PubRank

Shane J O'Neill

Author PubWeight™ 50.13‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis. Am J Respir Crit Care Med 2011 2.37
2 Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes. Am J Respir Crit Care Med 2014 2.14
3 Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis. N Engl J Med 2012 1.93
4 Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant. Chest 2004 1.88
5 Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease. Am J Respir Crit Care Med 2009 1.86
6 Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosis. Am J Respir Crit Care Med 2005 1.57
7 Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency. J Immunol 2004 1.53
8 Alpha-1 antitrypsin deficiency. Respir Med 2010 1.51
9 miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α1-antitrypsin deficiency. Am J Respir Crit Care Med 2014 1.46
10 Extubation versus tracheostomy in withdrawal of treatment-ethical, clinical, and legal perspectives. J Crit Care 2009 1.44
11 Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4. FEBS Lett 2003 1.38
12 α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. J Clin Invest 2010 1.38
13 miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression. J Immunol 2010 1.38
14 Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. Respir Res 2007 1.31
15 Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis. J Infect Dis 2004 1.25
16 LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline. J Immunol 2009 1.22
17 Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. J Biol Chem 2008 1.20
18 Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells. Infect Immun 2004 1.20
19 Antimicrobial proteins and polypeptides in pulmonary innate defence. Respir Res 2006 1.18
20 Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease. Am J Respir Crit Care Med 2005 1.18
21 Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression. J Immunol 2007 1.17
22 Sputum Candida albicans presages FEV₁ decline and hospital-treated exacerbations in cystic fibrosis. Chest 2010 1.09
23 17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor. Am J Respir Crit Care Med 2010 1.08
24 Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis. Blood 2002 1.06
25 Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiency. J Immunol 2010 1.05
26 Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis. J Biol Chem 2008 1.03
27 Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency. J Biol Chem 2009 1.01
28 Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway. J Biol Chem 2006 1.00
29 Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad. Hepatology 2007 0.95
30 Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia? Respirology 2009 0.94
31 Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis. J Inflamm Res 2013 0.91
32 IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J Immunol 2009 0.91
33 Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways. J Immunol 2011 0.89
34 Inhibition of Toll-like receptor 2-mediated interleukin-8 production in Cystic Fibrosis airway epithelial cells via the alpha7-nicotinic acetylcholine receptor. Mediators Inflamm 2010 0.88
35 Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases. Biol Chem 2010 0.88
36 Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression. J Biol Chem 2007 0.86
37 Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung. Pulm Med 2011 0.82
38 Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor. Cell Microbiol 2006 0.80
39 Intracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease. Biomed Res Int 2013 0.79
40 Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells. J Immunol 2005 0.79
41 Lung involvement at presentation predicts disease activity and permanent organ damage at 6, 12 and 24 months follow - up in ANCA - associated vasculitis. BMC Immunol 2014 0.77
42 Delayed radiotherapy-related effusions: malignant or not malignant, that is the question? Respirology 2008 0.75
43 Alpha-1 antitrypsin deficiency and computed tomography findings. J Comput Assist Tomogr 2005 0.75