PubRank

Serge Przedborski

Author PubWeight™ 181.48‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012 20.08
2 Parkinson's disease: mechanisms and models. Neuron 2003 14.84
3 PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A 2009 8.25
4 Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci 2007 7.77
5 Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 2002 4.38
6 Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 2002 4.21
7 The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A 2008 3.65
8 Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci 2009 3.24
9 Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest 2008 3.23
10 Mitochondria: the next (neurode)generation. Neuron 2011 3.06
11 Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc 2007 3.00
12 NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci U S A 2003 2.91
13 DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A 2007 2.87
14 Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proc Natl Acad Sci U S A 2003 2.74
15 Toxin-induced models of Parkinson's disease. NeuroRx 2005 2.67
16 Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proc Natl Acad Sci U S A 2002 2.64
17 Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci 2003 2.31
18 D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. J Clin Invest 2003 2.25
19 Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci 2010 2.15
20 Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proc Natl Acad Sci U S A 2006 2.10
21 CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem 2005 2.08
22 JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 2004 2.05
23 Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 2004 2.01
24 Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PLoS One 2008 1.99
25 Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med 2012 1.99
26 Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci 2008 1.92
27 The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proc Natl Acad Sci U S A 2006 1.90
28 Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 2003 1.87
29 Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia. Ann Neurol 2005 1.83
30 Genetic clues to the pathogenesis of Parkinson's disease. Nat Med 2004 1.76
31 Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. J Neurosci 2003 1.74
32 Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proc Natl Acad Sci U S A 2005 1.68
33 Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice. PLoS One 2008 1.65
34 Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS. Ann Neurol 2002 1.52
35 Classic and new animal models of Parkinson's disease. J Biomed Biotechnol 2012 1.45
36 The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proc Natl Acad Sci U S A 2009 1.43
37 Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease. Proc Natl Acad Sci U S A 2007 1.41
38 Mitophagy: the latest problem for Parkinson's disease. Trends Mol Med 2010 1.41
39 Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. J Neurosci 2005 1.40
40 Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotox Res 2009 1.35
41 Alpha-synuclein overexpression increases cytosolic catecholamine concentration. J Neurosci 2006 1.30
42 Inflammation in ALS and SMA: sorting out the good from the evil. Neurobiol Dis 2009 1.29
43 Nitric oxide and reactive oxygen species in Parkinson's disease. IUBMB Life 2003 1.26
44 Pathogenic role of glial cells in Parkinson's disease. Mov Disord 2003 1.25
45 Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis. Amyotroph Lateral Scler Frontotemporal Degener 2013 1.21
46 Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons. J Neurosci 2012 1.19
47 Fractalkine: moving from chemotaxis to neuroprotection. Nat Neurosci 2006 1.19
48 Neurodegeneration and inflammation in Parkinson's disease. Parkinsonism Relat Disord 2012 1.19
49 A tale on animal models of Parkinson's disease. Mov Disord 2011 1.18
50 Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Hum Mol Genet 2011 1.18
51 Programmed cell death in amyotrophic lateral sclerosis. J Clin Invest 2003 1.17
52 Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS. Mol Cell Neurosci 2002 1.17
53 Enriched environment confers resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: involvement of dopamine transporter and trophic factors. J Neurosci 2003 1.16
54 α-Synuclein is localized to mitochondria-associated ER membranes. J Neurosci 2014 1.13
55 Pathogenesis of Parkinson's disease. Mov Disord 2012 1.13
56 Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. J Neurosci 2004 1.13
57 Proteasome inhibition and Parkinson's disease modeling. Ann Neurol 2006 1.10
58 Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis. Sci Transl Med 2012 1.10
59 Animal models of Parkinson's disease. Parkinsonism Relat Disord 2012 1.07
60 Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode. J Biol Chem 2012 1.06
61 Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit. Neuron 2012 1.05
62 Gene dosage and pathogenesis of Parkinson's disease. Trends Mol Med 2005 1.04
63 Mutant superoxide dismutase 1 (SOD1), a cause of amyotrophic lateral sclerosis, disrupts the recruitment of SMN, the spinal muscular atrophy protein to nuclear Cajal bodies. Hum Mol Genet 2012 1.01
64 L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease. Ann Neurol 2004 1.01
65 Mitophagy and Parkinson's disease: be eaten to stay healthy. Mol Cell Neurosci 2012 0.98
66 Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy. EMBO Rep 2013 0.98
67 Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. J Neuroimmunol 2006 0.96
68 The Role of the Innate Immune System in ALS. Front Pharmacol 2012 0.95
69 Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease. J Neurochem 2003 0.95
70 Apoptosis-inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins. Ann Neurol 2010 0.94
71 Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells. J Neurosci 2006 0.93
72 What can pluripotent stem cells teach us about neurodegenerative diseases? Nat Neurosci 2010 0.93
73 PINK1/Parkin direct mitochondria to autophagy. Autophagy 2010 0.92
74 D-β-hydroxybutyrate is protective in mouse models of Huntington's disease. PLoS One 2011 0.92
75 Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. Free Radic Biol Med 2009 0.91
76 PINK1 points Parkin to mitochondria. Autophagy 2010 0.91
77 Neuroinflammation and Parkinson's disease. Handb Clin Neurol 2007 0.90
78 The rotenone model of Parkinson's disease. Trends Neurosci 2003 0.86
79 Mitophagy in cells with mtDNA mutations: being sick is not enough. Autophagy 2012 0.83
80 Glial cell response: A pathogenic factor in Parkinson's disease. J Neurovirol 2002 0.83
81 Intrabody and Parkinson's disease. Biochim Biophys Acta 2008 0.80
82 Control of mitochondrial integrity in Parkinson's disease. Prog Brain Res 2010 0.80
83 Is prostaglandin E(2) a pathogenic factor in amyotrophic lateral sclerosis? Ann Neurol 2006 0.80
84 A sequel to the tale of p25/Cdk5 in neurodegeneration. Neuron 2008 0.79
85 Randomized control trials in ALS: lessons learned. Amyotroph Lateral Scler Other Motor Neuron Disord 2004 0.77
86 Clarification: Pathogenic role of glial cells in Parkinson's disease. Mov Disord 2004 0.77
87 Is amyotrophic lateral sclerosis a mitochondrial channelopathy? Neuron 2010 0.76
88 Is there a pathogenic role for mitochondria in Parkinson's disease? Parkinsonism Relat Disord 2009 0.76
89 Peroxiredoxin-2 links Cdk5 to neurodegeneration. Nat Med 2007 0.76
90 When Schwann cells conspire with mitochondria, neighboring axons are under attack by glia-derived neurotoxic lipids. Neuron 2013 0.75