Published in Respir Res on February 17, 2006
Epidemic influenza and vitamin D. Epidemiol Infect (2006) 5.32
Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells (2010) 2.72
Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med (2013) 2.60
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases. Pharmacol Rev (2010) 1.97
Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med (2008) 1.44
Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol (2010) 1.34
The impact of successive infections on the lung microenvironment. Immunology (2007) 1.21
Evidence for limited genetic compartmentalization of HIV-1 between lung and blood. PLoS One (2009) 1.09
Role of the lysozyme inhibitor Ivy in growth or survival of Escherichia coli and Pseudomonas aeruginosa bacteria in hen egg white and in human saliva and breast milk. Appl Environ Microbiol (2008) 1.05
Cathelicidins: family of antimicrobial peptides. A review. Mol Biol Rep (2012) 1.02
Decreased expression of intelectin 1 in the human airway epithelium of smokers compared to nonsmokers. J Immunol (2008) 1.01
Inhaled innate immune ligands to prevent pneumonia. Br J Pharmacol (2011) 0.97
Airway hydration and COPD. Cell Mol Life Sci (2015) 0.94
Inhaled therapeutics for prevention and treatment of pneumonia. Expert Opin Drug Saf (2009) 0.89
Alcohol use disorders affect antimicrobial proteins and anti-pneumococcal activity in epithelial lining fluid obtained via bronchoalveolar lavage. Alcohol Alcohol (2010) 0.85
Antiproteases as therapeutics to target inflammation in cystic fibrosis. Open Respir Med J (2010) 0.84
Innate immune responses of pulmonary epithelial cells to Burkholderia pseudomallei infection. PLoS One (2009) 0.84
Importance of bacterial replication and alveolar macrophage-independent clearance mechanisms during early lung infection with Streptococcus pneumoniae. Infect Immun (2015) 0.80
Oral administration of iron-saturated bovine lactoferrin-loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism. Int J Nanomedicine (2015) 0.79
Airway clearance techniques to treat acute respiratory disorders in previously healthy children: where is the evidence? Eur J Pediatr (2008) 0.78
Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia. Respir Res (2010) 0.77
Suppression of antimicrobial peptide expression by ureaplasma species. Infect Immun (2014) 0.77
Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities. Front Immunol (2016) 0.77
Lung Microbiota and Its Impact on the Mucosal Immune Phenotype. Microbiol Spectr (2017) 0.75
Nicotinic alpha 7 receptor expression and modulation of the lung epithelial response to lipopolysaccharide. PLoS One (2017) 0.75
Black cobra (Naja naja karachiensis) lysates exhibit broad-spectrum antimicrobial activities. Pathog Glob Health (2014) 0.75
Validation of antibody reagents for mucin analysis in chronic inflammatory airway diseases. MAbs (2016) 0.75
Bacterial biofilms: a common cause of persistent infections. Science (1999) 40.82
Neutrophil extracellular traps kill bacteria. Science (2004) 23.64
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J Biol Chem (2000) 6.19
A component of innate immunity prevents bacterial biofilm development. Nature (2002) 4.73
A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science (1999) 3.90
Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85
A bactericidal effect for human lactoferrin. Science (1977) 3.73
Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood (2001) 3.49
Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett (1995) 3.21
The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood (2000) 3.09
Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J Biol Chem (1996) 2.78
Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol (2000) 2.66
Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol (2000) 2.66
Biofilm resistance to antimicrobial agents. Microbiology (2000) 2.66
Surfactant proteins a and d and pulmonary host defense. Annu Rev Physiol (2001) 2.61
The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol (2002) 2.57
Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am J Physiol Lung Cell Mol Physiol (2000) 2.55
Killing of gram-negative bacteria by lactoferrin and lysozyme. J Clin Invest (1991) 2.54
Antibacterial activity of antileukoprotease. Infect Immun (1996) 2.48
Inhibition of human immunodeficiency virus type 1 infectivity by secretory leukocyte protease inhibitor occurs prior to viral reverse transcription. Blood (1997) 2.41
Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. Science (1997) 2.38
Defensins and other endogenous peptide antibiotics of vertebrates. J Leukoc Biol (1995) 2.25
Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun (1999) 2.19
Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol (2002) 2.17
Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. J Infect Dis (1995) 2.16
The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils. Blood (1997) 2.16
The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung. J Clin Invest (2002) 2.13
The lactoperoxidase system functions in bacterial clearance of airways. Am J Respir Cell Mol Biol (2000) 2.08
Activity of abundant antimicrobials of the human airway. Am J Respir Cell Mol Biol (1999) 1.93
Cathelicidins--a family of multifunctional antimicrobial peptides. Cell Mol Life Sci (2003) 1.89
CD14-dependent lipopolysaccharide-induced beta-defensin-2 expression in human tracheobronchial epithelium. J Biol Chem (2000) 1.89
Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol (1994) 1.88
Collectins and pulmonary innate immunity. Immunol Rev (2000) 1.68
Lower respiratory tract lactoferrin and lysozyme arise primarily in the airways and are elevated in association with chronic bronchitis. J Lab Clin Med (1990) 1.67
Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding. J Exp Med (2005) 1.65
Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis: inhibition by chitin oligosaccharides. Infect Immun (1985) 1.64
Cationic polypeptides are required for antibacterial activity of human airway fluid. J Immunol (2002) 1.58
Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I. Oral Dis (1997) 1.58
Lactoperoxidase and human airway host defense. Am J Respir Cell Mol Biol (2003) 1.57
Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process. Clin Chem Lab Med (1999) 1.55
Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents. Blood (2000) 1.54
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. J Biol Chem (2002) 1.53
Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. J Clin Invest (1999) 1.50
Role of the bactericidal/permeability-increasing protein in host defence. Curr Opin Immunol (1998) 1.49
Lysozyme secretion by submucosal glands protects the airway from bacterial infection. Am J Respir Cell Mol Biol (2005) 1.49
Lactoferrin-catalysed hydroxyl radical production. Additional requirement for a chelating agent. Biochem J (1983) 1.47
Expression of the secretory leukoprotease inhibitor gene in epithelial cells. J Clin Invest (1991) 1.37
Defensins are mitogenic for epithelial cells and fibroblasts. J Cell Physiol (1993) 1.35
Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19. Eur J Immunol (2001) 1.33
Bacterial killing is enhanced by expression of lysozyme in the lungs of transgenic mice. J Immunol (2000) 1.32
Anti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor. J Clin Invest (1991) 1.31
Kinetics of the inhibition of leukocyte elastase by the bronchial inhibitor. Biochim Biophys Acta (1982) 1.31
The effect of human serum transferrin and milk lactoferrin on hydroxyl radical formation from superoxide and hydrogen peroxide. J Biol Chem (1984) 1.31
Human neutrophil defensins induce lung epithelial cell proliferation in vitro. J Leukoc Biol (2002) 1.30
Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor. J Biol Chem (2001) 1.30
Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. Protein Sci (2001) 1.29
Pseudomonas aeruginosa elastase degrades surfactant proteins A and D. Am J Respir Cell Mol Biol (2003) 1.28
CCL20 is an inducible product of human airway epithelia with innate immune properties. Am J Respir Cell Mol Biol (2003) 1.28
Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis. J Infect Dis (2004) 1.25
Inhibition of NF-kappaB activation and augmentation of IkappaBbeta by secretory leukocyte protease inhibitor during lung inflammation. Am J Pathol (1999) 1.23
Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide. Respir Res (2005) 1.21
Degradation of pulmonary surfactant protein D by Pseudomonas aeruginosa elastase abrogates innate immune function. J Biol Chem (2004) 1.19
The biology of transferrin. Clin Chim Acta (1990) 1.19
Lipopolysaccharide-related stimuli induce expression of the secretory leukocyte protease inhibitor, a macrophage-derived lipopolysaccharide inhibitor. Infect Immun (1998) 1.16
Distribution of lysozyme and mucin (MUC2 and MUC3) mRNA in human bronchus. Exp Lung Res (1995) 1.15
Macrophage-independent fungicidal action of the pulmonary collectins. J Biol Chem (2003) 1.13
The protective effects of lactoferrin feeding against endotoxin lethal shock in germfree piglets. Infect Immun (1998) 1.09
Localization and release of lysozyme from ferret trachea: effects of adrenergic and cholinergic drugs. Cell Tissue Res (1983) 1.08
Secretory leukocyte protease inhibitor in mice regulates local and remote organ inflammatory injury induced by hepatic ischemia/reperfusion. Gastroenterology (1999) 1.08
The roles of surfactant proteins A and D in innate immunity. Immunol Rev (2000) 1.08
The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense. J Leukoc Biol (1998) 1.06
Human macrophage inflammatory protein-3alpha/CCL20/LARC/Exodus/SCYA20 is transcriptionally upregulated by tumor necrosis factor-alpha via a non-standard NF-kappaB site. FEBS Lett (2001) 1.06
Antibacterial proteins of granulocytes differ in interaction with endotoxin. Comparison of bactericidal/permeability-increasing protein, p15s, and defensins. J Immunol (1995) 1.05
Modulation of in vitro fungicidal activity of human lactoferrin against Candida albicans by extracellular cation concentration and target cell metabolic activity. Antimicrob Agents Chemother (2004) 1.03
Inhibition of Candida albicans by the Peroxidase/SCN-/H2O2 system. Oral Microbiol Immunol (1992) 1.01
Surfactant protein A and other bronchoalveolar lavage fluid proteins are altered in cystic fibrosis. Eur Respir J (2001) 0.99
Distribution of secretory leukoprotease inhibitor in the human nasal airway. Am Rev Respir Dis (1993) 0.98
Saliva can contribute in quick inhibition of HIV infectivity. AIDS (1991) 0.98
Ultrastructural localisation of lactoferrin and glycoprotein in human bronchial glands. Thorax (1981) 0.98
Surfactant protein A binds Mycoplasma pneumoniae with high affinity and attenuates its growth by recognition of disaturated phosphatidylglycerols. J Biol Chem (2004) 0.97
Local impairment of anti-neutrophil elastase capacity in community-acquired pneumonia. J Infect Dis (2003) 0.95
Lactoferrin. Antiviral activity of lactoferrin. Adv Exp Med Biol (1998) 0.94
The effect of human lactoferrin on the MICs of doxycycline and rifampicin for Burkholderia cepacia and Pseudomonas aeruginosa strains. J Antimicrob Chemother (1999) 0.92
Lactoferrin inhibits hepatitis B virus infection in cultured human hepatocytes. Hepatol Res (2002) 0.91
Lactoferrin, a potent tryptase inhibitor, abolishes late-phase airway responses in allergic sheep. Am J Respir Crit Care Med (1997) 0.89
Virucidal effects of glucose oxidase and peroxidase or their protein conjugates on human immunodeficiency virus type 1. Antimicrob Agents Chemother (1993) 0.89
Lactoferrin inhibits the lipopolysaccharide-induced expression and proteoglycan-binding ability of interleukin-8 in human endothelial cells. Infect Immun (2002) 0.88
Lactoferrin binds CpG-containing oligonucleotides and inhibits their immunostimulatory effects on human B cells. J Immunol (2001) 0.88
House dust mite Der p 1 downregulates defenses of the lung by inactivating elastase inhibitors. Am J Respir Cell Mol Biol (2003) 0.87
Holocrine secretion of calprotectin: a neutrophil-mediated defense against Candida albicans? J Lab Clin Med (1993) 0.86
Lactoferrin increases the susceptibility of S. epidermidis biofilms to lysozyme and vancomycin. Curr Eye Res (1999) 0.86
Lysozyme: a major secretory product of a human colon carcinoma cell line. Biochemistry (1985) 0.85
The therapeutic potential of lactoferrin. Expert Opin Investig Drugs (2003) 0.83
Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice. J Med Microbiol (2005) 0.82
Analysis of secretory leukocyte protease inhibitor (SLPI) in bronchial secretions from patients with hypersecretory respiratory diseases. Tokushima J Exp Med (1993) 0.81
Inactivation of yeast and filamentous fungi by the lactoperoxidase-hydrogen peroxide-thiocyanate-system. Nahrung (1997) 0.81
Technology evaluation: rh lactoferrin, Agennix. Curr Opin Mol Ther (2004) 0.77
The serine proteinase inhibitory proteins of the human intervertebral disc: their isolation, characterization and variation with ageing and degeneration. Matrix (1992) 0.77
Effects of delmopinol on antimicrobial peroxidase systems and lysozyme in vitro and in human whole saliva. Eur J Oral Sci (1995) 0.76
Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results. Hum Gene Ther (2011) 2.75
Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med (2009) 2.52
Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis. Am J Respir Crit Care Med (2011) 2.37
Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes. Am J Respir Crit Care Med (2014) 2.14
Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis. N Engl J Med (2012) 1.93
Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant. Chest (2004) 1.88
Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease. Am J Respir Crit Care Med (2009) 1.86
TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. J Immunol (2005) 1.67
Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding. J Exp Med (2005) 1.65
Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosis. Am J Respir Crit Care Med (2005) 1.57
Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency. J Immunol (2004) 1.53
Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination. J Biol Chem (2002) 1.52
Alpha-1 antitrypsin deficiency. Respir Med (2010) 1.51
Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α. Mol Cell (2011) 1.48
miR-199a-5p silencing regulates the unfolded protein response in chronic obstructive pulmonary disease and α1-antitrypsin deficiency. Am J Respir Crit Care Med (2014) 1.46
α1-Antitrypsin activates protein phosphatase 2A to counter lung inflammatory responses. Am J Respir Crit Care Med (2014) 1.45
miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production. Am J Respir Crit Care Med (2014) 1.45
Extubation versus tracheostomy in withdrawal of treatment-ethical, clinical, and legal perspectives. J Crit Care (2009) 1.44
Adult-onset nemaline myopathy presenting as respiratory failure. Respir Care (2008) 1.40
Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4. FEBS Lett (2003) 1.38
α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. J Clin Invest (2010) 1.38
miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression. J Immunol (2010) 1.38
Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. Respir Res (2007) 1.31
Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis. J Infect Dis (2004) 1.25
MicroRNAs in inflammatory lung disease--master regulators or target practice? Respir Res (2010) 1.24
Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins. J Immunol (2003) 1.24
LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline. J Immunol (2009) 1.22
Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide. Respir Res (2005) 1.21
Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. J Biol Chem (2008) 1.20
Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression. J Clin Invest (2013) 1.20
Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells. Infect Immun (2004) 1.20
Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery. Br J Pharmacol (2009) 1.18
Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease. Am J Respir Crit Care Med (2005) 1.18
Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression. J Immunol (2007) 1.17
SLPI and elafin: multifunctional antiproteases of the WFDC family. Biochem Soc Trans (2011) 1.12
Toll-like receptor expression and function in airway epithelial cells. Arch Immunol Ther Exp (Warsz) (2005) 1.09
Sputum Candida albicans presages FEV₁ decline and hospital-treated exacerbations in cystic fibrosis. Chest (2010) 1.09
17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor. Am J Respir Crit Care Med (2010) 1.08
Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation. J Immunol (2009) 1.07
Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis. Blood (2002) 1.06
Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiency. J Immunol (2010) 1.05
Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis. J Biol Chem (2008) 1.03