
|
Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses.
|
J Renin Angiotensin Aldosterone Syst
|
2011
|
0.92
|
|
57
|
Process irregularity of cortisol and adrenocorticotropin secretion in men with major depressive disorder.
|
Psychoneuroendocrinology
|
2004
|
0.90
|
|
58
|
Aldosterone dysregulation with aging predicts renal vascular function and cardiovascular risk.
|
Hypertension
|
2014
|
0.88
|
|
59
|
The association of plasma resistin with dietary sodium manipulation, the renin-angiotensin-aldosterone system, and 25-hydroxyvitamin D3 in human hypertension.
|
Clin Endocrinol (Oxf)
|
2011
|
0.87
|
|
60
|
Activation of the mineralocorticoid receptor increases striatin levels.
|
Am J Hypertens
|
2011
|
0.87
|
|
61
|
Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension.
|
Am J Hypertens
|
2012
|
0.87
|
|
62
|
Cell membrane-associated mineralocorticoid receptors? New evidence.
|
Hypertension
|
2011
|
0.86
|
|
63
|
Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity.
|
J Am Soc Nephrol
|
2002
|
0.86
|
|
64
|
Effects of conjugated oestrogen and droloxifene on the renin-angiotensin system, blood pressure and renal blood flow in postmenopausal women.
|
Clin Endocrinol (Oxf)
|
2004
|
0.86
|
|
65
|
Simulated microgravity induces microvolt T wave alternans.
|
Ann Noninvasive Electrocardiol
|
2005
|
0.86
|
|
66
|
Why is orthostatic tolerance lower in women than in men? Renal and cardiovascular responses to simulated microgravity and the role of midodrine.
|
J Investig Med
|
2006
|
0.86
|
|
67
|
The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics study.
|
J Clin Endocrinol Metab
|
2010
|
0.86
|
|
68
|
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
|
Diabetes
|
2012
|
0.86
|
|
69
|
Rationale for the use of aldosterone antagonists in congestive heart failure.
|
Drugs
|
2002
|
0.85
|
|
70
|
Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized rats.
|
J Endocrinol
|
2008
|
0.85
|
|
71
|
Aggregation of high-normal thyroid-stimulating hormone in hypertensive families.
|
J Clin Endocrinol Metab
|
2005
|
0.84
|
|
72
|
Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart.
|
J Endocrinol
|
2011
|
0.84
|
|
73
|
Nonmodulation as the mechanism for salt sensitivity of blood pressure in individuals with hypertension and type 2 diabetes mellitus.
|
J Clin Endocrinol Metab
|
2012
|
0.84
|
|
74
|
The mineralocorticoid receptor agonist, fludrocortisone, differentially inhibits pituitary-adrenal activity in humans with psychotic major depression.
|
Psychoneuroendocrinology
|
2012
|
0.84
|
|
75
|
Acute angiotensin II increases plasma F2-isoprostanes in salt-replete human hypertensives.
|
Free Radic Biol Med
|
2003
|
0.84
|
|
76
|
Familial aggregation of insulin resistance and cardiovascular risk factors in hypertension.
|
J Clin Hypertens (Greenwich)
|
2006
|
0.84
|
|
77
|
Sex differences in the genetic basis of morning serum cortisol levels: genome-wide screen identifies two novel loci specific to women.
|
J Clin Endocrinol Metab
|
2005
|
0.83
|
|
78
|
Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization.
|
Am J Physiol Heart Circ Physiol
|
2011
|
0.83
|
|
79
|
Direct renin inhibition modulates insulin resistance in caveolin-1-deficient mice.
|
Metabolism
|
2012
|
0.83
|
|
80
|
The association of the angiotensinogen gene with insulin sensitivity in humans: a tagging single nucleotide polymorphism and haplotype approach.
|
Metabolism
|
2011
|
0.83
|
|
81
|
Nonmodulation and essential hypertension.
|
Curr Hypertens Rep
|
2006
|
0.82
|
|
82
|
Hypertriglyceridemia but not diabetes status is associated with VLDL containing apolipoprotein CIII in patients with coronary heart disease.
|
Atherosclerosis
|
2003
|
0.82
|
|
83
|
Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance.
|
Metabolism
|
2011
|
0.82
|
|
84
|
Familial aggregation of low-renin hypertension.
|
Hypertension
|
2002
|
0.81
|
|
85
|
Different polymorphisms of the mineralocorticoid receptor gene are associated with either glucocorticoid or mineralocorticoid levels in hypertension.
|
J Clin Endocrinol Metab
|
2012
|
0.81
|
|
86
|
Results of the Controlled ONset Verapamil INvestigation of Cardiovascular Endpoints (CONVINCE) trial by geographical region.
|
J Hypertens
|
2005
|
0.80
|
|
87
|
Angiotensinogen genotype predicts abnormal renal hemodynamics in young hypertensive patients.
|
J Hypertens
|
2008
|
0.80
|
|
88
|
Renal, endocrine, and cardiovascular responses to bed rest in male subjects on a constant diet.
|
J Investig Med
|
2004
|
0.80
|
|
89
|
Readaptation from simulated microgravity as a stimulus for improved orthostatic tolerance: role of the renal, cardioendocrine, and cardiovascular systems.
|
J Investig Med
|
2005
|
0.79
|
|
90
|
Aldosterone's mechanism of action: roles of lysine-specific demethylase 1, caveolin and striatin.
|
Curr Opin Nephrol Hypertens
|
2014
|
0.79
|
|
91
|
PAI-1 in human hypertension: relation to hypertensive groups.
|
Am J Hypertens
|
2002
|
0.78
|
|
92
|
Aldosterone: villain or protector?
|
Hypertension
|
2007
|
0.78
|
|
93
|
Altered systemic hemodynamic and baroreflex response to angiotensin II in postural tachycardia syndrome.
|
Circ Arrhythm Electrophysiol
|
2012
|
0.78
|
|
94
|
Effects of simulated microgravity on closed-loop cardiovascular regulation and orthostatic intolerance: analysis by means of system identification.
|
J Appl Physiol (1985)
|
2003
|
0.78
|
|
95
|
Cardiovascular benefits of aldosterone receptor antagonists: what about potassium?
|
Hypertension
|
2005
|
0.78
|
|
96
|
The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes.
|
Metabolism
|
2012
|
0.77
|
|
97
|
Effect of low dose mineralocorticoid receptor antagonist eplerenone on glucose and lipid metabolism in healthy adult males.
|
Metabolism
|
2012
|
0.77
|
|
98
|
Loss of sodium modulation of plasma kinins in human hypertension.
|
J Pharmacol Exp Ther
|
2004
|
0.76
|
|
99
|
Symptoms and the distress they cause: comparison of an aldosterone antagonist and a calcium channel blocking agent in patients with systolic hypertension.
|
Arch Intern Med
|
2003
|
0.76
|
|
100
|
Bed rest effects on human calf hemodynamics and orthostatic intolerance: a model-based analysis.
|
Aviat Space Environ Med
|
2005
|
0.76
|
|
101
|
Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake.
|
Age (Dordr)
|
2012
|
0.75
|
|
102
|
Correlation of glycyrrhetinic acid-like factors (kidney 11beta-HSD2-GALFs) with urinary free cortisol and plasma renin activity in essential hypertension.
|
J Am Soc Hypertens
|
2008
|
0.75
|
|
103
|
Sleep restriction does not affect orthostatic tolerance in the simulated microgravity environment.
|
J Appl Physiol (1985)
|
2004
|
0.75
|
|
104
|
OS 19-03 TREATMENT WITH PATIROMER RESULTED IN DECREASES IN ALDOSTERONE IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HYPERKALEMIA ON RAAS INHIBITORS: RESULTS FROM OPAL-HK.
|
J Hypertens
|
2016
|
0.75
|
|
105
|
OS 19-03 TREATMENT WITH PATIROMER RESULTED IN DECREASES IN ALDOSTERONE IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HYPERKALEMIA ON RAAS INHIBITORS: RESULTS FROM OPAL-HK.
|
J Hypertens
|
2016
|
0.75
|
|
106
|
Education for physician clinical researchers: should one size fit all?
|
Clin Transl Sci
|
2010
|
0.75
|
|
107
|
Mineralocorticoid receptor antagonists and hypertension: is there a rationale?
|
Curr Hypertens Rep
|
2004
|
0.75
|