Published in Autophagy on March 01, 2010
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol (2012) 3.90
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. J Neurosci (2010) 2.05
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron (2013) 1.70
The genetics and neuropathology of frontotemporal lobar degeneration. Acta Neuropathol (2012) 1.42
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis. J Cell Sci (2014) 1.32
AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization. Proc Natl Acad Sci U S A (2012) 1.22
The complexities of p97 function in health and disease. Mol Biosyst (2010) 1.17
Retracted Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH. J Biol Chem (2013) 1.16
Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken. Acta Neuropathol (2015) 0.94
Structure and function of the AAA+ ATPase p97/Cdc48p. Gene (2016) 0.94
Role of p97/VCP (Cdc48) in genome stability. Front Genet (2013) 0.94
Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase. J Biol Chem (2013) 0.93
Sporadic inclusion body myositis: new insights and potential therapy. Curr Opin Neurol (2014) 0.92
Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infection. J Virol (2012) 0.91
Valosin-containing protein and neurofibromin interact to regulate dendritic spine density. J Clin Invest (2011) 0.91
Rapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem proteinopathy. PLoS One (2015) 0.87
Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini-review. Transl Neurodegener (2013) 0.87
Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells. J Biol Chem (2013) 0.83
From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation. J Biomed Sci (2012) 0.80
Targeting p97 to Disrupt Protein Homeostasis in Cancer. Front Oncol (2016) 0.79
CDC48 function during TMV infection: regulation of virus movement and replication by degradation? Plant Signal Behav (2012) 0.79
The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97. J Biol Chem (2015) 0.78
Ongoing developments in sporadic inclusion body myositis. Curr Rheumatol Rep (2014) 0.78
Regulation of mitochondrial genome inheritance by autophagy and ubiquitin-proteasome system: implications for health, fitness, and fertility. Biomed Res Int (2014) 0.77
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation. Nat Commun (2016) 0.76
Cytokine profiling in patients with VCP-associated disease. Clin Transl Sci (2013) 0.75
Autophagy and proteasome interconnect to coordinate cross-presentation through MHC class I pathway in B cells. Immunol Cell Biol (2016) 0.75
It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin. Am J Physiol Cell Physiol (2016) 0.75
Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors. BMC Genomics (2016) 0.75
The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress. Am J Pathol (2016) 0.75
A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase. Front Mol Biosci (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature (2013) 4.03
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol (2009) 3.50
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease. J Biol Chem (2008) 1.82
Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy. Hum Mol Genet (2010) 1.75
Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations. Nat Cell Biol (2011) 1.69
Quantitation of "autophagic flux" in mature skeletal muscle. Autophagy (2010) 1.53
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43. J Biol Chem (2010) 1.47
Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy. Ann Neurol (2012) 1.35
Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1. Hum Mol Genet (2010) 1.32
Inflammatory myopathies with mitochondrial pathology and protein aggregates. J Neurol Sci (2008) 1.28
Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy (2009) 1.25
Motor neuron involvement in multisystem proteinopathy: implications for ALS. Neurology (2013) 1.08
Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones. Hum Mol Genet (2013) 0.99
Acute and bilateral blindness due to optic neuropathy associated with copper deficiency. Arch Neurol (2009) 0.96
mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy. Hum Mol Genet (2012) 0.96
A knock-in mouse model for the R120G mutation of αB-crystallin recapitulates human hereditary myopathy and cataracts. PLoS One (2011) 0.95
Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers. J Biol Chem (2014) 0.90
p62 expression and autophagy in αB-crystallin R120G mutant knock-in mouse model of hereditary cataract. Exp Eye Res (2013) 0.87
Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCP-associated myopathy. Autophagy (2013) 0.87
Mitochondrial pathology in immune and inflammatory myopathies. Curr Opin Rheumatol (2010) 0.87
Increased autophagy accelerates colchicine-induced muscle toxicity. Autophagy (2013) 0.85
An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors. Hum Mol Genet (2011) 0.84
Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function. FASEB J (2014) 0.84
In vivo kinetic approach reveals slow SOD1 turnover in the CNS. J Clin Invest (2015) 0.81
Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination. Cell Rep (2017) 0.75
Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy (2010) 0.75