Published in J Pharmacol Exp Ther on January 21, 2010
Inhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injury. J Urol (2012) 1.05
Understanding and targeting the Rho kinase pathway in erectile dysfunction. Nat Rev Urol (2014) 0.93
Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1. Hypertension (2011) 0.87
Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation. J Sex Med (2013) 0.84
Smooth muscle specific Rac1 deficiency induces hypertension by preventing p116RIP3-dependent RhoA inhibition. J Am Heart Assoc (2014) 0.83
Sickling cells, cyclic nucleotides, and protein kinases: the pathophysiology of urogenital disorders in sickle cell anemia. Anemia (2012) 0.76
Impaired Corpus Cavernosum Relaxation Is Accompanied by Increased Oxidative Stress and Up-Regulation of the Rho-Kinase Pathway in Diabetic (Db/Db) Mice. PLoS One (2016) 0.75
Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol (2004) 3.18
RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proc Natl Acad Sci U S A (2004) 2.53
Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem (2003) 2.28
Pharmacology of penile erection. Pharmacol Rev (2001) 1.91
Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med (2001) 1.87
Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase beta. Int J Impot Res (2003) 1.85
Physiology of penile erection and pathophysiology of erectile dysfunction. Urol Clin North Am (2005) 1.81
Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension. Circ J (2009) 1.77
Cellular regulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol (2001) 1.77
Smooth muscle contraction and relaxation. Adv Physiol Educ (2003) 1.67
The role of the RhoA/Rho-kinase signaling pathway in renal vascular reactivity in endothelial nitric oxide synthase null mice. J Hypertens (2006) 1.50
cGMP-dependent protein kinase phosphorylates and inactivates RhoA. Biochem Biophys Res Commun (2001) 1.37
Activation of myosin light chain phosphatase in intact arterial smooth muscle during nitric oxide-induced relaxation. J Biol Chem (2001) 1.31
RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling. Am J Respir Crit Care Med (2009) 1.28
RhoA-mediated Ca2+ sensitization in erectile function. J Biol Chem (2002) 1.25
Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling. Hypertension (2002) 1.24
Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction. FASEB J (2006) 1.19
Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats. J Hypertens (2007) 1.10
Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum. Br J Pharmacol (2001) 1.03
Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation. J Appl Physiol (1985) (2001) 1.02
RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights. Clin Sci (Lond) (2006) 0.99
Human and rabbit cavernosal smooth muscle cells express Rho-kinase. Int J Impot Res (2002) 0.93
Neurophysiological basis of penile erection. Acta Pharmacol Sin (2007) 0.90
Nitrergic-noradrenergic interaction in penile erection: a new insight into erectile dysfunction. Drugs Today (Barc) (2003) 0.85
Increased corpus cavernosum smooth muscle tone associated with partial bladder outlet obstruction is mediated via Rho-kinase. Am J Physiol Regul Integr Comp Physiol (2005) 0.85
Proerectile effects of the Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the rat penis. J Pharmacol Exp Ther (2005) 0.85
Long term partial bladder outlet obstruction induced contractile dysfunction in male rabbits: a role for Rho-kinase. Neurourol Urodyn (2007) 0.84
Expression and functional role of the RhoA/Rho-kinase pathway in rat coeliac artery. Clin Exp Pharmacol Physiol (2005) 0.83
Inhibition of tonic contraction--a novel way to approach erectile dysfunction. J Androl (2002) 0.81
Molecular Yin and Yang of erectile function and dysfunction. Asian J Androl (2008) 0.80
Release of endothelial nitric oxide in coronary arteries by celiprolol, a beta(1)-adrenoceptor antagonist: possible clinical relevance. Eur J Pharmacol (2001) 0.77
RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proc Natl Acad Sci U S A (2004) 2.53
Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation (2011) 2.52
Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol (2011) 2.23
Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. Arterioscler Thromb Vasc Biol (2008) 1.97
Effect of early particulate air pollution exposure on obesity in mice: role of p47phox. Arterioscler Thromb Vasc Biol (2010) 1.88
Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta. Am J Physiol Heart Circ Physiol (2004) 1.86
Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res (2011) 1.83
Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats. Biochem Biophys Res Commun (2002) 1.53
Oxidative stress impairs vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats. Am J Hypertens (2009) 1.48
The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries. Crit Care Med (2009) 1.48
Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats. Clin Sci (Lond) (2009) 1.47
Perivascular adipose tissue: more than just structural support. Clin Sci (Lond) (2012) 1.29
Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling. Hypertension (2002) 1.24
RhoA/Rho-kinase and vascular diseases: what is the link? Cell Mol Life Sci (2010) 1.24
Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats. Clin Sci (Lond) (2012) 1.23
Cardiovascular remodeling in response to long-term exposure to fine particulate matter air pollution. Circ Heart Fail (2012) 1.20
Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction to Angiotensin II and Endothelin-1. J Am Soc Hypertens (2010) 1.18
Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive rats. J Pharmacol Exp Ther (2006) 1.18
Increased activation of stromal interaction molecule-1/Orai-1 in aorta from hypertensive rats: a novel insight into vascular dysfunction. Hypertension (2008) 1.15
Cigarette smoking and erectile dysfunction: focus on NO bioavailability and ROS generation. J Sex Med (2008) 1.15
Hypertensive response to acute stress is attenuated in interleukin-6 knockout mice. Hypertension (2004) 1.14
Reduced expression of SKCa and IKCa channel proteins in rat small mesenteric arteries during angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol (2007) 1.14
Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature. Hypertension (2004) 1.14
Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats. Am J Physiol Regul Integr Comp Physiol (2004) 1.13
PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA. Arterioscler Thromb Vasc Biol (2009) 1.12
Vasoactive factors in sickle cell disease: in vitro evidence for endothelin-1-mediated vasoconstriction. Am J Hematol (2004) 1.11
Molecular aspects of arterial smooth muscle contraction: focus on Rho. Exp Biol Med (Maywood) (2005) 1.11
Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats. J Hypertens (2007) 1.10
Impaired vasodilator activity in deoxycorticosterone acetate-salt hypertension is associated with increased protein O-GlcNAcylation. Hypertension (2009) 1.09
Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension. Am J Physiol Heart Circ Physiol (2013) 1.08
Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways. Vascul Pharmacol (2011) 1.07
Sympathetic and angiotensin-dependent hypertension during cage-switch stress in mice. Am J Physiol Regul Integr Comp Physiol (2004) 1.07
Mitochondrial damage-associated molecular patterns and vascular function. Eur Heart J (2014) 1.06
Altered vascular reactivity in mice made hypertensive by nitric oxide synthase inhibition. J Cardiovasc Pharmacol (2005) 1.05
Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice. Environ Health Perspect (2013) 1.05
Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility. Genesis (2004) 1.05
Angiotensin II up-regulates the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF), a regulator of G protein signaling domain-containing RhoGEF, in vascular smooth muscle cells. Mol Pharmacol (2005) 1.03
Dynamic association of nitric oxide downstream signaling molecules with endothelial caveolin-1 in rat aorta. J Pharmacol Exp Ther (2005) 1.02
Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes. Cardiovasc Res (2009) 1.00
Arginase II deletion increases corpora cavernosa relaxation in diabetic mice. J Sex Med (2010) 1.00
The influence of perivascular adipose tissue on vascular homeostasis. Vasc Health Risk Manag (2013) 1.00
Differential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta. J Pharmacol Exp Ther (2005) 0.99
Mechanisms underlying relaxation of rabbit aorta by BAY 41-2272, a nitric oxide-independent soluble guanylate cyclase activator. Clin Exp Pharmacol Physiol (2005) 0.99
Regional heterogeneity in acetylcholine-induced relaxation in rat vascular bed: role of calcium-activated K+ channels. Am J Physiol Heart Circ Physiol (2006) 0.98
Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia. Clin Sci (Lond) (2012) 0.98
Extracellular signal-regulated kinase 1/2 activation, via downregulation of mitogen-activated protein kinase phosphatase 1, mediates sex differences in desoxycorticosterone acetate-salt hypertension vascular reactivity. Hypertension (2009) 0.97
Interleukin-10 inhibits the in vivo and in vitro adverse effects of TNF-alpha on the endothelium of murine aorta. Am J Physiol Heart Circ Physiol (2010) 0.97
Interleukin-10 counteracts impaired endothelium-dependent relaxation induced by ANG II in murine aortic rings. Am J Physiol Heart Circ Physiol (2007) 0.97
Endoplasmic reticulum stress contributes to aortic stiffening via proapoptotic and fibrotic signaling mechanisms. Hypertension (2013) 0.96
O-GlcNAcylation contributes to augmented vascular reactivity induced by endothelin 1. Hypertension (2009) 0.96
Epidemiological and experimental links between air pollution and type 2 diabetes. Toxicol Pathol (2012) 0.96
Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol (2013) 0.95
Endothelin, sex and hypertension. Clin Sci (Lond) (2008) 0.95
NADPH oxidase activation: a mechanism of hypertension-associated erectile dysfunction. J Sex Med (2008) 0.95
Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise. Eur J Appl Physiol (2008) 0.95
Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet. Part Fibre Toxicol (2013) 0.94
Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat. Neuroendocrinology (2003) 0.93
O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway. Cardiovasc Res (2010) 0.92
Increased vascular O-GlcNAcylation augments reactivity to constrictor stimuli - VASOACTIVE PEPTIDE SYMPOSIUM. J Am Soc Hypertens (2010) 0.92
Rho-kinase inhibition reduces pressure-mediated autoregulatory adjustments in afferent arteriolar diameter. Am J Physiol Renal Physiol (2009) 0.91
Heme-dependent and independent soluble guanylate cyclase activators and vasodilation. J Cardiovasc Pharmacol (2010) 0.91
Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Part Fibre Toxicol (2014) 0.91
P2X7 receptor activation amplifies lipopolysaccharide-induced vascular hyporeactivity via interleukin-1 beta release. J Pharmacol Exp Ther (2008) 0.90
Vasorelaxing effect of BAY 41-2272 in rat basilar artery: involvement of cGMP-dependent and independent mechanisms. Hypertension (2006) 0.90
Impaired vasodilation and nitric oxide synthase activity in glucocorticoid-induced hypertension. Biol Res Nurs (2002) 0.90
Neurophysiological basis of penile erection. Acta Pharmacol Sin (2007) 0.90
Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension. Front Immunol (2013) 0.89
Synthesis and pharmacological evaluations of sildenafil analogues for treatment of erectile dysfunction. J Med Chem (2008) 0.89
Determination of adenosine effects and adenosine receptors in murine corpus cavernosum. J Pharmacol Exp Ther (2007) 0.89
O-GlcNAcylation: a novel post-translational mechanism to alter vascular cellular signaling in health and disease: focus on hypertension. J Am Soc Hypertens (2010) 0.89
Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathy. Am J Nephrol (2011) 0.89
Therapeutic targets in hypertension: is there a place for antagonists of the most potent vasoconstrictors? Expert Opin Ther Targets (2008) 0.89
Increaseed expression of mRNA for regulator of G protein signaling domain-containing Rho guanine nucleotide exchange factors in aorta from stroke-prone spontaneously hypertensive rats. Am J Hypertens (2004) 0.89
Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus. Part Fibre Toxicol (2014) 0.89
New insights into hypertension-associated erectile dysfunction. Curr Opin Nephrol Hypertens (2012) 0.89
Angiotensin II utilizes Janus kinase 2 in hypertension, but not in the physiological control of blood pressure, during low-salt intake. Am J Physiol Regul Integr Comp Physiol (2011) 0.89
Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract. Biochem Pharmacol (2007) 0.88
Relaxing effects induced by the soluble guanylyl cyclase stimulator BAY 41-2272 in human and rabbit corpus cavernosum. Eur J Pharmacol (2003) 0.88
Penile erection requires association of soluble guanylyl cyclase with endothelial caveolin-1 in rat corpus cavernosum. Am J Physiol Regul Integr Comp Physiol (2005) 0.88
Erectile dysfunction in young non-obese type II diabetic Goto-Kakizaki rats is associated with decreased eNOS phosphorylation at Ser1177. J Sex Med (2010) 0.88
Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection. Eur J Pharmacol (2002) 0.88
Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse. J Sex Med (2008) 0.88
Regulation on energy metabolism and protection on mitochondria of Panax ginseng polysaccharide. Am J Chin Med (2009) 0.87
Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function. PLoS One (2013) 0.87
Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1. Hypertension (2011) 0.87
Methyl-beta-cyclodextrin prevents angiotensin II-induced tachyphylactic contractile responses in rat aorta. J Pharmacol Exp Ther (2007) 0.86
TNF-alpha infusion impairs corpora cavernosa reactivity. J Sex Med (2009) 0.86
Upregulation of intermediate calcium-activated potassium channels counterbalance the impaired endothelium-dependent vasodilation in stroke-prone spontaneously hypertensive rats. Transl Res (2009) 0.86
Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. Am J Physiol Heart Circ Physiol (2007) 0.86
Ca2+ sensitization and the regulation of contractility in rat anococcygeus and retractor penis muscle. Biochem Pharmacol (2005) 0.85
Uridine adenosine tetraphosphate induces contraction and relaxation in rat aorta. Vascul Pharmacol (2008) 0.85