Published in Diabetes on February 25, 2010
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci (2010) 3.09
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes (2013) 2.70
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat Genet (2012) 2.55
Polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes (2014) 2.52
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab (2010) 2.21
Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes (2012) 1.78
SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion. Diabetologia (2012) 1.54
Differentiated human stem cells resemble fetal, not adult, β cells. Proc Natl Acad Sci U S A (2014) 1.44
Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes (2011) 1.31
Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity. Diabetes (2014) 1.26
Physiologic characterization of type 2 diabetes-related loci. Curr Diab Rep (2010) 1.24
Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese. PLoS One (2010) 1.23
Genetics of type 2 diabetes-pitfalls and possibilities. Genes (Basel) (2015) 1.16
Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C. J Lipid Res (2012) 1.04
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors. PLoS Genet (2015) 1.03
Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes. J Clin Invest (2011) 1.03
Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study. PLoS One (2010) 1.03
Factor structure underlying components of allostatic load. PLoS One (2012) 1.03
Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PLoS One (2013) 1.02
Pleiotropic genes for metabolic syndrome and inflammation. Mol Genet Metab (2014) 1.01
A central role for GRB10 in regulation of islet function in man. PLoS Genet (2014) 1.01
Exome sequencing and genetic testing for MODY. PLoS One (2012) 1.00
Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men. Diabetes (2011) 0.99
Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin. PLoS One (2011) 0.98
Recent advances in the molecular genetics of type 2 diabetes mellitus. World J Diabetes (2014) 0.97
Susceptibility to type 2 diabetes mellitus--from genes to prevention. Nat Rev Endocrinol (2014) 0.94
Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals. Diabetologia (2013) 0.93
Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose. Curr Diab Rep (2013) 0.92
G6PC2: a negative regulator of basal glucose-stimulated insulin secretion. Diabetes (2012) 0.92
Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp. PLoS One (2012) 0.92
Limitations in surrogate measures of insulin resistance. J Clin Endocrinol Metab (2010) 0.91
The architecture of risk for type 2 diabetes: understanding Asia in the context of global findings. Int J Endocrinol (2014) 0.91
Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism. Diabetologia (2011) 0.91
Interactions between genetic background, insulin resistance and β-cell function. Diabetes Obes Metab (2012) 0.90
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest (2015) 0.90
Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance. Diabetologia (2013) 0.89
The genetics of insulin resistance: Where's Waldo? Curr Diab Rep (2010) 0.89
Genetics of type 2 diabetes in European populations. J Diabetes (2012) 0.89
Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats. Physiol Genomics (2012) 0.87
Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program. PLoS One (2012) 0.87
Association between genetics of diabetes, coronary artery disease, and macrovascular complications: exploring a common ground hypothesis. Rev Diabet Stud (2011) 0.87
Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children. PLoS One (2011) 0.86
TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes. Diabetes (2015) 0.85
HOMA and Matsuda indices of insulin sensitivity: poor correlation with minimal model-based estimates of insulin sensitivity in longitudinal settings. Diabetologia (2013) 0.85
Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice. Diabetologia (2013) 0.84
A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity. Obesity (Silver Spring) (2015) 0.84
What will diabetes genomes tell us? Curr Diab Rep (2012) 0.84
Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits. Genome Biol (2013) 0.83
Prevention of type 2 diabetes: the strategic approach for implementation. Horm Metab Res (2011) 0.83
A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta Diabetol (2013) 0.83
Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses. Hum Mol Genet (2012) 0.82
The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function. J Clin Endocrinol Metab (2014) 0.82
Fatty Acid desaturase gene polymorphisms and metabolic measures in schizophrenia and bipolar patients taking antipsychotics. Cardiovasc Psychiatry Neurol (2013) 0.82
Deeper, longer phenotyping to accelerate the discovery of the genetic architectures of diseases. Genome Biol (2014) 0.82
A fasting insulin-raising allele at IGF1 locus is associated with circulating levels of IGF-1 and insulin sensitivity. PLoS One (2013) 0.82
Type 2 diabetes: genetic data sharing to advance complex disease research. Nat Rev Genet (2016) 0.82
Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study. Nutr Metab (Lond) (2011) 0.81
Adaptive selection of an incretin gene in Eurasian populations. Genome Res (2010) 0.81
The rs340874 PROX1 type 2 diabetes mellitus risk variant is associated with visceral fat accumulation and alterations in postprandial glucose and lipid metabolism. Genes Nutr (2015) 0.81
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun (2014) 0.81
Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque. Diabetes Metab Syndr Obes (2016) 0.80
A tale of two glucose transporters: how GLUT2 re-emerged as a contender for glucose transport into the human beta cell. Diabetologia (2012) 0.80
The pancreatic β cell: recent insights from human genetics. Trends Endocrinol Metab (2014) 0.80
Association of African genetic ancestry with fasting glucose and HbA1c levels in non-diabetic individuals: the Boston Area Community Health (BACH) Prediabetes Study. Diabetologia (2014) 0.80
Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans. Diabetologia (2014) 0.80
Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes. Diabetes Care (2013) 0.79
Identification of metabolic modifiers that underlie phenotypic variations in energy-balance regulation. Diabetes (2011) 0.79
The heritability of beta cell function parameters in a mixed meal test design. Diabetologia (2011) 0.79
Genetic basis of a cognitive complexity metric. PLoS One (2015) 0.79
Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev (2016) 0.78
Genetics of Insulin Resistance and the Metabolic Syndrome. Curr Cardiol Rep (2016) 0.78
IG20/MADD plays a critical role in glucose-induced insulin secretion. Diabetes (2013) 0.78
FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome. Sci Rep (2016) 0.77
Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants. Diabetes (2015) 0.77
G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance. Endocrinology (2016) 0.76
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. Diabetes (2016) 0.76
Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal women. BMC Cancer (2017) 0.75
Effects of G6pc2 deletion on body weight and cholesterol in mice. J Mol Endocrinol (2017) 0.75
Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice. Am J Physiol Endocrinol Metab (2016) 0.75
The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents. J Lipid Res (2015) 0.75
From genotype to human β cell phenotype and beyond. Islets (2012) 0.75
Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology. F1000Res (2016) 0.75
Assessment of the environmental and genetic factors influencing prevalence of metabolic syndrome in Saudi Arabia. Saudi Med J (2016) 0.75
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases. J Lipid Res (2017) 0.75
Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells. Diabetes (2015) 0.75
Gene Editing and Human Pluripotent Stem Cells: Tools for Advancing Diabetes Disease Modeling and Beta-Cell Development. Curr Diab Rep (2017) 0.75
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A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia (2003) 7.88
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet (2008) 5.23
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet (2008) 4.84
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Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet (2006) 4.13
In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci (2006) 3.82
Diabetes mellitus and genetically programmed defects in beta-cell function. Nature (2001) 3.51
Validation of the insulin sensitivity index (ISI(0,120)): comparison with other measures. Diabetes Res Clin Pract (2000) 3.13
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum Mol Genet (2009) 3.07
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Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes (2009) 2.92
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Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia (2008) 2.57
A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet (2006) 2.44
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Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J (2009) 1.64
Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes (2001) 1.51
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Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS One (2008) 1.40
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