Published in Tissue Eng Part B Rev on June 01, 2010
Modeling Ewing sarcoma tumors in vitro with 3D scaffolds. Proc Natl Acad Sci U S A (2013) 1.23
Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model. Clin Exp Metastasis (2013) 1.18
Advanced cell culture techniques for cancer drug discovery. Biology (Basel) (2014) 1.01
Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities. Crit Rev Biomed Eng (2012) 1.00
Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges. Cell (2015) 0.99
Evaluation of chemotherapeutics in a three-dimensional breast cancer model. J Cancer Res Clin Oncol (2015) 0.95
Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS One (2012) 0.90
Cancer research by means of tissue engineering--is there a rationale? J Cell Mol Med (2013) 0.88
Hydrogels to model 3D in vitro microenvironment of tumor vascularization. Adv Drug Deliv Rev (2014) 0.85
Microengineered tumor models: insights & opportunities from a physical sciences-oncology perspective. Biomed Microdevices (2013) 0.84
A spheroid-based 3-D culture model for pancreatic cancer drug testing, using the acid phosphatase assay. Braz J Med Biol Res (2013) 0.84
Hydrogel-based 3D model of patient-derived prostate xenograft tumors suitable for drug screening. Mol Pharm (2014) 0.83
An update to space biomedical research: tissue engineering in microgravity bioreactors. Bioimpacts (2012) 0.83
Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer models. Biomatter (2014) 0.81
Cancer Tissue Engineering: A Novel 3D Polystyrene Scaffold for In Vitro Isolation and Amplification of Lymphoma Cancer Cells from Heterogeneous Cell Mixtures. J Tissue Eng (2011) 0.81
Development of three-dimensional lung multicellular spheroids in air- and liquid-interface culture for the evaluation of anticancer therapeutics. Int J Oncol (2016) 0.79
Flow Cytometry: Impact on Early Drug Discovery. J Biomol Screen (2015) 0.78
Prostate cancer xenografts engineered from 3D precision-porous poly(2-hydroxyethyl methacrylate) hydrogels as models for tumorigenesis and dormancy escape. Biomaterials (2014) 0.78
Mouse Models in Prostate Cancer Translational Research: From Xenograft to PDX. Biomed Res Int (2016) 0.78
Toward 3D biomimetic models to understand the behavior of glioblastoma multiforme cells. Tissue Eng Part B Rev (2013) 0.77
In vivo microdialysis sampling of adipokines CCL2, IL-6, and leptin in the mammary fat pad of adult female rats. Mol Biosyst (2014) 0.77
Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model. Theranostics (2016) 0.77
Capillary force seeding of sphere-templated hydrogels for tissue-engineered prostate cancer xenografts. Tissue Eng Part C Methods (2013) 0.77
The effect of primary cancer cell culture models on the results of drug chemosensitivity assays: the application of perfusion microbioreactor system as cell culture vessel. Biomed Res Int (2015) 0.77
Poly(vinyl alcohol)/gelatin Hydrogels Cultured with HepG2 Cells as a 3D Model of Hepatocellular Carcinoma: A Morphological Study. J Funct Biomater (2015) 0.77
The efficacy of cetuximab in a tissue-engineered three-dimensional in vitro model of colorectal cancer. J Tissue Eng (2014) 0.76
Tissue-Engineered Model of Human Osteolytic Bone Tumor. Tissue Eng Part C Methods (2017) 0.75
Bioengineering Models for Breast Cancer Research. Breast Cancer (Auckl) (2016) 0.75
3D Cell Culture in Alginate Hydrogels. Microarrays (Basel) (2015) 0.75
Advances in multicellular spheroids formation. J R Soc Interface (2017) 0.75
Bioreactor-Based Tumor Tissue Engineering. Acta Naturae (2016) 0.75
Human Organotypic Lung Tumor Models: Suitable For Preclinical 18F-FDG PET-Imaging. PLoS One (2016) 0.75
Coaxial 3D bioprinting of self-assembled multicellular heterogeneous tumor fibers. Sci Rep (2017) 0.75
Rheological characterization of an injectable alginate gel system. BMC Biotechnol (2015) 0.75
Mineral particles modulate osteo-chondrogenic differentiation of embryonic stem cell aggregates. Acta Biomater (2015) 0.75
Colony, hanging drop, and methylcellulose three dimensional hypoxic growth optimization of renal cell carcinoma cell lines. Cytotechnology (2017) 0.75
Targeting multidrug resistance in cancer. Nat Rev Drug Discov (2006) 10.55
Electrospinning of polymeric nanofibers for tissue engineering applications: a review. Tissue Eng (2006) 4.53
Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration. Biomacromolecules (2006) 3.01
Biomimetic materials for tissue engineering. Biomaterials (2003) 2.87
Strategic directions in tissue engineering. Tissue Eng (2007) 2.70
Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces. Proc Natl Acad Sci U S A (2003) 2.42
Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release (2005) 2.32
Thermoresponsive hydrogels in biomedical applications. Eur J Pharm Biopharm (2007) 2.25
Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc Natl Acad Sci U S A (2002) 2.24
Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model. Bone (2008) 2.19
A stromal gene signature associated with inflammatory breast cancer. Int J Cancer (2008) 2.18
In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation. Proc Natl Acad Sci U S A (2006) 2.03
Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells. BMC Cell Biol (2008) 2.00
Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial. Lancet Oncol (2013) 1.99
Injectable matrices and scaffolds for drug delivery in tissue engineering. Adv Drug Deliv Rev (2007) 1.97
Modulation of the inflammatory response for enhanced bone tissue regeneration. Tissue Eng Part B Rev (2008) 1.92
Tissue engineering of bone: material and matrix considerations. J Bone Joint Surg Am (2008) 1.91
Effect of bone extracellular matrix synthesized in vitro on the osteoblastic differentiation of marrow stromal cells. Biomaterials (2005) 1.85
Tissue engineering strategies for bone regeneration. Adv Biochem Eng Biotechnol (2005) 1.80
Design of a flow perfusion bioreactor system for bone tissue-engineering applications. Tissue Eng (2003) 1.79
Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials (2007) 1.78
Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering. J Control Release (2005) 1.68
Fabrication of porous ultra-short single-walled carbon nanotube nanocomposite scaffolds for bone tissue engineering. Biomaterials (2007) 1.67
Dose effect of dual delivery of vascular endothelial growth factor and bone morphogenetic protein-2 on bone regeneration in a rat critical-size defect model. Tissue Eng Part A (2009) 1.67
Ewing's sarcoma: standard and experimental treatment options. Curr Treat Options Oncol (2009) 1.66
Delivery of TGF-beta1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications. Biomaterials (2005) 1.63
Single-dose palifermin prevents severe oral mucositis during multicycle chemotherapy in patients with cancer: a randomized trial. Ann Intern Med (2010) 1.62
Flow perfusion culture induces the osteoblastic differentiation of marrow stroma cell-scaffold constructs in the absence of dexamethasone. J Biomed Mater Res A (2005) 1.61
Injectable biomaterials for regenerating complex craniofacial tissues. Adv Mater (2009) 1.60
Use of stereolithography to manufacture critical-sized 3D biodegradable scaffolds for bone ingrowth. J Biomed Mater Res B Appl Biomater (2003) 1.59
Osteochondral repair in the rabbit model utilizing bilayered, degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds. J Biomed Mater Res A (2005) 1.58
Strategies for controlled delivery of growth factors and cells for bone regeneration. Adv Drug Deliv Rev (2012) 1.57
Engineering complex tissues. Sci Transl Med (2012) 1.54
Photocrosslinking characteristics and mechanical properties of diethyl fumarate/poly(propylene fumarate) biomaterials. Biomaterials (2002) 1.52
In vitro release of transforming growth factor-beta 1 from gelatin microparticles encapsulated in biodegradable, injectable oligo(poly(ethylene glycol) fumarate) hydrogels. J Control Release (2003) 1.52
Nanobiomaterial applications in orthopedics. J Orthop Res (2007) 1.51
Evaluation of bone regeneration using the rat critical size calvarial defect. Nat Protoc (2012) 1.51
Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor. Cancer (2011) 1.50
Effect of initial cell seeding density on early osteogenic signal expression of rat bone marrow stromal cells cultured on cross-linked poly(propylene fumarate) disks. Biomacromolecules (2009) 1.48
Bioactive poly(L-lactic acid) conduits seeded with Schwann cells for peripheral nerve regeneration. Biomaterials (2002) 1.47
Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor. J Biomed Mater Res (2002) 1.46
Transforming growth factor-beta 1 release from oligo(poly(ethylene glycol) fumarate) hydrogels in conditions that model the cartilage wound healing environment. J Control Release (2004) 1.45
Thermally cross-linked oligo(poly(ethylene glycol) fumarate) hydrogels support osteogenic differentiation of encapsulated marrow stromal cells in vitro. Biomacromolecules (2004) 1.45
Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2. Acta Biomater (2008) 1.43
Osteogenic differentiation of mesenchymal stem cells on pregenerated extracellular matrix scaffolds in the absence of osteogenic cell culture supplements. Tissue Eng Part A (2010) 1.38
Harnessing and modulating inflammation in strategies for bone regeneration. Tissue Eng Part B Rev (2011) 1.37
In vivo biocompatibility of ultra-short single-walled carbon nanotube/biodegradable polymer nanocomposites for bone tissue engineering. Bone (2008) 1.35
Review: mineralization of synthetic polymer scaffolds for bone tissue engineering. Tissue Eng (2007) 1.35
Effect of poly(ethylene glycol) molecular weight on tensile and swelling properties of oligo(poly(ethylene glycol) fumarate) hydrogels for cartilage tissue engineering. J Biomed Mater Res (2002) 1.34
Pre-culture period of mesenchymal stem cells in osteogenic media influences their in vivo bone forming potential. J Biomed Mater Res A (2007) 1.34
Universal marker and detection tool for human sarcoma circulating tumor cells. Cancer Res (2014) 1.34
In vitro osteogenic differentiation of marrow stromal cells encapsulated in biodegradable hydrogels. J Biomed Mater Res A (2004) 1.32
Soft and hard tissue response to photocrosslinked poly(propylene fumarate) scaffolds in a rabbit model. J Biomed Mater Res (2002) 1.31
Kinetics of poly(propylene fumarate) synthesis by step polymerization of diethyl fumarate and propylene glycol using zinc chloride as a catalyst. J Biomater Sci Polym Ed (2002) 1.30
Flow perfusion enhances the calcified matrix deposition of marrow stromal cells in biodegradable nonwoven fiber mesh scaffolds. Ann Biomed Eng (2005) 1.29
In vitro cytotoxicity of injectable and biodegradable poly(propylene fumarate)-based networks: unreacted macromers, cross-linked networks, and degradation products. Biomacromolecules (2003) 1.29
The influence of an in vitro generated bone-like extracellular matrix on osteoblastic gene expression of marrow stromal cells. Biomaterials (2008) 1.29
Modeling Ewing sarcoma tumors in vitro with 3D scaffolds. Proc Natl Acad Sci U S A (2013) 1.23
Influence of the porosity of starch-based fiber mesh scaffolds on the proliferation and osteogenic differentiation of bone marrow stromal cells cultured in a flow perfusion bioreactor. Tissue Eng (2006) 1.23
Injectable nanocomposites of single-walled carbon nanotubes and biodegradable polymers for bone tissue engineering. Biomacromolecules (2006) 1.23
Modulation of differentiation and mineralization of marrow stromal cells cultured on biomimetic hydrogels modified with Arg-Gly-Asp containing peptides. J Biomed Mater Res A (2004) 1.22
Modulation of marrow stromal osteoblast adhesion on biomimetic oligo[poly(ethylene glycol) fumarate] hydrogels modified with Arg-Gly-Asp peptides and a poly(ethyleneglycol) spacer. J Biomed Mater Res (2002) 1.22
Angiogenesis with biomaterial-based drug- and cell-delivery systems. J Biomater Sci Polym Ed (2004) 1.21
In vitro and in vivo release of vascular endothelial growth factor from gelatin microparticles and biodegradable composite scaffolds. Pharm Res (2008) 1.21
Modulation of osteogenic properties of biodegradable polymer/extracellular matrix scaffolds generated with a flow perfusion bioreactor. Acta Biomater (2010) 1.21
Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model. Acta Biomater (2009) 1.21
Synthesis of poly(propylene fumarate). Nat Protoc (2009) 1.20
Effect of flow perfusion on the osteogenic differentiation of bone marrow stromal cells cultured on starch-based three-dimensional scaffolds. J Biomed Mater Res A (2003) 1.20
In vivo bone and soft tissue response to injectable, biodegradable oligo(poly(ethylene glycol) fumarate) hydrogels. Biomaterials (2003) 1.19
Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites. J Biomed Mater Res A (2009) 1.18
Effect of swelling ratio of injectable hydrogel composites on chondrogenic differentiation of encapsulated rabbit marrow mesenchymal stem cells in vitro. Biomacromolecules (2009) 1.18
Synthesis and characterization of injectable, thermally and chemically gelable, amphiphilic poly(N-isopropylacrylamide)-based macromers. Biomacromolecules (2008) 1.18
Osteogenic differentiation of rat bone marrow stromal cells cultured on Arg-Gly-Asp modified hydrogels without dexamethasone and beta-glycerol phosphate. Biomaterials (2005) 1.17
Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. J Med Chem (2009) 1.17
Enhanced chondrogenesis in co-cultures with articular chondrocytes and mesenchymal stem cells. Biomaterials (2012) 1.17
Bioactive polymer/extracellular matrix scaffolds fabricated with a flow perfusion bioreactor for cartilage tissue engineering. Biomaterials (2010) 1.16
In vitro localization of bone growth factors in constructs of biodegradable scaffolds seeded with marrow stromal cells and cultured in a flow perfusion bioreactor. Tissue Eng (2006) 1.15
In vitro generation of an osteochondral construct using injectable hydrogel composites encapsulating rabbit marrow mesenchymal stem cells. Biomaterials (2009) 1.13
Attachment, proliferation, and migration of marrow stromal osteoblasts cultured on biomimetic hydrogels modified with an osteopontin-derived peptide. Biomaterials (2004) 1.13
Uncultured marrow mononuclear cells delivered within fibrin glue hydrogels to porous scaffolds enhance bone regeneration within critical-sized rat cranial defects. Tissue Eng Part A (2010) 1.12
Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds. Osteoarthritis Cartilage (2005) 1.11
In vitro degradation of polymeric networks of poly(propylene fumarate) and the crosslinking macromer poly(propylene fumarate)-diacrylate. Biomaterials (2003) 1.11
Two-dimensional nanostructure-reinforced biodegradable polymeric nanocomposites for bone tissue engineering. Biomacromolecules (2013) 1.11
The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds. Biomaterials (2013) 1.10