Published in J Neurochem on August 31, 2005
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75
From endoplasmic-reticulum stress to the inflammatory response. Nature (2008) 7.17
The impact of the unfolded protein response on human disease. J Cell Biol (2012) 4.36
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci U S A (2008) 3.58
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med (2010) 3.48
Targeting the unfolded protein response in disease. Nat Rev Drug Discov (2013) 3.37
ER stress-induced cell death mechanisms. Biochim Biophys Acta (2013) 3.07
Cellular stress responses: cell survival and cell death. Int J Cell Biol (2010) 2.74
Regulation of basal cellular physiology by the homeostatic unfolded protein response. J Cell Biol (2010) 2.40
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J Neurosci (2012) 2.35
Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem (2012) 2.10
Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron (2012) 1.97
Clinical progression in Parkinson disease and the neurobiology of axons. Ann Neurol (2010) 1.88
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration. PLoS One (2015) 1.55
Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Proc Natl Acad Sci U S A (2006) 1.51
Stressing out the ER: a role of the unfolded protein response in prion-related disorders. Curr Mol Med (2006) 1.49
Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps. Apoptosis (2009) 1.43
Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease? Front Neuroanat (2016) 1.39
Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration. Ann Neurol (2011) 1.38
Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. J Neurosci (2011) 1.28
Loss of mitofusin 2 promotes endoplasmic reticulum stress. J Biol Chem (2012) 1.28
AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth. Mol Ther (2011) 1.25
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling. J Cell Mol Med (2008) 1.24
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS One (2012) 1.18
Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease. Pharmacol Ther (2007) 1.17
Mechanisms of alcohol-induced endoplasmic reticulum stress and organ injuries. Biochem Res Int (2011) 1.14
The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells. Diabetes Obes Metab (2010) 1.14
Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjögren syndrome. Hum Mol Genet (2010) 1.13
Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo. J Neurosci (2008) 1.12
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1. Proc Natl Acad Sci U S A (2014) 1.11
JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration. J Neurochem (2008) 1.11
The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem (2010) 1.09
Ethanol promotes endoplasmic reticulum stress-induced neuronal death: involvement of oxidative stress. J Neurosci Res (2008) 1.06
Programmed cell death in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.04
Nerve growth factor improves functional recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis in rats with spinal cord injury. J Transl Med (2014) 1.01
Thiamine deficiency induces endoplasmic reticulum stress in neurons. Neuroscience (2006) 1.01
Potential for therapeutic manipulation of the UPR in disease. Semin Immunopathol (2013) 0.99
Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response. Mol Pharmacol (2012) 0.98
The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins. Hum Mol Genet (2011) 0.94
Programmed cell death and new discoveries in the genetics of parkinsonism. J Neurochem (2007) 0.94
Brain-derived neurotrophic factor suppresses tunicamycin-induced upregulation of CHOP in neurons. J Neurosci Res (2007) 0.93
The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration. Front Cell Dev Biol (2016) 0.91
C/EBP homologous protein (CHOP) mediates neuronal apoptosis in rats with spinal cord injury. Exp Ther Med (2012) 0.89
Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. Proc Natl Acad Sci U S A (2016) 0.89
Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders. Autophagy (2016) 0.88
Ablation of the proapoptotic genes CHOP or Ask1 does not prevent or delay loss of visual function in a P23H transgenic mouse model of retinitis pigmentosa. PLoS One (2014) 0.88
ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson's disease. PLoS One (2012) 0.87
Sequential and concerted gene expression changes in a chronic in vitro model of parkinsonism. Neuroscience (2008) 0.87
Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration. Front Aging Neurosci (2012) 0.87
6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death. Mol Neurodegener (2011) 0.86
Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes. Mol Cancer Res (2011) 0.86
Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules. J Neurosci (2016) 0.86
Chemical stress induces the unfolded protein response in olfactory sensory neurons. J Comp Neurol (2010) 0.85
Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal Degeneration. J Ophthalmic Vis Res (2012) 0.84
Endoplasmic reticulum stress response in yeast and humans. Biosci Rep (2014) 0.83
Intracellular signalling pathways in dopamine cell death and axonal degeneration. Prog Brain Res (2010) 0.83
Tunicamycin-induced unfolded protein response in the developing mouse brain. Toxicol Appl Pharmacol (2015) 0.82
Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1. Cell Death Dis (2013) 0.82
Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. J Neurochem (2011) 0.81
The role of ER stress in lipid metabolism and lipotoxicity. J Lipid Res (2016) 0.81
Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models. J Neurosci (2015) 0.80
Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. J Neurosci (2016) 0.79
Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations. Brain Res (2016) 0.79
ER proteostasis disturbances in Parkinson's disease: novel insights. Front Aging Neurosci (2015) 0.78
Effect of cabergoline on increase of several ER stress-related molecules in 6-OHDA-lesioned mice. Neurol Sci (2012) 0.78
Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease. FEBS Lett (2015) 0.78
Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease. Am J Transl Res (2014) 0.78
Chop Deficiency Protects Mice Against Bleomycin-induced Pulmonary Fibrosis by Attenuating M2 Macrophage Production. Mol Ther (2016) 0.77
Inhibition of Endoplasmic Reticulum Stress is Involved in the Neuroprotective Effect of bFGF in the 6-OHDA-Induced Parkinson's Disease Model. Aging Dis (2016) 0.77
Role of Endoplasmic Reticulum Stress and Unfolded Protein Responses in Health and Diseases. Indian J Clin Biochem (2015) 0.77
ER Stress Induced by Tunicamycin Triggers α-Synuclein Oligomerization, Dopaminergic Neurons Death and Locomotor Impairment: a New Model of Parkinson's Disease. Mol Neurobiol (2016) 0.75
ER stress and the unfolded protein response in neurodegeneration. Nat Rev Neurol (2017) 0.75
Endoplasmic reticulum membrane potassium channel dysfunction in high fat diet induced stress in rat hepatocytes. EXCLI J (2014) 0.75
C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis. Lab Invest (2016) 0.75
C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease. Oncotarget (2016) 0.75
Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress. J Am Heart Assoc (2017) 0.75
Physiological/pathological ramifications of transcription factors in the unfolded protein response. Genes Dev (2017) 0.75
Lipidomics reveals accumulation of the oxidized cholesterol in erythrocytes of heart failure patients. Redox Biol (2017) 0.75
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature (1998) 21.49
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A (1976) 21.06
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature (2002) 16.52
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev (1999) 13.24
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev (1998) 11.86
Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ (2004) 9.96
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet (2000) 7.83
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev (1992) 7.66
The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J (1998) 6.37
Cell death during development of the nervous system. Annu Rev Neurosci (1991) 6.37
Apoptosis in the nervous system. Nature (2000) 5.82
Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J Comp Neurol (1996) 4.42
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell (2001) 4.41
Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol (2000) 4.17
Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J Cell Biol (1988) 4.06
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem (2000) 3.86
Identification of novel stress-induced genes downstream of chop. EMBO J (1998) 2.93
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci (2002) 2.83
Role and regulation of the ER chaperone BiP. Semin Cell Dev Biol (1999) 2.81
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proc Natl Acad Sci U S A (2003) 2.74
Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration (1995) 2.71
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett (1996) 2.53
Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience (1994) 2.40
Pharmacological actions of 6-hydroxydopamine. Pharmacol Rev (1974) 2.32
Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci (2003) 2.31
The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety. J Neurochem (2001) 2.18
In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience (1997) 2.07
Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J Biol Chem (2003) 2.02
Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proc Natl Acad Sci U S A (2000) 1.97
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J Biol Chem (1974) 1.90
The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann Neurol (1992) 1.89
Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels. J Biol Chem (1997) 1.82
Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science (1984) 1.72
Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J Biol Chem (2002) 1.68
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. J Neurosci (2001) 1.64
Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element. Biochem J (1996) 1.62
Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Exp Cell Res (2001) 1.54
The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease. Ann N Y Acad Sci (2003) 1.53
Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes. Dev Biol (1990) 1.46
Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis. J Neurosci (2001) 1.31
Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism. Neurology (1996) 1.26
Medial forebrain bundle axotomy during development induces apoptosis in dopamine neurons of the substantia nigra and activation of caspases in their degenerating axons. J Comp Neurol (2002) 1.23
Regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal glial cell line-derived neurotrophic factor in vivo. J Neurosci (2003) 1.12
Induction of CHOP and apoptosis by nitric oxide in p53-deficient microglial cells. FEBS Lett (2001) 1.10
Analysis of gene expression changes in a cellular model of Parkinson disease. Neurobiol Dis (2005) 1.08
6-Hydroxydopamine: evidence for superoxide radical as an oxidative intermediate. Science (1973) 1.07
Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response. FEBS Lett (1999) 1.07
Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II. Mol Cell Biol (1995) 1.06
The time course of developmental cell death in phenotypically defined dopaminergic neurons of the substantia nigra. Brain Res Dev Brain Res (1997) 0.99
Early developmental destruction of terminals in the striatal target induces apoptosis in dopamine neurons of the substantia nigra. J Neurosci (1997) 0.98
CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6-hydroxydopamine. J Neurochem (2004) 0.93
Induction of glucose-regulated protein (glucose-regulated protein 78/BiP and glucose-regulated protein 94) and heat shock protein 70 transcripts in the immature rat brain following status epilepticus. Neuroscience (1996) 0.92
Naturally Occurring Cell Death during Postnatal Development of the Substantia Nigra Pars Compacta of Rat. Mol Cell Neurosci (1993) 0.91
Acute and persistent suppression of preproenkephalin mRNA expression in the striatum following developmental hypoxic-ischemic injury. J Neurochem (1994) 0.91
Induction of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling. Endocrinology (2001) 0.90
Activation of caspase-3 in developmental models of programmed cell death in neurons of the substantia nigra. J Neurochem (1999) 0.90
Immunochemical demonstration of reversible reduction in choline acetyltransferase concentration in rat hypoglossal nucleus after hypoglossal nerve transection. Nature (1978) 0.90
Apoptosis in substantia nigra following developmental striatal excitotoxic injury. Proc Natl Acad Sci U S A (1994) 0.86
The expression of mRNAs for the proteasome complex is developmentally regulated in the rat mesencephalon. Brain Res Dev Brain Res (2001) 0.85
Distinct nuclear and cytoplasmic localization of caspase cleavage products in two models of induced apoptotic death in dopamine neurons of the substantia nigra. Exp Neurol (2002) 0.84
Stereotaxic electrode placement in the neonatal rat. J Neurosci Methods (1979) 0.82
Transneuronal degeneration in substantia nigra pars reticulata following striatal excitotoxic injury in adult rat: time-course, distribution, and morphology of cell death. Neuroscience (1996) 0.82
Genes associated with pro-apoptotic and protective mechanisms are affected differently on exposure of neuronal cell cultures to arsenite. No indication for endoplasmic reticulum stress despite activation of grp78 and gadd153 expression. Brain Res Mol Brain Res (2002) 0.81
Apoptotic neuron death in rat substantia nigra induced by striatal excitotoxic injury is developmentally dependent. Neurosci Lett (1996) 0.79
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature (2002) 16.52
The unfolded protein response: from stress pathway to homeostatic regulation. Science (2011) 15.71
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
Parkinson's disease: mechanisms and models. Neuron (2003) 14.84
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev (2004) 9.24
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci (2007) 7.77
Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol (2002) 6.48
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature (2004) 6.37
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol (2003) 6.34
Endoplasmic reticulum stress signaling in disease. Physiol Rev (2006) 5.90
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol (2004) 5.44
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature (2011) 4.92
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity (2005) 4.53
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol (2007) 4.45
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci (2002) 4.38
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest (2008) 4.30
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature (2002) 4.21
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest (2010) 3.91
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J (2005) 3.79
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J (2004) 3.77
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J (2010) 3.76
The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A (2008) 3.65
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol (2004) 3.57
Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab (2009) 3.51
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab (2008) 3.45
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci (2004) 3.31
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science (2011) 3.29
Stress-induced gene expression requires programmed recovery from translational repression. EMBO J (2003) 3.26
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell (2010) 3.26
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest (2008) 3.23
The mitochondrial UPR - protecting organelle protein homeostasis. J Cell Sci (2010) 3.06
Mitochondria: the next (neurode)generation. Neuron (2011) 3.06
Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc (2007) 3.00
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 3.00
Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice. Neuron (2008) 2.95
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci U S A (2002) 2.93
NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci U S A (2003) 2.91
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A (2007) 2.87
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci (2002) 2.83
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proc Natl Acad Sci U S A (2003) 2.74
Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes (2002) 2.74
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell (2010) 2.74
A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. J Cell Biol (2002) 2.72
Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol (2004) 2.68
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature (2005) 2.67
Toxin-induced models of Parkinson's disease. NeuroRx (2005) 2.67
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol (2009) 2.66
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proc Natl Acad Sci U S A (2002) 2.64
Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Am J Physiol Cell Physiol (2002) 2.62
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell (2007) 2.61
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab (2006) 2.55
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell (2006) 2.54
Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Mol Cell (2010) 2.51
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A (2012) 2.45
Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol (2009) 2.42
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A (2009) 2.37
Targeting programmed cell death in neurodegenerative diseases. Nat Rev Neurosci (2003) 2.31
Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One (2009) 2.30
Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics (2006) 2.29
Pitx3 is required for development of substantia nigra dopaminergic neurons. Proc Natl Acad Sci U S A (2003) 2.27
D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. J Clin Invest (2003) 2.25
Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation. J Neurosci (2004) 2.22
Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci U S A (2009) 2.22
Malignant pheochromocytoma: current status and initiatives for future progress. Endocr Relat Cancer (2004) 2.20
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol Cell Biol (2006) 2.16
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol (2003) 2.15
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci (2010) 2.15
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proc Natl Acad Sci U S A (2006) 2.10
Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol (2004) 2.10
Paneth cells as a site of origin for intestinal inflammation. Nature (2013) 2.09
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 2.05
Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02
Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 2.01
Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PLoS One (2008) 1.99
Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med (2012) 1.99
Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci (2008) 1.92
The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91
The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proc Natl Acad Sci U S A (2006) 1.90
Clinical progression in Parkinson disease and the neurobiology of axons. Ann Neurol (2010) 1.88