Published in Am J Pathol on January 21, 2010
From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest (2012) 2.01
Protein kinase C and cancer: what we know and what we do not. Oncogene (2013) 1.09
Protein arginine methyltransferase 5 (PRMT5) signaling suppresses protein kinase Cδ- and p38δ-dependent signaling and keratinocyte differentiation. J Biol Chem (2011) 0.86
The many hats of protein kinase Cδ: one enzyme with many functions. Biochem Soc Trans (2014) 0.79
Repeated Treatments with Ingenol Mebutate Prevents Progression of UV-Induced Photodamage in Hairless Mice. PLoS One (2016) 0.78
Congenital anomalies and rhabdoid tumor associated with 22q11 germline deletion and somatic inactivation of the SMARCB1 tumor suppressor. Genes Chromosomes Cancer (2011) 0.77
Protein kinase C: an attractive target for cancer therapy. Cancers (Basel) (2011) 0.75
Laser-capture microdissection. Nat Protoc (2006) 3.80
Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation. J Biol Chem (1997) 2.55
Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol (1998) 2.15
Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies. Proc Natl Acad Sci U S A (1992) 1.91
Ras gene mutation and amplification in human nonmelanoma skin cancers. Mol Carcinog (1991) 1.70
Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the eta and delta isoforms of protein kinase C. Mol Cell Biol (1998) 1.50
NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell (2006) 1.41
Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta. J Biol Chem (1993) 1.37
Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C. Cell Death Differ (2002) 1.35
Protein kinase C delta. Eur J Biochem (1999) 1.34
Proteins of the ETS family with transcriptional repressor activity. Oncogene (2000) 1.23
Regulation of human involucrin promoter activity by novel protein kinase C isoforms. J Biol Chem (2000) 1.17
Transgenic mice overexpressing protein kinase Cdelta in the epidermis are resistant to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res (1999) 1.11
The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas. Oncogene (2006) 1.11
Androgens regulate protein kinase Cdelta transcription and modulate its apoptotic function in prostate cancer cells. Cancer Res (2006) 1.04
The protein kinase C delta catalytic fragment targets Mcl-1 for degradation to trigger apoptosis. J Biol Chem (2006) 1.04
Role of p53 in UVB-induced apoptosis in human HaCaT keratinocytes. J Invest Dermatol (1997) 1.02
A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis. Cell Death Differ (2005) 1.02
Analysis of protein kinase C delta (PKC delta) expression in endometrial tumors. Hum Pathol (2007) 1.01
Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy. Am J Clin Pathol (2001) 1.01
Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas. Eur Urol (2004) 1.01
Bax activation and induction of apoptosis in human keratinocytes by the protein kinase C delta catalytic domain. J Invest Dermatol (2004) 0.98
Epidermal morphogenesis and keratin expression in c-Ha-ras-transfected tumorigenic clones of the human HaCaT cell line. Cancer Res (1991) 0.97
Cutaneous malignancies and their management. Otolaryngol Clin North Am (2001) 0.93
Genomic structure and promoter analysis of PKC-delta. Genomics (2003) 0.93
YY-1 and c-Jun transcription factors participate in the repression of the human involucrin promoter. Int J Oncol (2005) 0.85
Loss of protein kinase C delta from human HaCaT keratinocytes upon ras transfection is mediated by TGF alpha. Exp Cell Res (1995) 0.84
p63 and p73, members of the p53 gene family, transactivate PKCdelta. Biochem Pharmacol (2006) 0.83
Deletion monitoring in skin tumors by interphase-FISH using band-specific DNA probes. Int J Oncol (1999) 0.81
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer. J Invest Dermatol (1997) 0.81
Activation of the nuclear transcription factor SP-1 by insulin rapidly increases the expression of protein kinase C delta in skeletal muscle. Cell Signal (2006) 0.80
Role for protein kinase C-alpha in keratinocyte growth arrest. J Invest Dermatol (2009) 1.65
Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Res (2006) 1.64
Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. J Cell Biol (2008) 1.47
Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA. Cancer Res (2006) 1.41
Inhibition of PAX3 by TGF-beta modulates melanocyte viability. Mol Cell (2008) 1.26
P21Waf1 control of epithelial cell cycle and cell fate. Crit Rev Oral Biol Med (2002) 1.25
Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration. Mol Carcinog (2010) 1.24
Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes. Oncogene (2002) 1.05
The protein kinase C delta catalytic fragment targets Mcl-1 for degradation to trigger apoptosis. J Biol Chem (2006) 1.04
Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes. J Biol Chem (2002) 1.01
The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling. FASEB J (2010) 1.01
Bax activation and induction of apoptosis in human keratinocytes by the protein kinase C delta catalytic domain. J Invest Dermatol (2004) 0.98
PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration. J Invest Dermatol (2006) 0.95
Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis. Oncogene (2005) 0.93
Activation of protein kinase C triggers irreversible cell cycle withdrawal in human keratinocytes. J Invest Dermatol (2002) 0.93
Life and death signaling pathways contributing to skin cancer. J Investig Dermatol Symp Proc (2002) 0.90
Mcl-1 functions as major epidermal survival protein required for proper keratinocyte differentiation. J Invest Dermatol (2009) 0.87
PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway. Exp Cell Res (2008) 0.86
Low-dose UV-radiation sensitizes keratinocytes to TRAIL-induced apoptosis. J Cell Physiol (2004) 0.85
The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint. J Biol Chem (2009) 0.82
Defining the caspase-containing apoptotic machinery contributing to cornification in human epidermal equivalents. Exp Dermatol (2006) 0.79
Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition. Am J Hematol (2005) 0.78
Role for Id-1 in immunobiology of normal keratinocytes and in basal cell carcinoma. Exp Dermatol (2003) 0.76
Functional alterations in protein kinase C beta II expression in melanoma. Pigment Cell Melanoma Res (2009) 0.75
FYNagling divergent adhesive functions for Fyn in keratinocytes. Exp Dermatol (2014) 0.75
Mouse models of the skin: models to define mechanisms of skin carcinogenesis. J Skin Cancer (2013) 0.75
Evidence from the UK Zoonoses Action Plan in favour of localised anomalies of Salmonella infection on United Kingdom pig farms. Prev Vet Med (2009) 0.75
Long QT2 mutation on the Kv11.1 ion channel inhibits current activity by ablating a protein kinase Cα consensus site. Mol Pharmacol (2012) 0.75